DE1906322A1 - Neue alpha-Alkyl-5-hydroxytryptophanester - Google Patents

Neue alpha-Alkyl-5-hydroxytryptophanester

Info

Publication number
DE1906322A1
DE1906322A1 DE19691906322 DE1906322A DE1906322A1 DE 1906322 A1 DE1906322 A1 DE 1906322A1 DE 19691906322 DE19691906322 DE 19691906322 DE 1906322 A DE1906322 A DE 1906322A DE 1906322 A1 DE1906322 A1 DE 1906322A1
Authority
DE
Germany
Prior art keywords
ethyl
compound
hydroxy
carbon atoms
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19691906322
Other languages
German (de)
English (en)
Inventor
Heinzelman Richard Voorhees
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DE1906322A1 publication Critical patent/DE1906322A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
DE19691906322 1968-02-16 1969-02-08 Neue alpha-Alkyl-5-hydroxytryptophanester Pending DE1906322A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70592268A 1968-02-16 1968-02-16

Publications (1)

Publication Number Publication Date
DE1906322A1 true DE1906322A1 (de) 1969-09-25

Family

ID=24835493

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19691906322 Pending DE1906322A1 (de) 1968-02-16 1969-02-08 Neue alpha-Alkyl-5-hydroxytryptophanester

Country Status (6)

Country Link
BE (1) BE728421A (fr)
DE (1) DE1906322A1 (fr)
ES (1) ES363559A1 (fr)
FR (1) FR2002067A1 (fr)
GB (1) GB1184538A (fr)
NL (1) NL6902421A (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001169A2 (fr) * 1991-07-05 1993-01-21 Merck Sharp & Dohme Limited Composes aromatiques, compositions pharmaceutiques les contenant et leur utilisation therapeutique
US5328927A (en) * 1992-03-03 1994-07-12 Merck Sharpe & Dohme, Ltd. Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073795A (en) * 1976-06-22 1978-02-14 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4256641A (en) 1976-06-22 1981-03-17 Hoffmann-La Roche Inc. Novel syntheses of tryptophans
US4316847A (en) * 1979-07-30 1982-02-23 Hoffmann-La Roche Inc. Pyrroles and pyrrolidines
EP2098524A1 (fr) * 2008-03-05 2009-09-09 4Sc Ag Procédé pour la préparation d'indolopyrinidines énantiomériquement pures

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001169A2 (fr) * 1991-07-05 1993-01-21 Merck Sharp & Dohme Limited Composes aromatiques, compositions pharmaceutiques les contenant et leur utilisation therapeutique
WO1993001169A3 (fr) * 1991-07-05 1993-11-11 Merck Sharp & Dohme Composes aromatiques, compositions pharmaceutiques les contenant et leur utilisation therapeutique
US5472978A (en) * 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
US5328927A (en) * 1992-03-03 1994-07-12 Merck Sharpe & Dohme, Ltd. Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
US5514718A (en) * 1992-03-03 1996-05-07 Merck, Sharp & Dohme Limited Heterocyclic compounds, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
BE728421A (fr) 1969-08-14
FR2002067A1 (fr) 1969-10-03
GB1184538A (en) 1970-03-18
ES363559A1 (es) 1971-01-01
NL6902421A (fr) 1969-08-19

Similar Documents

Publication Publication Date Title
DE1795836C2 (de) 3-MethyI-2,3,4,4a-tetrahydro-lH- pyrazine [1,2-f] phenanthridin
DE69531956T2 (de) Imidazol derivate mit proteinkinase, insbesondere egf-r tyrosinkinase, inhibierender wirkung
DE2445584C3 (de) L- bzw. DL-2-Methyl-3- (3', 4'-dihydroxyphenyl)-alanin-ester, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2311570C2 (de) 4-Aminochinoline, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
DD294254A5 (de) Verfahren zur herstellung von salzen des azelastins
AT395853B (de) Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
DE2460689A1 (de) Neue substituierte propanol-(2)-derivate und deren nikotinsaeureester sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE1593027A1 (de) Alkensaeuren und Verfahren zu ihrer Herstellung
EP0000784B1 (fr) Dérivés de 4-hydroxy benzimidazolin-2-one, procédé de préparation et leurs compositions pharmaceutiques
DE1906322A1 (de) Neue alpha-Alkyl-5-hydroxytryptophanester
DE2743166A1 (de) 2-(3-phenyl-2-amino-propionyloxy)- essigsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE3326724A1 (de) In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
EP0002672B1 (fr) Pyrrolidines substituées, procédé pour leur préparation et médicaments les contenant
EP0065295A1 (fr) Dérivés de la tryptamine et de la thiényloxypropanolamine, procédé pour leur préparation, compositions pharmaceutiques les contenant et préparation de celles-ci
DE2535599C2 (de) Substituierte Zimtsäureamide, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen, welche diese Verbindungen enthalten
AT344151B (de) Verfahren zur herstellung von neuen naphthalinderivaten
DE1967080C3 (de) t-(3,4-Methylendioxybeiizoyl)-2methyl-5-methoxy-3-indolylessigsäureester, Verfahren zu ihrer Herstellung und Arzneipräparate
DE2413125C2 (de) Indolylacetylaminosäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneipräparate
DE1926359A1 (de) oxylkansaeuren
DE1963317A1 (de) Chemische Verfahren und Produkte
DE1915230B2 (de) Hydroxyphenylalkylaminderivate, verfahren zu deren herstellung und arzneimittel auf deren basis
EP0003286B1 (fr) Dérivés d'alcaloides ergopeptidiques, procédé pour leur préparation et compositions pharmaceutiques les contenant
DE2615129C3 (de) Tripeptide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
DE3101093A1 (de) 1-phenyl-4-morpholino-but-1-en-3-ol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2004301A1 (de) Phenylserinderivate