DE209728C - - Google Patents
Info
- Publication number
- DE209728C DE209728C DENDAT209728D DE209728DA DE209728C DE 209728 C DE209728 C DE 209728C DE NDAT209728 D DENDAT209728 D DE NDAT209728D DE 209728D A DE209728D A DE 209728DA DE 209728 C DE209728 C DE 209728C
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- hydrogen
- parts
- alcohol
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 229940083251 peripheral vasodilators Purine derivatives Drugs 0.000 claims description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 150000007530 organic bases Chemical class 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 150000007513 acids Chemical class 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 235000002639 sodium chloride Nutrition 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 3
- 150000003230 pyrimidines Chemical class 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M NaHCO3 Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N Theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 230000001396 anti-anti-diuretic Effects 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 230000000875 corresponding Effects 0.000 description 2
- 230000001882 diuretic Effects 0.000 description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000001264 neutralization Effects 0.000 description 2
- 150000003212 purines Chemical class 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 229940083082 Pyrimidine derivatives acting on arteriolar smooth muscle Drugs 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N Sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 229960000278 Theophylline Drugs 0.000 description 1
- QFKJCKFAYFUXRQ-UHFFFAOYSA-N barium;hydrate Chemical compound O.[Ba] QFKJCKFAYFUXRQ-UHFFFAOYSA-N 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
- -1 dimethylaminoacetylpyrimidine Chemical compound 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Publications (1)
Publication Number | Publication Date |
---|---|
DE209728C true DE209728C (fr) |
Family
ID=471672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DENDAT209728D Active DE209728C (fr) |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE209728C (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1001272B (de) * | 1954-11-29 | 1957-01-24 | Knoll Ag | Verfahren zur Herstellung von 8-(n-Dibutylamino-alkyl)-theophyllinabkoemmlingen |
DE1058516B (de) * | 1957-08-17 | 1959-06-04 | Knoll Ag | Verfahren zur Herstellung von 8-(ª‡-Dimethylaminoaethyl)-theophyllin |
-
0
- DE DENDAT209728D patent/DE209728C/de active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1001272B (de) * | 1954-11-29 | 1957-01-24 | Knoll Ag | Verfahren zur Herstellung von 8-(n-Dibutylamino-alkyl)-theophyllinabkoemmlingen |
DE1058516B (de) * | 1957-08-17 | 1959-06-04 | Knoll Ag | Verfahren zur Herstellung von 8-(ª‡-Dimethylaminoaethyl)-theophyllin |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE1793745A1 (de) | Arylsubstituierte biguanide | |
DE209728C (fr) | ||
DE2534962B2 (de) | cis-3,4-Ureylenthiophan-l,1-dioxid und Verfahren zu seiner Herstellung | |
DE2166270C3 (de) | Nicotinoylaminoäthansulfonyl-2amino-thiazol | |
DE165224C (fr) | ||
DE156055C (fr) | ||
DE901650C (de) | Verfahren zur Herstellung von therapeutisch wertvollen Verbindungen des p-Aminobenzolsulfonhydrazids | |
DE158592C (fr) | ||
DE166448C (fr) | ||
DE1720031A1 (de) | Biologisch wirksame 5-Benzylpyrimidin-Derivate und Verfahren zu ihrer Herstellung | |
DE1200308B (de) | Verfahren zur Herstellung von 4, 6-Dihydroxy-pyrimidinen | |
DE1445662C (de) | 4- eckige Klammer auf 2-(5-Nitrofuryl)vinyl eckige Klammer zu -pyrimidine und Verfahren zu ihrer Herstellung | |
DE844899C (de) | Verfahren zur Herstellung von organischen Thioverbindungen bzw. deren Salzen mit Metallen oder Saeuren | |
DE756489C (de) | Verfahren zur Herstellung von C-Cycloheptenylbarbitursaeuren | |
DE195656C (fr) | ||
DE153861C (fr) | ||
DE264009C (fr) | ||
DE737931C (de) | Verfahren zur Herstellung von 2, 4-Diaminochinazolin | |
DE838141C (de) | Verfahren zur Herstellung von 2-Chlorpyrimiddn | |
DE158621C (fr) | ||
DE713079C (de) | Verfahren zur Darstellung von Abkoemmlingen der 4-Aminobenzolsulfonamide | |
DE210644C (fr) | ||
AT213896B (de) | Verfahren zur Herstellung von neuen, basisch substituierten Thioäthern von Pyrimidinen | |
AT251585B (de) | Verfahren zur Herstellung von neuen 6,7-Dihydro-5H-pyrrolo-[3,4-d]-pyrimidinen | |
DE170586C (fr) |