DE1795522A1 - Halogenmercuri-N-carboxyanhydride von basischen Aminosaeuren - Google Patents

Halogenmercuri-N-carboxyanhydride von basischen Aminosaeuren

Info

Publication number
DE1795522A1
DE1795522A1 DE19661795522 DE1795522A DE1795522A1 DE 1795522 A1 DE1795522 A1 DE 1795522A1 DE 19661795522 DE19661795522 DE 19661795522 DE 1795522 A DE1795522 A DE 1795522A DE 1795522 A1 DE1795522 A1 DE 1795522A1
Authority
DE
Germany
Prior art keywords
mixture
adjusted
amino acids
added
sulfuric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19661795522
Other languages
German (de)
English (en)
Inventor
Conn John B
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE1795522A1 publication Critical patent/DE1795522A1/de
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/086General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing sulfur
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695Corticotropin [ACTH]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1019Tetrapeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1021Tetrapeptides with the first amino acid being acidic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Arc Welding In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19661795522 1965-07-02 1966-07-01 Halogenmercuri-N-carboxyanhydride von basischen Aminosaeuren Pending DE1795522A1 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US46931065A 1965-07-02 1965-07-02
US50497865A 1965-10-24 1965-10-24
US50498265A 1965-10-24 1965-10-24
US53854266A 1966-03-30 1966-03-30
US53856066A 1966-03-30 1966-03-30
US54435866A 1966-04-22 1966-04-22
US54438066A 1966-04-22 1966-04-22
US54585766A 1966-04-28 1966-04-28
US54586266A 1966-04-28 1966-04-28
US54585566A 1966-04-28 1966-04-28
GB27965/66A GB1158721A (en) 1965-07-02 1966-06-22 Peptide synthesis

Publications (1)

Publication Number Publication Date
DE1795522A1 true DE1795522A1 (de) 1972-01-13

Family

ID=27581645

Family Applications (8)

Application Number Title Priority Date Filing Date
DE19661795522 Pending DE1795522A1 (de) 1965-07-02 1966-07-01 Halogenmercuri-N-carboxyanhydride von basischen Aminosaeuren
DE19661793597 Pending DE1793597A1 (de) 1965-07-02 1966-07-01 Metallchelate von Hydroxy-alpha-aminosaeuren mit UEbergangsmetallen und ein Verfahren zu ihrer Herstellung
DE19661795524 Pending DE1795524A1 (de) 1965-07-02 1966-07-01 Trihalogenacetylester von N-Carboxy- und N-Thiocarboxyanhydriden von aliphatischen Hydroxy-alpha-aminosaeuren und Verfahren zu ihrer Herstellung
DE19661795523 Pending DE1795523A1 (de) 1965-07-02 1966-07-01 Tetrahydropyranylderivate von N-Carboxy- oder N-Thiocarboxyanhydriden von aromatischen Hydroxy- alpha-Aminosaeuren und Verfahren zu ihrer Herstellung
DE19661795521 Pending DE1795521A1 (de) 1965-07-02 1966-07-01 N-Carboxyasparaginsaeureanhydrid und ein Verfahren zu seiner Herstellung
DE19661795519 Pending DE1795519A1 (de) 1965-07-02 1966-07-01 N-Carboxyasparaginanhydrid und N-Carboxyglutmainanhydrid und Verfahren zu deren Herstellung
DE19661795528 Pending DE1795528A1 (de) 1965-07-02 1966-07-01 O-Tri-niedrig-alkylsilyl-Derivate von N-Carboxyanhydriden von Hydroxy-alpha-aminosaeuren und Verfahren zu ihrer Herstellung
DE19661795529 Pending DE1795529A1 (de) 1965-07-02 1966-07-01 Hydrobromide und Hydrochloride von N-Carboxyargininanhydrid und N-Carboxyhistidinanhydrid und Verfahren zu ihrer Herstellung

Family Applications After (7)

Application Number Title Priority Date Filing Date
DE19661793597 Pending DE1793597A1 (de) 1965-07-02 1966-07-01 Metallchelate von Hydroxy-alpha-aminosaeuren mit UEbergangsmetallen und ein Verfahren zu ihrer Herstellung
DE19661795524 Pending DE1795524A1 (de) 1965-07-02 1966-07-01 Trihalogenacetylester von N-Carboxy- und N-Thiocarboxyanhydriden von aliphatischen Hydroxy-alpha-aminosaeuren und Verfahren zu ihrer Herstellung
DE19661795523 Pending DE1795523A1 (de) 1965-07-02 1966-07-01 Tetrahydropyranylderivate von N-Carboxy- oder N-Thiocarboxyanhydriden von aromatischen Hydroxy- alpha-Aminosaeuren und Verfahren zu ihrer Herstellung
DE19661795521 Pending DE1795521A1 (de) 1965-07-02 1966-07-01 N-Carboxyasparaginsaeureanhydrid und ein Verfahren zu seiner Herstellung
DE19661795519 Pending DE1795519A1 (de) 1965-07-02 1966-07-01 N-Carboxyasparaginanhydrid und N-Carboxyglutmainanhydrid und Verfahren zu deren Herstellung
DE19661795528 Pending DE1795528A1 (de) 1965-07-02 1966-07-01 O-Tri-niedrig-alkylsilyl-Derivate von N-Carboxyanhydriden von Hydroxy-alpha-aminosaeuren und Verfahren zu ihrer Herstellung
DE19661795529 Pending DE1795529A1 (de) 1965-07-02 1966-07-01 Hydrobromide und Hydrochloride von N-Carboxyargininanhydrid und N-Carboxyhistidinanhydrid und Verfahren zu ihrer Herstellung

Country Status (13)

Country Link
US (3) US3435046A (enExample)
JP (1) JPS4737921B1 (enExample)
AT (4) AT307630B (enExample)
BR (1) BR6680930D0 (enExample)
CH (1) CH495956A (enExample)
DE (8) DE1795522A1 (enExample)
DK (1) DK138369B (enExample)
FI (1) FI48184C (enExample)
GB (7) GB1158727A (enExample)
IL (6) IL34876A (enExample)
NO (1) NO128326B (enExample)
SE (4) SE345998B (enExample)
YU (1) YU31197B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1675379B1 (de) * 1968-01-13 1972-03-09 Roesinger Heinz Rollringdichtung fuer muffenrohr verbindungen
NL7002228A (enExample) * 1970-02-18 1971-08-20
FR2569111B1 (fr) * 1984-08-16 1987-04-17 Rhone Poulenc Sante Nouveaux medicaments contenant des tripeptides
DE3542784A1 (de) * 1985-12-04 1987-06-11 Hella Kg Hueck & Co Scheinwerfer fuer kraftfahrzeuge
JPH0383990A (ja) * 1989-08-28 1991-04-09 Nippon Paint Co Ltd オキサゾリジン化合物
IN184759B (enExample) * 1997-07-22 2000-09-23 Kaneka Corp
WO2000005247A1 (en) * 1998-07-21 2000-02-03 Kaneka Corporation Method for crystallizing maleic acid salt of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-l-proline
DE19936976A1 (de) 1999-08-05 2001-02-08 Emil Siegwart Flanschverbindung von Rohren, insbesondere Luftleitungsrohren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2993053A (en) * 1961-07-18 Production of n-carboxy-a-amino
US2716647A (en) * 1952-07-30 1955-08-30 Monsanto Chemicals N-carboxy anhydride of alpha-amino acids

Also Published As

Publication number Publication date
AT290490B (de) 1971-06-11
YU31197B (en) 1973-02-28
GB1158726A (en) 1969-07-16
DK138369C (enExample) 1979-02-05
IL34877A (en) 1971-03-24
IL25974A (en) 1971-02-25
DE1795529A1 (de) 1972-01-13
DE1795528A1 (de) 1972-01-13
SE347512B (enExample) 1972-08-07
SE345998B (enExample) 1972-06-19
SE364716B (enExample) 1974-03-04
GB1158727A (en) 1969-07-16
DE1793597A1 (de) 1972-03-16
SE349038B (enExample) 1972-09-18
IL34879A (en) 1971-03-24
FI48184B (enExample) 1974-04-01
AT289105B (de) 1971-04-13
GB1158725A (en) 1969-07-16
DK138369B (da) 1978-08-21
GB1158723A (en) 1969-07-16
BR6680930D0 (pt) 1973-11-13
DE1795521A1 (de) 1972-01-13
NO128326B (enExample) 1973-10-29
DE1795519A1 (de) 1972-01-13
AT297677B (de) 1972-04-10
GB1158721A (en) 1969-07-16
US3435046A (en) 1969-03-25
IL34878A (en) 1971-02-25
FI48184C (fi) 1974-07-10
GB1158724A (en) 1969-07-16
DE1795523A1 (de) 1972-01-13
IL34876A (en) 1971-02-25
IL34880A (en) 1970-11-30
US3467667A (en) 1969-09-16
DE1795524A1 (de) 1972-01-13
CH495956A (de) 1970-09-15
AT307630B (de) 1973-05-25
JPS4737921B1 (enExample) 1972-09-25
US3459760A (en) 1969-08-05
GB1158722A (en) 1969-07-16

Similar Documents

Publication Publication Date Title
CH643532A5 (de) Verfahren zur herstellung eines dipeptidesters.
DE69430206T2 (de) Nichtalkalische reinigung von aminophosphonsäuren
DE3827121A1 (de) Verfahren zur herstellung von des-b30-insulinen und des-b30-insulinderivaten
DE2714141A1 (de) Dipeptid-analoge und verfahren zu ihrer herstellung
DE1795522A1 (de) Halogenmercuri-N-carboxyanhydride von basischen Aminosaeuren
DE2822528C2 (enExample)
DE69010155T2 (de) Verfahren zur Trennung von Aminosäuren.
DE2813712A1 (de) Verfahren zur trennung von racemischen alpha-aminonitrilen
DE2547548A1 (de) Optische spaltung von phenylglycinamid
DE3885671T2 (de) Verfahren zur Racemisierung von optisch aktivem Serin.
DE69507309T2 (de) Verfahren zur herstellung von 3,4-dihydroxy-5-nitrobenzaldehyd
DE3538746C2 (enExample)
DE2301358B2 (de) Verfahren zur Herstellung von Hydroxy-L-prolin oder N-Acetyl-hydroxy-L-prolin aus hydrolysierter Gelatine
DE1770720A1 (de) Peptidderivate
DE69514115T2 (de) Verfahren zur herstellung von levobupivacain und analogue aus l-lysin
DE2208631C3 (de) N-Isobornyloxycarbonylcephalosporin C, Verfahren zu seiner Herstellung und Verwendung zur Herstellung von Cephalosporin C
EP0015478A1 (de) Alterungsbeständige Chromgerbstoffe
EP0218886B1 (de) 1-Hydroxipyrazol-4-carbonsäure, Verfahren zu ihrer Herstellung und Verwendung
DE1493975A1 (de) C-Chlor-Derivate von Aminosaeuren und Verfahren zu ihrer Herstellung
DE2022032A1 (de) Verfahren zur Herstellung von Peptiden
DE877605C (de) Verfahren zur Herstellung von Saeureamiden durch Abbau ª‡-substituierter Carbonsaeuren
EP0066856A1 (de) Verfahren zur Herstellung von polyfunktionalen organischen Verbindungen mit wenigstens einer tert. Butyläther- oder -estergruppe
DE2503921C2 (de) Verfahren zur Gewinnung von D,L- Homocystein
DE1770715A1 (de) Peptidderivate
DE68907596T2 (de) Herstellung von 2-Phenyl-propan-1,3-diol und dessen Dicarbamat.