DE2402414A1 - Verfahren zur bestimmung der freisetzung von proteingebundenem bilirubin - Google Patents
Verfahren zur bestimmung der freisetzung von proteingebundenem bilirubinInfo
- Publication number
- DE2402414A1 DE2402414A1 DE19742402414 DE2402414A DE2402414A1 DE 2402414 A1 DE2402414 A1 DE 2402414A1 DE 19742402414 DE19742402414 DE 19742402414 DE 2402414 A DE2402414 A DE 2402414A DE 2402414 A1 DE2402414 A1 DE 2402414A1
- Authority
- DE
- Germany
- Prior art keywords
- bilirubin
- protein
- absorption maximum
- release
- decrease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 title claims description 154
- 238000000034 method Methods 0.000 title claims description 24
- 238000010521 absorption reaction Methods 0.000 claims description 41
- 102000004169 proteins and genes Human genes 0.000 claims description 33
- 108090000623 proteins and genes Proteins 0.000 claims description 33
- 239000013043 chemical agent Substances 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 15
- 238000007792 addition Methods 0.000 claims description 9
- 238000005259 measurement Methods 0.000 claims description 8
- 238000010790 dilution Methods 0.000 claims description 6
- 239000012895 dilution Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 4
- 229960004025 sodium salicylate Drugs 0.000 claims description 4
- 238000004611 spectroscopical analysis Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 description 15
- 102000009027 Albumins Human genes 0.000 description 13
- 108010088751 Albumins Proteins 0.000 description 13
- 239000000523 sample Substances 0.000 description 12
- 102000004506 Blood Proteins Human genes 0.000 description 11
- 108010017384 Blood Proteins Proteins 0.000 description 11
- 239000000203 mixture Substances 0.000 description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- NHUHCSRWZMLRLA-UHFFFAOYSA-N Sulfisoxazole Chemical compound CC1=NOC(NS(=O)(=O)C=2C=CC(N)=CC=2)=C1C NHUHCSRWZMLRLA-UHFFFAOYSA-N 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 229960000654 sulfafurazole Drugs 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical class OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 208000021130 Bilirubin encephalopathy Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 208000005107 Premature Birth Diseases 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 208000027119 bilirubin metabolic disease Diseases 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 208000036796 hyperbilirubinemia Diseases 0.000 description 1
- 208000006663 kernicterus Diseases 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- ZZORFUFYDOWNEF-UHFFFAOYSA-N sulfadimethoxine Chemical compound COC1=NC(OC)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ZZORFUFYDOWNEF-UHFFFAOYSA-N 0.000 description 1
- 229960000973 sulfadimethoxine Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/728—Bilirubin; including biliverdin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32471373A | 1973-01-18 | 1973-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2402414A1 true DE2402414A1 (de) | 1974-07-25 |
Family
ID=23264762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19742402414 Pending DE2402414A1 (de) | 1973-01-18 | 1974-01-18 | Verfahren zur bestimmung der freisetzung von proteingebundenem bilirubin |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5047693A (enrdf_load_stackoverflow) |
| DE (1) | DE2402414A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2214888A1 (enrdf_load_stackoverflow) |
| NL (1) | NL7400294A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0022673A1 (en) * | 1979-07-11 | 1981-01-21 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Method for selective determination of conjugated or unconjugated bilirubin |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751190A (en) * | 1985-07-22 | 1988-06-14 | Abbott Laboratories | Fluorescence polarization immunoassay and reagents for use therein |
-
1974
- 1974-01-09 NL NL7400294A patent/NL7400294A/xx unknown
- 1974-01-16 FR FR7401428A patent/FR2214888A1/fr not_active Withdrawn
- 1974-01-16 JP JP717074A patent/JPS5047693A/ja active Pending
- 1974-01-18 DE DE19742402414 patent/DE2402414A1/de active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0022673A1 (en) * | 1979-07-11 | 1981-01-21 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Method for selective determination of conjugated or unconjugated bilirubin |
| EP0031842B1 (en) * | 1979-07-11 | 1984-12-12 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Method for selective determination of conjugated or unconjugated bilirubin |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7400294A (enrdf_load_stackoverflow) | 1974-07-22 |
| FR2214888A1 (en) | 1974-08-19 |
| JPS5047693A (enrdf_load_stackoverflow) | 1975-04-28 |
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