DE2461406C2 - Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel - Google Patents

Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel

Info

Publication number
DE2461406C2
DE2461406C2 DE2461406A DE2461406A DE2461406C2 DE 2461406 C2 DE2461406 C2 DE 2461406C2 DE 2461406 A DE2461406 A DE 2461406A DE 2461406 A DE2461406 A DE 2461406A DE 2461406 C2 DE2461406 C2 DE 2461406C2
Authority
DE
Germany
Prior art keywords
general formula
azolyl
methane
phenyl
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2461406A
Other languages
German (de)
English (en)
Other versions
DE2461406A1 (de
Inventor
Karl Heinz Dr. Büchel
Wilfried Dr. Draber
Manfred Dr. 5600 Wuppertal Plempel
Erik Regel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=5934560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE2461406(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE2461406A priority Critical patent/DE2461406C2/de
Priority to AR261716A priority patent/AR207492A1/es
Priority to GB4359475A priority patent/GB1469617A/en
Priority to US05/638,274 priority patent/US4118487A/en
Priority to CA241,458A priority patent/CA1059134A/en
Priority to HU75BA00003351A priority patent/HU172927B/hu
Priority to SU752199177A priority patent/SU624574A3/ru
Priority to DD190189A priority patent/DD124729A5/xx
Priority to CS758673A priority patent/CS188985B2/cs
Priority to CH1643675A priority patent/CH619454A5/de
Priority to IL48704A priority patent/IL48704A/xx
Priority to AT974575A priority patent/AT349462B/de
Priority to SE7514518A priority patent/SE421314B/xx
Priority to LU74082A priority patent/LU74082A1/xx
Priority to NLAANVRAGE7514940,A priority patent/NL180509C/xx
Priority to BE162987A priority patent/BE836924A/xx
Priority to FI753619A priority patent/FI62291C/fi
Priority to PL1975185863A priority patent/PL101375B1/pl
Priority to JP50152023A priority patent/JPS5191260A/ja
Priority to DK589975AA priority patent/DK140802B/da
Priority to ES443785A priority patent/ES443785A1/es
Priority to AU87807/75A priority patent/AU496332B2/en
Priority to IE2812/75A priority patent/IE42291B1/en
Priority to YU03283/75A priority patent/YU328375A/xx
Priority to FR7539739A priority patent/FR2295747A1/fr
Publication of DE2461406A1 publication Critical patent/DE2461406A1/de
Priority to KE3022A priority patent/KE3022A/xx
Priority to HK191/80A priority patent/HK19180A/xx
Publication of DE2461406C2 publication Critical patent/DE2461406C2/de
Application granted granted Critical
Priority to GT198500081A priority patent/GT198500081A/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE2461406A 1974-12-24 1974-12-24 Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel Expired DE2461406C2 (de)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DE2461406A DE2461406C2 (de) 1974-12-24 1974-12-24 Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
AR261716A AR207492A1 (es) 1974-12-24 1975-01-01 Procedimiento para la produccion de bifenil-fenoxi-fenil-fenilitio-fenil-fenilitionil-fenil-y fenilsulfonil-fenil-azolil-(1)-metanos y sus sales
GB4359475A GB1469617A (en) 1974-12-24 1975-10-23 Azolyl-1-methanes and their salts processes for their preparation and their use as medicaments
US05/638,274 US4118487A (en) 1974-12-24 1975-12-05 Substituted azol-1-ylmethanes
CA241,458A CA1059134A (en) 1974-12-24 1975-12-10 Substituted azol-1-ylmethanes
HU75BA00003351A HU172927B (hu) 1974-12-24 1975-12-16 Sposob poluchenija azolil-/1/-metanov, ikh solej i lechebnykh preparatov soderzhahhikh takoe aktivnoe vehhestvo
SU752199177A SU624574A3 (ru) 1974-12-24 1975-12-16 Способ получени азолил(1)-метанов или их солей
DD190189A DD124729A5 (en, 2012) 1974-12-24 1975-12-16
CS758673A CS188985B2 (en) 1974-12-24 1975-12-18 Method of producing aryl-1-azolylmethanes
CH1643675A CH619454A5 (en, 2012) 1974-12-24 1975-12-18
NLAANVRAGE7514940,A NL180509C (nl) 1974-12-24 1975-12-22 Werkwijze ter bereiding van farmaceutische preparaten met werkzaamheid tegen micro-organismen, alsmede een werkwijze ter bereiding van voor gebruik bij eerstgenoemde werkwijze geschikte, antimycotisch en antibacterieel werkzame 1-azolylarylmethaanderivaten.
AT974575A AT349462B (de) 1974-12-24 1975-12-22 Verfahren zur herstellung von neuen imidazol- , pyrazol- oder 1,2,4-triazolderivaten und deren salzen
SE7514518A SE421314B (sv) 1974-12-24 1975-12-22 Sett att framstella azolyl-(1)-meaner och deras fysiologiskt fordragbara salter
LU74082A LU74082A1 (en, 2012) 1974-12-24 1975-12-22
IL48704A IL48704A (en) 1974-12-24 1975-12-22 Imidazolyl,pyrazolyl and 1,2,4-triazolyl-biphenylyl methanes and their salts,their preparation and pharmaceutical compositions containing them
BE162987A BE836924A (fr) 1974-12-24 1975-12-22 Nouveaux azolyl - (1) - methanes et leurs sels, leur procede de preparation et medicament les contenant
FI753619A FI62291C (fi) 1974-12-24 1975-12-22 Foerfarande foer framstaellning av terapeutiskt anvaendbara azlyl-(1)-metaner och syraadditionssalter daerav
PL1975185863A PL101375B1 (pl) 1974-12-24 1975-12-22 Sposob wytwarzania nowych azolilo-/1/-metanow
JP50152023A JPS5191260A (en) 1974-12-24 1975-12-22 Azoriruu*1* metanruioyobi soreranoennoseizohoho
AU87807/75A AU496332B2 (en) 1974-12-24 1975-12-23 Azolyl-(1)-methanes and their salts processes for their preparation and their use as medicaments
ES443785A ES443785A1 (es) 1974-12-24 1975-12-23 Procedimiento para preparar azolil-(1)-metanos.
DK589975AA DK140802B (da) 1974-12-24 1975-12-23 Analogifremgangsmåde til fremstilling af imidazolyl-(1)-methaner eller salte deraf med syrer.
IE2812/75A IE42291B1 (en) 1974-12-24 1975-12-23 Azolyl-(1)-methanes and their salts, processes for their preparation and their use as medicamtents
YU03283/75A YU328375A (en) 1974-12-24 1975-12-23 Process for preparing aryl-imidazolyl-ketones
FR7539739A FR2295747A1 (fr) 1974-12-24 1975-12-24 Nouveaux azolyl-(1)-methanes et leurs sels, leur procede de preparation et medicaments les contenant
KE3022A KE3022A (en) 1974-12-24 1980-02-15 Azolyl-(1)-methanes and their salts,process for their preparation and their use as medicaments
HK191/80A HK19180A (en) 1974-12-24 1980-04-10 Azolyl-(1)-methanes and their salts,processes for their preparation and their use as medicaments
GT198500081A GT198500081A (es) 1974-12-24 1985-09-12 Azolil-(1)-metanos y sus sales, procedimientos para su pro--duccion, asi como su aplicacion como medicamentos.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2461406A DE2461406C2 (de) 1974-12-24 1974-12-24 Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
DE2461406A1 DE2461406A1 (de) 1976-07-08
DE2461406C2 true DE2461406C2 (de) 1984-06-14

Family

ID=5934560

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2461406A Expired DE2461406C2 (de) 1974-12-24 1974-12-24 Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel

Country Status (27)

Country Link
US (1) US4118487A (en, 2012)
JP (1) JPS5191260A (en, 2012)
AR (1) AR207492A1 (en, 2012)
AT (1) AT349462B (en, 2012)
BE (1) BE836924A (en, 2012)
CA (1) CA1059134A (en, 2012)
CH (1) CH619454A5 (en, 2012)
CS (1) CS188985B2 (en, 2012)
DD (1) DD124729A5 (en, 2012)
DE (1) DE2461406C2 (en, 2012)
DK (1) DK140802B (en, 2012)
ES (1) ES443785A1 (en, 2012)
FI (1) FI62291C (en, 2012)
FR (1) FR2295747A1 (en, 2012)
GB (1) GB1469617A (en, 2012)
GT (1) GT198500081A (en, 2012)
HK (1) HK19180A (en, 2012)
HU (1) HU172927B (en, 2012)
IE (1) IE42291B1 (en, 2012)
IL (1) IL48704A (en, 2012)
KE (1) KE3022A (en, 2012)
LU (1) LU74082A1 (en, 2012)
NL (1) NL180509C (en, 2012)
PL (1) PL101375B1 (en, 2012)
SE (1) SE421314B (en, 2012)
SU (1) SU624574A3 (en, 2012)
YU (1) YU328375A (en, 2012)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2643563A1 (de) * 1976-09-28 1978-03-30 Bayer Ag Alpha-(4-biphenylyl)-benzyl-azolium- salze, verfahren zu ihrer herstellung sowie ihre verwendung zur bekaempfung von mikroorganismen
DE2808086A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Substituierte diphenyl-imidazolyl- methane, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DK531479A (da) * 1979-01-19 1980-07-20 Pfizer Fremgangsmaade til fremstilling af imidazolderivater og salte deraf
US4927839A (en) * 1979-03-07 1990-05-22 Imperial Chemical Industries Plc Method of preventing fungal attack on wood, hides, leather or paint films using a triazole
DE3070778D1 (en) * 1979-08-11 1985-07-25 Bayer Ag Antimycotic agents with enhanced release of the active ingredients
DE3045913A1 (de) * 1980-12-05 1982-07-08 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung
DE3045914A1 (de) * 1980-12-05 1982-07-22 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern
DE3045915A1 (de) * 1980-12-05 1982-07-08 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern
DE3106635A1 (de) * 1981-02-23 1982-09-09 Bayer Ag Antimykotisches mittel mit hoher wirkstoff-freisetzung in form von stiften
JPS6026391B2 (ja) * 1981-10-15 1985-06-24 北興化学工業株式会社 １，２，４−トリアゾ−ル誘導体および農園芸用殺菌剤
DE3311701A1 (de) * 1983-03-30 1984-10-04 Bayer Ag Antimykotische mittel mit hoher wirkstoff-freisetzung in form von creme
DE3311700A1 (de) * 1983-03-30 1984-10-04 Bayer Ag Antimykotische mittel mit hoher wirkstoff-freisetzung in form von loesung und spray
DE3313073A1 (de) * 1983-04-12 1984-10-18 Bayer Ag, 5090 Leverkusen 1-azolyl-3-pyrazolyl-2-propanol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
US4612323A (en) * 1983-06-27 1986-09-16 Sumitomo Chemical Company, Limited Insecticidal and acaricidal derivatives of 1-benzylbenzimidazole
US4636520A (en) * 1984-07-16 1987-01-13 Fujisawa Pharmaceutical Co., Ltd. Antifungal composition employing pyrrolnitrin in combination with an imidazole compound
JPS61151176A (ja) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
DE3520098A1 (de) * 1985-06-05 1986-12-11 Bayer Ag, 5090 Leverkusen Azolderivate enthaltende formulierungen sowie ihre verwendung zur atraumatischen nagelentfernung
US5098920A (en) * 1990-05-04 1992-03-24 G. D. Searle & Co. 1h-substituted-1,2,4-triazole compounds and methods of use thereof for treatment of cardiovascular disorders
US5155117A (en) * 1991-04-12 1992-10-13 G. D. Searle & Co. 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
US6297239B1 (en) 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
CN1207286C (zh) 2000-05-17 2005-06-22 翁凡尔多·布凡莱父子制品有限公司 二苯基咪唑基－(1)－甲苯和相关化合物的合成方法
EP1279666A1 (en) * 2001-07-24 2003-01-29 Pfizer Products Inc. 1-diphenylmethyl-pyrazole derivatives as opioid receptor ligands
US8093279B2 (en) * 2005-12-13 2012-01-10 Gillian Reed, legal representative Compound
GB0525323D0 (en) * 2005-12-13 2006-01-18 Sterix Ltd Compound
FR2900404B1 (fr) * 2006-04-27 2008-07-18 Sod Conseils Rech Applic Nouveaux derives d'imidazoles, leur preparation et leur utilisation en tant que medicament
CN101143853B (zh) * 2007-11-05 2012-05-16 沈阳药科大学 联苯四氮唑类化合物及其制备方法
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
US8809372B2 (en) 2011-09-30 2014-08-19 Asana Biosciences, Llc Pyridine derivatives
CN104788439A (zh) * 2014-01-21 2015-07-22 安阳师范学院 含有2,4-二卤代联苯基的新型唑类化合物及其合成方法及其用途
EP3558304A2 (en) 2016-12-23 2019-10-30 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases
CN107459486B (zh) * 2017-09-30 2018-11-13 山东华峰新材料科技有限公司 一锅法制备联苯苄唑
CN116874429A (zh) * 2023-06-28 2023-10-13 山东创新药物研发有限公司 一种药用联苯苄唑的制备方法
CN118955385A (zh) * 2024-07-31 2024-11-15 湖南玉新药业有限公司 一种联苯苄唑的合成方法
CN118852020B (zh) * 2024-09-23 2025-01-28 南京桦冠生物技术有限公司 一种高纯度药用联苯苄唑的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1964995A1 (de) * 1969-12-24 1971-07-01 Bayer Ag N-Benzyltriazole,Verfahren zu ihrer Herstellung und ihre Verwendung zur Regulierung des Pflanzenwachstums
DE2007794A1 (de) * 1970-02-20 1971-09-02 Farbenfabriken Bayer Aktiengesell schaft, 5090 Leverkusen Fungizide Mittel
DE2009020C3 (de) * 1970-02-26 1979-09-13 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von N-(l,l,l-trisubstituierten)-Methylazolen
US3833603A (en) * 1970-04-09 1974-09-03 Bayer Ag 1-(alpha,alpha-disubstituted 4-phenoxy-benzyl)imidazoles
DE2016839C3 (de) * 1970-04-09 1979-03-22 Bayer Ag, 5090 Leverkusen PhenyM4-phenoxyphenyi)-imidazol-1-yl-methane, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
CH619454A5 (en, 2012) 1980-09-30
ES443785A1 (es) 1977-04-16
HU172927B (hu) 1979-01-28
FI62291B (fi) 1982-08-31
IE42291B1 (en) 1980-07-16
FI62291C (fi) 1982-12-10
JPS5738582B2 (en, 2012) 1982-08-16
US4118487A (en) 1978-10-03
IE42291L (en) 1976-06-24
DD124729A5 (en, 2012) 1977-03-09
IL48704A (en) 1979-07-25
JPS5191260A (en) 1976-08-10
CA1059134A (en) 1979-07-24
SE7514518L (sv) 1976-06-25
GB1469617A (en) 1977-04-06
FR2295747A1 (fr) 1976-07-23
SU624574A3 (ru) 1978-09-15
DK140802B (da) 1979-11-19
FI753619A7 (en, 2012) 1976-06-25
DK140802C (en, 2012) 1980-04-28
DE2461406A1 (de) 1976-07-08
ATA974575A (de) 1978-09-15
LU74082A1 (en, 2012) 1976-11-11
AU8780775A (en) 1977-06-30
BE836924A (fr) 1976-06-22
DK589975A (en, 2012) 1976-06-25
IL48704A0 (en) 1976-02-29
KE3022A (en) 1980-02-29
FR2295747B1 (en, 2012) 1981-12-24
YU328375A (en) 1982-05-31
GT198500081A (es) 1987-03-06
AR207492A1 (es) 1976-10-08
CS188985B2 (en) 1979-03-30
PL101375B1 (pl) 1978-12-30
SE421314B (sv) 1981-12-14
AT349462B (de) 1979-04-10
NL180509C (nl) 1987-03-02
NL7514940A (nl) 1976-06-28
HK19180A (en) 1980-04-18

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