DE2020407A1 - Technisches Verfahren zur Isolierung von Silimarin - Google Patents
Technisches Verfahren zur Isolierung von SilimarinInfo
- Publication number
- DE2020407A1 DE2020407A1 DE19702020407 DE2020407A DE2020407A1 DE 2020407 A1 DE2020407 A1 DE 2020407A1 DE 19702020407 DE19702020407 DE 19702020407 DE 2020407 A DE2020407 A DE 2020407A DE 2020407 A1 DE2020407 A1 DE 2020407A1
- Authority
- DE
- Germany
- Prior art keywords
- isolation
- silimarin
- extracted
- technical process
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 8
- 238000002955 isolation Methods 0.000 title claims description 4
- SEBFKMXJBCUCAI-UHFFFAOYSA-N 3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one Chemical compound C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 title description 4
- 239000003925 fat Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- 150000002430 hydrocarbons Chemical class 0.000 claims description 3
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- -1 Fatty acid ester Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 description 3
- 229960004245 silymarin Drugs 0.000 description 3
- 235000017700 silymarin Nutrition 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 102100023708 Coiled-coil domain-containing protein 80 Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 101000978383 Homo sapiens Coiled-coil domain-containing protein 80 Proteins 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 235000019439 ethyl acetate Nutrition 0.000 description 1
- 238000003810 ethyl acetate extraction Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/40—Separation, e.g. from natural material; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702020407 DE2020407A1 (de) | 1970-04-27 | 1970-04-27 | Technisches Verfahren zur Isolierung von Silimarin |
| FR7114669A FR2092095A1 (en) | 1970-04-27 | 1971-04-23 | Silymarin isolation |
| BE766228A BE766228A (fr) | 1970-04-27 | 1971-04-23 | Procede industriel d'isolement de la silymarine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702020407 DE2020407A1 (de) | 1970-04-27 | 1970-04-27 | Technisches Verfahren zur Isolierung von Silimarin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2020407A1 true DE2020407A1 (de) | 1971-11-11 |
Family
ID=5769446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702020407 Pending DE2020407A1 (de) | 1970-04-27 | 1970-04-27 | Technisches Verfahren zur Isolierung von Silimarin |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE766228A (enExample) |
| DE (1) | DE2020407A1 (enExample) |
| FR (1) | FR2092095A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008039271A1 (de) | 2007-12-23 | 2009-06-25 | Euromed Sa | Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung |
| EP2959910A1 (de) | 2014-06-26 | 2015-12-30 | Bionorica Se | Mariendistelextrakt aus Mariendistelfrüchteschalen, Verfahren zur Herstellung und Verwendung |
| EP4696313A1 (en) | 2024-08-13 | 2026-02-18 | WÖRWAG Pharma GmbH & Co.KG | Formulation of krill oil and silymarin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773932A (en) * | 1968-06-01 | 1973-11-20 | Madaus & Co Dr | Method for recovering silymarin comprising polyhydroxyphenyl chromanones |
-
1970
- 1970-04-27 DE DE19702020407 patent/DE2020407A1/de active Pending
-
1971
- 1971-04-23 BE BE766228A patent/BE766228A/xx unknown
- 1971-04-23 FR FR7114669A patent/FR2092095A1/fr active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008039271A1 (de) | 2007-12-23 | 2009-06-25 | Euromed Sa | Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung |
| EP2567703A2 (de) | 2007-12-23 | 2013-03-13 | Euromed SA | Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung |
| EP2959910A1 (de) | 2014-06-26 | 2015-12-30 | Bionorica Se | Mariendistelextrakt aus Mariendistelfrüchteschalen, Verfahren zur Herstellung und Verwendung |
| WO2015197854A1 (de) | 2014-06-26 | 2015-12-30 | Bionorica Se | Mariendistelextrakt aus mariendistelfrüchteschalen, verfahren zur herstellung und verwendung |
| EP4696313A1 (en) | 2024-08-13 | 2026-02-18 | WÖRWAG Pharma GmbH & Co.KG | Formulation of krill oil and silymarin |
Also Published As
| Publication number | Publication date |
|---|---|
| BE766228A (fr) | 1971-10-25 |
| FR2092095A1 (en) | 1972-01-21 |
| FR2092095B1 (enExample) | 1974-09-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2214817C2 (ru) | Экстракт околоплодника zanthoxylum bungeanum, фармацевтическая и косметическая композиция | |
| JP6541040B2 (ja) | 固液抽出 | |
| ES521524A0 (es) | Procedimiento para la preparacion de cuerpos grasos de pepitas del genero ribes. | |
| DE102009050407A1 (de) | Entzündungshemmendes Mittel enthaltend Hydrolysate aus Pflanzenextrakten | |
| DE2020407A1 (de) | Technisches Verfahren zur Isolierung von Silimarin | |
| DE3319184A1 (de) | Verfahren zur abtrennung von allergenen aus arnikablueten mittels co(pfeil abwaerts)2(pfeil abwaerts)-hochdruckextraktion | |
| CN107868113A (zh) | 一种从芍药籽粕中提取芍药苷的方法 | |
| DE2133107C3 (enExample) | ||
| DE1911862C3 (de) | Verfahren zur Gewinnung eines standardisierten, spasmolytisch wirksamen Petasites-Extraktes mit einem Gehalt von 50 bis 55% an genuinem Petasin | |
| DE2335334B2 (de) | Verfahren zur gewinnung von hochgereinigten phosphatiden aus tierischen organen | |
| DE2515670C2 (de) | Verfahren zum Isolieren von Substanzen mit uteroevakuierender Wirkung aus der Zoapatl-Pflanze und diese Substanzen enthaltende Arzneimittel | |
| DE3112737C2 (enExample) | ||
| DE1902608A1 (de) | Verfahren zur Gewinnung eines aescinreichen Wirkstoffkonzentrates aus Rosskastaniensamen | |
| DE707028C (de) | Verfahren zur Herstellung eines antithyreoidalen Stoffes | |
| AT333437B (de) | Verfahren zur herstellung von phosphatidkomplexen mit erhohtem phosphatidylathanolamingehalt aus tierischem material | |
| JP3377997B2 (ja) | サブスタンスｐ拮抗剤 | |
| DE741873C (de) | Verfahren zur Herstellung von Futtermitteln aus Rapssaat, aus deren Presskuchen oder ihrem Extraktionsschrot unter Entfernung des Senfoels | |
| JPS55153720A (en) | Production of substance with antiulcerative activity | |
| DE403050C (de) | Verfahren zur Darstellung von Glyzerinbenzylaether | |
| AT245730B (de) | Verfahren zur Herstellung von 7-Aminocephalosporansäure | |
| DE563258C (de) | Verfahren zur Darstellung wasserloeslicher, hormonartiger, wachstumfoerdernder Stoffe aus Thymusdruesen | |
| DE590159C (de) | Verfahren zur Reindarstellung von Hormonen aus Harn menschlicher oder tierischer Herkunft | |
| DE1053731B (de) | Verfahren zur Herstellung von Wirkstoffen aus Milzen | |
| DE712161C (de) | Verfahren zur Trennung und Reinigung der uterus- und blutdruckwirksamen Hormone des Hypophysenhinterlappens | |
| DE806879C (de) | Verfahren zur Anreicherung des Darmwirkstoffes aus tierischen Organen |