DE19600301C2 - Durch Cyclooligomerisierung des einfachen Kohlensuboxids C¶3¶O¶2¶ aufgebaute makrocyclische Verbindungen, Verfahren zu deren Herstellung und Gewinnung sowie deren Verwendung - Google Patents

Durch Cyclooligomerisierung des einfachen Kohlensuboxids C¶3¶O¶2¶ aufgebaute makrocyclische Verbindungen, Verfahren zu deren Herstellung und Gewinnung sowie deren Verwendung

Info

Publication number
DE19600301C2
DE19600301C2 DE19600301A DE19600301A DE19600301C2 DE 19600301 C2 DE19600301 C2 DE 19600301C2 DE 19600301 A DE19600301 A DE 19600301A DE 19600301 A DE19600301 A DE 19600301A DE 19600301 C2 DE19600301 C2 DE 19600301C2
Authority
DE
Germany
Prior art keywords
active ingredient
macrocyclic compounds
com
compounds according
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19600301A
Other languages
German (de)
English (en)
Other versions
DE19600301A1 (de
Inventor
Franz Kerek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Donatur Dr Kerek GmbH
Original Assignee
Donatur Dr Kerek GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Donatur Dr Kerek GmbH filed Critical Donatur Dr Kerek GmbH
Priority to DE19600301A priority Critical patent/DE19600301C2/de
Priority to TW085115731A priority patent/TW376386B/zh
Priority to JO19961945A priority patent/JO1945B1/en
Priority to IL12516596A priority patent/IL125165A0/xx
Priority to KR1019980705130A priority patent/KR19990077000A/ko
Priority to EP96944678A priority patent/EP0874851B1/en
Priority to EE9800211A priority patent/EE9800211A/xx
Priority to PCT/EP1996/005867 priority patent/WO1997025333A2/en
Priority to CN96180086A priority patent/CN1209132A/zh
Priority to PL96327657A priority patent/PL327657A1/xx
Priority to ES96944678T priority patent/ES2194128T3/es
Priority to CA002241870A priority patent/CA2241870A1/en
Priority to HU9904191A priority patent/HUP9904191A2/hu
Priority to US09/101,401 priority patent/US6187810B1/en
Priority to BR9612430-0A priority patent/BR9612430A/pt
Priority to JP52482597A priority patent/JP4195089B2/ja
Priority to AT96944678T priority patent/ATE233768T1/de
Priority to SK885-98A priority patent/SK88598A3/sk
Priority to TR1998/01288T priority patent/TR199801288T2/xx
Priority to AU13074/97A priority patent/AU1307497A/en
Priority to CZ982088A priority patent/CZ208898A3/cs
Priority to SI9630605T priority patent/SI0874851T1/xx
Priority to DE69626548T priority patent/DE69626548T2/de
Priority to ZA9714A priority patent/ZA9714B/xx
Priority to HR19600301.6A priority patent/HRP970002A2/hr
Priority to ARP970100019A priority patent/AR005350A1/es
Publication of DE19600301A1 publication Critical patent/DE19600301A1/de
Priority to BG102599A priority patent/BG102599A/xx
Application granted granted Critical
Publication of DE19600301C2 publication Critical patent/DE19600301C2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Rehabilitation Therapy (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
DE19600301A 1996-01-05 1996-01-05 Durch Cyclooligomerisierung des einfachen Kohlensuboxids C¶3¶O¶2¶ aufgebaute makrocyclische Verbindungen, Verfahren zu deren Herstellung und Gewinnung sowie deren Verwendung Expired - Fee Related DE19600301C2 (de)

Priority Applications (27)

Application Number Priority Date Filing Date Title
DE19600301A DE19600301C2 (de) 1996-01-05 1996-01-05 Durch Cyclooligomerisierung des einfachen Kohlensuboxids C¶3¶O¶2¶ aufgebaute makrocyclische Verbindungen, Verfahren zu deren Herstellung und Gewinnung sowie deren Verwendung
TW085115731A TW376386B (en) 1996-01-05 1996-12-18 Bioregulatory active substance, method for its production and use thereof
JO19961945A JO1945B1 (en) 1996-01-05 1996-12-23 A bioactive active substance and a way to prepare and use it
TR1998/01288T TR199801288T2 (xx) 1996-01-05 1996-12-30 Oksid�l birimlerinden yap�lm�� macrosiklik bile�enler
EP96944678A EP0874851B1 (en) 1996-01-05 1996-12-30 Macrocyclic compounds made from carbon suboxide units
EE9800211A EE9800211A (et) 1996-01-05 1996-12-30 Alaoksiidühikutest valmistatud makrotsüklilised ühendid
PCT/EP1996/005867 WO1997025333A2 (en) 1996-01-05 1996-12-30 Macrocyclic compounds made from suboxide units
CN96180086A CN1209132A (zh) 1996-01-05 1996-12-30 由二氧化三碳单元制成的大环化合物
PL96327657A PL327657A1 (en) 1996-01-05 1996-12-30 Macrocyclic compounds obtained from suboxide units
ES96944678T ES2194128T3 (es) 1996-01-05 1996-12-30 Compuestos microciclicos constituidos de unidades de suboxido de carbono.
CA002241870A CA2241870A1 (en) 1996-01-05 1996-12-30 Macrocyclic compounds made from suboxide units
HU9904191A HUP9904191A2 (hu) 1996-01-05 1996-12-30 Szuboxidegységekből előállított makrociklusos vegyületek
US09/101,401 US6187810B1 (en) 1996-01-05 1996-12-30 Macrocyclic compounds made from suboxide units
BR9612430-0A BR9612430A (pt) 1996-01-05 1996-12-30 Compostos macrocìclicos obtidos a partir de unidades de subóxido.
IL12516596A IL125165A0 (en) 1996-01-05 1996-12-30 Macrocyclic compounds made from suboxide units
AT96944678T ATE233768T1 (de) 1996-01-05 1996-12-30 Macrocyclische verbindungen die aus kohlensuboxi- gruppen besteht
SK885-98A SK88598A3 (en) 1996-01-05 1996-12-30 Macrocyclic compounds made from suboxide units
KR1019980705130A KR19990077000A (ko) 1996-01-05 1996-12-30 아산화물 단위로 제조된 대환식 화합물
AU13074/97A AU1307497A (en) 1996-01-05 1996-12-30 Macrocyclic compounds made from suboxide units
CZ982088A CZ208898A3 (cs) 1996-01-05 1996-12-30 Makrocyklické sloučeniny vytvořené ze suboxidových jednotek
SI9630605T SI0874851T1 (en) 1996-01-05 1996-12-30 Macrocyclic compounds made from carbon suboxide units
DE69626548T DE69626548T2 (de) 1996-01-05 1996-12-30 Macrocyclische verbindungen die aus kohlensuboxi-gruppen besteht
JP52482597A JP4195089B2 (ja) 1996-01-05 1996-12-30 亜酸化物単位から製造される巨大環式化合物
ZA9714A ZA9714B (en) 1996-01-05 1997-01-02 Bioregulatory active substance method for its production and use thereof
HR19600301.6A HRP970002A2 (en) 1996-01-05 1997-01-03 Bioregulatory active substance, process for its preparation and its use
ARP970100019A AR005350A1 (es) 1996-01-05 1997-01-03 Una substancia activa biorreguladora, usos de la misma, metodos para producirla y aislarla, agente farmaceutico que comprende dicha substancia,agentes de diagnostico y metodos para el diagnostico de enfermedades
BG102599A BG102599A (en) 1996-01-05 1998-07-03 Macrocyclic compounds produced from suboxide units

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19600301A DE19600301C2 (de) 1996-01-05 1996-01-05 Durch Cyclooligomerisierung des einfachen Kohlensuboxids C¶3¶O¶2¶ aufgebaute makrocyclische Verbindungen, Verfahren zu deren Herstellung und Gewinnung sowie deren Verwendung

Publications (2)

Publication Number Publication Date
DE19600301A1 DE19600301A1 (de) 1997-07-10
DE19600301C2 true DE19600301C2 (de) 1999-12-09

Family

ID=7782233

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19600301A Expired - Fee Related DE19600301C2 (de) 1996-01-05 1996-01-05 Durch Cyclooligomerisierung des einfachen Kohlensuboxids C¶3¶O¶2¶ aufgebaute makrocyclische Verbindungen, Verfahren zu deren Herstellung und Gewinnung sowie deren Verwendung
DE69626548T Expired - Lifetime DE69626548T2 (de) 1996-01-05 1996-12-30 Macrocyclische verbindungen die aus kohlensuboxi-gruppen besteht

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69626548T Expired - Lifetime DE69626548T2 (de) 1996-01-05 1996-12-30 Macrocyclische verbindungen die aus kohlensuboxi-gruppen besteht

Country Status (26)

Country Link
US (1) US6187810B1 (enExample)
EP (1) EP0874851B1 (enExample)
JP (1) JP4195089B2 (enExample)
KR (1) KR19990077000A (enExample)
CN (1) CN1209132A (enExample)
AR (1) AR005350A1 (enExample)
AT (1) ATE233768T1 (enExample)
AU (1) AU1307497A (enExample)
BG (1) BG102599A (enExample)
BR (1) BR9612430A (enExample)
CA (1) CA2241870A1 (enExample)
CZ (1) CZ208898A3 (enExample)
DE (2) DE19600301C2 (enExample)
EE (1) EE9800211A (enExample)
ES (1) ES2194128T3 (enExample)
HR (1) HRP970002A2 (enExample)
HU (1) HUP9904191A2 (enExample)
IL (1) IL125165A0 (enExample)
JO (1) JO1945B1 (enExample)
PL (1) PL327657A1 (enExample)
SI (1) SI0874851T1 (enExample)
SK (1) SK88598A3 (enExample)
TR (1) TR199801288T2 (enExample)
TW (1) TW376386B (enExample)
WO (1) WO1997025333A2 (enExample)
ZA (1) ZA9714B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO280796A0 (en) * 1996-10-07 1996-10-31 Austin Research Institute, The Methods of activating or enhancing FC receptors
DE10260537A1 (de) 2002-12-21 2004-07-15 Kerek, Franz, Dr. Peptide mit hohem Cysteingehalt
US20060067055A1 (en) * 2004-09-30 2006-03-30 Heffner Kenneth H Thermally conductive composite and uses for microelectronic packaging
US20080007890A1 (en) * 2004-09-30 2008-01-10 Harmon Julianne P Thermally conductive composite and uses for microelectronic packaging
CN119613750B (zh) * 2024-12-10 2025-08-12 杭州师范大学 一种机械及pH双重调控的蝶形钾离子通道分子及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2565115A (en) 1948-10-28 1951-08-21 Squibb & Sons Inc Method of obtaining a conjugated estrogen preparation
US2720483A (en) 1951-02-21 1955-10-11 Olin Mathieson Method of obtaining a conjugatedestrogen preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Gmelins Handbuch d. anorgan. Chemie, 8.Aufl., Kohlenstoff, Teil C, Lfg.1, Syst. Nr. 14, Ver- lag Chemie, Weinheim (1970), S.90-96 *

Also Published As

Publication number Publication date
DE69626548D1 (de) 2003-04-10
WO1997025333A2 (en) 1997-07-17
US6187810B1 (en) 2001-02-13
BR9612430A (pt) 1999-12-28
ES2194128T3 (es) 2003-11-16
SK88598A3 (en) 1998-12-02
AU1307497A (en) 1997-08-01
ZA9714B (en) 1997-07-23
DE69626548T2 (de) 2003-12-24
TR199801288T2 (xx) 1998-11-23
WO1997025333A3 (en) 1997-12-24
PL327657A1 (en) 1998-12-21
TW376386B (en) 1999-12-11
SI0874851T1 (en) 2003-10-31
CN1209132A (zh) 1999-02-24
JO1945B1 (en) 1997-12-15
IL125165A0 (en) 1999-01-26
KR19990077000A (ko) 1999-10-25
CA2241870A1 (en) 1997-07-17
ATE233768T1 (de) 2003-03-15
HUP9904191A2 (hu) 2000-05-28
EP0874851B1 (en) 2003-03-05
AR005350A1 (es) 1999-04-28
JP2000503015A (ja) 2000-03-14
HRP970002A2 (en) 1998-04-30
BG102599A (en) 1999-03-31
JP4195089B2 (ja) 2008-12-10
EP0874851A2 (en) 1998-11-04
EE9800211A (et) 1998-12-15
DE19600301A1 (de) 1997-07-10
CZ208898A3 (cs) 1998-10-14

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