DE2262262C2 - Verfahren zur Herstellung von Cefazolin - Google Patents

Verfahren zur Herstellung von Cefazolin

Info

Publication number
DE2262262C2
DE2262262C2 DE19722262262 DE2262262A DE2262262C2 DE 2262262 C2 DE2262262 C2 DE 2262262C2 DE 19722262262 DE19722262262 DE 19722262262 DE 2262262 A DE2262262 A DE 2262262A DE 2262262 C2 DE2262262 C2 DE 2262262C2
Authority
DE
Germany
Prior art keywords
acid
cefazolin
added
mixture
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE19722262262
Other languages
German (de)
English (en)
Other versions
DE2262262A1 (de
Inventor
Kazuo Kyoto Kariyone
Masaru Takatsuki Osaka Kurita
Teruo Kyoto Oku
Hisatoyo Toyonaka Osaka Yazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE2262262A1 publication Critical patent/DE2262262A1/de
Application granted granted Critical
Publication of DE2262262C2 publication Critical patent/DE2262262C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19722262262 1971-12-23 1972-12-20 Verfahren zur Herstellung von Cefazolin Expired DE2262262C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP251772A JPS55392B2 (enExample) 1971-12-23 1971-12-23

Publications (2)

Publication Number Publication Date
DE2262262A1 DE2262262A1 (de) 1973-06-28
DE2262262C2 true DE2262262C2 (de) 1986-09-11

Family

ID=11531551

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19722262262 Expired DE2262262C2 (de) 1971-12-23 1972-12-20 Verfahren zur Herstellung von Cefazolin

Country Status (8)

Country Link
JP (1) JPS55392B2 (enExample)
AT (1) AT328611B (enExample)
BE (1) BE793037A (enExample)
CA (1) CA999572A (enExample)
CH (1) CH578006A5 (enExample)
DE (1) DE2262262C2 (enExample)
FR (1) FR2170496A5 (enExample)
NL (1) NL7217630A (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989694A (en) * 1974-12-27 1976-11-02 Smithkline Corporation 7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins
ZA76451B (en) * 1975-02-27 1977-01-26 Smithkline Corp New cephalosporin compounds
US4220644A (en) 1976-05-03 1980-09-02 Smithkline Corporation 7-Acylamino-3-(substituted tetrazolyl thiomethyl) cephalosporins
GB1555335A (en) * 1976-05-14 1979-11-07 Beecham Group Ltd 3-(carboxymethyl substituted-heterocyclicthio)-cephalosporins methods for their preparation and compositions containing them
CA1215969A (en) * 1979-10-12 1986-12-30 Tsutomu Teraji Cephem compounds and processes for preparation thereof
GB9726989D0 (en) * 1997-12-22 1998-02-18 Ciba Geigy Ag Organic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1933187C3 (de) * 1968-07-01 1980-07-03 Bristol Myers Co Verfahren zur Herstellung von 7-Aminocephalosporansäure
DE1953861C2 (de) * 1969-10-25 1982-12-23 Fujisawa Pharmaceutical Co., Ltd., Osaka 7-Tetrazolylacetamido-3-thiomethyl-3-cephem-4- carbonsäuren
BE758587A (fr) * 1969-11-17 1971-05-06 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 7-aminocephalosporanique et nouveaux produits ainsi obtenus
BE759064A (fr) * 1969-12-17 1971-05-17 Lilly Co Eli Une methode pour transformer la cephalosporine c. en un derive soluble dans un solvant organique, et le compose qui en

Also Published As

Publication number Publication date
BE793037A (fr) 1973-06-20
ATA1092972A (de) 1975-06-15
NL7217630A (enExample) 1973-06-26
FR2170496A5 (en) 1973-09-14
CA999572A (en) 1976-11-09
AT328611B (de) 1976-03-25
DE2262262A1 (de) 1973-06-28
CH578006A5 (enExample) 1976-07-30
JPS55392B2 (enExample) 1980-01-08
JPS4868592A (enExample) 1973-09-18

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Legal Events

Date Code Title Description
OD Request for examination
8128 New person/name/address of the agent

Representative=s name: TUERK, D., DIPL.-CHEM. DR.RER.NAT. GILLE, C., DIPL

D2 Grant after examination
8364 No opposition during term of opposition