DE2317198A1 - Geraet zur anwendung bei radioimmunologischen ermittlungen sowie verfahren zur ermittlung des gehalts an einem spezifischen hormon in einer serumprobe - Google Patents
Geraet zur anwendung bei radioimmunologischen ermittlungen sowie verfahren zur ermittlung des gehalts an einem spezifischen hormon in einer serumprobeInfo
- Publication number
- DE2317198A1 DE2317198A1 DE2317198A DE2317198A DE2317198A1 DE 2317198 A1 DE2317198 A1 DE 2317198A1 DE 2317198 A DE2317198 A DE 2317198A DE 2317198 A DE2317198 A DE 2317198A DE 2317198 A1 DE2317198 A1 DE 2317198A1
- Authority
- DE
- Germany
- Prior art keywords
- sponge
- hormone
- radioactive
- antibodies
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 229940088597 hormone Drugs 0.000 title claims description 31
- 239000005556 hormone Substances 0.000 title claims description 31
- 210000002966 serum Anatomy 0.000 title claims description 17
- 238000000034 method Methods 0.000 title claims description 11
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 58
- 229940125396 insulin Drugs 0.000 claims description 32
- 230000002285 radioactive effect Effects 0.000 claims description 28
- 102000004877 Insulin Human genes 0.000 claims description 27
- 108090001061 Insulin Proteins 0.000 claims description 27
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 238000011534 incubation Methods 0.000 claims description 13
- 239000004033 plastic Substances 0.000 claims description 10
- 229920003023 plastic Polymers 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 8
- 102000036124 hormone binding proteins Human genes 0.000 claims description 7
- 108091011044 hormone binding proteins Proteins 0.000 claims description 7
- 238000011835 investigation Methods 0.000 claims description 5
- 229920002635 polyurethane Polymers 0.000 claims description 5
- 239000004814 polyurethane Substances 0.000 claims description 5
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 239000000243 solution Substances 0.000 description 12
- 239000000126 substance Substances 0.000 description 7
- 239000011230 binding agent Substances 0.000 description 6
- 230000003054 hormonal effect Effects 0.000 description 6
- -1 polypropylene Polymers 0.000 description 6
- 239000012857 radioactive material Substances 0.000 description 6
- 238000005259 measurement Methods 0.000 description 5
- 239000004743 Polypropylene Substances 0.000 description 4
- 230000002349 favourable effect Effects 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000941 radioactive substance Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004026 insulin derivative Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 102000015731 Peptide Hormones Human genes 0.000 description 1
- 108010038988 Peptide Hormones Proteins 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 229940029329 intrinsic factor Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1272—Sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7205223A NL7205223A (enrdf_load_stackoverflow) | 1972-04-19 | 1972-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2317198A1 true DE2317198A1 (de) | 1973-10-25 |
Family
ID=19815871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2317198A Ceased DE2317198A1 (de) | 1972-04-19 | 1973-04-06 | Geraet zur anwendung bei radioimmunologischen ermittlungen sowie verfahren zur ermittlung des gehalts an einem spezifischen hormon in einer serumprobe |
Country Status (11)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5543031Y2 (enrdf_load_stackoverflow) * | 1974-12-03 | 1980-10-08 | ||
| ZA761751B (en) * | 1975-04-07 | 1977-03-30 | Summa Corp | Immobilized immunoadsorbent |
| JPS521879A (en) * | 1975-06-24 | 1977-01-08 | Nippon Kokan Kk <Nkk> | Filtrate collecting trunk for slurry carrying ship |
| JPS522793U (enrdf_load_stackoverflow) * | 1975-06-24 | 1977-01-10 | ||
| JPS523034U (enrdf_load_stackoverflow) * | 1975-06-24 | 1977-01-10 | ||
| JPS526391U (enrdf_load_stackoverflow) * | 1975-06-27 | 1977-01-17 | ||
| JPS54111892A (en) * | 1978-02-17 | 1979-09-01 | Ii Mairusu Rooton | Method and device for inspecting numerous data |
| FR2418457A1 (fr) * | 1978-02-22 | 1979-09-21 | Commissariat Energie Atomique | Dispositif pour analyser une solution |
| US4170454A (en) * | 1978-03-30 | 1979-10-09 | Union Carbide Corporation | Process for the preparation of a solid-phase radioimmunoassay support and use thereof |
| JPS5837482Y2 (ja) * | 1978-04-19 | 1983-08-24 | 共立エコ−物産株式会社 | スプレ−ヤの給水装置 |
| US4292296A (en) * | 1978-09-12 | 1981-09-29 | Baxter Travenol Laboratories, Inc. | Diagnostic method |
| US4477578A (en) * | 1982-03-04 | 1984-10-16 | Medical & Scientific, Inc. | Method and apparatus for performing assays |
| SE8300553D0 (sv) * | 1983-02-02 | 1983-02-02 | Pharmacia Diagnostics Ab | Sett och anordning vid biospecifika affinitetsreaktioner |
| SE8306052D0 (sv) * | 1983-11-03 | 1983-11-03 | Pharmacia Ab | Anordning for hantering av porosa analysmatriser |
| US6099307A (en) * | 1998-11-09 | 2000-08-08 | Centrix, Inc. | Dental capsule for containing and dispensing low viscosity dental material and method of filling and applying said low viscosity material |
-
1962
- 1962-01-25 CA CA168,828A patent/CA990416A/en not_active Expired
-
1972
- 1972-04-19 NL NL7205223A patent/NL7205223A/xx not_active Application Discontinuation
-
1973
- 1973-04-06 DE DE2317198A patent/DE2317198A1/de not_active Ceased
- 1973-04-09 ZA ZA732432A patent/ZA732432B/xx unknown
- 1973-04-16 SE SE7305361A patent/SE407114B/xx unknown
- 1973-04-16 CH CH539673A patent/CH585906A5/xx not_active IP Right Cessation
- 1973-04-16 GB GB1819073A patent/GB1392912A/en not_active Expired
- 1973-04-16 IT IT23075/73A patent/IT988640B/it active
- 1973-04-17 JP JP4273573A patent/JPS56742B2/ja not_active Expired
- 1973-04-17 BE BE130137A patent/BE798359A/xx unknown
- 1973-04-18 FR FR7314168A patent/FR2181379A5/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE798359A (fr) | 1973-10-17 |
| JPS56742B2 (enrdf_load_stackoverflow) | 1981-01-09 |
| IT988640B (it) | 1975-04-30 |
| NL7205223A (enrdf_load_stackoverflow) | 1973-10-23 |
| CA990416A (en) | 1976-06-01 |
| SE407114B (sv) | 1979-03-12 |
| JPS4921187A (enrdf_load_stackoverflow) | 1974-02-25 |
| GB1392912A (en) | 1975-05-07 |
| FR2181379A5 (enrdf_load_stackoverflow) | 1973-11-30 |
| ZA732432B (en) | 1974-11-27 |
| CH585906A5 (enrdf_load_stackoverflow) | 1977-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| OGA | New person/name/address of the applicant | ||
| 8131 | Rejection |