DE2051871A1 - Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents - Google Patents
Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agentsInfo
- Publication number
- DE2051871A1 DE2051871A1 DE19702051871 DE2051871A DE2051871A1 DE 2051871 A1 DE2051871 A1 DE 2051871A1 DE 19702051871 DE19702051871 DE 19702051871 DE 2051871 A DE2051871 A DE 2051871A DE 2051871 A1 DE2051871 A1 DE 2051871A1
- Authority
- DE
- Germany
- Prior art keywords
- compound
- formula
- group
- reaction
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19702051871 DE2051871A1 (en) | 1969-05-16 | 1970-05-15 | Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2517169 | 1969-05-16 | ||
DE19702051871 DE2051871A1 (en) | 1969-05-16 | 1970-05-15 | Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE2051871A1 true DE2051871A1 (en) | 1971-11-18 |
DE2051871C2 DE2051871C2 (hu) | 1987-05-27 |
Family
ID=25759946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19702051871 Granted DE2051871A1 (en) | 1969-05-16 | 1970-05-15 | Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE2051871A1 (hu) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013126360A3 (en) * | 2012-02-21 | 2013-10-31 | Celgene Corporation | Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine |
US9018243B2 (en) | 2002-03-20 | 2015-04-28 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US9468605B2 (en) | 2013-06-17 | 2016-10-18 | Celgene Corporation | Formulations of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US10300042B2 (en) | 2014-06-23 | 2019-05-28 | Celgene Corporation | Apremilast for the treatment of a liver disease or a liver function abnormality |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3049544A (en) * | 1962-08-14 | Method for the preparation of | ||
NL6609626A (hu) * | 1965-07-08 | 1967-01-09 | ||
DE1445176A1 (de) * | 1959-09-03 | 1968-10-17 | Wellcome Found | Neuartige organische chemische Verbindungen sowie Verfahren zu deren Herstellung |
DE2066039B2 (de) * | 1969-03-06 | 1979-01-11 | The Wellcome Foundation Ltd., London | Verfahren zur Herstellung von 23-Diamitio-5-benzylpyrimidinen |
-
1970
- 1970-05-15 DE DE19702051871 patent/DE2051871A1/de active Granted
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3049544A (en) * | 1962-08-14 | Method for the preparation of | ||
DE1445176A1 (de) * | 1959-09-03 | 1968-10-17 | Wellcome Found | Neuartige organische chemische Verbindungen sowie Verfahren zu deren Herstellung |
NL6609626A (hu) * | 1965-07-08 | 1967-01-09 | ||
DE2066039B2 (de) * | 1969-03-06 | 1979-01-11 | The Wellcome Foundation Ltd., London | Verfahren zur Herstellung von 23-Diamitio-5-benzylpyrimidinen |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9433606B2 (en) | 2002-03-20 | 2016-09-06 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US9018243B2 (en) | 2002-03-20 | 2015-04-28 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US9586897B2 (en) | 2012-02-21 | 2017-03-07 | Celgene Corporation | Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine |
AU2013203283B2 (en) * | 2012-02-21 | 2015-11-26 | Amgen (Europe) GmbH | Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine |
US9187417B2 (en) | 2012-02-21 | 2015-11-17 | Celgene Corporation | Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine |
WO2013126360A3 (en) * | 2012-02-21 | 2013-10-31 | Celgene Corporation | Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine |
US9688623B2 (en) | 2012-02-21 | 2017-06-27 | Celgene Corporation | Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine |
RU2632875C2 (ru) * | 2012-02-21 | 2017-10-11 | Селджин Корпорейшн | Способы получения (s)-1-(3-этокси-4-метоксифенил)-2- метансульфонилэтиламина |
EP3312156A1 (en) * | 2012-02-21 | 2018-04-25 | Celgene Corporation | Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine |
CN112812044A (zh) * | 2012-02-21 | 2021-05-18 | 安进(欧洲)有限责任公司 | 用于制备(s)-1-(3-乙氧基-4-甲氧基苯基)-2-甲烷磺酰基乙胺的工艺 |
CN112812044B (zh) * | 2012-02-21 | 2023-05-30 | 安进(欧洲)有限责任公司 | 用于制备(s)-1-(3-乙氧基-4-甲氧基苯基)-2-甲烷磺酰基乙胺的工艺 |
US9468605B2 (en) | 2013-06-17 | 2016-10-18 | Celgene Corporation | Formulations of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US10300042B2 (en) | 2014-06-23 | 2019-05-28 | Celgene Corporation | Apremilast for the treatment of a liver disease or a liver function abnormality |
Also Published As
Publication number | Publication date |
---|---|
DE2051871C2 (hu) | 1987-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8125 | Change of the main classification |
Ipc: C07D239/48 |
|
AC | Divided out of |
Ref country code: DE Ref document number: 2023977 Format of ref document f/p: P |
|
D2 | Grant after examination | ||
8364 | No opposition during term of opposition | ||
8310 | Action for declaration of annulment | ||
8314 | Invalidation rejected |