DE19741739B4 - Supramolekulares Paarungssystem, dessen Herstellung und Verwendung - Google Patents
Supramolekulares Paarungssystem, dessen Herstellung und Verwendung Download PDFInfo
- Publication number
- DE19741739B4 DE19741739B4 DE19741739A DE19741739A DE19741739B4 DE 19741739 B4 DE19741739 B4 DE 19741739B4 DE 19741739 A DE19741739 A DE 19741739A DE 19741739 A DE19741739 A DE 19741739A DE 19741739 B4 DE19741739 B4 DE 19741739B4
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- Prior art keywords
- oligomer
- amino
- compound according
- cyclohexyl
- compound
- Prior art date
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- HPYNZHMRTTWQTB-UHFFFAOYSA-N dimethylpyridine Natural products CC1=CC=CN=C1C HPYNZHMRTTWQTB-UHFFFAOYSA-N 0.000 description 1
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- 239000000706 filtrate Substances 0.000 description 1
- GFAUNYMRSKVDJL-UHFFFAOYSA-N formyl chloride Chemical compound ClC=O GFAUNYMRSKVDJL-UHFFFAOYSA-N 0.000 description 1
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- JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
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- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
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- 210000000056 organ Anatomy 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000010970 precious metal Substances 0.000 description 1
- 125000003132 pyranosyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000012048 reactive intermediate Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
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- 238000010992 reflux Methods 0.000 description 1
- 239000012508 resin bead Substances 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
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- 230000035945 sensitivity Effects 0.000 description 1
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- 230000002522 swelling effect Effects 0.000 description 1
- RUPAXCPQAAOIPB-UHFFFAOYSA-N tert-butyl formate Chemical compound CC(C)(C)OC=O RUPAXCPQAAOIPB-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19741739A DE19741739B4 (de) | 1997-09-22 | 1997-09-22 | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
| PCT/EP1998/006002 WO1999015509A2 (de) | 1997-09-22 | 1998-09-21 | Cyclohexyl- und heterocyclyl-nukleosid derivate, die herstellung und verwendung dieser derivate, deren oligomere bzw. konjugate in paarungs- und/oder testsystemen |
| EP98947540A EP1049678B1 (de) | 1997-09-22 | 1998-09-21 | Cyclohexyl- und heterocyclyl-nukleosid derivate, die herstellung und verwendung dieser derivate, deren oligomere bzw. konjugate in paarungs- und/oder testsystemen |
| CA002301641A CA2301641A1 (en) | 1997-09-22 | 1998-09-21 | Supramolecular pairing system, its preparation and use |
| BR9812375-0A BR9812375A (pt) | 1997-09-22 | 1998-09-21 | Derivativos de nucleosìdeo de ciclohexila e heterociclila, método para produção destes derivados, e o emprego dos derivados e seus oligÈmeros ou conjugados em sistemas de emparelhamento e/ou teste |
| JP2000512817A JP4514330B2 (ja) | 1997-09-22 | 1998-09-21 | 超分子ペアリングシステムその製造及び使用 |
| AU94412/98A AU752521B2 (en) | 1997-09-22 | 1998-09-21 | Cyclohexyl and heterocyclyl nucleoside derivatives, method for producing these derivatives, and the use of the derivatives and their oligomers or conjugates in pairing and/or testing systems |
| KR1020007003009A KR20010030658A (ko) | 1997-09-22 | 1998-09-21 | 사이클로헥실 및 헤테로사이클릴 뉴클레오사이드 유도체,이의 제조 방법, 및 짝형성 및/또는 시험 시스템에서유도체와 이의 올리고머 또는 접합체의 용도 |
| US09/509,040 US6689884B1 (en) | 1997-09-22 | 1998-09-21 | Supramolecular pairing system, its preparation and use |
| US10/746,678 US7439345B2 (en) | 1997-09-22 | 2003-12-23 | Supramolecular pairing system, its preparation and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19741739A DE19741739B4 (de) | 1997-09-22 | 1997-09-22 | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE19741739A1 DE19741739A1 (de) | 1999-04-01 |
| DE19741739B4 true DE19741739B4 (de) | 2006-04-27 |
Family
ID=7843200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19741739A Expired - Fee Related DE19741739B4 (de) | 1997-09-22 | 1997-09-22 | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6689884B1 (enExample) |
| EP (1) | EP1049678B1 (enExample) |
| JP (1) | JP4514330B2 (enExample) |
| KR (1) | KR20010030658A (enExample) |
| AU (1) | AU752521B2 (enExample) |
| BR (1) | BR9812375A (enExample) |
| CA (1) | CA2301641A1 (enExample) |
| DE (1) | DE19741739B4 (enExample) |
| WO (1) | WO1999015509A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19741739B4 (de) * | 1997-09-22 | 2006-04-27 | Nanogen Recognomics Gmbh | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
| DE19837387A1 (de) * | 1998-08-18 | 2000-02-24 | Aventis Res & Tech Gmbh & Co | 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung |
| WO2002040481A2 (en) * | 2000-11-20 | 2002-05-23 | Millennium Pharmaceuticals, Inc. | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof |
| US6893822B2 (en) | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
| DE10139730A1 (de) * | 2001-08-13 | 2003-02-27 | Nanogen Recognomics Gmbh | Verfahren zur Herstellung CNA |
| CA2463719A1 (en) | 2003-04-05 | 2004-10-05 | F. Hoffmann-La Roche Ag | Nucleotide analogs with six membered rings |
| US20060199207A1 (en) * | 2005-02-24 | 2006-09-07 | Matysiak Stefan M | Self-assembly of molecules using combinatorial hybridization |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0468352A2 (en) * | 1990-07-24 | 1992-01-29 | Nippon Kayaku Kabushiki Kaisha | Novel nucleic acid derivatives |
| US5382580A (en) * | 1994-05-27 | 1995-01-17 | The Scripps Research Institute | N9 morpholino derivatives of 7,8-disubstituted guanines |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| DK0618925T4 (da) * | 1991-12-24 | 2012-07-09 | Isis Pharmaceuticals Inc | Antisense-oligonukleotider |
| JPH06263793A (ja) * | 1993-03-04 | 1994-09-20 | Asahi Breweries Ltd | ピラノース型ヌクレオシド誘導体 |
| US5491074A (en) | 1993-04-01 | 1996-02-13 | Affymax Technologies Nv | Association peptides |
| US5718915A (en) | 1994-10-31 | 1998-02-17 | Burstein Laboratories, Inc. | Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme |
| ES2250978T3 (es) | 1994-11-01 | 2006-04-16 | Ariad Gene Therapeutics, Inc. | Nuevo metodo de identificacion y examen de moleculas con actividad bilogica. |
| DE19619373A1 (de) * | 1996-05-14 | 1997-11-20 | Hoechst Ag | Neue Substanzbibliothek und damit hergestellte supramolekulare Komplexe |
| US20020028442A1 (en) * | 1997-05-09 | 2002-03-07 | Christian Miculka | Novel substance library and supramolecular complexes produced therewith |
| DE19651560A1 (de) * | 1996-12-11 | 1998-06-18 | Hoechst Ag | Neue funktionelle supramolekulare Nanosysteme |
| DE19741715A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung |
| DE19741738A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Linker-Nucleosid, seine Herstellung und Verwendung |
| DE19741739B4 (de) * | 1997-09-22 | 2006-04-27 | Nanogen Recognomics Gmbh | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
| DE19815901A1 (de) * | 1998-04-08 | 1999-10-14 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung von Pentopyranosyl-Nucleosiden |
| DE19837387A1 (de) * | 1998-08-18 | 2000-02-24 | Aventis Res & Tech Gmbh & Co | 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung |
| US6893822B2 (en) * | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
-
1997
- 1997-09-22 DE DE19741739A patent/DE19741739B4/de not_active Expired - Fee Related
-
1998
- 1998-09-21 EP EP98947540A patent/EP1049678B1/de not_active Expired - Lifetime
- 1998-09-21 KR KR1020007003009A patent/KR20010030658A/ko not_active Withdrawn
- 1998-09-21 JP JP2000512817A patent/JP4514330B2/ja not_active Expired - Fee Related
- 1998-09-21 CA CA002301641A patent/CA2301641A1/en not_active Abandoned
- 1998-09-21 AU AU94412/98A patent/AU752521B2/en not_active Ceased
- 1998-09-21 BR BR9812375-0A patent/BR9812375A/pt not_active IP Right Cessation
- 1998-09-21 US US09/509,040 patent/US6689884B1/en not_active Expired - Lifetime
- 1998-09-21 WO PCT/EP1998/006002 patent/WO1999015509A2/de not_active Ceased
-
2003
- 2003-12-23 US US10/746,678 patent/US7439345B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0468352A2 (en) * | 1990-07-24 | 1992-01-29 | Nippon Kayaku Kabushiki Kaisha | Novel nucleic acid derivatives |
| US5382580A (en) * | 1994-05-27 | 1995-01-17 | The Scripps Research Institute | N9 morpholino derivatives of 7,8-disubstituted guanines |
Non-Patent Citations (3)
| Title |
|---|
| IODOLACTAMIZATION: 8-exo-IODO-2-AZABICYCLO[3.3.0] OCTAN-3-ONE. In: J. Med. Chem. 36, 1993, S.2033-2040 * |
| Org. Synthesis 70, S.101-109 (1995) * |
| VERHEGGEN,Ilse, et.al.: Synthesis and Antiherpes Virus Activity of 1,5-Anhydrohexitol Nucleosides. In: J. Med. Chem. 1993, 36, S.2033-2040 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU9441298A (en) | 1999-04-12 |
| EP1049678A2 (de) | 2000-11-08 |
| JP4514330B2 (ja) | 2010-07-28 |
| AU752521B2 (en) | 2002-09-19 |
| KR20010030658A (ko) | 2001-04-16 |
| US7439345B2 (en) | 2008-10-21 |
| EP1049678B1 (de) | 2012-10-24 |
| CA2301641A1 (en) | 1999-04-01 |
| WO1999015509A2 (de) | 1999-04-01 |
| DE19741739A1 (de) | 1999-04-01 |
| WO1999015509A3 (de) | 1999-06-24 |
| JP2001517659A (ja) | 2001-10-09 |
| BR9812375A (pt) | 2000-09-19 |
| US6689884B1 (en) | 2004-02-10 |
| US20040142451A1 (en) | 2004-07-22 |
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