DE1900196A1 - Medikamente enthaltende,elastische,ringfoermige Vorrichtung zur intravaginalen Placierung - Google Patents
Medikamente enthaltende,elastische,ringfoermige Vorrichtung zur intravaginalen PlacierungInfo
- Publication number
- DE1900196A1 DE1900196A1 DE19691900196 DE1900196A DE1900196A1 DE 1900196 A1 DE1900196 A1 DE 1900196A1 DE 19691900196 DE19691900196 DE 19691900196 DE 1900196 A DE1900196 A DE 1900196A DE 1900196 A1 DE1900196 A1 DE 1900196A1
- Authority
- DE
- Germany
- Prior art keywords
- drug
- ring
- medication
- vagina
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69601168A | 1968-01-04 | 1968-01-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1900196A1 true DE1900196A1 (de) | 1969-07-31 |
Family
ID=24795343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19691900196 Pending DE1900196A1 (de) | 1968-01-04 | 1969-01-03 | Medikamente enthaltende,elastische,ringfoermige Vorrichtung zur intravaginalen Placierung |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3545439A (es) |
| JP (1) | JPS5125677B1 (es) |
| BE (1) | BE726454A (es) |
| BR (1) | BR6905338D0 (es) |
| CA (1) | CA985173A (es) |
| CH (1) | CH554172A (es) |
| DE (1) | DE1900196A1 (es) |
| ES (1) | ES360946A1 (es) |
| FR (1) | FR1604934A (es) |
| GB (1) | GB1252021A (es) |
| GT (1) | GT196811877A (es) |
| MY (1) | MY7500059A (es) |
| NL (1) | NL6818655A (es) |
| SE (1) | SE369375B (es) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3503679A1 (de) * | 1984-02-08 | 1985-08-08 | Farmitalia Carlo Erba S.p.A., Mailand/Milano | Pharmazeutische zusammensetzungen |
| EP0274762A1 (en) * | 1987-01-15 | 1988-07-20 | Fortune Capital Management B.V. | Pessary |
Families Citing this family (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3887699A (en) * | 1969-03-24 | 1975-06-03 | Seymour Yolles | Biodegradable polymeric article for dispensing drugs |
| US4344431A (en) * | 1969-03-24 | 1982-08-17 | University Of Delaware | Polymeric article for dispensing drugs |
| US3880991A (en) * | 1969-03-24 | 1975-04-29 | Brook David E | Polymeric article for dispensing drugs |
| CH508391A (fr) * | 1969-04-08 | 1971-06-15 | Charis Aka Charilaos George Ma | Dispositif gynécologique destiné à être introduit dans l'utérus |
| US3911911A (en) * | 1969-06-16 | 1975-10-14 | Reese Hospital Michael | Anti-fertility device |
| AU449029B2 (en) * | 1969-08-28 | 1974-04-17 | Commonwealth Scientific And Industrial Research Organisation | Device for administration to ruminants |
| US3656483A (en) * | 1970-01-15 | 1972-04-18 | Biolog Concepts Inc | Intrauterine medicator |
| US3809076A (en) * | 1971-06-16 | 1974-05-07 | I Chabon | Intrauterine contraceptive device |
| US3892238A (en) * | 1971-09-16 | 1975-07-01 | Abbott Lab | Drug supporting anchor |
| BE795384A (fr) * | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
| US4016251A (en) * | 1972-08-17 | 1977-04-05 | Alza Corporation | Vaginal drug dispensing device |
| BE788505A (fr) * | 1972-09-05 | 1973-03-07 | Moyer Dean L | Dispositif et procede pour l'utilisation d'un medicament irritant-toxique, antipaludeen ou antiamibien |
| US3996933A (en) * | 1972-10-02 | 1976-12-14 | Morton Gutnick | Intrauterine contraceptive devices and processes |
| US4102998A (en) * | 1972-10-02 | 1978-07-25 | Morton Gutnick | Process for the prevention of venereal disease |
| US3888975A (en) * | 1972-12-27 | 1975-06-10 | Alza Corp | Erodible intrauterine device |
| US3854476A (en) * | 1973-04-05 | 1974-12-17 | R Dickinson | Intra-vaginal device and method |
| GB1465684A (en) * | 1973-07-27 | 1977-02-23 | Emmett L | Contraceptive device |
| US4111196A (en) * | 1973-07-27 | 1978-09-05 | Lionel C. R. Emmett | Intrauterine contraceptive device of c or omega form with tubular inserter and method of placement |
| US3924622A (en) * | 1973-10-11 | 1975-12-09 | Mead Johnson & Co | Zero-order release method |
| US3851648A (en) * | 1973-10-11 | 1974-12-03 | Mead Johnson & Co | Zero-order release device |
| US3901232A (en) * | 1973-10-26 | 1975-08-26 | Alza Corp | Integrated device for administering beneficial drug at programmed rate |
| US3976071A (en) * | 1974-01-07 | 1976-08-24 | Dynatech Corporation | Methods of improving control of release rates and products useful in same |
| US4014987A (en) * | 1974-06-04 | 1977-03-29 | Alza Corporation | Device for delivery of useful agent |
| US4018220A (en) * | 1974-07-19 | 1977-04-19 | Lionel C. R. Emmett | Method of insertion for intrauterine device of C or omega form with tubular inserter |
| US3948263A (en) * | 1974-08-14 | 1976-04-06 | Minnesota Mining And Manufacturing Company | Ballistic animal implant |
| DE2445971A1 (de) * | 1974-09-24 | 1976-04-08 | Schering Ag | Arzneimittelwirkstofftraeger ii |
| US4155991A (en) * | 1974-10-18 | 1979-05-22 | Schering Aktiengesellschaft | Vaginal ring |
| US3946106A (en) * | 1974-10-24 | 1976-03-23 | G. D. Searle & Co. | Microsealed pharmaceutical delivery device |
| US3992518A (en) * | 1974-10-24 | 1976-11-16 | G. D. Searle & Co. | Method for making a microsealed delivery device |
| US4053580A (en) * | 1975-01-01 | 1977-10-11 | G. D. Searle & Co. | Microsealed pharmaceutical delivery device |
| US4024871A (en) * | 1975-07-23 | 1977-05-24 | Ethicon, Inc. | Antimicrobial sutures |
| US4031886A (en) * | 1975-09-11 | 1977-06-28 | Morhenn Vera B | Occlusive pessary |
| US3991760A (en) * | 1975-12-02 | 1976-11-16 | The Procter & Gamble Company | Vaginal medicament dispensing means |
| US3995633A (en) * | 1975-12-02 | 1976-12-07 | The Procter & Gamble Company | Vaginal Medicament dispensing device |
| US4043339A (en) * | 1976-02-02 | 1977-08-23 | The Upjohn Company | Method of and vaginal insert for prostaglandin administration |
| US4310510A (en) * | 1976-12-27 | 1982-01-12 | Sherman Kenneth N | Self administrable anti-fertility composition |
| US4093490A (en) * | 1977-04-29 | 1978-06-06 | Ortho Pharmaceutical Corporation | Method of making vaginal diaphragm |
| GB1601777A (en) * | 1977-04-29 | 1981-11-04 | Ortho Pharma Corp | Vaginal diaphragm and a method for the production thereof |
| US4300544A (en) * | 1978-09-05 | 1981-11-17 | Dia-Sert Corp. | Disposable female contraceptive |
| US4191741A (en) * | 1978-09-22 | 1980-03-04 | Eli Lilly And Company | Removable drug implant |
| US4215691A (en) * | 1978-10-11 | 1980-08-05 | Alza Corporation | Vaginal contraceptive system made from block copolymer |
| US4237885A (en) * | 1978-10-23 | 1980-12-09 | Alza Corporation | Delivery system with mated members for storing and releasing a plurality of beneficial agents |
| EP0010987B1 (en) * | 1978-11-07 | 1983-10-05 | Beecham Group Plc | Device for oral administration to a ruminant animal |
| US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
| US4250611A (en) * | 1979-04-19 | 1981-02-17 | Alza Corporation | Process for making drug delivery device with reservoir |
| US4264576A (en) * | 1979-06-28 | 1981-04-28 | Eli Lilly And Company | Contraceptive methods and compositions |
| US4264575A (en) * | 1979-07-16 | 1981-04-28 | Eli Lilly And Company | Contraceptive methods and compositions |
| US4264578A (en) * | 1979-07-16 | 1981-04-28 | Eli Lilly And Company | Contraceptive methods and compositions |
| US4264577A (en) * | 1979-08-03 | 1981-04-28 | Eli Lilly And Company | Contraceptive methods and compositions |
| US4326510A (en) * | 1979-11-20 | 1982-04-27 | World Health Organization | Barrier contraceptive torus |
| US4402695A (en) * | 1980-01-21 | 1983-09-06 | Alza Corporation | Device for delivering agent in vagina |
| DE3040978A1 (de) * | 1980-10-28 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Vaginalring |
| US4629449A (en) * | 1982-07-29 | 1986-12-16 | Alza Corporation | Vaginal dispenser for dispensing beneficial hormone |
| US4469671A (en) * | 1983-02-22 | 1984-09-04 | Eli Lilly And Company | Contraceptive device |
| US4589880A (en) * | 1983-07-14 | 1986-05-20 | Southern Research Institute | Disposable spermicide-releasing diaphragm |
| US4690683A (en) * | 1985-07-02 | 1987-09-01 | Rutgers, The State University Of New Jersey | Transdermal varapamil delivery device |
| US4816257A (en) * | 1985-09-20 | 1989-03-28 | Research & Education Institute, Harbor-Ucla Medical Center Inc. | Method for producing an in vivo environment suitable for human embryo transfer |
| NZ217844A (en) * | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
| NL8600250A (nl) * | 1986-02-01 | 1987-09-01 | Fundatech Sa | Vaginaal anticonceptiemiddel. |
| US5422118A (en) * | 1986-11-07 | 1995-06-06 | Pure Pac, Inc. | Transdermal administration of amines with minimal irritation and high transdermal flux rate |
| US5146931A (en) * | 1988-08-15 | 1992-09-15 | Kurz Karl Heinz | Device to be placed in the uterus |
| GB8819477D0 (en) * | 1988-08-16 | 1988-09-21 | Wellcome Found | Medicaments |
| US5181505A (en) * | 1989-03-08 | 1993-01-26 | Lew Chel W | Method and apparatus for delivery of a medicament in the oral cavity |
| US5002540A (en) * | 1989-05-22 | 1991-03-26 | Warren Kirschbaum | Intravaginal device and method for delivering a medicament |
| GB2254002B (en) * | 1991-01-16 | 1995-03-22 | Controlled Therapeutics | Retrievable pessary |
| US5224493A (en) * | 1991-01-30 | 1993-07-06 | Cadco Corporation | Contraceptive intracervical device and novel nonsystemic agents for the prevention of conception and disease |
| FI95768C (fi) | 1993-06-17 | 1996-03-25 | Leiras Oy | Emättimensisäinen antosysteemi |
| FI93922C (fi) * | 1993-06-17 | 1995-06-26 | Leiras Oy | Vaikuttavaa ainetta luovuttava laite |
| CA2113218A1 (en) * | 1993-10-01 | 1995-04-02 | Michael J. Oldham | Method of using lectins for contraception and prophylaxis against diseases transmittable by sexual contact and apparatus for administering lectins |
| IL116433A (en) * | 1994-12-19 | 2002-02-10 | Galen Chemicals Ltd | INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS |
| GB9522403D0 (en) * | 1995-11-01 | 1996-01-03 | Hoechst Roussel Ltd | Intravaginal drug delivery device |
| NZ286492A (en) | 1996-05-01 | 1998-02-26 | Dec International Nz Ltd Subst | Intra vaginal devices for synchronising oestrus of animals is made up of cured silicone rubber material with 5% by weight of progesterone |
| US5972372A (en) * | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
| FR2756493B1 (fr) | 1996-12-02 | 2001-04-13 | Delab | Dispositif d'administration locale de formulations solides ou semi-solides |
| US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
| US6361780B1 (en) * | 1998-11-12 | 2002-03-26 | Cardiac Pacemakers, Inc. | Microporous drug delivery system |
| US6486207B2 (en) | 1998-12-10 | 2002-11-26 | Nexmed (Holdings), Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
| US20070191320A1 (en) * | 1998-12-10 | 2007-08-16 | Nexmed Holdings, Inc. | Methods of treatment for female sexual arousal disorder |
| US6825234B2 (en) | 1998-12-10 | 2004-11-30 | Nexmed (Holdings) , Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
| GB0009914D0 (en) | 2000-04-20 | 2000-06-07 | Metris Therapeutics Limited | Device |
| ATE455526T1 (de) * | 2000-08-24 | 2010-02-15 | Sidney Lerner | Nicht-hormonales vaginales verhütungsmittel |
| US7187980B2 (en) * | 2001-11-09 | 2007-03-06 | Oscor Inc. | Cardiac lead with steroid eluting ring |
| WO2003080019A1 (en) * | 2002-03-27 | 2003-10-02 | Galen (Chemicals) Limited | Intravaginal reservoir drug delivery devices |
| DE602004026173D1 (de) * | 2003-04-29 | 2010-05-06 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
| TWI336627B (en) * | 2003-05-23 | 2011-02-01 | Organon Nv | Drug delivery system,and use and manufacturing method thereof |
| US8404272B2 (en) | 2003-06-26 | 2013-03-26 | Poly-Med, Inc. | Fiber-reinforced composite rings for intravaginal controlled drug delivery |
| US8399013B2 (en) | 2003-06-26 | 2013-03-19 | Poly-Med, Inc. | Partially absorbable fiber-reinforced composites for controlled drug delivery |
| US8217219B2 (en) * | 2003-12-29 | 2012-07-10 | Kimberly-Clark Worldwide, Inc. | Anatomically conforming vaginal insert |
| US20060270640A1 (en) * | 2004-02-18 | 2006-11-30 | Mercian Corporation | Method of preventing, medicating, and/or treating hypocalcemia of domestic mammal |
| WO2006010097A2 (en) * | 2004-07-09 | 2006-01-26 | The Population Council, Inc. | Sustained release compositions containing progesterone receptor modulators |
| WO2007012006A1 (en) | 2005-07-19 | 2007-01-25 | The Population Council, Inc. | Methods and compositions for emergency contraception using endothelin receptor antagonists |
| US7910126B2 (en) * | 2006-03-20 | 2011-03-22 | Teva Women's Health, Inc. | Flexible, compressed intravaginal rings, methods of making and using the same, and apparatus for making the same |
| US7824383B2 (en) * | 2006-06-16 | 2010-11-02 | Family Health International | Vaginal drug delivery system and method |
| TW200930343A (en) * | 2007-09-21 | 2009-07-16 | Organon Nv | Drug delivery system |
| WO2009094573A2 (en) * | 2008-01-25 | 2009-07-30 | The University Of Utah Research Foundation | Linear order release polymer |
| CA2713943C (en) * | 2008-02-04 | 2018-10-23 | Teva Women's Health, Inc. | Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof |
| US9034365B2 (en) | 2008-05-20 | 2015-05-19 | Poly-Med, Inc. | Biostable, multipurpose, microbicidal intravaginal devices |
| US20100040671A1 (en) * | 2008-08-12 | 2010-02-18 | Ahmed Salah U | Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof |
| JP5695035B2 (ja) | 2009-06-03 | 2015-04-01 | フォーサイト・ビジョン５・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ５，Ｉｎｃ． | 前眼部薬物供給 |
| CN102497855B (zh) | 2009-07-21 | 2013-12-25 | 人口委员会股份有限公司 | 多层梯度的阴道环 |
| CA2798034A1 (en) * | 2010-03-28 | 2011-10-13 | Evestra, Inc. | Intravaginal drug delivery device |
| US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
| EP2637730B1 (en) * | 2010-11-12 | 2021-08-25 | The University of Utah Research Foundation | Intravaginal devices for controlled delivery of lubricants |
| AU2012308317B2 (en) | 2011-09-14 | 2017-01-05 | Forsight Vision5, Inc. | Ocular insert apparatus and methods |
| EP2641602A1 (en) | 2012-03-23 | 2013-09-25 | PregLem S.A. | Method for treating gynecological diseases |
| US20130324380A1 (en) * | 2012-06-04 | 2013-12-05 | Caryn M. Horsley | Medical exercise device |
| US9095744B2 (en) * | 2012-06-04 | 2015-08-04 | Caryn M. Horsley | Medical exercise device |
| HUE046128T2 (hu) | 2012-10-26 | 2020-02-28 | Forsight Vision5 Inc | Szemészeti rendszer gyógyszer szembe való késleltetett kibocsátására |
| NZ712984A (en) | 2013-04-10 | 2020-07-31 | Preglem Sa | Progesteron receptor modulators for use in the therapy of uterine fibroids |
| WO2015055789A1 (en) | 2013-10-17 | 2015-04-23 | Bayer Pharma Aktiengesellschaft | INTRAVAGINAL USE OF 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, INTRAVAGINAL RINGS COMPRISING 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, AND USE THEREOF IN CONTRACEPTION |
| US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
| US10413504B2 (en) | 2013-12-11 | 2019-09-17 | Merck Sharp & Dohme Corp. | Intravaginal ring drug delivery system |
| US10596103B2 (en) | 2013-12-11 | 2020-03-24 | Merek Sharp & Dohme B.V. | Drug delivery system for delivery of anti-virals |
| US20160089380A1 (en) * | 2014-09-29 | 2016-03-31 | Yale University | Progesterone impregnated vaginal ring/pessary |
| US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
| BR112020008231A2 (pt) | 2017-10-27 | 2020-10-27 | Renovia, Inc. | dispositivos, sistemas e métodos para treinamento dos músculos do assoalho pélvico |
| USD935018S1 (en) * | 2020-04-07 | 2021-11-02 | The Population Council, Inc. | Contraceptive |
| WO2023200974A1 (en) | 2022-04-14 | 2023-10-19 | Yale University | Nanoparticles and nanoparticle-releasing vaginal rings |
-
1968
- 1968-01-04 US US696011A patent/US3545439A/en not_active Expired - Lifetime
- 1968-11-26 CA CA036,202A patent/CA985173A/en not_active Expired
- 1968-11-30 ES ES360946A patent/ES360946A1/es not_active Expired
- 1968-12-05 GT GT196811877A patent/GT196811877A/es unknown
- 1968-12-18 JP JP43092402A patent/JPS5125677B1/ja active Pending
- 1968-12-18 CH CH1889268A patent/CH554172A/xx not_active IP Right Cessation
- 1968-12-23 FR FR1604934D patent/FR1604934A/fr not_active Expired
- 1968-12-24 NL NL6818655A patent/NL6818655A/xx unknown
- 1968-12-30 SE SE18010/68A patent/SE369375B/xx unknown
-
1969
- 1969-01-02 GB GB1252021D patent/GB1252021A/en not_active Expired
- 1969-01-03 BE BE726454D patent/BE726454A/xx unknown
- 1969-01-03 DE DE19691900196 patent/DE1900196A1/de active Pending
- 1969-01-03 BR BR205338/69A patent/BR6905338D0/pt unknown
-
1975
- 1975-12-30 MY MY59/75A patent/MY7500059A/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3503679A1 (de) * | 1984-02-08 | 1985-08-08 | Farmitalia Carlo Erba S.p.A., Mailand/Milano | Pharmazeutische zusammensetzungen |
| EP0274762A1 (en) * | 1987-01-15 | 1988-07-20 | Fortune Capital Management B.V. | Pessary |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1252021A (es) | 1971-11-03 |
| BE726454A (es) | 1969-07-03 |
| BR6905338D0 (pt) | 1973-03-07 |
| GT196811877A (es) | 1970-05-29 |
| SE369375B (es) | 1974-08-26 |
| US3545439A (en) | 1970-12-08 |
| CA985173A (en) | 1976-03-09 |
| MY7500059A (en) | 1975-12-31 |
| FR1604934A (es) | 1971-05-15 |
| ES360946A1 (es) | 1970-08-01 |
| CH554172A (de) | 1974-09-30 |
| NL6818655A (es) | 1969-07-08 |
| JPS5125677B1 (es) | 1976-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SH | Request for examination between 03.10.1968 and 22.04.1971 |