DE19602930A1 - Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung - Google Patents
Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren HerstellungInfo
- Publication number
- DE19602930A1 DE19602930A1 DE19602930A DE19602930A DE19602930A1 DE 19602930 A1 DE19602930 A1 DE 19602930A1 DE 19602930 A DE19602930 A DE 19602930A DE 19602930 A DE19602930 A DE 19602930A DE 19602930 A1 DE19602930 A1 DE 19602930A1
- Authority
- DE
- Germany
- Prior art keywords
- water
- porous matrix
- mol
- fatty acid
- gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
- C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
- C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
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- Medicinal Preparation (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19602930A DE19602930A1 (de) | 1996-01-18 | 1996-01-18 | Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung |
| PCT/EP1997/000208 WO1997026016A2 (de) | 1996-01-18 | 1997-01-16 | Gasblasensuspensionen und deren verwendung als ultraschallkontrastmittel |
| EP97902178A EP0874644A2 (de) | 1996-01-18 | 1997-01-16 | Gasblasensuspensionen und deren verwendung als ultraschallkontrastmittel |
| JP9525697A JP2000504317A (ja) | 1996-01-18 | 1997-01-16 | 気泡懸濁物と超音波造影剤への応用 |
| AU15925/97A AU1592597A (en) | 1996-01-18 | 1997-01-16 | Gas bubble suspensions and their application as an ultrasound contrast medium |
| CA002243174A CA2243174A1 (en) | 1996-01-18 | 1997-01-16 | Gas bubble suspensions and their application as an ultrasound contrast medium |
| ZA97414A ZA97414B (en) | 1996-01-18 | 1997-01-17 | Porous matrices that consist of low-molecular substances for generating stable gas bubble suspensions their use as ultrasonic contrast media as well as process for their production |
| NO983332A NO983332D0 (no) | 1996-01-18 | 1998-07-17 | Gassboblesuspensjoner og deres anvendelse som ultralydkontrastmiddel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19602930A DE19602930A1 (de) | 1996-01-18 | 1996-01-18 | Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19602930A1 true DE19602930A1 (de) | 1997-07-24 |
Family
ID=7783852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19602930A Withdrawn DE19602930A1 (de) | 1996-01-18 | 1996-01-18 | Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0874644A2 (no) |
| JP (1) | JP2000504317A (no) |
| AU (1) | AU1592597A (no) |
| CA (1) | CA2243174A1 (no) |
| DE (1) | DE19602930A1 (no) |
| NO (1) | NO983332D0 (no) |
| WO (1) | WO1997026016A2 (no) |
| ZA (1) | ZA97414B (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070123478A1 (en) * | 2005-11-28 | 2007-05-31 | Rowe Vernon D | Compositions useful for reducing nephrotoxicity and methods of use thereof |
| JP5196896B2 (ja) * | 2007-07-13 | 2013-05-15 | 花王株式会社 | 微細気泡前駆体の製造方法 |
| JP2010005512A (ja) * | 2008-06-25 | 2010-01-14 | Kao Corp | 微細気泡前駆体組成物 |
| KR101927614B1 (ko) | 2017-03-30 | 2018-12-10 | 숭실대학교산학협력단 | 초음파 영상을 위한 안정한 생체적합 산소-나노버블 조영제 제조방법 |
| JP7211699B2 (ja) * | 2017-09-11 | 2023-01-24 | バイエル ファーマ アクチエンゲゼルシャフト | 超音波診断用造影剤 |
| US20240226418A1 (en) * | 2021-01-26 | 2024-07-11 | Agitated Solutions Inc. | Syringe-Based Microbubble Generator |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0077752A2 (de) * | 1981-10-16 | 1983-04-27 | Schering Aktiengesellschaft | Flüssige Mischung zur Aufnahme und Stabilisierung von Gasbläschen zur Verwendung als Kontrastmittel für die Ultraschalldiagnostik und deren Herstellung |
| EP0365467A2 (de) * | 1988-10-07 | 1990-04-25 | Schering Aktiengesellschaft | Ultraschallkontrastmittel aus Gasbläschen und Fettsäure-enthaltenden Mikropartikeln |
| WO1993000930A1 (en) * | 1991-07-05 | 1993-01-21 | Holmes, Michael, John | Improvements in or relating to contrast agents |
| WO1993005819A1 (en) * | 1991-09-17 | 1993-04-01 | Sonus Pharmaceuticals, Inc | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media |
| EP0554213A1 (en) * | 1992-01-24 | 1993-08-04 | BRACCO International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| WO1994009829A1 (en) * | 1992-11-02 | 1994-05-11 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| WO1995003835A1 (en) * | 1993-07-30 | 1995-02-09 | Alliance Pharmaceutical Corp. | Stabilized microbubble compositions for ultrasound |
| WO1995016467A1 (en) * | 1993-12-15 | 1995-06-22 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media |
| WO1995021631A1 (en) * | 1994-02-15 | 1995-08-17 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| WO1995022994A1 (de) * | 1994-02-23 | 1995-08-31 | Schering Aktiengesellschaft | Gas enthaltende mikropartikel, diese enthaltende mittel, deren verwendung in der ultraschalldiagnostik, sowie verfahren zur herstellung der partikel und mittel |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3313946A1 (de) * | 1983-04-15 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel |
| DE3313947A1 (de) * | 1983-04-15 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel |
| DE3709851A1 (de) * | 1987-03-24 | 1988-10-06 | Silica Gel Gmbh Adsorptions Te | Nmr-diagnostische fluessigkeitszusammensetzungen |
| US5147631A (en) * | 1991-04-30 | 1992-09-15 | Du Pont Merck Pharmaceutical Company | Porous inorganic ultrasound contrast agents |
| ATE151992T1 (de) * | 1991-06-03 | 1997-05-15 | Nycomed Imaging As | Verbesserungen im bezug auf kontrastmittel |
| EP0593627A1 (en) * | 1991-07-05 | 1994-04-27 | The University Of Rochester | Ultrasmall non-aggregated porous particles entrapping gas-bubbles |
| GB9200388D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
| US5798091A (en) * | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
-
1996
- 1996-01-18 DE DE19602930A patent/DE19602930A1/de not_active Withdrawn
-
1997
- 1997-01-16 AU AU15925/97A patent/AU1592597A/en not_active Abandoned
- 1997-01-16 WO PCT/EP1997/000208 patent/WO1997026016A2/de not_active Application Discontinuation
- 1997-01-16 CA CA002243174A patent/CA2243174A1/en not_active Abandoned
- 1997-01-16 JP JP9525697A patent/JP2000504317A/ja active Pending
- 1997-01-16 EP EP97902178A patent/EP0874644A2/de not_active Withdrawn
- 1997-01-17 ZA ZA97414A patent/ZA97414B/xx unknown
-
1998
- 1998-07-17 NO NO983332A patent/NO983332D0/no not_active Application Discontinuation
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0077752A2 (de) * | 1981-10-16 | 1983-04-27 | Schering Aktiengesellschaft | Flüssige Mischung zur Aufnahme und Stabilisierung von Gasbläschen zur Verwendung als Kontrastmittel für die Ultraschalldiagnostik und deren Herstellung |
| EP0365467A2 (de) * | 1988-10-07 | 1990-04-25 | Schering Aktiengesellschaft | Ultraschallkontrastmittel aus Gasbläschen und Fettsäure-enthaltenden Mikropartikeln |
| WO1993000930A1 (en) * | 1991-07-05 | 1993-01-21 | Holmes, Michael, John | Improvements in or relating to contrast agents |
| WO1993005819A1 (en) * | 1991-09-17 | 1993-04-01 | Sonus Pharmaceuticals, Inc | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media |
| EP0554213A1 (en) * | 1992-01-24 | 1993-08-04 | BRACCO International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| WO1994009829A1 (en) * | 1992-11-02 | 1994-05-11 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| WO1995003835A1 (en) * | 1993-07-30 | 1995-02-09 | Alliance Pharmaceutical Corp. | Stabilized microbubble compositions for ultrasound |
| WO1995016467A1 (en) * | 1993-12-15 | 1995-06-22 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media |
| WO1995021631A1 (en) * | 1994-02-15 | 1995-08-17 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| WO1995022994A1 (de) * | 1994-02-23 | 1995-08-31 | Schering Aktiengesellschaft | Gas enthaltende mikropartikel, diese enthaltende mittel, deren verwendung in der ultraschalldiagnostik, sowie verfahren zur herstellung der partikel und mittel |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0874644A2 (de) | 1998-11-04 |
| WO1997026016A2 (de) | 1997-07-24 |
| ZA97414B (en) | 1997-07-17 |
| NO983332L (no) | 1998-07-17 |
| CA2243174A1 (en) | 1997-07-24 |
| WO1997026016A3 (de) | 1997-10-23 |
| AU1592597A (en) | 1997-08-11 |
| NO983332D0 (no) | 1998-07-17 |
| JP2000504317A (ja) | 2000-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8130 | Withdrawal |