JP2001517659A5 - - Google Patents
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- Publication number
- JP2001517659A5 JP2001517659A5 JP2000512817A JP2000512817A JP2001517659A5 JP 2001517659 A5 JP2001517659 A5 JP 2001517659A5 JP 2000512817 A JP2000512817 A JP 2000512817A JP 2000512817 A JP2000512817 A JP 2000512817A JP 2001517659 A5 JP2001517659 A5 JP 2001517659A5
- Authority
- JP
- Japan
- Prior art keywords
- equal
- nucleobase
- independently
- group
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 claims 2
- DRAVOWXCEBXPTN-UHFFFAOYSA-N isoguanine Chemical compound NC1=NC(=O)NC2=C1NC=N2 DRAVOWXCEBXPTN-UHFFFAOYSA-N 0.000 claims 2
- 125000005499 phosphonyl group Chemical group 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- XQCZBXHVTFVIFE-UHFFFAOYSA-N 2-amino-4-hydroxypyrimidine Chemical compound NC1=NC=CC(O)=N1 XQCZBXHVTFVIFE-UHFFFAOYSA-N 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 229930024421 Adenine Natural products 0.000 claims 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 claims 1
- 229960000643 adenine Drugs 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
- 229940075420 xanthine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19741739.6 | 1997-09-22 | ||
| DE19741739A DE19741739B4 (de) | 1997-09-22 | 1997-09-22 | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
| PCT/EP1998/006002 WO1999015509A2 (de) | 1997-09-22 | 1998-09-21 | Cyclohexyl- und heterocyclyl-nukleosid derivate, die herstellung und verwendung dieser derivate, deren oligomere bzw. konjugate in paarungs- und/oder testsystemen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001517659A JP2001517659A (ja) | 2001-10-09 |
| JP2001517659A5 true JP2001517659A5 (enExample) | 2010-01-21 |
| JP4514330B2 JP4514330B2 (ja) | 2010-07-28 |
Family
ID=7843200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000512817A Expired - Fee Related JP4514330B2 (ja) | 1997-09-22 | 1998-09-21 | 超分子ペアリングシステムその製造及び使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6689884B1 (enExample) |
| EP (1) | EP1049678B1 (enExample) |
| JP (1) | JP4514330B2 (enExample) |
| KR (1) | KR20010030658A (enExample) |
| AU (1) | AU752521B2 (enExample) |
| BR (1) | BR9812375A (enExample) |
| CA (1) | CA2301641A1 (enExample) |
| DE (1) | DE19741739B4 (enExample) |
| WO (1) | WO1999015509A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19741739B4 (de) * | 1997-09-22 | 2006-04-27 | Nanogen Recognomics Gmbh | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
| DE19837387A1 (de) | 1998-08-18 | 2000-02-24 | Aventis Res & Tech Gmbh & Co | 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung |
| WO2002040481A2 (en) * | 2000-11-20 | 2002-05-23 | Millennium Pharmaceuticals, Inc. | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof |
| US6893822B2 (en) | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
| DE10139730A1 (de) * | 2001-08-13 | 2003-02-27 | Nanogen Recognomics Gmbh | Verfahren zur Herstellung CNA |
| CA2463719A1 (en) | 2003-04-05 | 2004-10-05 | F. Hoffmann-La Roche Ag | Nucleotide analogs with six membered rings |
| US20060199207A1 (en) * | 2005-02-24 | 2006-09-07 | Matysiak Stefan M | Self-assembly of molecules using combinatorial hybridization |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0468352A3 (en) * | 1990-07-24 | 1992-07-15 | Nippon Kayaku Kabushiki Kaisha | Novel nucleic acid derivatives |
| DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| EP1044987B1 (en) * | 1991-12-24 | 2006-02-15 | Isis Pharmaceuticals, Inc. | Gapped 2'-modified oligonucleotides |
| JPH06263793A (ja) * | 1993-03-04 | 1994-09-20 | Asahi Breweries Ltd | ピラノース型ヌクレオシド誘導体 |
| US5491074A (en) | 1993-04-01 | 1996-02-13 | Affymax Technologies Nv | Association peptides |
| US5382580A (en) * | 1994-05-27 | 1995-01-17 | The Scripps Research Institute | N9 morpholino derivatives of 7,8-disubstituted guanines |
| US5718915A (en) | 1994-10-31 | 1998-02-17 | Burstein Laboratories, Inc. | Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme |
| EP0787207B1 (en) | 1994-11-01 | 2005-10-26 | Ariad Gene Therapeutics, Inc. | New method for identifying and evaluating biologically active molecules |
| DE19619373A1 (de) * | 1996-05-14 | 1997-11-20 | Hoechst Ag | Neue Substanzbibliothek und damit hergestellte supramolekulare Komplexe |
| US20020028442A1 (en) * | 1997-05-09 | 2002-03-07 | Christian Miculka | Novel substance library and supramolecular complexes produced therewith |
| DE19651560A1 (de) * | 1996-12-11 | 1998-06-18 | Hoechst Ag | Neue funktionelle supramolekulare Nanosysteme |
| DE19741738A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Linker-Nucleosid, seine Herstellung und Verwendung |
| DE19741739B4 (de) * | 1997-09-22 | 2006-04-27 | Nanogen Recognomics Gmbh | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
| DE19741715A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung |
| DE19815901A1 (de) * | 1998-04-08 | 1999-10-14 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung von Pentopyranosyl-Nucleosiden |
| DE19837387A1 (de) * | 1998-08-18 | 2000-02-24 | Aventis Res & Tech Gmbh & Co | 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung |
| US6893822B2 (en) * | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
-
1997
- 1997-09-22 DE DE19741739A patent/DE19741739B4/de not_active Expired - Fee Related
-
1998
- 1998-09-21 EP EP98947540A patent/EP1049678B1/de not_active Expired - Lifetime
- 1998-09-21 US US09/509,040 patent/US6689884B1/en not_active Expired - Lifetime
- 1998-09-21 JP JP2000512817A patent/JP4514330B2/ja not_active Expired - Fee Related
- 1998-09-21 AU AU94412/98A patent/AU752521B2/en not_active Ceased
- 1998-09-21 KR KR1020007003009A patent/KR20010030658A/ko not_active Withdrawn
- 1998-09-21 CA CA002301641A patent/CA2301641A1/en not_active Abandoned
- 1998-09-21 WO PCT/EP1998/006002 patent/WO1999015509A2/de not_active Ceased
- 1998-09-21 BR BR9812375-0A patent/BR9812375A/pt not_active IP Right Cessation
-
2003
- 2003-12-23 US US10/746,678 patent/US7439345B2/en not_active Expired - Fee Related
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