DE2027044C3 - Steriles Ampieillin-Trihydrat und Verfahren zu seiner Herstellung - Google Patents
Steriles Ampieillin-Trihydrat und Verfahren zu seiner HerstellungInfo
- Publication number
- DE2027044C3 DE2027044C3 DE2027044A DE2027044A DE2027044C3 DE 2027044 C3 DE2027044 C3 DE 2027044C3 DE 2027044 A DE2027044 A DE 2027044A DE 2027044 A DE2027044 A DE 2027044A DE 2027044 C3 DE2027044 C3 DE 2027044C3
- Authority
- DE
- Germany
- Prior art keywords
- sterile
- ampicillin
- particle size
- trihydrate
- ampicillin trihydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims 2
- 150000004684 trihydrates Chemical class 0.000 title claims 2
- 229960003311 ampicillin trihydrate Drugs 0.000 claims description 28
- 239000002245 particle Substances 0.000 claims description 25
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- RXDALBZNGVATNY-CWLIKTDRSA-N ampicillin trihydrate Chemical compound O.O.O.C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 RXDALBZNGVATNY-CWLIKTDRSA-N 0.000 claims 6
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000008174 sterile solution Substances 0.000 claims 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 40
- 229960000723 ampicillin Drugs 0.000 description 17
- 239000000725 suspension Substances 0.000 description 17
- 239000013078 crystal Substances 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000007794 irritation Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- 238000010255 intramuscular injection Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 229940067606 lecithin Drugs 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 239000007900 aqueous suspension Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- KLOHDWPABZXLGI-YWUHCJSESA-M ampicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=CC=C1 KLOHDWPABZXLGI-YWUHCJSESA-M 0.000 description 1
- 229960001931 ampicillin sodium Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- WHRVRSCEWKLAHX-LQDWTQKMSA-N benzylpenicillin procaine Chemical compound [H+].CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 WHRVRSCEWKLAHX-LQDWTQKMSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83122569A | 1969-06-06 | 1969-06-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2027044A1 DE2027044A1 (de) | 1970-12-17 |
| DE2027044B2 DE2027044B2 (de) | 1980-01-17 |
| DE2027044C3 true DE2027044C3 (de) | 1980-09-11 |
Family
ID=25258589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2027044A Expired DE2027044C3 (de) | 1969-06-06 | 1970-06-02 | Steriles Ampieillin-Trihydrat und Verfahren zu seiner Herstellung |
Country Status (14)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1532993A (en) * | 1975-03-07 | 1978-11-22 | Beecham Group Ltd | Injectable antibiotic compositions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6705789A (enrdf_load_stackoverflow) * | 1967-03-08 | 1968-09-09 |
-
1969
- 1969-06-06 US US831225A patent/US3703511A/en not_active Expired - Lifetime
- 1969-12-19 BR BR215337/69A patent/BR6915337D0/pt unknown
-
1970
- 1970-05-26 ZA ZA703565A patent/ZA703565B/xx unknown
- 1970-05-26 IE IE681/70A patent/IE34226B1/xx unknown
- 1970-05-26 CA CA083,754A patent/CA946285A/en not_active Expired
- 1970-06-01 BE BE751261D patent/BE751261A/xx not_active IP Right Cessation
- 1970-06-02 DE DE2027044A patent/DE2027044C3/de not_active Expired
- 1970-06-02 FR FR7020146A patent/FR2052937B1/fr not_active Expired
- 1970-06-03 NL NL7008083A patent/NL7008083A/xx unknown
- 1970-06-04 CH CH839970A patent/CH525240A/fr not_active IP Right Cessation
- 1970-06-04 DK DK291670AA patent/DK126835B/da not_active IP Right Cessation
- 1970-06-05 JP JP45048627A patent/JPS4913963B1/ja active Pending
- 1970-06-05 GB GB2612470A patent/GB1316625A/en not_active Expired
- 1970-06-05 ES ES380448A patent/ES380448A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE34226B1 (en) | 1975-03-05 |
| DK126835B (da) | 1973-08-27 |
| BR6915337D0 (pt) | 1973-03-13 |
| DE2027044B2 (de) | 1980-01-17 |
| FR2052937A1 (enrdf_load_stackoverflow) | 1971-04-16 |
| BE751261A (fr) | 1970-12-01 |
| DE2027044A1 (de) | 1970-12-17 |
| GB1316625A (en) | 1973-05-09 |
| CH525240A (fr) | 1972-07-15 |
| IE34226L (en) | 1970-12-06 |
| NL7008083A (enrdf_load_stackoverflow) | 1970-12-08 |
| JPS4913963B1 (enrdf_load_stackoverflow) | 1974-04-04 |
| FR2052937B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| CA946285A (en) | 1974-04-30 |
| US3703511A (en) | 1972-11-21 |
| ZA703565B (en) | 1971-01-27 |
| ES380448A1 (es) | 1972-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69109279T2 (de) | Wässrige suspension als injektionszubereitung, verfahren zur herstellung derselben und verwendung für schmerzstillung. | |
| DE10018783A1 (de) | Lagerstabile Infusionslösung des Ciprofloxacins mit verringertem Säuregehalt | |
| DE2834702C2 (enrdf_load_stackoverflow) | ||
| DE3740588C2 (de) | Temperaturstabiles Breitband-Antibiotikum | |
| DE2317768C3 (de) | Verfahren zur Herstellung eines antazid wirkenden Arzneimittels | |
| DE2027044C3 (de) | Steriles Ampieillin-Trihydrat und Verfahren zu seiner Herstellung | |
| DE69209335T2 (de) | Mittel zur Zersetzung von Gallensteinen | |
| DE60101979T2 (de) | Lösung enthaltend N-[O-(p-pivaloyloxybenzenesulfonylamino)benzoyl]glyzin Mononatriumsalz Tetrahydrat und diese Lösung enthaltendes Arzneimittel | |
| DE10048510A1 (de) | Lagerstabile Infusionslösung des Ciprofloxacins mit verringertem Säuregehalt | |
| DE2505814C2 (de) | Verfahren zur Herstellung feinverteilter Mikropartikel von Tyrosin mit einem Gehalt eines darin dispergierten, mit Glutaraldehyd modifizierten Allergens und diese Mikropartikel als Wirkstoff enthaltende injizierbare Lösung | |
| DE1086012B (de) | Verfahren zur Herstellung von protrahiert wirkenden Vitamin-B-Praeparaten | |
| EP0744951A1 (de) | Verfahren zur herstellung eines sterilen prednisolongels | |
| DE69100053T2 (de) | Arzneimittelzusammensetzung in stabiler wässriger Suspensionsform auf der Basis von Sucralfat und einem Antacidum sowie Verfahren zu ihrer Herstellung. | |
| Tsuzuki | SYNTHESE EINIGER BRÜCKENDERIVATE DER WEINSÄURE DURCH ACETALISIERUNG IHRER ESTER MIT ACETON, ACETALDEHYD AND FORMALDEHYD | |
| CH652306A5 (de) | Verfahren zur herstellung einer pharmazeutischen, parenteralen dosiseinheit des natriumsalzes von piperacillin. | |
| DE2950832C2 (de) | Spritzfertige injizierbare wäßrige Lösungen der Alkalisalze von Canrenoinsäure und Furosemid | |
| DE1944906A1 (de) | Aliphatische Sulfate des Erythromycins | |
| DE1906159A1 (de) | Zusammensetzung zur Foerderung der Heilung von Wunden | |
| DE890562C (de) | Verfahren zur Gewinnung eines Arzneimittels zur Behandlung von krankhaftem Zellenwachstum | |
| DE1252610B (de) | Verfahren zum Stabilisieren von Katalase | |
| DE955060C (de) | Verfahren zur Herstellung von Penicillinsalzen | |
| DE1901915C3 (de) | Arzneimittel auf der Basis von a -Aminobenzylpenicillintrihydrat | |
| DE951724C (de) | Verfahren zur Herstellung injizierbarer Derivate des Gramicidins S | |
| AT381024B (de) | Verfahren zur herstellung eines pharmazeutischen mittels zur rekonstitution mit wasser | |
| AT221230B (enrdf_load_stackoverflow) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |