DE19747261A1 - Osmotisches Arzneimittelfreisetzungssystem - Google Patents
Osmotisches ArzneimittelfreisetzungssystemInfo
- Publication number
- DE19747261A1 DE19747261A1 DE19747261A DE19747261A DE19747261A1 DE 19747261 A1 DE19747261 A1 DE 19747261A1 DE 19747261 A DE19747261 A DE 19747261A DE 19747261 A DE19747261 A DE 19747261A DE 19747261 A1 DE19747261 A1 DE 19747261A1
- Authority
- DE
- Germany
- Prior art keywords
- weight
- core
- drug delivery
- delivery system
- osmotic drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 210000003608 fece Anatomy 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000001055 magnesium Nutrition 0.000 description 1
- 229940091250 magnesium supplement Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229960000227 nisoldipine Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000002924 oxiranes Chemical class 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
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- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
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- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19747261A DE19747261A1 (de) | 1997-10-25 | 1997-10-25 | Osmotisches Arzneimittelfreisetzungssystem |
| AU12278/99A AU1227899A (en) | 1997-10-25 | 1998-10-12 | Osmotic medicament releasing system |
| AT98955434T ATE211907T1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
| JP2000517695A JP4295916B2 (ja) | 1997-10-25 | 1998-10-12 | 浸透圧性薬剤放出系 |
| ES98955434T ES2172239T3 (es) | 1997-10-25 | 1998-10-12 | Sistema osmotico de liberacion de farmacos. |
| EP98955434A EP1024793B1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
| US09/530,158 US6294201B1 (en) | 1997-10-12 | 1998-10-12 | Osmotic medicament releasing system |
| PCT/EP1998/006454 WO1999021535A1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
| CA002307018A CA2307018C (en) | 1997-10-25 | 1998-10-12 | Osmotic medicament releasing system |
| DE59802670T DE59802670D1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19747261A DE19747261A1 (de) | 1997-10-25 | 1997-10-25 | Osmotisches Arzneimittelfreisetzungssystem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19747261A1 true DE19747261A1 (de) | 1999-04-29 |
Family
ID=7846661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19747261A Withdrawn DE19747261A1 (de) | 1997-10-12 | 1997-10-25 | Osmotisches Arzneimittelfreisetzungssystem |
| DE59802670T Expired - Lifetime DE59802670D1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59802670T Expired - Lifetime DE59802670D1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6294201B1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1024793B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4295916B2 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE211907T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU1227899A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2307018C (cg-RX-API-DMAC10.html) |
| DE (2) | DE19747261A1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2172239T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO1999021535A1 (cg-RX-API-DMAC10.html) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002011702A3 (en) * | 2000-08-09 | 2002-11-28 | Pfizer Prod Inc | Hydrogel-driven drug dosage form |
| WO2003086365A1 (en) * | 2002-04-12 | 2003-10-23 | Zentiva, A.S. | Analgesical oral composition with controlled release of an opioid |
| WO2007003330A3 (de) * | 2005-07-06 | 2008-01-10 | Bayer Healthcare Ag | Pharmazeutische darreichungsformen enthaltend eine wirkstoffkombination von nifedipin und/oder nisoldipin und einem angiotensin-ii antagonisten |
| WO2010060564A1 (de) * | 2008-11-27 | 2010-06-03 | Bayer Schering Pharma Aktiengesellschaft | Pharmazeutische darreichungsform enthaltend nifedipin oder nisoldipin und einen angiotensin-ii antagonisten und/oder ein diuretikum |
| WO2020020790A1 (de) * | 2018-07-24 | 2020-01-30 | Bayer Aktiengesellschaft | Oral applizierbare pharmazeutische darreichungsform mit modifizierter freisetzung |
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| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
| DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| JP2005525299A (ja) * | 2001-09-14 | 2005-08-25 | スコラー インコーポレイテッド | アミノ酸調節性の長期放出投薬形態 |
| PT1424997E (pt) * | 2001-09-14 | 2008-02-28 | Scolr Inc | Forma de dosagem de libertação prolongada modulada por aminoácidos |
| US6572889B1 (en) | 2002-03-07 | 2003-06-03 | Noveon Ip Holdings Corp. | Controlled release solid dosage carbamazepine formulations |
| AU2003269744A1 (en) * | 2002-05-15 | 2003-12-02 | Sun Pharmaceutical Industries Limited | Oral osmotic controlled drug delivery system |
| US20070077301A1 (en) * | 2002-12-23 | 2007-04-05 | Meyer Glenn A | Venlafaxine osmotic device formulation |
| US8293799B2 (en) * | 2003-12-29 | 2012-10-23 | Osmotica Keresleedelmo és Szolgáltató KFT | Osmotic device containing a venlafaxine salt and a salt having an ion in common |
| DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| US20050042289A1 (en) * | 2003-04-29 | 2005-02-24 | Yamanouchi Pharma Technologies, Inc. | Tablets and methods for modified release of hydrophylic and other active agents |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| AR053986A1 (es) | 2004-12-03 | 2007-05-30 | Osmotica Pharmaceutical Argent | Dispositivo osmotico que contiene amantadina y una sal osmotica |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) * | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| WO2006116247A1 (en) * | 2005-04-25 | 2006-11-02 | Teva Pharmaceuticals Usa, Inc. | Extended release formulations |
| US20070071819A1 (en) * | 2005-05-30 | 2007-03-29 | Kesarwani Amit K | Multiple unit modified release compositions of carbamazepine and process for their preparation |
| DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| US7855279B2 (en) * | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
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| DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
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| CA2841386A1 (en) | 2005-12-30 | 2007-07-12 | Zensun (Shanghai) Science & Technology Limited | Extended release of neuregulin for improved cardiac function |
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| DK3178835T3 (da) | 2009-02-03 | 2019-06-24 | Amunix Pharmaceuticals Inc | Forlængede rekombinante polypeptider og sammensætninger omfattende samme |
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| WO2013123457A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
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| UY34856A (es) | 2012-07-03 | 2013-12-31 | Bayer Pharma AG | Formas de presentación farmacéuticas que contienen 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4- morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofencarboxamida |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
| EA201691111A1 (ru) | 2014-01-10 | 2017-01-30 | Байоджен Ма Инк. | Химерные белки фактора viii и их применение |
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| TW202019402A (zh) * | 2018-07-24 | 2020-06-01 | 德商拜耳廠股份有限公司 | 可口服之修飾釋放藥物劑型 |
| US10905667B2 (en) | 2018-07-24 | 2021-02-02 | Bayer Pharma Aktiengesellschaft | Orally administrable modified-release pharmaceutical dosage form |
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| DE2328409A1 (de) * | 1972-06-05 | 1973-12-20 | Alza Corp | Nach dem osmose-prinzip arbeitender wirkstoff-spender |
| EP0277092A1 (de) * | 1987-01-14 | 1988-08-03 | Ciba-Geigy Ag | Therapeutisches System für schwerlösliche Wirkstoffe |
| DE3833282A1 (de) * | 1987-10-02 | 1989-04-20 | Alza Corp | Osmotische dosierungsform zur verabreichung von isradipin |
| US4892741A (en) * | 1987-06-24 | 1990-01-09 | Bayer Aktiengesellschaft | Press coated DHP tablets |
| US4933186A (en) * | 1987-08-11 | 1990-06-12 | Bayer Aktiengesellschaft | Dihydropyridine depot formulation |
| US5156850A (en) * | 1990-08-31 | 1992-10-20 | Alza Corporation | Dosage form for time-varying patterns of drug delivery |
| US5240713A (en) * | 1991-09-27 | 1993-08-31 | Alza Corporation | Dual rate agent delivery device |
| WO1996040080A1 (en) * | 1995-06-07 | 1996-12-19 | Andrx Pharmaceuticals, Inc. | Controlled release formulation having a preformed passageway |
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| DE19515972A1 (de) | 1995-05-02 | 1996-11-07 | Bayer Ag | Arzneizubereitungen mit kontrollierter Freisetzung und Verfahren zu ihrer Herstellung |
-
1997
- 1997-10-25 DE DE19747261A patent/DE19747261A1/de not_active Withdrawn
-
1998
- 1998-10-12 AT AT98955434T patent/ATE211907T1/de not_active IP Right Cessation
- 1998-10-12 AU AU12278/99A patent/AU1227899A/en not_active Abandoned
- 1998-10-12 DE DE59802670T patent/DE59802670D1/de not_active Expired - Lifetime
- 1998-10-12 EP EP98955434A patent/EP1024793B1/de not_active Expired - Lifetime
- 1998-10-12 US US09/530,158 patent/US6294201B1/en not_active Expired - Lifetime
- 1998-10-12 CA CA002307018A patent/CA2307018C/en not_active Expired - Lifetime
- 1998-10-12 ES ES98955434T patent/ES2172239T3/es not_active Expired - Lifetime
- 1998-10-12 WO PCT/EP1998/006454 patent/WO1999021535A1/de not_active Ceased
- 1998-10-12 JP JP2000517695A patent/JP4295916B2/ja not_active Expired - Lifetime
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| DE2328409A1 (de) * | 1972-06-05 | 1973-12-20 | Alza Corp | Nach dem osmose-prinzip arbeitender wirkstoff-spender |
| EP0277092A1 (de) * | 1987-01-14 | 1988-08-03 | Ciba-Geigy Ag | Therapeutisches System für schwerlösliche Wirkstoffe |
| US4992278A (en) * | 1987-01-14 | 1991-02-12 | Ciba-Geigy Corporation | Therapeutic system for sparingly soluble active ingredients |
| US4892741A (en) * | 1987-06-24 | 1990-01-09 | Bayer Aktiengesellschaft | Press coated DHP tablets |
| US4933186A (en) * | 1987-08-11 | 1990-06-12 | Bayer Aktiengesellschaft | Dihydropyridine depot formulation |
| DE3833282A1 (de) * | 1987-10-02 | 1989-04-20 | Alza Corp | Osmotische dosierungsform zur verabreichung von isradipin |
| US5156850A (en) * | 1990-08-31 | 1992-10-20 | Alza Corporation | Dosage form for time-varying patterns of drug delivery |
| US5240713A (en) * | 1991-09-27 | 1993-08-31 | Alza Corporation | Dual rate agent delivery device |
| WO1996040080A1 (en) * | 1995-06-07 | 1996-12-19 | Andrx Pharmaceuticals, Inc. | Controlled release formulation having a preformed passageway |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002011702A3 (en) * | 2000-08-09 | 2002-11-28 | Pfizer Prod Inc | Hydrogel-driven drug dosage form |
| WO2003086365A1 (en) * | 2002-04-12 | 2003-10-23 | Zentiva, A.S. | Analgesical oral composition with controlled release of an opioid |
| WO2007003330A3 (de) * | 2005-07-06 | 2008-01-10 | Bayer Healthcare Ag | Pharmazeutische darreichungsformen enthaltend eine wirkstoffkombination von nifedipin und/oder nisoldipin und einem angiotensin-ii antagonisten |
| US8153160B2 (en) | 2005-07-06 | 2012-04-10 | Bayer Pharma Aktiengesellschaft | Pharmaceutical dosage forms comprising an active ingredient combination of nifedipine and/or nisoldipine and an angiotensin II antagonist |
| WO2010060564A1 (de) * | 2008-11-27 | 2010-06-03 | Bayer Schering Pharma Aktiengesellschaft | Pharmazeutische darreichungsform enthaltend nifedipin oder nisoldipin und einen angiotensin-ii antagonisten und/oder ein diuretikum |
| EA025485B1 (ru) * | 2008-11-27 | 2016-12-30 | Байер Интеллектуэль Проперти Гмбх | Фармацевтические формы применения, содержащие нифедипин или низолдипин и антагонист ангиотензина-ii и/или диуретик |
| US9993432B2 (en) | 2008-11-27 | 2018-06-12 | Bayer Intellectual Property Gmbh | Pharmaceutical dosage form comprising nifedipine or nisoldipine and an angiotensin II antagonist and/or a diuretic |
| WO2020020790A1 (de) * | 2018-07-24 | 2020-01-30 | Bayer Aktiengesellschaft | Oral applizierbare pharmazeutische darreichungsform mit modifizierter freisetzung |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE211907T1 (de) | 2002-02-15 |
| ES2172239T3 (es) | 2002-09-16 |
| AU1227899A (en) | 1999-05-17 |
| CA2307018A1 (en) | 1999-05-06 |
| US6294201B1 (en) | 2001-09-25 |
| JP2001520985A (ja) | 2001-11-06 |
| CA2307018C (en) | 2006-12-12 |
| DE59802670D1 (de) | 2002-02-21 |
| EP1024793B1 (de) | 2002-01-16 |
| EP1024793A1 (de) | 2000-08-09 |
| WO1999021535A1 (de) | 1999-05-06 |
| JP4295916B2 (ja) | 2009-07-15 |
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