DE19802378C2 - Vorrichtung und Verfahren zum Analysieren von Chemikalien in einem Array mit einer Mehrzahl von Arrayelementen - Google Patents
Vorrichtung und Verfahren zum Analysieren von Chemikalien in einem Array mit einer Mehrzahl von ArrayelementenInfo
- Publication number
- DE19802378C2 DE19802378C2 DE19802378A DE19802378A DE19802378C2 DE 19802378 C2 DE19802378 C2 DE 19802378C2 DE 19802378 A DE19802378 A DE 19802378A DE 19802378 A DE19802378 A DE 19802378A DE 19802378 C2 DE19802378 C2 DE 19802378C2
- Authority
- DE
- Germany
- Prior art keywords
- pixels
- pixel
- array
- line
- fluorescence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 claims description 2
- 229960005542 ethidium bromide Drugs 0.000 claims description 2
- 229910052747 lanthanoid Inorganic materials 0.000 claims description 2
- 150000002602 lanthanoids Chemical class 0.000 claims description 2
- 150000004893 oxazines Chemical class 0.000 claims description 2
- QWYZFXLSWMXLDM-UHFFFAOYSA-M pinacyanol iodide Chemical class [I-].C1=CC2=CC=CC=C2N(CC)C1=CC=CC1=CC=C(C=CC=C2)C2=[N+]1CC QWYZFXLSWMXLDM-UHFFFAOYSA-M 0.000 claims description 2
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 claims description 2
- OALHHIHQOFIMEF-UHFFFAOYSA-N 3',6'-dihydroxy-2',4',5',7'-tetraiodo-3h-spiro[2-benzofuran-1,9'-xanthene]-3-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 OALHHIHQOFIMEF-UHFFFAOYSA-N 0.000 claims 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medical Treatment And Welfare Office Work (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/790,775 US5837475A (en) | 1997-01-30 | 1997-01-30 | Apparatus and method for scanning a chemical array |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE19802378A1 DE19802378A1 (de) | 1998-08-06 |
| DE19802378C2 true DE19802378C2 (de) | 2000-07-13 |
Family
ID=25151713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19802378A Expired - Fee Related DE19802378C2 (de) | 1997-01-30 | 1998-01-22 | Vorrichtung und Verfahren zum Analysieren von Chemikalien in einem Array mit einer Mehrzahl von Arrayelementen |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US5837475A (https=) |
| JP (1) | JP4106120B2 (https=) |
| DE (1) | DE19802378C2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10038080A1 (de) * | 2000-08-04 | 2002-02-21 | Giesing Michael | Verfahren und Vorrichtung zum ortsaufgelösten fluoreszenzoptischen Nachweis von auf einer Oberfläche eines planaren Trägers immobilisierten Substanzen |
| DE10225841A1 (de) * | 2002-06-03 | 2003-12-11 | Proteosys Ag | Differentielle Anzeige von markierten Molekülen |
| DE10148102B4 (de) * | 2001-09-28 | 2006-03-30 | Biotez Berlin-Buch Gmbh | Biochip zum quantitativen fotometrischen Nachweis von Biomolekülen, seine Verwendung und Verfahren zum quantitativen Nachweis von Biomolekülen durch fotometrisches Erfassen einer Farbreaktion |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
| US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
| US6990221B2 (en) * | 1998-02-07 | 2006-01-24 | Biodiscovery, Inc. | Automated DNA array image segmentation and analysis |
| US6349144B1 (en) | 1998-02-07 | 2002-02-19 | Biodiscovery, Inc. | Automated DNA array segmentation and analysis |
| US6320196B1 (en) | 1999-01-28 | 2001-11-20 | Agilent Technologies, Inc. | Multichannel high dynamic range scanner |
| US6251685B1 (en) | 1999-02-18 | 2001-06-26 | Agilent Technologies, Inc. | Readout method for molecular biological electronically addressable arrays |
| US6518056B2 (en) | 1999-04-27 | 2003-02-11 | Agilent Technologies Inc. | Apparatus, systems and method for assaying biological materials using an annular format |
| US6371370B2 (en) * | 1999-05-24 | 2002-04-16 | Agilent Technologies, Inc. | Apparatus and method for scanning a surface |
| DE19925402C2 (de) * | 1999-06-02 | 2001-12-20 | Molecular Machines & Ind Gmbh | Screening von Target-Ligand-Wechselwirkungen |
| US7099502B2 (en) * | 1999-10-12 | 2006-08-29 | Biodiscovery, Inc. | System and method for automatically processing microarrays |
| US7027629B2 (en) * | 1999-11-05 | 2006-04-11 | Agilent Technologies, Inc. | Method of extracting locations of nucleic acid array features |
| US6587579B1 (en) * | 2000-01-26 | 2003-07-01 | Agilent Technologies Inc. | Feature quality in array fabrication |
| US7198939B2 (en) * | 2000-01-28 | 2007-04-03 | Agilent Technologies, Inc. | Apparatus for interrogating an addressable array |
| DE60124598T2 (de) * | 2000-06-06 | 2007-09-06 | Agilent Technologies, Inc., Palo Alto | Verfahren und System zur Bestimmung der Orientierung eines Microarrays |
| US6591196B1 (en) * | 2000-06-06 | 2003-07-08 | Agilent Technologies Inc. | Method and system for extracting data from surface array deposited features |
| US7158224B2 (en) * | 2000-06-25 | 2007-01-02 | Affymetrix, Inc. | Optically active substrates |
| DE10036457A1 (de) * | 2000-07-26 | 2002-02-14 | Giesing Michael | Verwendung eines bildgebenden photoelektrischen Flächensensors zur Auswertung von Biochips und Bildgebungsverfahren hierfür |
| US20060141507A1 (en) * | 2000-09-27 | 2006-06-29 | Kronick Mel N | Manufacture and use of non-standard size microarray slides |
| US6864097B1 (en) | 2000-09-27 | 2005-03-08 | Agilent Technologies, Inc. | Arrays and their reading |
| JP2002168787A (ja) * | 2000-12-04 | 2002-06-14 | Fuji Photo Film Co Ltd | 画像読み取り方法および装置 |
| US6907146B2 (en) * | 2000-12-11 | 2005-06-14 | Affymetrix, Inc. | Methods, systems and computer software for detecting pixel stutter |
| US6756202B2 (en) * | 2001-04-30 | 2004-06-29 | Agilent Technologies, Inc. | Reading multi-featured arrays |
| US6993172B2 (en) * | 2001-06-29 | 2006-01-31 | Agilent Technologies, Inc. | Method and system for automated outlying feature and outlying feature background detection during processing of data scanned from a molecular array |
| US7205154B2 (en) * | 2002-01-31 | 2007-04-17 | Agilent Technologies, Inc. | Calibrating array scanners |
| US20070059760A1 (en) * | 2002-02-21 | 2007-03-15 | Dorsel Andreas N | Multi-featured arrays with reflective coating |
| US7018842B2 (en) * | 2002-02-28 | 2006-03-28 | Agilent Technologies, Inc. | Reading dry chemical arrays through the substrate |
| US6791690B2 (en) * | 2002-04-30 | 2004-09-14 | Agilent Technologies, Inc. | Reading dry chemical arrays |
| US20030220746A1 (en) * | 2002-05-21 | 2003-11-27 | Srinka Ghosh | Method and system for computing and applying a global, multi-channel background correction to a feature-based data set obtained from scanning a molecular array |
| US20030232427A1 (en) * | 2002-06-18 | 2003-12-18 | Montagu Jean I. | Optically active substrates for examination of biological materials |
| US20040021055A1 (en) * | 2002-07-31 | 2004-02-05 | Corson John F. | Extended life biopolymer array scanner system |
| US7900836B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
| US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
| US7126755B2 (en) | 2002-09-12 | 2006-10-24 | Moon John A | Method and apparatus for labeling using diffraction grating-based encoded optical identification elements |
| US7923260B2 (en) | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
| US7164533B2 (en) | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
| US7508608B2 (en) | 2004-11-17 | 2009-03-24 | Illumina, Inc. | Lithographically fabricated holographic optical identification element |
| US7441703B2 (en) | 2002-08-20 | 2008-10-28 | Illumina, Inc. | Optical reader for diffraction grating-based encoded optical identification elements |
| EP1535241A1 (en) | 2002-08-20 | 2005-06-01 | Cyvera Corporation | Diffraction grating-based optical identification element |
| US7901630B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
| WO2004025561A1 (en) | 2002-09-12 | 2004-03-25 | Cyvera Corporation | Chemical synthesis using diffraction grating-based encoded optical elements |
| US7092160B2 (en) | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
| CA2498933C (en) | 2002-09-12 | 2012-08-28 | Cyvera Corporation | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
| US20100255603A9 (en) | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
| AU2003270726A1 (en) | 2002-09-12 | 2004-04-30 | Cidra Corporation | Diffraction grating-based encoded micro-particles for multiplexed experiments |
| US7512496B2 (en) * | 2002-09-25 | 2009-03-31 | Soheil Shams | Apparatus, method, and computer program product for determining confidence measures and combined confidence measures for assessing the quality of microarrays |
| US20040243341A1 (en) * | 2003-05-30 | 2004-12-02 | Le Cocq Christian A. | Feature extraction methods and systems |
| US20050038839A1 (en) * | 2003-08-11 | 2005-02-17 | Srinka Ghosh | Method and system for evaluating a set of normalizing features and for iteratively refining a set of normalizing features |
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| US7787126B2 (en) | 2007-03-26 | 2010-08-31 | Purdue Research Foundation | Method and apparatus for conjugate quadrature interferometric detection of an immunoassay |
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| JP2024518331A (ja) | 2021-04-29 | 2024-05-01 | アボット・ラボラトリーズ | 生体試料のハイスループット核酸検査 |
| WO2025030178A1 (en) | 2023-08-03 | 2025-02-06 | Abbott Laboratories | Isothermal amplification of nucleic acids |
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| WO2025137528A1 (en) | 2023-12-20 | 2025-06-26 | Abbott Laboratories | Reducing agent compositions for isothermal amplification of nucleic acids |
| WO2025240630A1 (en) | 2024-05-14 | 2025-11-20 | Abbott Laboratories | Reagent compositions for isothermal amplification of nucleic acids |
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| WO1991007087A1 (en) * | 1989-11-13 | 1991-05-30 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| WO1992010588A1 (en) * | 1990-12-06 | 1992-06-25 | Affymax Technologies N.V. | Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides |
| WO1992010587A1 (en) * | 1990-12-06 | 1992-06-25 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microfluorescence detection |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5459325A (en) * | 1994-07-19 | 1995-10-17 | Molecular Dynamics, Inc. | High-speed fluorescence scanner |
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| US33241A (en) * | 1861-09-10 | Improvement in gates and chutes for water-wheels | ||
| JPS5958745A (ja) * | 1982-09-28 | 1984-04-04 | Hamamatsu Tv Kk | 微弱発光現象の観測装置 |
| SE455736B (sv) * | 1984-03-15 | 1988-08-01 | Sarastro Ab | Forfaringssett och anordning for mikrofotometrering och efterfoljande bildsammanstellning |
| DD254998A1 (de) * | 1985-07-26 | 1988-03-16 | Zeiss Jena Veb Carl | Anordnung zur bildlichen darstellung und analyse von fluoreszenzsignalen |
| JPH02218941A (ja) * | 1989-02-18 | 1990-08-31 | Shimadzu Corp | 蛍光検出型ゲル電気泳動パターン解析装置 |
| US5108179A (en) * | 1989-08-09 | 1992-04-28 | Myers Stephen A | System and method for determining changes in fluorescence of stained nucleic acid in electrophoretically separated bands |
| GB9015793D0 (en) * | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
| DE4111903A1 (de) * | 1991-04-12 | 1992-10-15 | Bayer Ag | Spektroskopiekorrelierte licht-rastermikroskopie |
| US5117466A (en) * | 1991-04-30 | 1992-05-26 | The United States Of America As Represented By The United States Department Of Energy | Integrated fluorescence analysis system |
| JP3145486B2 (ja) * | 1992-06-12 | 2001-03-12 | シスメックス株式会社 | イメージングフローサイトメータ |
| US5381224A (en) * | 1993-08-30 | 1995-01-10 | A. E. Dixon | Scanning laser imaging system |
| US5705821A (en) * | 1996-11-07 | 1998-01-06 | Sandia Corporation | Scanning fluorescent microthermal imaging apparatus and method |
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- 1998-01-19 JP JP00791198A patent/JP4106120B2/ja not_active Expired - Fee Related
- 1998-01-22 DE DE19802378A patent/DE19802378C2/de not_active Expired - Fee Related
- 1998-08-17 US US09/132,068 patent/US5945679A/en not_active Expired - Fee Related
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10038080A1 (de) * | 2000-08-04 | 2002-02-21 | Giesing Michael | Verfahren und Vorrichtung zum ortsaufgelösten fluoreszenzoptischen Nachweis von auf einer Oberfläche eines planaren Trägers immobilisierten Substanzen |
| DE10148102B4 (de) * | 2001-09-28 | 2006-03-30 | Biotez Berlin-Buch Gmbh | Biochip zum quantitativen fotometrischen Nachweis von Biomolekülen, seine Verwendung und Verfahren zum quantitativen Nachweis von Biomolekülen durch fotometrisches Erfassen einer Farbreaktion |
| DE10225841A1 (de) * | 2002-06-03 | 2003-12-11 | Proteosys Ag | Differentielle Anzeige von markierten Molekülen |
Also Published As
| Publication number | Publication date |
|---|---|
| US5837475A (en) | 1998-11-17 |
| US5945679A (en) | 1999-08-31 |
| DE19802378A1 (de) | 1998-08-06 |
| JP4106120B2 (ja) | 2008-06-25 |
| JPH10311796A (ja) | 1998-11-24 |
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