DE2329253A1 - Mundpraeparat - Google Patents
MundpraeparatInfo
- Publication number
- DE2329253A1 DE2329253A1 DE2329253A DE2329253A DE2329253A1 DE 2329253 A1 DE2329253 A1 DE 2329253A1 DE 2329253 A DE2329253 A DE 2329253A DE 2329253 A DE2329253 A DE 2329253A DE 2329253 A1 DE2329253 A1 DE 2329253A1
- Authority
- DE
- Germany
- Prior art keywords
- agglutinin
- concanavalin
- dextranase
- antibody
- biologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010001682 Dextranase Proteins 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 29
- 239000000910 agglutinin Substances 0.000 claims description 24
- HBOMLICNUCNMMY-KJFJCRTCSA-N 1-[(4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1C1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-KJFJCRTCSA-N 0.000 claims description 23
- 230000015572 biosynthetic process Effects 0.000 claims description 21
- 230000000694 effects Effects 0.000 claims description 21
- 102000004169 proteins and genes Human genes 0.000 claims description 21
- 108090000623 proteins and genes Proteins 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 20
- 150000007944 thiolates Chemical class 0.000 claims description 20
- 101710186708 Agglutinin Proteins 0.000 claims description 19
- 101710146024 Horcolin Proteins 0.000 claims description 19
- 101710189395 Lectin Proteins 0.000 claims description 19
- 101710179758 Mannose-specific lectin Proteins 0.000 claims description 19
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 claims description 19
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 claims description 19
- 108090000790 Enzymes Proteins 0.000 claims description 17
- 102000004190 Enzymes Human genes 0.000 claims description 17
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 208000002064 Dental Plaque Diseases 0.000 claims description 14
- 108090001090 Lectins Proteins 0.000 claims description 13
- 102000004856 Lectins Human genes 0.000 claims description 13
- 239000002523 lectin Substances 0.000 claims description 13
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 12
- 230000003115 biocidal effect Effects 0.000 claims description 12
- 108010001478 Bacitracin Proteins 0.000 claims description 10
- 229960000723 ampicillin Drugs 0.000 claims description 10
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 10
- 229960003071 bacitracin Drugs 0.000 claims description 10
- 229930184125 bacitracin Natural products 0.000 claims description 10
- 239000003242 anti bacterial agent Substances 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 7
- 229960004308 acetylcysteine Drugs 0.000 claims description 7
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 claims description 7
- OROGUZVNAFJPHA-UHFFFAOYSA-N 3-hydroxy-2,4-dimethyl-2H-thiophen-5-one Chemical compound CC1SC(=O)C(C)=C1O OROGUZVNAFJPHA-UHFFFAOYSA-N 0.000 claims description 6
- ZKZNWRUUTQNYTH-UHFFFAOYSA-N 4-azidobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=C(N=[N+]=[N-])C=C1 ZKZNWRUUTQNYTH-UHFFFAOYSA-N 0.000 claims description 6
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 6
- 230000002882 anti-plaque Effects 0.000 claims description 6
- 229960003276 erythromycin Drugs 0.000 claims description 6
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- 229960003165 vancomycin Drugs 0.000 claims description 4
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims description 4
- 108010059993 Vancomycin Proteins 0.000 claims description 3
- 239000003054 catalyst Substances 0.000 claims description 3
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- 238000012986 modification Methods 0.000 claims description 3
- 238000011160 research Methods 0.000 claims description 3
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 claims description 2
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- 230000008685 targeting Effects 0.000 claims 1
- CFMYXEVWODSLAX-QOZOJKKESA-N tetrodotoxin Chemical compound O([C@@]([C@H]1O)(O)O[C@H]2[C@@]3(O)CO)[C@H]3[C@@H](O)[C@]11[C@H]2[C@@H](O)N=C(N)N1 CFMYXEVWODSLAX-QOZOJKKESA-N 0.000 claims 1
- 108010062580 Concanavalin A Proteins 0.000 description 33
- 239000000243 solution Substances 0.000 description 19
- 229940088598 enzyme Drugs 0.000 description 15
- 239000008363 phosphate buffer Substances 0.000 description 15
- 239000011541 reaction mixture Substances 0.000 description 15
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- 229940088710 antibiotic agent Drugs 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
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- 150000004676 glycans Chemical class 0.000 description 5
- 229920001282 polysaccharide Polymers 0.000 description 5
- 239000005017 polysaccharide Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 229920002307 Dextran Polymers 0.000 description 4
- 241000194032 Enterococcus faecalis Species 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 4
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- 239000008351 acetate buffer Substances 0.000 description 4
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- 125000003396 thiol group Chemical group [H]S* 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- NRFJZTXWLKPZAV-UHFFFAOYSA-N N-(2-oxo-3-thiolanyl)acetamide Chemical compound CC(=O)NC1CCSC1=O NRFJZTXWLKPZAV-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
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- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- JRBJSXQPQWSCCF-UHFFFAOYSA-N 3,3'-Dimethoxybenzidine Chemical compound C1=C(N)C(OC)=CC(C=2C=C(OC)C(N)=CC=2)=C1 JRBJSXQPQWSCCF-UHFFFAOYSA-N 0.000 description 2
- 239000004382 Amylase Substances 0.000 description 2
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- 241000282693 Cercopithecidae Species 0.000 description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2704872A GB1433593A (en) | 1972-06-09 | 1972-06-09 | Conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2329253A1 true DE2329253A1 (de) | 1973-12-13 |
Family
ID=10253320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2329253A Pending DE2329253A1 (de) | 1972-06-09 | 1973-06-08 | Mundpraeparat |
Country Status (12)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217341A (en) * | 1977-12-07 | 1980-08-12 | The University of Louisville | Composition and method for inhibiting the adherence of dental plaque-producing bacteria to smooth surfaces |
| US5851527A (en) * | 1988-04-18 | 1998-12-22 | Immunomedics, Inc. | Method for antibody targeting of therapeutic agents |
| SE461570B (sv) * | 1988-06-06 | 1990-03-05 | Rama Bio Link Ab | Farmaceutiskt preparat och konjugat av en baktericid och en antikropp |
| AU642979B2 (en) * | 1990-03-21 | 1993-11-04 | Quest International B.V. | Utilization and delivery of enzymes |
| AU641736B2 (en) * | 1990-03-21 | 1993-09-30 | Quest International B.V. | Delivery of agents |
| JP2873256B2 (ja) * | 1991-02-01 | 1999-03-24 | シャープ 株式会社 | 液晶表示装置 |
| KR19980075132A (ko) * | 1997-03-28 | 1998-11-05 | 민병무 | 중간사슬지방산(medium-chain fatty acids)을 유효성분으로 하는 치아우식증 및 치주질환 치료제용 의약조성물 |
| US5871714A (en) * | 1997-10-16 | 1999-02-16 | Pharmacal Biotechnologies, Inc. | Compositions for controlling bacterial colonization |
| US5972311A (en) * | 1998-01-26 | 1999-10-26 | Duke University | Method of preventing dental caries and other oral lesions |
| AU3489700A (en) * | 1999-02-12 | 2000-08-29 | Pharmacal Biotechnologies, Llc | Oral compositions and methods of production thereof |
| US6447754B1 (en) | 2000-01-24 | 2002-09-10 | Akpharma Inc. | Oral rinse methods and compositions |
| WO2002019833A2 (en) * | 2000-09-07 | 2002-03-14 | Akpharma Inc. | Edible candy compositions and methods of using the same |
| US20020099037A1 (en) * | 2001-01-19 | 2002-07-25 | Akpharma, Inc. | Method for alleviating syndromes and conditions of discomfort of the mammalian intestinal and genito-urinary tracts |
| GB2555391B (en) * | 2016-10-21 | 2019-06-26 | Algipharma As | Bacitracin-alginate oligomer conjugates |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3538230A (en) * | 1966-12-05 | 1970-11-03 | Lever Brothers Ltd | Oral compositions containing silica xerogels as cleaning and polishing agents |
| DE1617886A1 (de) * | 1967-03-06 | 1971-01-28 | Dr Med Karl Theurer | Verfahren zur Herstellung von Arzneimitteln mit selektivem Tropismus gegen Krebs und bestimmte Organe |
-
1972
- 1972-06-09 GB GB2704872A patent/GB1433593A/en not_active Expired
-
1973
- 1973-06-04 ZA ZA733745A patent/ZA733745B/xx unknown
- 1973-06-06 AU AU56594/73A patent/AU5659473A/en not_active Expired
- 1973-06-06 IE IE899/73A patent/IE37742B1/xx unknown
- 1973-06-07 US US05/367,892 patent/US3952092A/en not_active Expired - Lifetime
- 1973-06-07 NL NL7307927A patent/NL7307927A/xx unknown
- 1973-06-07 IL IL42462A patent/IL42462A0/xx unknown
- 1973-06-08 BE BE132080A patent/BE800695A/xx unknown
- 1973-06-08 DE DE2329253A patent/DE2329253A1/de active Pending
- 1973-06-08 IT IT50561/73A patent/IT1078724B/it active
- 1973-06-09 ES ES415753A patent/ES415753A1/es not_active Expired
- 1973-06-12 FR FR7321285A patent/FR2187294B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES415753A1 (es) | 1976-06-16 |
| ZA733745B (en) | 1974-04-24 |
| FR2187294B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-12-31 |
| NL7307927A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-12-11 |
| US3952092A (en) | 1976-04-20 |
| IL42462A0 (en) | 1973-08-29 |
| FR2187294A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-01-18 |
| AU5659473A (en) | 1974-12-12 |
| BE800695A (fr) | 1973-12-10 |
| IE37742B1 (en) | 1977-09-28 |
| IE37742L (en) | 1973-12-09 |
| GB1433593A (en) | 1976-04-28 |
| IT1078724B (it) | 1985-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHJ | Non-payment of the annual fee |