DE2505218A1 - Neue orale roentgenkontrastmittel und verfahren zu ihrer herstellung - Google Patents
Neue orale roentgenkontrastmittel und verfahren zu ihrer herstellungInfo
- Publication number
- DE2505218A1 DE2505218A1 DE19752505218 DE2505218A DE2505218A1 DE 2505218 A1 DE2505218 A1 DE 2505218A1 DE 19752505218 DE19752505218 DE 19752505218 DE 2505218 A DE2505218 A DE 2505218A DE 2505218 A1 DE2505218 A1 DE 2505218A1
- Authority
- DE
- Germany
- Prior art keywords
- berlin
- buffer
- account
- bank
- berliner
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims description 4
- 239000000872 buffer Substances 0.000 claims description 22
- 239000002872 contrast media Substances 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 239000003826 tablet Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 235000015244 frankfurter Nutrition 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 14
- 229940039231 contrast media Drugs 0.000 description 10
- 230000036765 blood level Effects 0.000 description 7
- 239000001384 succinic acid Substances 0.000 description 7
- 229930006000 Sucrose Natural products 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 4
- 229960004503 metoclopramide Drugs 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- -1 (dimethylaminomethyleneamino) -2,4,6-triiodophenyl Chemical group 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 3
- 241001122767 Theaceae Species 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 210000000013 bile duct Anatomy 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 210000000232 gallbladder Anatomy 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- OIRFJRBSRORBCM-UHFFFAOYSA-N Iopanoic acid Chemical compound CCC(C(O)=O)CC1=C(I)C=C(I)C(N)=C1I OIRFJRBSRORBCM-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- YMOXVLQZFAUUKI-UHFFFAOYSA-N tyropanoate Chemical compound CCCC(=O)NC1=C(I)C=C(I)C(CC(CC)C(O)=O)=C1I YMOXVLQZFAUUKI-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- FJYJNLIEGUTPIJ-UHFFFAOYSA-N Iobenzamic acid Chemical compound NC1=C(I)C=C(I)C(C(=O)N(CCC(O)=O)C=2C=CC=CC=2)=C1I FJYJNLIEGUTPIJ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- HDRXZJPWHTXQRI-BHDTVMLSSA-N diltiazem hydrochloride Chemical compound [Cl-].C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CC[NH+](C)C)C2=CC=CC=C2S1 HDRXZJPWHTXQRI-BHDTVMLSSA-N 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229960000963 iobenzamic acid Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229960002979 iopanoic acid Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229960005268 tyropanoate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0495—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound intended for oral administration
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/90—In vivo diagnostic or in vivo test agent which contains an additional ingredient to reduce the toxicity or side effects of the active ingredient
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752505218 DE2505218A1 (de) | 1975-02-05 | 1975-02-05 | Neue orale roentgenkontrastmittel und verfahren zu ihrer herstellung |
| US05/652,333 US4101647A (en) | 1975-02-05 | 1976-01-26 | Oral dosage form for X-ray contrast media containing a pharmaceutically acceptable base and method of use thereof |
| CH113476A CH630262A5 (de) | 1975-02-05 | 1976-01-29 | Neues orales roentgenkontrastmittel und verfahren zu seiner herstellung. |
| IT19799/76A IT1055049B (it) | 1975-02-05 | 1976-02-02 | Mezzi di contrasto per raggi x somminstrabili per via orale e procedimento per la loro preparazione |
| NL7601051A NL7601051A (nl) | 1975-02-05 | 1976-02-02 | Werkwijze voor het bereiden van een oraal toe te dienen roentgencontrastmiddel. |
| GB764181A GB1542677A (en) | 1975-02-05 | 1976-02-03 | Oral x-ray contrast preparations |
| LU74303A LU74303A1 (enExample) | 1975-02-05 | 1976-02-03 | |
| AT78176A AT355202B (de) | 1975-02-05 | 1976-02-04 | Orales roentgenkontrastmittel |
| IE221/76A IE42950B1 (en) | 1975-02-05 | 1976-02-04 | Improvements in or relating to oral x-ray contrast preparations |
| JP51011182A JPS51104020A (enExample) | 1975-02-05 | 1976-02-04 | |
| SE7601197A SE436686B (sv) | 1975-02-05 | 1976-02-04 | Nya orala rontgenkontrastmedel for kolecystcholangiografi |
| NO760367A NO146045C (no) | 1975-02-05 | 1976-02-04 | Oralt roentgenkontrastmiddel for cholecystangiografi |
| DK47576A DK147671C (da) | 1975-02-05 | 1976-02-05 | Oralt roentgenkontrastmiddel |
| FR7603166A FR2299854A1 (fr) | 1975-02-05 | 1976-02-05 | Agents de contraste radiologique administrables par la voie orale |
| BE164112A BE838293A (fr) | 1975-02-05 | 1976-02-05 | Nouveaux produits de contraste aux rayons x et leur procede de preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752505218 DE2505218A1 (de) | 1975-02-05 | 1975-02-05 | Neue orale roentgenkontrastmittel und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2505218A1 true DE2505218A1 (de) | 1976-08-19 |
Family
ID=5938374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19752505218 Withdrawn DE2505218A1 (de) | 1975-02-05 | 1975-02-05 | Neue orale roentgenkontrastmittel und verfahren zu ihrer herstellung |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4101647A (enExample) |
| JP (1) | JPS51104020A (enExample) |
| AT (1) | AT355202B (enExample) |
| BE (1) | BE838293A (enExample) |
| CH (1) | CH630262A5 (enExample) |
| DE (1) | DE2505218A1 (enExample) |
| DK (1) | DK147671C (enExample) |
| FR (1) | FR2299854A1 (enExample) |
| GB (1) | GB1542677A (enExample) |
| IE (1) | IE42950B1 (enExample) |
| IT (1) | IT1055049B (enExample) |
| LU (1) | LU74303A1 (enExample) |
| NL (1) | NL7601051A (enExample) |
| NO (1) | NO146045C (enExample) |
| SE (1) | SE436686B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0014821A1 (de) * | 1979-02-19 | 1980-09-03 | Chemie Linz Aktiengesellschaft | Flüssiges Präparat zur Verwendung bei der peroralen Schnellcholecystographie und Verfahren zu ihrer Herstellung |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK155714C (da) * | 1978-07-04 | 1989-10-30 | Nyegaard & Co As | Fremgangsmaade til fremstilling af en steril, injicerbar, fysiologisk acceptabel oploesning af et roentgenkontrastmiddel, samt en oploesning af roentgenkontrastmidlet til brug ved fremgangsmaaden |
| US4455292A (en) * | 1982-04-05 | 1984-06-19 | Board Of Regents, The University Of Texas System | Radiological contrast composition and methods |
| US4405575A (en) * | 1982-04-23 | 1983-09-20 | Henderson Albert E | Method of defluorinating phosphates |
| US5948387A (en) * | 1990-06-01 | 1999-09-07 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| US5420176A (en) * | 1990-06-01 | 1995-05-30 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| AU650466B2 (en) * | 1990-06-01 | 1994-06-23 | Evan C. Unger | Contrast media for ultrasonic imaging |
| DE4316722A1 (de) * | 1993-05-19 | 1994-11-24 | Fresenius Ag | Parenteral verabreichbare, unter Hitzesterilisationsbedingungen stabile O/W-Emulsion eines Röntgenkontrastmittels |
| IT1316031B1 (it) * | 2000-12-19 | 2003-03-26 | Trelleborg Wheel Systems S P A | Procedimento per radiografare i tessuti di rinforzo tessili neipneumatici e nei manufatti in genere realizzati con detti tessuti. |
| US20050255175A1 (en) * | 2004-05-17 | 2005-11-17 | Burgess W P | Method for protecting nephron against injury caused by disruption of a chemical environment in the kidneys |
| US20050255176A1 (en) * | 2004-05-17 | 2005-11-17 | Burgess W P | Method for attenuating free radical formation resulting from bodily insult |
| US7019035B2 (en) * | 2004-05-17 | 2006-03-28 | Md Scientific Llc | Method for attenuating free radical formation resulting from bodily insult |
| US7625586B2 (en) * | 2004-10-28 | 2009-12-01 | Md Scientific, Llc | Method for mitigating injury to a kidney resulting from an ischemic event |
| WO2013135737A1 (en) * | 2012-03-15 | 2013-09-19 | Fresenius Kabi Deutschland Gmbh | Compositions for dysphagia assessment |
| US9827265B1 (en) | 2012-04-06 | 2017-11-28 | Md Scientific, Llc | Method for attenuating free radical formation resulting from a bodily insult |
| EP3076947B1 (en) * | 2013-12-04 | 2018-06-13 | Hovione Scientia Limited | Contrast media containing taste masking formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2940996A (en) * | 1960-06-14 | M-hocbhxchzch | ||
| US2307189A (en) * | 1940-03-02 | 1943-01-05 | Bell William | X-ray contrast composition |
| US2659690A (en) * | 1950-06-08 | 1953-11-17 | Elmer H Slaybaugh | Effervescent barium sulfate-pectin x-ray contrast composition |
| US2996433A (en) * | 1958-09-11 | 1961-08-15 | Sterling Drug Inc | Radiopaque formulations |
| US3359278A (en) * | 1963-05-24 | 1967-12-19 | Mallinckrodt Chemical Works | Nu-substituted-2, 4, 6-triiodoanilic acids and salts thereof |
| FR1437666A (fr) * | 1965-03-25 | 1966-05-06 | Schering Ag | Forme d'application pour agents de contraste radiologiques administrés par voie perorale |
| CH483261A (de) * | 1967-05-29 | 1969-12-31 | Bracco Ind Chimica Spa | Neue Röntgenkontrastmittel und Verfahren zu ihrer Herstellung |
| GB1268188A (en) * | 1968-06-11 | 1972-03-22 | Nyegaard & Co As | N-hydroxyalkyl-2,4,6-triiodosuccinanilic acids and their use as x-ray contrast agents |
-
1975
- 1975-02-05 DE DE19752505218 patent/DE2505218A1/de not_active Withdrawn
-
1976
- 1976-01-26 US US05/652,333 patent/US4101647A/en not_active Expired - Lifetime
- 1976-01-29 CH CH113476A patent/CH630262A5/de not_active IP Right Cessation
- 1976-02-02 IT IT19799/76A patent/IT1055049B/it active
- 1976-02-02 NL NL7601051A patent/NL7601051A/xx unknown
- 1976-02-03 LU LU74303A patent/LU74303A1/xx unknown
- 1976-02-03 GB GB764181A patent/GB1542677A/en not_active Expired
- 1976-02-04 IE IE221/76A patent/IE42950B1/en unknown
- 1976-02-04 NO NO760367A patent/NO146045C/no unknown
- 1976-02-04 JP JP51011182A patent/JPS51104020A/ja active Pending
- 1976-02-04 SE SE7601197A patent/SE436686B/xx unknown
- 1976-02-04 AT AT78176A patent/AT355202B/de not_active IP Right Cessation
- 1976-02-05 FR FR7603166A patent/FR2299854A1/fr active Granted
- 1976-02-05 DK DK47576A patent/DK147671C/da not_active IP Right Cessation
- 1976-02-05 BE BE164112A patent/BE838293A/xx not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Barke, R.: Röntgenkontrastmittel, 1970, S. 79 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0014821A1 (de) * | 1979-02-19 | 1980-09-03 | Chemie Linz Aktiengesellschaft | Flüssiges Präparat zur Verwendung bei der peroralen Schnellcholecystographie und Verfahren zu ihrer Herstellung |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7601051A (nl) | 1976-08-09 |
| DK147671B (da) | 1984-11-12 |
| IE42950B1 (en) | 1980-11-19 |
| BE838293A (fr) | 1976-08-05 |
| IE42950L (en) | 1976-08-05 |
| NO760367L (enExample) | 1976-08-06 |
| JPS51104020A (enExample) | 1976-09-14 |
| NO146045B (no) | 1982-04-13 |
| SE436686B (sv) | 1985-01-21 |
| FR2299854B1 (enExample) | 1978-08-18 |
| ATA78176A (de) | 1979-07-15 |
| NO146045C (no) | 1982-08-04 |
| AT355202B (de) | 1980-02-25 |
| SE7601197L (sv) | 1976-08-06 |
| GB1542677A (en) | 1979-03-21 |
| FR2299854A1 (fr) | 1976-09-03 |
| IT1055049B (it) | 1981-12-21 |
| CH630262A5 (de) | 1982-06-15 |
| DK47576A (da) | 1976-08-06 |
| LU74303A1 (enExample) | 1976-06-18 |
| US4101647A (en) | 1978-07-18 |
| DK147671C (da) | 1985-05-28 |
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