DE2061515A1 - 2,5 disubstituierte Imidazole und Ver fahren zur Herstellung derselben - Google Patents
2,5 disubstituierte Imidazole und Ver fahren zur Herstellung derselbenInfo
- Publication number
- DE2061515A1 DE2061515A1 DE19702061515 DE2061515A DE2061515A1 DE 2061515 A1 DE2061515 A1 DE 2061515A1 DE 19702061515 DE19702061515 DE 19702061515 DE 2061515 A DE2061515 A DE 2061515A DE 2061515 A1 DE2061515 A1 DE 2061515A1
- Authority
- DE
- Germany
- Prior art keywords
- lower alkyl
- aryl
- compound
- substituted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/93—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by halogen atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88536269A | 1969-12-15 | 1969-12-15 | |
US26501572A | 1972-06-21 | 1972-06-21 | |
US00265016A US3818014A (en) | 1969-12-15 | 1972-06-21 | 2-quinolyl-4(5)-trifluoromethylimidazoles |
US45610274A | 1974-03-29 | 1974-03-29 | |
US61090375A | 1975-09-05 | 1975-09-05 | |
US05/610,904 US4032522A (en) | 1969-12-15 | 1975-09-05 | 2-pyrazinyl-trifluoromethylimidazoles and a method for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2061515A1 true DE2061515A1 (de) | 1971-06-24 |
Family
ID=27559450
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2061489A Expired DE2061489C2 (de) | 1969-12-15 | 1970-12-14 | Anti-Gichtmittel und anti-hyperurikämische Mittel |
DE19702061515 Pending DE2061515A1 (de) | 1969-12-15 | 1970-12-14 | 2,5 disubstituierte Imidazole und Ver fahren zur Herstellung derselben |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2061489A Expired DE2061489C2 (de) | 1969-12-15 | 1970-12-14 | Anti-Gichtmittel und anti-hyperurikämische Mittel |
Country Status (10)
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2155558A1 (US06262066-20010717-C00058.png) * | 1970-11-16 | 1972-06-29 | ||
US4058614A (en) * | 1973-12-04 | 1977-11-15 | Merck & Co., Inc. | Substituted imidazole compounds and therapeutic compositions therewith |
WO2000018763A2 (en) * | 1998-09-29 | 2000-04-06 | Neurogen Corporation | 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands |
US6284759B1 (en) | 1998-09-30 | 2001-09-04 | Neurogen Corporation | 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands |
US6288230B1 (en) | 1998-09-29 | 2001-09-11 | Neurogen Corporation | 2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7017486A (US06262066-20010717-C00058.png) * | 1969-12-15 | 1971-06-17 | ||
GB1481512A (en) * | 1973-07-12 | 1977-08-03 | Lucas Electrical Ltd | Radiation-sensitive switching circuits |
DE2414280C2 (de) * | 1974-03-25 | 1981-12-17 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von 1-Methyl-5-nitroimidazolen |
US4853383A (en) * | 1975-03-03 | 1989-08-01 | Merck & Co., Inc. | β-blocking substituted imidazoles |
US4134983A (en) * | 1975-03-03 | 1979-01-16 | Merck & Co., Inc. | 3-amino-2-or-propoxyaryl substituted imidazoles |
US4199580A (en) * | 1975-03-03 | 1980-04-22 | Merck & Co., Inc. | 3-Amino-2-or-propoxy-tetrahydronaphthyl or indanyl-substituted imidazoles and use |
US4179512A (en) * | 1977-03-01 | 1979-12-18 | Merck & Co., Inc. | 4-Substituted-2-arylimidazoles |
US4314844A (en) * | 1979-01-11 | 1982-02-09 | Rohm And Haas Company | Herbicidal substituted imidazoles |
US4281005A (en) * | 1979-03-05 | 1981-07-28 | Merck & Co., Inc. | Novel 2-pyridylimidazole compounds |
DE3121736C2 (de) * | 1980-06-02 | 1994-04-07 | American Cyanamid Co | 2-(2-Imidazolin-2-yl)-pyridine und -chinoline, Verfahren und Zwischenstufen zur Herstellung derselben und Verwendung derselben als herbizide Wirkstoffe |
IL62794A0 (en) * | 1980-06-02 | 1981-07-31 | American Cyanamid Co | Substituted nicotinic acid esters and salts thereof and their use as herbicidal agents |
US4315021A (en) * | 1980-12-03 | 1982-02-09 | Syntex (U.S.A.) Inc. | 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles |
US4499097A (en) * | 1983-03-10 | 1985-02-12 | American Cyanamid Company | 2-(Pyridyl)imidazolyl ketones |
US4602093A (en) * | 1984-02-08 | 1986-07-22 | Merck & Co., Inc. | Novel substituted imidazoles, their preparation and use |
FR2576308B1 (fr) * | 1985-01-18 | 1987-02-20 | Synthelabo | Derives de tetrahydroquinoleine, leur preparation et leur application en therapeutique |
GB8705183D0 (en) * | 1987-03-05 | 1987-04-08 | May & Baker Ltd | Compositions of matter |
US4914207A (en) * | 1989-05-09 | 1990-04-03 | Pfizer Inc. | Arylthiazolylimidazoles |
FR2649999B1 (fr) * | 1989-07-21 | 1991-09-20 | Payen Cie L | Procede et machine pour la fabrication en continu d'un fil elastique a base d'elasthane |
YU47834B (sr) * | 1989-08-10 | 1996-01-09 | Schering Agrochemical Limited | Azolni pesticid |
US5189053A (en) * | 1989-08-10 | 1993-02-23 | Schering Agrochemicals Limited | Imidazol(in)e substituted haloarylpyrazole pesticides |
JP3393891B2 (ja) * | 1992-08-18 | 2003-04-07 | 塩野義製薬株式会社 | イミダゾール類の製造方法 |
AU2630595A (en) * | 1994-06-09 | 1996-01-04 | Nippon Soda Co., Ltd. | Imidazole derivative, production process, and herbicide |
GB2344588B (en) * | 1997-07-25 | 2001-11-14 | Black James Foundation | 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands |
GB9715814D0 (en) * | 1997-07-25 | 1997-10-01 | Black James Foundation | Histamine H3 receptor ligands |
AU1520699A (en) | 1997-11-07 | 1999-05-31 | Johns Hopkins University, The | Methods for treatment of disorders of cardiac contractility |
ATE422357T1 (de) * | 2000-06-28 | 2009-02-15 | Merck & Co Inc | Verwendung von allopurinol zur behandlung von bluthochdruck |
ATE529110T1 (de) | 2002-03-05 | 2011-11-15 | Transtech Pharma Inc | Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen |
ZA200508300B (en) * | 2003-05-20 | 2007-03-28 | Transtech Pharma Inc | RAGE antagonists as agents to reverse amyloidosis and diseases associated therewith |
WO2007043400A1 (ja) * | 2005-10-07 | 2007-04-19 | Kissei Pharmaceutical Co., Ltd. | 含窒素芳香族複素環化合物およびそれを含有する医薬組成物 |
ES2467923T3 (es) | 2009-09-30 | 2014-06-13 | Transtech Pharma, Llc | Derivados de imidazol substituidos para el tratamiento de la enfermedad de Alzheimer |
HU1000676D0 (en) * | 2010-12-17 | 2011-02-28 | Pharmahungary 2000 Kft | Inhibitors of matrix metalloproteinase, pharmaceutical compositions thereof and use of them for preventing and treating diseases where the activation of mmp is involved |
US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3202674A (en) * | 1960-03-05 | 1965-08-24 | American Home Prod | Phenethylamine derivatives |
US3399211A (en) * | 1964-03-10 | 1968-08-27 | Merck & Co Inc | Production of 2-aryl-4(5)-nitroimidazoles |
NL6816241A (US06262066-20010717-C00058.png) * | 1967-12-01 | 1969-06-03 | ||
US3652579A (en) * | 1969-06-26 | 1972-03-28 | Hoffmann La Roche | 1-methyl-2-substituted 5-nitroimidazoles |
NL7017486A (US06262066-20010717-C00058.png) * | 1969-12-15 | 1971-06-17 | ||
US3691178A (en) * | 1970-03-16 | 1972-09-12 | Merck & Co Inc | Substituted imidazoles |
-
1970
- 1970-11-30 NL NL7017486A patent/NL7017486A/xx not_active Application Discontinuation
- 1970-12-02 CA CA099,661A patent/CA945161A/en not_active Expired
- 1970-12-07 GB GB5794270A patent/GB1301754A/en not_active Expired
- 1970-12-10 CH CH1827770A patent/CH566994A5/xx not_active IP Right Cessation
- 1970-12-14 BE BE760289A patent/BE760289A/xx unknown
- 1970-12-14 FR FR7044962A patent/FR2081360B1/fr not_active Expired
- 1970-12-14 DE DE2061489A patent/DE2061489C2/de not_active Expired
- 1970-12-14 DE DE19702061515 patent/DE2061515A1/de active Pending
- 1970-12-14 SE SE7016885A patent/SE388855B/xx unknown
- 1970-12-15 AT AT1126970A patent/AT300788B/de active
-
1972
- 1972-06-21 US US00265016A patent/US3818014A/en not_active Expired - Lifetime
- 1972-06-21 US US00265015A patent/US3786061A/en not_active Expired - Lifetime
-
1975
- 1975-09-05 US US05/610,904 patent/US4032522A/en not_active Expired - Lifetime
-
1977
- 1977-02-02 US US05/764,796 patent/US4125530A/en not_active Expired - Lifetime
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2155558A1 (US06262066-20010717-C00058.png) * | 1970-11-16 | 1972-06-29 | ||
US4058614A (en) * | 1973-12-04 | 1977-11-15 | Merck & Co., Inc. | Substituted imidazole compounds and therapeutic compositions therewith |
WO2000018763A2 (en) * | 1998-09-29 | 2000-04-06 | Neurogen Corporation | 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands |
WO2000018763A3 (en) * | 1998-09-29 | 2000-05-25 | Neurogen Corp | 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands |
US6288230B1 (en) | 1998-09-29 | 2001-09-11 | Neurogen Corporation | 2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands |
US6284759B1 (en) | 1998-09-30 | 2001-09-04 | Neurogen Corporation | 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands |
US6432958B1 (en) | 1998-09-30 | 2002-08-13 | Neurogen Corporation | 2-piperazinoalkylaminobenzoazole derivatives: dopamine receptor subtype specific ligands |
Also Published As
Publication number | Publication date |
---|---|
US4125530A (en) | 1978-11-14 |
BE760289A (fr) | 1971-06-14 |
NL7017486A (US06262066-20010717-C00058.png) | 1971-06-17 |
US3818014A (en) | 1974-06-18 |
GB1301754A (US06262066-20010717-C00058.png) | 1973-01-04 |
FR2081360A1 (US06262066-20010717-C00058.png) | 1971-12-03 |
DE2061489A1 (de) | 1971-07-29 |
FR2081360B1 (US06262066-20010717-C00058.png) | 1974-08-23 |
CH566994A5 (US06262066-20010717-C00058.png) | 1975-09-30 |
SE388855B (sv) | 1976-10-18 |
AT300788B (de) | 1972-08-10 |
US4032522A (en) | 1977-06-28 |
CA945161A (en) | 1974-04-09 |
US3786061A (en) | 1974-01-15 |
DE2061489C2 (de) | 1982-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
OD | Request for examination | ||
OHW | Rejection |