DE2140177A1 - Oral applizierbare, radioaktives jod enthaltende kapsel zur schilddruesenfunktionsdiagnostik und verfahren zu ihrer herstellung - Google Patents
Oral applizierbare, radioaktives jod enthaltende kapsel zur schilddruesenfunktionsdiagnostik und verfahren zu ihrer herstellungInfo
- Publication number
- DE2140177A1 DE2140177A1 DE19712140177 DE2140177A DE2140177A1 DE 2140177 A1 DE2140177 A1 DE 2140177A1 DE 19712140177 DE19712140177 DE 19712140177 DE 2140177 A DE2140177 A DE 2140177A DE 2140177 A1 DE2140177 A1 DE 2140177A1
- Authority
- DE
- Germany
- Prior art keywords
- capsules
- iodine
- capsule
- radioactive iodine
- dispersion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 41
- 230000002285 radioactive effect Effects 0.000 title claims abstract description 13
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims description 15
- 229910052740 iodine Inorganic materials 0.000 title claims description 15
- 239000011630 iodine Substances 0.000 title claims description 15
- 238000009601 thyroid function test Methods 0.000 title abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 6
- 229930195729 fatty acid Natural products 0.000 claims abstract description 6
- 239000000194 fatty acid Substances 0.000 claims abstract description 6
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 6
- 229920000159 gelatin Polymers 0.000 claims abstract description 3
- 235000019322 gelatine Nutrition 0.000 claims abstract description 3
- 239000000829 suppository Substances 0.000 claims abstract description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000002612 dispersion medium Substances 0.000 claims description 12
- 239000006185 dispersion Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000002609 medium Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 230000036760 body temperature Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 210000001685 thyroid gland Anatomy 0.000 claims description 5
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 claims description 4
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002195 soluble material Substances 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 150000002148 esters Chemical class 0.000 abstract description 3
- 239000001828 Gelatine Substances 0.000 abstract description 2
- 150000003839 salts Chemical class 0.000 abstract description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000013543 active substance Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 150000002497 iodine compounds Chemical class 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000941 radioactive substance Substances 0.000 description 1
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1262—Capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712140177 DE2140177A1 (de) | 1971-08-11 | 1971-08-11 | Oral applizierbare, radioaktives jod enthaltende kapsel zur schilddruesenfunktionsdiagnostik und verfahren zu ihrer herstellung |
| NL7210728A NL7210728A (enrdf_load_stackoverflow) | 1971-08-11 | 1972-08-04 | |
| JP47080327A JPS4826914A (enrdf_load_stackoverflow) | 1971-08-11 | 1972-08-10 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712140177 DE2140177A1 (de) | 1971-08-11 | 1971-08-11 | Oral applizierbare, radioaktives jod enthaltende kapsel zur schilddruesenfunktionsdiagnostik und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2140177A1 true DE2140177A1 (de) | 1973-02-22 |
Family
ID=5816424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712140177 Pending DE2140177A1 (de) | 1971-08-11 | 1971-08-11 | Oral applizierbare, radioaktives jod enthaltende kapsel zur schilddruesenfunktionsdiagnostik und verfahren zu ihrer herstellung |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS4826914A (enrdf_load_stackoverflow) |
| DE (1) | DE2140177A1 (enrdf_load_stackoverflow) |
| NL (1) | NL7210728A (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0001822A3 (de) * | 1977-11-03 | 1979-08-22 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung pharmazeutischer Präparate |
| DE3115053A1 (de) * | 1980-04-14 | 1982-02-18 | E.R. Squibb & Sons, Inc., 08540 Princeton, N.J. | Radioaktive verbindungen enthaltende kapseln und verfahren zum fuellen derselben |
| EP0060434A3 (en) * | 1981-03-13 | 1984-03-07 | Akademie Der Wissenschaften Der Ddr | Process for the preparation of a diagnostic or therapeutic composition containing iodine 131 |
| WO1996008236A1 (de) * | 1994-09-13 | 1996-03-21 | Nuclear Research Institute Rez Plc | Kapseln mit innenseitig hydrophober beschichtung zur aufnahme von matrix-adsorbierten wässrigen (radioaktiven) lösungen und verfahren zur herstellung obiger kapseln |
| EP3076947B1 (en) * | 2013-12-04 | 2018-06-13 | Hovione Scientia Limited | Contrast media containing taste masking formulations |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5314678A (en) * | 1992-01-28 | 1994-05-24 | Mallinckrodt Medical, Inc. | Sodium iodide 131 I capsules |
-
1971
- 1971-08-11 DE DE19712140177 patent/DE2140177A1/de active Pending
-
1972
- 1972-08-04 NL NL7210728A patent/NL7210728A/xx unknown
- 1972-08-10 JP JP47080327A patent/JPS4826914A/ja active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0001822A3 (de) * | 1977-11-03 | 1979-08-22 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung pharmazeutischer Präparate |
| EP0049909A1 (de) * | 1977-11-03 | 1982-04-21 | Hoechst Aktiengesellschaft | Verbesserte pharmazeutische Präparate in Form von festen Dosiereinheiten sowie Verfahren zu ihrer Herstellung |
| DE3115053A1 (de) * | 1980-04-14 | 1982-02-18 | E.R. Squibb & Sons, Inc., 08540 Princeton, N.J. | Radioaktive verbindungen enthaltende kapseln und verfahren zum fuellen derselben |
| EP0060434A3 (en) * | 1981-03-13 | 1984-03-07 | Akademie Der Wissenschaften Der Ddr | Process for the preparation of a diagnostic or therapeutic composition containing iodine 131 |
| WO1996008236A1 (de) * | 1994-09-13 | 1996-03-21 | Nuclear Research Institute Rez Plc | Kapseln mit innenseitig hydrophober beschichtung zur aufnahme von matrix-adsorbierten wässrigen (radioaktiven) lösungen und verfahren zur herstellung obiger kapseln |
| EP3076947B1 (en) * | 2013-12-04 | 2018-06-13 | Hovione Scientia Limited | Contrast media containing taste masking formulations |
| AU2014358858B2 (en) * | 2013-12-04 | 2018-09-13 | Hovione Scientia Limited | Contrast media taste masking formulations |
| RU2683568C1 (ru) * | 2013-12-04 | 2019-03-29 | Ховионе Сайентиа Лимитед | Композиции, корригирующие вкус контрастных средств |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7210728A (enrdf_load_stackoverflow) | 1973-02-13 |
| JPS4826914A (enrdf_load_stackoverflow) | 1973-04-09 |
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