DE19726626C1 - Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats - Google Patents

Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats

Info

Publication number
DE19726626C1
DE19726626C1 DE19726626A DE19726626A DE19726626C1 DE 19726626 C1 DE19726626 C1 DE 19726626C1 DE 19726626 A DE19726626 A DE 19726626A DE 19726626 A DE19726626 A DE 19726626A DE 19726626 C1 DE19726626 C1 DE 19726626C1
Authority
DE
Germany
Prior art keywords
hyaluronidase
precipitation
solution
fraction
ammonium sulfate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19726626A
Other languages
German (de)
English (en)
Inventor
Gudrun Von Below
Bernard Schweigle
Bernd Goericke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals GmbH
Original Assignee
Pharma Dessau GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7833389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19726626(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharma Dessau GmbH filed Critical Pharma Dessau GmbH
Priority to DE19726626A priority Critical patent/DE19726626C1/de
Priority to EP98250209A priority patent/EP0892045B1/de
Priority to ES05090293T priority patent/ES2306004T3/es
Priority to DE59813491T priority patent/DE59813491D1/de
Priority to EP05090293A priority patent/EP1624057B1/de
Priority to DK05090293T priority patent/DK1624057T3/da
Priority to AT05090293T priority patent/ATE398171T1/de
Priority to AT98250209T priority patent/ATE323760T1/de
Priority to DE59814240T priority patent/DE59814240D1/de
Priority to ES98250209T priority patent/ES2263190T3/es
Priority to CZ19981910A priority patent/CZ289560B6/cs
Publication of DE19726626C1 publication Critical patent/DE19726626C1/de
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE19726626A 1997-06-17 1997-06-17 Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats Expired - Fee Related DE19726626C1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE19726626A DE19726626C1 (de) 1997-06-17 1997-06-17 Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats
AT05090293T ATE398171T1 (de) 1997-06-17 1998-06-15 Hyaluronidase enthaltendes präparat und pharmazeutische verwendung davon
DE59814240T DE59814240D1 (de) 1997-06-17 1998-06-15 Hyaluronidase enthaltendes Präparat und pharmazeutische Verwendung davon
DE59813491T DE59813491D1 (de) 1997-06-17 1998-06-15 Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats
EP05090293A EP1624057B1 (de) 1997-06-17 1998-06-15 Hyaluronidase enthaltendes Präparat und pharmazeutische Verwendung davon
DK05090293T DK1624057T3 (da) 1997-06-17 1998-06-15 Hyaluronidaseholdigt præparat samt dets farmaceutiske anvendelse
EP98250209A EP0892045B1 (de) 1997-06-17 1998-06-15 Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats
AT98250209T ATE323760T1 (de) 1997-06-17 1998-06-15 Verfahren zur herstellung eines eine hyaluronidase enthaltenden präparats
ES05090293T ES2306004T3 (es) 1997-06-17 1998-06-15 Un preparado que contiene hialuronidasa y su uso farmaceutico.
ES98250209T ES2263190T3 (es) 1997-06-17 1998-06-15 Procedimiento para la produccion de un preparado conteniendo hialuronidasa.
CZ19981910A CZ289560B6 (cs) 1997-06-17 1998-06-17 Způsob výroby přípravku obsahujícího hyaluronidázu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19726626A DE19726626C1 (de) 1997-06-17 1997-06-17 Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats

Publications (1)

Publication Number Publication Date
DE19726626C1 true DE19726626C1 (de) 1998-09-03

Family

ID=7833389

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19726626A Expired - Fee Related DE19726626C1 (de) 1997-06-17 1997-06-17 Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats
DE59814240T Expired - Lifetime DE59814240D1 (de) 1997-06-17 1998-06-15 Hyaluronidase enthaltendes Präparat und pharmazeutische Verwendung davon
DE59813491T Expired - Lifetime DE59813491D1 (de) 1997-06-17 1998-06-15 Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE59814240T Expired - Lifetime DE59814240D1 (de) 1997-06-17 1998-06-15 Hyaluronidase enthaltendes Präparat und pharmazeutische Verwendung davon
DE59813491T Expired - Lifetime DE59813491D1 (de) 1997-06-17 1998-06-15 Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats

Country Status (6)

Country Link
EP (2) EP1624057B1 (cs)
AT (2) ATE398171T1 (cs)
CZ (1) CZ289560B6 (cs)
DE (3) DE19726626C1 (cs)
DK (1) DK1624057T3 (cs)
ES (2) ES2263190T3 (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0892045A3 (de) * 1997-06-17 2001-02-07 Pharma Dessau GmbH Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610292B2 (en) 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5866120A (en) 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
JP2006523461A (ja) * 2003-04-15 2006-10-19 イスタ・ファーマスーティカルズ・インコーポレイテッド 羊ヒアルロニダーゼを単離し精製する方法
CN103725659A (zh) * 2013-11-24 2014-04-16 青岛康原药业有限公司 一种从牛睾丸中提取玻璃酸酶的方法
DE102015107307B3 (de) * 2015-05-11 2016-09-08 Labor L + S Aktiengesellschaft Optisches Verfahren zur Gehaltsbestimmung von Hyaluronsäure

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD24229A (cs) *

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3708575A (en) * 1970-05-13 1973-01-02 Biorex Laboratories Ltd Method for the treatment of atherosclerosis employing glucuronoglycos-aminoglycan-hyaluronate-lyase
RU2027759C1 (ru) * 1992-02-03 1995-01-27 Пак Владимир Николаевич Способ получения гиалуронидазы
RU2054943C1 (ru) * 1992-03-30 1996-02-27 Харьковское предприятие по производству иммунобиологических и лекарственных препаратов "Биолек" Способ получения гиалуронидазы
US5747027A (en) * 1995-04-07 1998-05-05 The Regents Of The University Of California BH55 hyaluronidase
US5958750A (en) * 1996-07-03 1999-09-28 Inctye Pharmaceuticals, Inc. Human hyaluronidase
DE19726626C1 (de) * 1997-06-17 1998-09-03 Pharma Dessau Gmbh Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD24229A (cs) *

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CA 79:14839 *
CA 89:55346 *
WPIDS 96-237626 (24) *
WPIDS 97-279355 (25) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0892045A3 (de) * 1997-06-17 2001-02-07 Pharma Dessau GmbH Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats

Also Published As

Publication number Publication date
ES2306004T3 (es) 2008-11-01
ES2263190T3 (es) 2006-12-01
EP1624057A2 (de) 2006-02-08
EP0892045A3 (de) 2001-02-07
EP1624057A3 (de) 2007-03-07
ATE398171T1 (de) 2008-07-15
DE59814240D1 (de) 2008-07-24
CZ191098A3 (cs) 1999-01-13
DK1624057T3 (da) 2008-09-15
EP0892045B1 (de) 2006-04-19
DE59813491D1 (de) 2006-05-24
EP0892045A2 (de) 1999-01-20
ATE323760T1 (de) 2006-05-15
EP1624057B1 (de) 2008-06-11
CZ289560B6 (cs) 2002-02-13

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Legal Events

Date Code Title Description
8100 Publication of patent without earlier publication of application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMA DESSAU GMBH, 06846 DESSAU, DE

8327 Change in the person/name/address of the patent owner

Owner name: RIEMSER ARZNEIMITTEL AG, 17493 GREIFSWALD, DE

R082 Change of representative

Representative=s name: JUNGBLUT & SEUSS PATENTANWAELTE, DE

R081 Change of applicant/patentee

Owner name: RIEMSER PHARMA GMBH, DE

Free format text: FORMER OWNER: RIEMSER ARZNEIMITTEL AG, 17493 GREIFSWALD, DE

Effective date: 20130604

R082 Change of representative

Representative=s name: JUNGBLUT & SEUSS PATENTANWAELTE, DE

Effective date: 20130604

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20140101