DE2404609B2 - Freifließende, direkt tablettierbare pharmazeutische Wirksubstanz und Verfahren zu ihrer Herstellung - Google Patents

Freifließende, direkt tablettierbare pharmazeutische Wirksubstanz und Verfahren zu ihrer Herstellung

Info

Publication number
DE2404609B2
DE2404609B2 DE2404609A DE2404609A DE2404609B2 DE 2404609 B2 DE2404609 B2 DE 2404609B2 DE 2404609 A DE2404609 A DE 2404609A DE 2404609 A DE2404609 A DE 2404609A DE 2404609 B2 DE2404609 B2 DE 2404609B2
Authority
DE
Germany
Prior art keywords
active substance
particles
flowing
free
tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE2404609A
Other languages
German (de)
English (en)
Other versions
DE2404609A1 (de
Inventor
Pyare Lal Dr. Arlesheim Seth (Schweiz)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2404609A1 publication Critical patent/DE2404609A1/de
Publication of DE2404609B2 publication Critical patent/DE2404609B2/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
DE2404609A 1973-02-16 1974-01-31 Freifließende, direkt tablettierbare pharmazeutische Wirksubstanz und Verfahren zu ihrer Herstellung Ceased DE2404609B2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH233173 1973-02-16

Publications (2)

Publication Number Publication Date
DE2404609A1 DE2404609A1 (de) 1974-09-05
DE2404609B2 true DE2404609B2 (de) 1978-05-18

Family

ID=4231310

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2404609A Ceased DE2404609B2 (de) 1973-02-16 1974-01-31 Freifließende, direkt tablettierbare pharmazeutische Wirksubstanz und Verfahren zu ihrer Herstellung

Country Status (10)

Country Link
US (1) US3907983A (OSRAM)
JP (1) JPS49110820A (OSRAM)
AU (1) AU6401073A (OSRAM)
BE (1) BE811062A (OSRAM)
DE (1) DE2404609B2 (OSRAM)
FR (1) FR2218085B1 (OSRAM)
GB (1) GB1465781A (OSRAM)
IL (1) IL43853A0 (OSRAM)
NL (1) NL7400298A (OSRAM)
ZA (1) ZA739543B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122157A (en) 1977-03-04 1978-10-24 Richardson-Merrell Inc. Nitrofurantoin sustained release tablet

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5438167B2 (OSRAM) * 1974-04-27 1979-11-19
US4291016A (en) * 1976-07-27 1981-09-22 Sandoz Ltd. Enteric coated mixture of 4-(2-hydroxy-3-isopropylamino-propoxy) indole and sodium lauryl sulphate
JPS5668609A (en) 1979-11-07 1981-06-09 Nippon Kayaku Co Ltd Phthalazinol preparation
US4252786A (en) * 1979-11-16 1981-02-24 E. R. Squibb & Sons, Inc. Controlled release tablet
US4302440B1 (en) * 1980-07-31 1986-08-05 Easily-swallowed, powder-free and gastric-disintegrable aspirin tablet thinly-coated with hydroxypropyl methylcellulose and aqueous spray-coating preparation thereof
US4508702A (en) * 1982-06-14 1985-04-02 Key Pharmaceuticals, Inc. Sustained release aspirin
US4634587A (en) * 1982-07-09 1987-01-06 Key Pharmaceuticals, Inc. Sustained release quinidine dosage form
US4684516A (en) * 1983-08-01 1987-08-04 Alra Laboratories, Inc. Sustained release tablets and method of making same
US4555399A (en) * 1983-11-18 1985-11-26 Key Pharmaceuticals, Inc. Aspirin tablet
SE457505B (sv) * 1984-01-10 1989-01-09 Lejus Medical Ab Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning
GB2155330B (en) * 1984-03-08 1988-01-27 Squibb & Sons Inc Solvent granulation technique for forming solid formulations of nystatin
JPH0753663B2 (ja) * 1984-10-09 1995-06-07 武田薬品工業株式会社 チアミン塩の顆粒，その製造法および錠剤
DE3584522D1 (de) * 1984-12-14 1991-11-28 Gergely Gerhard Teilchen aus einer hydrophoben oder schwerloeslichen substanz und verfahren zu ihrer hydrophilisierung.
US4747881A (en) * 1985-02-05 1988-05-31 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4818539A (en) * 1985-02-05 1989-04-04 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4851392A (en) * 1985-02-05 1989-07-25 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4790991A (en) * 1985-02-05 1988-12-13 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4843098A (en) * 1985-02-05 1989-06-27 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
LU85943A1 (fr) * 1985-06-12 1987-01-13 Galephar Comprimes pharmaceutiques permettant l'administration aisee de pellets, leur preparation et leur utilisation
US4710519A (en) * 1985-09-30 1987-12-01 Basf Corporation Process for preparing spray dried acetaminophen powder and the powder prepared thereby
AU587863B2 (en) * 1985-10-07 1989-08-31 Basf Aktiengesellschaft Vitamin-containing granules and production thereof
US4837033A (en) * 1987-12-22 1989-06-06 Shin-Etsu Chemical Co., Ltd. Method for the preparation of a coated solid medicament
US5662922A (en) * 1992-01-20 1997-09-02 Christensen; Borge Holm Iron-containing composition for the prevention of anaemia and a method for producing the composition
DK6492D0 (da) * 1992-01-20 1992-01-20 Boerge Holm Christensen Tilskudsfoder
JP2669446B2 (ja) * 1992-03-23 1997-10-27 信越化学工業株式会社 医薬品コーティング液用原料粉粒体
AU4198793A (en) † 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
US5560927A (en) * 1995-07-28 1996-10-01 Isp Investments Inc. Co-processing method for making a free-flowing compressible powder and tablet therefrom
JP3555640B2 (ja) * 1996-05-10 2004-08-18 ライオン株式会社 天然カロチノイドを包含した多芯型構造のマイクロカプセル並びに錠剤、食品用及び医薬品用配合剤
US20070202182A1 (en) * 2006-02-26 2007-08-30 Kane Kevin M Preparing solid formulation of nanoparticles of pharmaceutical ingredient, including at least micron-sized particles
US20100034959A1 (en) * 2008-08-07 2010-02-11 Vector Corporation High solids, high molecular weight polymer coating

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1492034A1 (de) * 1965-05-18 1969-02-20 Merck Ag E Verfahren zur Herstellung fester haltbarer Zubereitungen von empfindlichen,in Wasser schwer loeslichen Wirkstoffen,vorzugsweise Arzneimitteln
AU1039170A (en) * 1969-02-24 1971-07-22 Abbott Laboratories Tableting medium
NL7112083A (OSRAM) * 1970-09-16 1972-03-20

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122157A (en) 1977-03-04 1978-10-24 Richardson-Merrell Inc. Nitrofurantoin sustained release tablet

Also Published As

Publication number Publication date
BE811062A (fr) 1974-08-16
NL7400298A (OSRAM) 1974-08-20
GB1465781A (en) 1977-03-02
DE2404609A1 (de) 1974-09-05
ZA739543B (en) 1975-03-26
FR2218085B1 (OSRAM) 1977-11-10
JPS49110820A (OSRAM) 1974-10-22
US3907983A (en) 1975-09-23
IL43853A0 (en) 1974-03-14
FR2218085A1 (OSRAM) 1974-09-13
AU6401073A (en) 1975-07-03

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