DE2157881A1 - Kombination aus L Dopa, 2 Imino 5 phe nyl 4 oxazohdinon und einem Aluminium oder Erdalkalisalz oder einer Aluminium oder Erdalkalibase, die zur Behandlung der Parkinsonschen Krankheit verwendet wird - Google Patents
Kombination aus L Dopa, 2 Imino 5 phe nyl 4 oxazohdinon und einem Aluminium oder Erdalkalisalz oder einer Aluminium oder Erdalkalibase, die zur Behandlung der Parkinsonschen Krankheit verwendet wirdInfo
- Publication number
- DE2157881A1 DE2157881A1 DE19712157881 DE2157881A DE2157881A1 DE 2157881 A1 DE2157881 A1 DE 2157881A1 DE 19712157881 DE19712157881 DE 19712157881 DE 2157881 A DE2157881 A DE 2157881A DE 2157881 A1 DE2157881 A1 DE 2157881A1
- Authority
- DE
- Germany
- Prior art keywords
- aluminum
- dopa
- alkaline earth
- disease
- imino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title description 28
- 150000003839 salts Chemical class 0.000 title description 25
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 title description 12
- 229910052782 aluminium Inorganic materials 0.000 title description 12
- 208000018737 Parkinson disease Diseases 0.000 title description 9
- 125000001841 imino group Chemical group [H]N=* 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 26
- 239000002585 base Substances 0.000 description 21
- 230000000694 effects Effects 0.000 description 14
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 11
- CVBMAZKKCSYWQR-BPJCFPRXSA-N Deserpidine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cccc3 CVBMAZKKCSYWQR-BPJCFPRXSA-N 0.000 description 10
- ISMCNVNDWFIXLM-WCGOZPBSSA-N deserpidine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 ISMCNVNDWFIXLM-WCGOZPBSSA-N 0.000 description 10
- 229960001993 deserpidine Drugs 0.000 description 10
- 238000011282 treatment Methods 0.000 description 10
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 9
- 239000000347 magnesium hydroxide Substances 0.000 description 9
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- -1 2-imino-5-phenyl-4-oxazolidinone compound Chemical class 0.000 description 4
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- 208000027089 Parkinsonian disease Diseases 0.000 description 3
- 206010034010 Parkinsonism Diseases 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 241000282693 Cercopithecidae Species 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010044565 Tremor Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- CSDQQAQKBAQLLE-UHFFFAOYSA-N 4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Chemical compound C1=CC(Cl)=CC=C1C1C(C=CS2)=C2CCN1 CSDQQAQKBAQLLE-UHFFFAOYSA-N 0.000 description 1
- 206010001541 Akinesia Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000015592 Involuntary movements Diseases 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 208000016285 Movement disease Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000036626 alertness Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 235000010210 aluminium Nutrition 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000002269 analeptic agent Substances 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000000648 anti-parkinson Effects 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 239000000939 antiparkinson agent Substances 0.000 description 1
- 229940124575 antispasmodic agent Drugs 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 150000003842 bromide salts Chemical class 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical class O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 description 1
- 150000003841 chloride salts Chemical class 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 235000011160 magnesium carbonates Nutrition 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 230000017311 musculoskeletal movement, spinal reflex action Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000004764 thiosulfuric acid derivatives Chemical class 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9216670A | 1970-11-23 | 1970-11-23 | |
| US11025671A | 1971-01-27 | 1971-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2157881A1 true DE2157881A1 (de) | 1972-06-08 |
Family
ID=26785355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712157881 Pending DE2157881A1 (de) | 1970-11-23 | 1971-11-22 | Kombination aus L Dopa, 2 Imino 5 phe nyl 4 oxazohdinon und einem Aluminium oder Erdalkalisalz oder einer Aluminium oder Erdalkalibase, die zur Behandlung der Parkinsonschen Krankheit verwendet wird |
Country Status (5)
| Country | Link |
|---|---|
| AU (1) | AU3509971A (enExample) |
| CA (1) | CA964581A (enExample) |
| DE (1) | DE2157881A1 (enExample) |
| FR (1) | FR2115239B1 (enExample) |
| GB (1) | GB1322095A (enExample) |
-
1971
- 1971-10-27 CA CA126,240A patent/CA964581A/en not_active Expired
- 1971-10-28 AU AU35099/71A patent/AU3509971A/en not_active Expired
- 1971-10-28 GB GB5023371A patent/GB1322095A/en not_active Expired
- 1971-11-18 FR FR7141334A patent/FR2115239B1/fr not_active Expired
- 1971-11-22 DE DE19712157881 patent/DE2157881A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2115239A1 (enExample) | 1972-07-07 |
| AU3509971A (en) | 1973-05-03 |
| CA964581A (en) | 1975-03-18 |
| GB1322095A (en) | 1973-07-04 |
| FR2115239B1 (enExample) | 1974-11-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT403122B (de) | Therapeutische infusionszubereitung auf basis von aminosäurederivaten | |
| DE10197266T5 (de) | Verfahren zur örtlichen Betäubung und Schmerzstillung | |
| DE2823174A1 (de) | Arzneimittel fuer die prophylaktische behandlung postoperativer tiefer venenthrombose | |
| DE3343934A1 (de) | M-chlor-(alpha)-tert.-butylaminopropiophenon und seine verwendung zur senkung des cholesterolspiegels | |
| DE3411225C2 (enExample) | ||
| DE3011437A1 (de) | Pharmazeutisches mittel zur heilung von entzuendlichen und/oder degenerativen und/oder atrophischen schleimhauterkrankungen | |
| DE1915798C3 (de) | Antacidum-Präparat in Form einer wäßrigen Suspension | |
| DE3916417C2 (enExample) | ||
| DE2523866A1 (de) | Schweisshemmendes mittel | |
| DD265328A5 (de) | Verfahren zur herstellung eines antihypertensiven kombinatspraeparates | |
| DE2325070A1 (de) | Pharmazeutische zubereitungen zur prophylaxe und zur behandlung von kapillarvenoesen erkrankungen | |
| DE2157881A1 (de) | Kombination aus L Dopa, 2 Imino 5 phe nyl 4 oxazohdinon und einem Aluminium oder Erdalkalisalz oder einer Aluminium oder Erdalkalibase, die zur Behandlung der Parkinsonschen Krankheit verwendet wird | |
| EP0018550B1 (de) | Mittel zur Behandlung von Muskelerkrankungen | |
| DE2128730A1 (de) | Mittel zur Kompensierung eines Dopaminmangels im Gehirn | |
| EP0820771A2 (de) | Arzneimittel zur Behandlung von Neuropathien, das ein lipidlösliches Thiamin und eine Magnesiumverbindung enthält | |
| DE3440140C2 (de) | Verwendung von Thiamphenicol gegen die Gewöhnung an zentral wirkende Analgetika | |
| DE3626128A1 (de) | Arzneimittel gegen uebelkeit, erbrechen od.dgl. | |
| DE2352618B2 (de) | Peroral oder rektal verabreichbares arzneimittel zur behandlung des parkinsonismus | |
| DE2320858A1 (de) | Heilmittel fuer die behandlung von gestoertem blutkreislauf | |
| DE102021119031B4 (de) | Behandlung von Polymyalgia Rheumatica | |
| DE1617508C3 (de) | Antidepressive Mittel | |
| DE2039169A1 (de) | Verfahren zur Kontrolle der Fertilitaet | |
| DE1767819C3 (de) | Antiseborrhoeische Mittel | |
| DE3872571T2 (de) | Mischung mit einem gehalt an einem zentralanalgetikum und forskolin als wirkstoffe. | |
| DE69506288T2 (de) | Synergistische pharmazeutische zusammensetungen, die triamcinolonacetonid und halcinonid enthalten |