DE2137811C3 - Derivate der 9-Oxo-15-hydroxyprostansäure und ihre Homologen und ein Verfahren zur Herstellung dieser Verbindungen - Google Patents

Derivate der 9-Oxo-15-hydroxyprostansäure und ihre Homologen und ein Verfahren zur Herstellung dieser Verbindungen

Info

Publication number
DE2137811C3
DE2137811C3 DE2137811A DE2137811A DE2137811C3 DE 2137811 C3 DE2137811 C3 DE 2137811C3 DE 2137811 A DE2137811 A DE 2137811A DE 2137811 A DE2137811 A DE 2137811A DE 2137811 C3 DE2137811 C3 DE 2137811C3
Authority
DE
Germany
Prior art keywords
compounds
hydroxy
acid
methyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2137811A
Other languages
German (de)
English (en)
Other versions
DE2137811A1 (enExample
DE2137811B2 (enExample
Inventor
J F Bagli
T Bogri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Canada Inc
Original Assignee
Ayerst Mckenna and Harrison Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ayerst Mckenna and Harrison Inc filed Critical Ayerst Mckenna and Harrison Inc
Publication of DE2137811A1 publication Critical patent/DE2137811A1/de
Publication of DE2137811B2 publication Critical patent/DE2137811B2/de
Application granted granted Critical
Publication of DE2137811C3 publication Critical patent/DE2137811C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/215—Saturated compounds having only one carboxyl group and containing keto groups containing singly bound oxygen containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE2137811A 1970-07-30 1971-07-28 Derivate der 9-Oxo-15-hydroxyprostansäure und ihre Homologen und ein Verfahren zur Herstellung dieser Verbindungen Expired DE2137811C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5970270A 1970-07-30 1970-07-30

Publications (3)

Publication Number Publication Date
DE2137811A1 DE2137811A1 (enExample) 1972-02-03
DE2137811B2 DE2137811B2 (enExample) 1980-02-28
DE2137811C3 true DE2137811C3 (de) 1980-10-30

Family

ID=22024690

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2137811A Expired DE2137811C3 (de) 1970-07-30 1971-07-28 Derivate der 9-Oxo-15-hydroxyprostansäure und ihre Homologen und ein Verfahren zur Herstellung dieser Verbindungen

Country Status (7)

Country Link
US (1) US3671570A (enExample)
CA (1) CA972749A (enExample)
CH (1) CH573896A5 (enExample)
DE (1) DE2137811C3 (enExample)
FR (1) FR2100971B1 (enExample)
NL (1) NL7110590A (enExample)
SE (1) SE375984B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903299A (en) * 1970-05-27 1975-09-02 May & Baker Ltd Pharmaceutical compositions containing cyclopentane derivatives
US3907998A (en) * 1971-06-28 1975-09-23 Ayerst Mckenna & Harrison Methods for relieving bronchial spasm with 9,15-dioxygenated prostanoic and prost-13-enoic acids and the like
US3987087A (en) * 1971-07-29 1976-10-19 The Upjohn Company Phenyl-substituted prostaglandin-f type analogs
US3974213A (en) * 1972-07-13 1976-08-10 Pfizer Inc. 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins
US3971826A (en) * 1972-07-13 1976-07-27 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandins
US3956284A (en) * 1972-07-13 1976-05-11 Pfizer Inc. Heterocyclic 15-substituted-ω-pentanorprostoglandins
US4011262A (en) * 1972-07-13 1977-03-08 Pfizer Inc. 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series
CA1018970A (en) * 1972-10-27 1977-10-11 American Home Products Corporation 15-substituted prostanoic acids
US3972917A (en) * 1972-10-27 1976-08-03 American Home Products Corporation 11-Deoxy 15-methyl prostaglandin E1
US4152527A (en) * 1972-11-08 1979-05-01 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandins
US3932463A (en) * 1974-06-03 1976-01-13 American Cyanamid Company 11-Deoxy-13-dihydro-prostaglandin-9-ketals
US4036832A (en) * 1974-07-03 1977-07-19 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandins
GB1499253A (en) * 1975-02-14 1978-01-25 Upjohn Co Prostaglandins
US4054741A (en) * 1975-06-27 1977-10-18 Ayerst Mckenna & Harrison Ltd. Derivatives of prostanoic acid
AU2006219152B2 (en) * 2005-03-04 2011-02-24 Sucampo Ag Method and composition for treating peripheral vascular diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1097533A (en) * 1965-08-16 1968-01-03 Upjohn Co Prostanoic acid derivatives
GB1198071A (en) * 1966-08-09 1970-07-08 George Erich Just Improvements in or relating to Prostaglandin Analogues and the Manufacture thereof

Also Published As

Publication number Publication date
CH573896A5 (enExample) 1976-03-31
NL7110590A (enExample) 1972-02-01
CA972749A (en) 1975-08-12
SE375984B (enExample) 1975-05-05
FR2100971B1 (enExample) 1975-02-07
DE2137811A1 (enExample) 1972-02-03
US3671570A (en) 1972-06-20
FR2100971A1 (enExample) 1972-03-24
DE2137811B2 (enExample) 1980-02-28

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Legal Events

Date Code Title Description
OD Request for examination
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee