DE19637042A1 - Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren - Google Patents

Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren

Info

Publication number
DE19637042A1
DE19637042A1 DE19637042A DE19637042A DE19637042A1 DE 19637042 A1 DE19637042 A1 DE 19637042A1 DE 19637042 A DE19637042 A DE 19637042A DE 19637042 A DE19637042 A DE 19637042A DE 19637042 A1 DE19637042 A1 DE 19637042A1
Authority
DE
Germany
Prior art keywords
group
substituted
amino
hydrogen
thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19637042A
Other languages
German (de)
English (en)
Inventor
Klaus Muehlegger
Herbert V D Dipl Chem Dr Eltz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE19637042A priority Critical patent/DE19637042A1/de
Priority to CA002265727A priority patent/CA2265727A1/en
Priority to DE59712871T priority patent/DE59712871D1/de
Priority to AT97909251T priority patent/ATE369360T1/de
Priority to PCT/EP1997/004972 priority patent/WO1998011104A1/de
Priority to EP97909251A priority patent/EP0927180B1/de
Priority to US09/254,644 priority patent/US6403786B1/en
Priority to ES97909251T priority patent/ES2292182T3/es
Priority to JP51326198A priority patent/JP4281976B2/ja
Publication of DE19637042A1 publication Critical patent/DE19637042A1/de
Priority to US10/096,786 priority patent/US6875859B2/en
Priority to US11/071,052 priority patent/US8013147B2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE19637042A 1996-09-12 1996-09-12 Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren Withdrawn DE19637042A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE19637042A DE19637042A1 (de) 1996-09-12 1996-09-12 Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren
EP97909251A EP0927180B1 (de) 1996-09-12 1997-09-11 Heterocyclische verbindungen und deren verwendung in der detektion von nucleinsäuren
DE59712871T DE59712871D1 (de) 1996-09-12 1997-09-11 Heterocyclische verbindungen und deren verwendung in der detektion von nucleinsäuren
AT97909251T ATE369360T1 (de) 1996-09-12 1997-09-11 Heterocyclische verbindungen und deren verwendung in der detektion von nucleinsäuren
PCT/EP1997/004972 WO1998011104A1 (de) 1996-09-12 1997-09-11 Heterocyclische verbindungen und deren verwendung in der detektion von nucleinsäuren
CA002265727A CA2265727A1 (en) 1996-09-12 1997-09-11 Heterocyclic compounds and their use for isolating nucleic acids
US09/254,644 US6403786B1 (en) 1996-09-12 1997-09-11 Heterocyclic compounds and their use for isolating nucleic acids
ES97909251T ES2292182T3 (es) 1996-09-12 1997-09-11 Compuestos heterociclicos y su empleo en la deteccion de acidos nuclecicos.
JP51326198A JP4281976B2 (ja) 1996-09-12 1997-09-11 複素環式化合物および核酸検出におけるその使用
US10/096,786 US6875859B2 (en) 1996-09-12 2002-03-11 Heterocyclic compounds and their use in the detection of nucleic acids
US11/071,052 US8013147B2 (en) 1996-09-12 2005-03-02 Heterocyclic compounds and their use in the detection of nucleic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19637042A DE19637042A1 (de) 1996-09-12 1996-09-12 Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren

Publications (1)

Publication Number Publication Date
DE19637042A1 true DE19637042A1 (de) 1998-03-19

Family

ID=7805344

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19637042A Withdrawn DE19637042A1 (de) 1996-09-12 1996-09-12 Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren
DE59712871T Expired - Lifetime DE59712871D1 (de) 1996-09-12 1997-09-11 Heterocyclische verbindungen und deren verwendung in der detektion von nucleinsäuren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59712871T Expired - Lifetime DE59712871D1 (de) 1996-09-12 1997-09-11 Heterocyclische verbindungen und deren verwendung in der detektion von nucleinsäuren

Country Status (8)

Country Link
US (3) US6403786B1 (https=)
EP (1) EP0927180B1 (https=)
JP (1) JP4281976B2 (https=)
AT (1) ATE369360T1 (https=)
CA (1) CA2265727A1 (https=)
DE (2) DE19637042A1 (https=)
ES (1) ES2292182T3 (https=)
WO (1) WO1998011104A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
US6864059B2 (en) 1996-01-23 2005-03-08 Affymetrix, Inc. Biotin containing C-glycoside nucleic acid labeling compounds
US7423143B2 (en) 1996-01-23 2008-09-09 Affymetrix. Inc. Nucleic acid labeling compounds
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
US7291463B2 (en) * 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds
DE19637042A1 (de) 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren
FR2780059B1 (fr) * 1998-06-17 2002-10-11 Bio Merieux Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus
US6719520B2 (en) 1998-10-08 2004-04-13 Smithkline Beecham Corporation Method and compounds
ATE284387T1 (de) * 1998-10-08 2004-12-15 Smithkline Beecham Plc 3-(3-chloro-4-hydroxyphenylamino)-4-(2- nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3)
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
RU2259368C2 (ru) * 2000-02-18 2005-08-27 Тояма Кемикал Ко., Лтд. Производные пиразина или их соли, фармацевтическая копозиция, содержащая данные соединения
RU2297414C2 (ru) * 2001-02-14 2007-04-20 Тояма Кемикал Ко., Лтд. Производные пиразина или их соли, фармацевтическая композиция, содержащая данные соединения, и промежуточные соединения для их получения
AU2002258502A1 (en) 2001-03-12 2002-09-24 Affymetrix, Inc. Nucleic acid labeling compounds
US7820030B2 (en) * 2003-04-16 2010-10-26 Handylab, Inc. System and method for electrochemical detection of biological compounds
RU2454423C1 (ru) * 2010-12-27 2012-06-27 Государственное образовательное учреждение высшего профессионального образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения и социального развития РФ 2-меркаптобензоилгидразоны моноз, обладающие антимикробной и противогрибковой активностью

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4096321A (en) * 1976-11-22 1978-06-20 Hoffmann-La Roche Inc. Process to produce oxazinomycin and intermediates
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4997928A (en) * 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
DE3836656A1 (de) * 1988-10-27 1990-05-03 Boehringer Mannheim Gmbh Neue digoxigenin-derivate und ihre verwendung
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
CA2129105A1 (en) * 1992-02-12 1993-08-19 Michael J. Conrad Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
US5616700A (en) * 1992-04-24 1997-04-01 Beckman Instruments, Inc. Processes for synthesizing nucleotides and modified nucleotides using N.sub.
DE19637042A1 (de) * 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren
EP1251708A1 (en) * 2001-04-18 2002-10-23 Siemens Information and Communication Networks S.p.A. Method for reducing the radio channel access delay in a wireless communication system

Also Published As

Publication number Publication date
JP4281976B2 (ja) 2009-06-17
EP0927180B1 (de) 2007-08-08
DE59712871D1 (de) 2007-09-20
US6875859B2 (en) 2005-04-05
US20050222056A1 (en) 2005-10-06
JP2001502665A (ja) 2001-02-27
US6403786B1 (en) 2002-06-11
WO1998011104A1 (de) 1998-03-19
ES2292182T3 (es) 2008-03-01
ATE369360T1 (de) 2007-08-15
US8013147B2 (en) 2011-09-06
EP0927180A1 (de) 1999-07-07
CA2265727A1 (en) 1998-03-19
US20020099202A1 (en) 2002-07-25

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: ROCHE DIAGNOSTICS GMBH, 68305 MANNHEIM, DE

8139 Disposal/non-payment of the annual fee