DE2246013A1 - Verfahren zur herstellung von poroesen tabletten - Google Patents
Verfahren zur herstellung von poroesen tablettenInfo
- Publication number
- DE2246013A1 DE2246013A1 DE2246013A DE2246013A DE2246013A1 DE 2246013 A1 DE2246013 A1 DE 2246013A1 DE 2246013 A DE2246013 A DE 2246013A DE 2246013 A DE2246013 A DE 2246013A DE 2246013 A1 DE2246013 A1 DE 2246013A1
- Authority
- DE
- Germany
- Prior art keywords
- tablets
- tablet
- excipient
- urethane
- mixed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 13
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 10
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims description 8
- 239000001099 ammonium carbonate Substances 0.000 claims description 8
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 7
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 5
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims description 5
- 239000005711 Benzoic acid Substances 0.000 claims description 5
- 241000723346 Cinnamomum camphora Species 0.000 claims description 5
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims description 5
- 235000010233 benzoic acid Nutrition 0.000 claims description 5
- 229930008380 camphor Natural products 0.000 claims description 5
- 229960000846 camphor Drugs 0.000 claims description 5
- 239000004202 carbamide Substances 0.000 claims description 5
- 235000010299 hexamethylene tetramine Nutrition 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims description 4
- 239000012439 solid excipient Substances 0.000 claims description 3
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 claims description 2
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 claims description 2
- 235000013877 carbamide Nutrition 0.000 claims description 2
- 239000004312 hexamethylene tetramine Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 description 56
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 239000008121 dextrose Substances 0.000 description 7
- 239000001103 potassium chloride Substances 0.000 description 7
- 235000011164 potassium chloride Nutrition 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000000314 lubricant Substances 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 235000012501 ammonium carbonate Nutrition 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000007932 molded tablet Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000012042 active reagent Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- -1 etc. Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/01—Wetting, emulsifying, dispersing, or stabilizing agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2246013A DE2246013A1 (de) | 1972-09-20 | 1972-09-20 | Verfahren zur herstellung von poroesen tabletten |
US395796A US3885026A (en) | 1972-09-20 | 1973-09-10 | Preparation of porous tablets |
GB4318773A GB1381588A (en) | 1972-09-20 | 1973-09-14 | Process for the preparation of porous tablets |
IT7328973A IT998618B (it) | 1972-09-20 | 1973-09-17 | Procedimento per la produzione di pastiglie porose |
CH1329273A CH579394A5 (enrdf_load_html_response) | 1972-09-20 | 1973-09-17 | |
FR7333392A FR2199973B1 (enrdf_load_html_response) | 1972-09-20 | 1973-09-18 | |
AT806973A AT324568B (de) | 1972-09-20 | 1973-09-19 | Verfahren zur herstellung von porosen tabletten |
SE7312753A SE395366B (sv) | 1972-09-20 | 1973-09-19 | Forfarande for framstellning av porosa tabletter |
JP48106458A JPS4969819A (enrdf_load_html_response) | 1972-09-20 | 1973-09-20 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2246013A DE2246013A1 (de) | 1972-09-20 | 1972-09-20 | Verfahren zur herstellung von poroesen tabletten |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2246013A1 true DE2246013A1 (de) | 1974-03-28 |
Family
ID=5856791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2246013A Pending DE2246013A1 (de) | 1972-09-20 | 1972-09-20 | Verfahren zur herstellung von poroesen tabletten |
Country Status (9)
Country | Link |
---|---|
US (1) | US3885026A (enrdf_load_html_response) |
JP (1) | JPS4969819A (enrdf_load_html_response) |
AT (1) | AT324568B (enrdf_load_html_response) |
CH (1) | CH579394A5 (enrdf_load_html_response) |
DE (1) | DE2246013A1 (enrdf_load_html_response) |
FR (1) | FR2199973B1 (enrdf_load_html_response) |
GB (1) | GB1381588A (enrdf_load_html_response) |
IT (1) | IT998618B (enrdf_load_html_response) |
SE (1) | SE395366B (enrdf_load_html_response) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2556561A1 (de) * | 1975-12-16 | 1977-06-30 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
DE2744493A1 (de) * | 1976-10-06 | 1978-04-13 | Wyeth John & Brother Ltd | Geformter traeger fuer chemikalien und/oder pharmaka |
DE3734796A1 (de) * | 1986-10-14 | 1988-04-21 | Beaufour Lab | Verfahren zur herstellung von loeslichen und/oder zerteilbaren tabletten und nach diesem verfahren erhaltene tabletten |
WO2024252015A1 (de) | 2023-06-09 | 2024-12-12 | euvorio GmbH | Verwendung kohlenhydrathaltiger zusammensetzungen in tablettenform zur behandlung von hypoglykämiezuständen |
Families Citing this family (72)
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US4076486A (en) * | 1975-03-10 | 1978-02-28 | University Of Southern California | Method of burning a fossil fuel |
GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
US4568547A (en) * | 1979-08-30 | 1986-02-04 | Herschler R J | Solid pharmaceutical compositions comprising MSM and their production |
US4883182A (en) * | 1985-05-31 | 1989-11-28 | Hughes Raymond J | Tamper evident capsule and insert device |
JP2614409B2 (ja) * | 1991-12-20 | 1997-05-28 | ファイザー・インコーポレーテッド | 多孔質の付形された放出製剤およびその製造方法 |
JP2640570B2 (ja) * | 1992-01-13 | 1997-08-13 | ファイザー インク. | 強度が増加した錠剤の製造 |
HUT75616A (en) * | 1992-03-17 | 1997-05-28 | Pfizer | Method for prooucing porous delivery devices |
EP0679088B1 (en) | 1992-09-29 | 2002-07-10 | Inhale Therapeutic Systems | Pulmonary delivery of active fragments of parathyroid hormone |
MX9603936A (es) | 1994-03-07 | 1997-05-31 | Inhale Therapeutic Syst | Metodos y composiciones para el suministro pulmonar de insulina. |
US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
WO1996008979A1 (en) | 1994-09-22 | 1996-03-28 | Quadrant Holdings Cambridge Limited | Compositions for use in rehydration and nutrition during athletic exercise and methods of making same |
US6964771B1 (en) | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
US5958455A (en) * | 1996-02-09 | 1999-09-28 | Quadrant Holdings Cambridge Ltd | Oral solid dosage forms, methods of making same and compositions thereof |
US5762961A (en) * | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
US6632648B1 (en) | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
KR100481583B1 (ko) * | 1996-06-14 | 2005-07-12 | 교와 핫꼬 고교 가부시끼가이샤 | 구강내에서빠르게붕괴하는정제 |
ES2243998T3 (es) * | 1996-06-14 | 2005-12-01 | Kyowa Hakko Kogyo Co., Ltd. | Comprimido de disgregacion rapida por via intrabucal. |
EA000913B1 (ru) | 1996-08-13 | 2000-06-26 | Кийова Хакко Когио Ко., Лтд. | Таблетка меченной изотопом мочевины |
US6468782B1 (en) | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
US20040023948A1 (en) * | 1997-03-24 | 2004-02-05 | Green Richard David | Fast-dispersing dosage form containing 5-HT1 agonists |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
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US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
DK1280520T4 (en) | 2000-05-10 | 2018-06-25 | Novartis Ag | Phospholipid based powders for drug delivery |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
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US9233491B2 (en) | 2012-05-01 | 2016-01-12 | Johnson & Johnson Consumer Inc. | Machine for production of solid dosage forms |
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US9511028B2 (en) | 2012-05-01 | 2016-12-06 | Johnson & Johnson Consumer Inc. | Orally disintegrating tablet |
CA2936216C (en) | 2014-01-10 | 2021-10-26 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
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LU60170A1 (enrdf_load_html_response) * | 1970-01-09 | 1971-11-18 | ||
US3653914A (en) * | 1970-03-20 | 1972-04-04 | Alberto Culver Co | Production of tablets |
US3632778A (en) * | 1970-06-10 | 1972-01-04 | Hoffmann La Roche | Tablets containing l-dopa |
US3739048A (en) * | 1971-05-26 | 1973-06-12 | Sumitomo Electric Industries | Method of granulating powder |
US3789119A (en) * | 1971-06-01 | 1974-01-29 | Parke Davis & Co | Stabilized molded sublingual nitroglycerin tablets |
-
1972
- 1972-09-20 DE DE2246013A patent/DE2246013A1/de active Pending
-
1973
- 1973-09-10 US US395796A patent/US3885026A/en not_active Expired - Lifetime
- 1973-09-14 GB GB4318773A patent/GB1381588A/en not_active Expired
- 1973-09-17 CH CH1329273A patent/CH579394A5/xx not_active IP Right Cessation
- 1973-09-17 IT IT7328973A patent/IT998618B/it active
- 1973-09-18 FR FR7333392A patent/FR2199973B1/fr not_active Expired
- 1973-09-19 SE SE7312753A patent/SE395366B/xx unknown
- 1973-09-19 AT AT806973A patent/AT324568B/de not_active IP Right Cessation
- 1973-09-20 JP JP48106458A patent/JPS4969819A/ja active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2556561A1 (de) * | 1975-12-16 | 1977-06-30 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
DE2744493A1 (de) * | 1976-10-06 | 1978-04-13 | Wyeth John & Brother Ltd | Geformter traeger fuer chemikalien und/oder pharmaka |
DE3734796A1 (de) * | 1986-10-14 | 1988-04-21 | Beaufour Lab | Verfahren zur herstellung von loeslichen und/oder zerteilbaren tabletten und nach diesem verfahren erhaltene tabletten |
WO2024252015A1 (de) | 2023-06-09 | 2024-12-12 | euvorio GmbH | Verwendung kohlenhydrathaltiger zusammensetzungen in tablettenform zur behandlung von hypoglykämiezuständen |
Also Published As
Publication number | Publication date |
---|---|
AT324568B (de) | 1975-09-10 |
SE395366B (sv) | 1977-08-15 |
IT998618B (it) | 1976-02-20 |
FR2199973B1 (enrdf_load_html_response) | 1979-01-05 |
FR2199973A1 (enrdf_load_html_response) | 1974-04-19 |
CH579394A5 (enrdf_load_html_response) | 1976-09-15 |
US3885026A (en) | 1975-05-20 |
GB1381588A (en) | 1975-01-22 |
JPS4969819A (enrdf_load_html_response) | 1974-07-05 |
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