BR9812375A - Derivativos de nucleosìdeo de ciclohexila e heterociclila, método para produção destes derivados, e o emprego dos derivados e seus oligÈmeros ou conjugados em sistemas de emparelhamento e/ou teste - Google Patents
Derivativos de nucleosìdeo de ciclohexila e heterociclila, método para produção destes derivados, e o emprego dos derivados e seus oligÈmeros ou conjugados em sistemas de emparelhamento e/ou testeInfo
- Publication number
- BR9812375A BR9812375A BR9812375-0A BR9812375A BR9812375A BR 9812375 A BR9812375 A BR 9812375A BR 9812375 A BR9812375 A BR 9812375A BR 9812375 A BR9812375 A BR 9812375A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- equal
- independently
- heterocyclyl
- conjugates
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 title 1
- -1 heterocyclyl nucleoside Chemical class 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 2
- DRAVOWXCEBXPTN-UHFFFAOYSA-N isoguanine Chemical compound NC1=NC(=O)NC2=C1NC=N2 DRAVOWXCEBXPTN-UHFFFAOYSA-N 0.000 abstract 2
- 125000005499 phosphonyl group Chemical group 0.000 abstract 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 2
- XQCZBXHVTFVIFE-UHFFFAOYSA-N 2-amino-4-hydroxypyrimidine Chemical compound NC1=NC=CC(O)=N1 XQCZBXHVTFVIFE-UHFFFAOYSA-N 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 229930024421 Adenine Natural products 0.000 abstract 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 abstract 1
- 241000207836 Olea <angiosperm> Species 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940104302 cytosine Drugs 0.000 abstract 1
- 125000001033 ether group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940113082 thymine Drugs 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
- 229940075420 xanthine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19741739A DE19741739B4 (de) | 1997-09-22 | 1997-09-22 | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
| PCT/EP1998/006002 WO1999015509A2 (de) | 1997-09-22 | 1998-09-21 | Cyclohexyl- und heterocyclyl-nukleosid derivate, die herstellung und verwendung dieser derivate, deren oligomere bzw. konjugate in paarungs- und/oder testsystemen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9812375A true BR9812375A (pt) | 2000-09-19 |
Family
ID=7843200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9812375-0A BR9812375A (pt) | 1997-09-22 | 1998-09-21 | Derivativos de nucleosìdeo de ciclohexila e heterociclila, método para produção destes derivados, e o emprego dos derivados e seus oligÈmeros ou conjugados em sistemas de emparelhamento e/ou teste |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6689884B1 (enExample) |
| EP (1) | EP1049678B1 (enExample) |
| JP (1) | JP4514330B2 (enExample) |
| KR (1) | KR20010030658A (enExample) |
| AU (1) | AU752521B2 (enExample) |
| BR (1) | BR9812375A (enExample) |
| CA (1) | CA2301641A1 (enExample) |
| DE (1) | DE19741739B4 (enExample) |
| WO (1) | WO1999015509A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19741739B4 (de) * | 1997-09-22 | 2006-04-27 | Nanogen Recognomics Gmbh | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
| DE19837387A1 (de) * | 1998-08-18 | 2000-02-24 | Aventis Res & Tech Gmbh & Co | 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung |
| WO2002040481A2 (en) * | 2000-11-20 | 2002-05-23 | Millennium Pharmaceuticals, Inc. | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof |
| US6893822B2 (en) | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
| DE10139730A1 (de) * | 2001-08-13 | 2003-02-27 | Nanogen Recognomics Gmbh | Verfahren zur Herstellung CNA |
| CA2463719A1 (en) | 2003-04-05 | 2004-10-05 | F. Hoffmann-La Roche Ag | Nucleotide analogs with six membered rings |
| US20060199207A1 (en) * | 2005-02-24 | 2006-09-07 | Matysiak Stefan M | Self-assembly of molecules using combinatorial hybridization |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0468352A3 (en) * | 1990-07-24 | 1992-07-15 | Nippon Kayaku Kabushiki Kaisha | Novel nucleic acid derivatives |
| DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| DK0618925T4 (da) * | 1991-12-24 | 2012-07-09 | Isis Pharmaceuticals Inc | Antisense-oligonukleotider |
| JPH06263793A (ja) * | 1993-03-04 | 1994-09-20 | Asahi Breweries Ltd | ピラノース型ヌクレオシド誘導体 |
| US5491074A (en) | 1993-04-01 | 1996-02-13 | Affymax Technologies Nv | Association peptides |
| US5382580A (en) * | 1994-05-27 | 1995-01-17 | The Scripps Research Institute | N9 morpholino derivatives of 7,8-disubstituted guanines |
| US5718915A (en) | 1994-10-31 | 1998-02-17 | Burstein Laboratories, Inc. | Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme |
| ES2250978T3 (es) | 1994-11-01 | 2006-04-16 | Ariad Gene Therapeutics, Inc. | Nuevo metodo de identificacion y examen de moleculas con actividad bilogica. |
| DE19619373A1 (de) * | 1996-05-14 | 1997-11-20 | Hoechst Ag | Neue Substanzbibliothek und damit hergestellte supramolekulare Komplexe |
| US20020028442A1 (en) * | 1997-05-09 | 2002-03-07 | Christian Miculka | Novel substance library and supramolecular complexes produced therewith |
| DE19651560A1 (de) * | 1996-12-11 | 1998-06-18 | Hoechst Ag | Neue funktionelle supramolekulare Nanosysteme |
| DE19741715A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung |
| DE19741738A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Linker-Nucleosid, seine Herstellung und Verwendung |
| DE19741739B4 (de) * | 1997-09-22 | 2006-04-27 | Nanogen Recognomics Gmbh | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
| DE19815901A1 (de) * | 1998-04-08 | 1999-10-14 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung von Pentopyranosyl-Nucleosiden |
| DE19837387A1 (de) * | 1998-08-18 | 2000-02-24 | Aventis Res & Tech Gmbh & Co | 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung |
| US6893822B2 (en) * | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
-
1997
- 1997-09-22 DE DE19741739A patent/DE19741739B4/de not_active Expired - Fee Related
-
1998
- 1998-09-21 EP EP98947540A patent/EP1049678B1/de not_active Expired - Lifetime
- 1998-09-21 KR KR1020007003009A patent/KR20010030658A/ko not_active Withdrawn
- 1998-09-21 JP JP2000512817A patent/JP4514330B2/ja not_active Expired - Fee Related
- 1998-09-21 CA CA002301641A patent/CA2301641A1/en not_active Abandoned
- 1998-09-21 AU AU94412/98A patent/AU752521B2/en not_active Ceased
- 1998-09-21 BR BR9812375-0A patent/BR9812375A/pt not_active IP Right Cessation
- 1998-09-21 US US09/509,040 patent/US6689884B1/en not_active Expired - Lifetime
- 1998-09-21 WO PCT/EP1998/006002 patent/WO1999015509A2/de not_active Ceased
-
2003
- 2003-12-23 US US10/746,678 patent/US7439345B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU9441298A (en) | 1999-04-12 |
| EP1049678A2 (de) | 2000-11-08 |
| JP4514330B2 (ja) | 2010-07-28 |
| AU752521B2 (en) | 2002-09-19 |
| KR20010030658A (ko) | 2001-04-16 |
| DE19741739B4 (de) | 2006-04-27 |
| US7439345B2 (en) | 2008-10-21 |
| EP1049678B1 (de) | 2012-10-24 |
| CA2301641A1 (en) | 1999-04-01 |
| WO1999015509A2 (de) | 1999-04-01 |
| DE19741739A1 (de) | 1999-04-01 |
| WO1999015509A3 (de) | 1999-06-24 |
| JP2001517659A (ja) | 2001-10-09 |
| US6689884B1 (en) | 2004-02-10 |
| US20040142451A1 (en) | 2004-07-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1112341T1 (el) | Χημικη ενωση πυριμιδινης και φαρμακευτικη συνθεση αυτης | |
| BR0014136A (pt) | Composto, uso do mesmo, métodos para a preparação de um composto, e para inibir aurora 2 quinase em um animal de sangue quente, e, composição farmacêutica | |
| ES2162786T3 (es) | Nuevos derivados de guanidina sustituida, su preparacion y uso. | |
| NZ303711A (en) | Azt phosphoramidates and their use | |
| KR900012916A (ko) | 치환된 피리미딘 유도체, 이의 제조방법 및 툴(tool)로서의 이의 용도 | |
| DE3850571D1 (de) | 2',3'-dideoxyribofuranoxid-derivate. | |
| CY1108313T1 (el) | Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6 | |
| BR0014133A (pt) | Uso de um composto, composto, métodos de preparação de um composto, e para inibir aurora 2 quinase em um animal de sangue quente, e, composição farmacêutica | |
| ATE51872T1 (de) | Adenosin-nukleosid-derivate, ihre herstellung und biologische verwendung. | |
| DE60211343D1 (de) | Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente | |
| NO932289L (no) | 2'-deoksy-2',2'-difluor(4-substituerte pyrimidin)nukleosider med antiviralog anticanceraktivitet og mellomprodukter | |
| DK0536936T3 (da) | Pyrimidinnukleosidderivater med anti-tumor-aktivitet, deres fremstilling og anvendelse | |
| BR9812375A (pt) | Derivativos de nucleosìdeo de ciclohexila e heterociclila, método para produção destes derivados, e o emprego dos derivados e seus oligÈmeros ou conjugados em sistemas de emparelhamento e/ou teste | |
| WO2003051881B1 (en) | Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies | |
| DE59704973D1 (de) | Nucleosid-derivate mit photolabilen schutzgruppen | |
| BR0014765A (pt) | Sìntese e métodos de uso de derivados de guanina 9-substituìdos | |
| DE602005005161D1 (de) | Thiazolderivate als a2b-antagonisten | |
| Karpenko et al. | Synthesis and antiherpetic activity of acyclovir phosphonates | |
| TR199801039T2 (xx) | Yeni fenilamidin t�revlerinin elde edilmesine y�nelik usul. | |
| Shugar et al. | New light on tautomerism of purines and pyrimidines and its biological and genetic implications | |
| SE9704272D0 (sv) | Novel Compounds | |
| DK1299388T3 (da) | Variolin-derivater som anti-cancermidler | |
| BR0016115A (pt) | Derivados peptìdicos de acriloìla, processo para sua preparação e seu uso como agentes inibidores de tumor | |
| JP2001517659A5 (enExample) | ||
| HIRATA | Studies on nucleosides and nucleotides. x. nucleophilic substitution of secondary sulfonyloxy groups of pyrimidine nucleosides. iii. reaction of 2', 3'-di-o-tosyluridine with methanolic ammonia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Free format text: NANOGEN RECOGNOMICS GMBH (DE) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6O, 7O, 8O E 9O ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |
|
| B15K | Others concerning applications: alteration of classification |
Ipc: C12Q 1/68 (2018.01) |