DE1768656C3 - - Google Patents
Info
- Publication number
- DE1768656C3 DE1768656C3 DE19681768656 DE1768656A DE1768656C3 DE 1768656 C3 DE1768656 C3 DE 1768656C3 DE 19681768656 DE19681768656 DE 19681768656 DE 1768656 A DE1768656 A DE 1768656A DE 1768656 C3 DE1768656 C3 DE 1768656C3
- Authority
- DE
- Germany
- Prior art keywords
- lysis
- phages
- breeding
- alternating
- bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000007935 neutral effect Effects 0.000 claims description 9
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- PIICEJLVQHRZGT-ZSJDYOACSA-N n,n'-dideuterioethane-1,2-diamine Chemical compound [2H]NCCN[2H] PIICEJLVQHRZGT-ZSJDYOACSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 description 40
- 238000009395 breeding Methods 0.000 description 19
- 230000001488 breeding effect Effects 0.000 description 19
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 241000894006 Bacteria Species 0.000 description 13
- WOLHOYHSEKDWQH-UHFFFAOYSA-N amantadine hydrochloride Chemical compound [Cl-].C1C(C2)CC3CC2CC1([NH3+])C3 WOLHOYHSEKDWQH-UHFFFAOYSA-N 0.000 description 11
- 239000000047 product Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 230000001580 bacterial effect Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 241000700605 Viruses Species 0.000 description 6
- 230000003111 delayed effect Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000000840 anti-viral effect Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 4
- 241001515965 unidentified phage Species 0.000 description 4
- 241000295644 Staphylococcaceae Species 0.000 description 3
- 241000543700 Staphylococcus virus Twort Species 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000001320 lysogenic effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001188 anti-phage Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000007541 cellular toxicity Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
- 230000029302 virus maturation Effects 0.000 description 1
- 239000004552 water soluble powder Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/265—Citric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/18—Saturated compounds containing keto groups
- C07C62/24—Saturated compounds containing keto groups the keto group being part of a ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2703067 | 1967-06-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE1768656A1 DE1768656A1 (enrdf_load_stackoverflow) | 1971-12-02 |
| DE1768656B2 DE1768656B2 (enrdf_load_stackoverflow) | 1974-01-24 |
| DE1768656C3 true DE1768656C3 (enrdf_load_stackoverflow) | 1974-08-15 |
Family
ID=10253022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19681768656 Expired DE1768656C3 (enrdf_load_stackoverflow) | 1967-06-12 | 1968-06-12 |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE715739A (enrdf_load_stackoverflow) |
| CH (1) | CH481036A (enrdf_load_stackoverflow) |
| DE (1) | DE1768656C3 (enrdf_load_stackoverflow) |
| ES (1) | ES354887A1 (enrdf_load_stackoverflow) |
| FR (2) | FR1587351A (enrdf_load_stackoverflow) |
| GB (1) | GB1176077A (enrdf_load_stackoverflow) |
| NL (2) | NL6808261A (enrdf_load_stackoverflow) |
-
0
- NL NL131914D patent/NL131914C/xx active
-
1967
- 1967-06-12 GB GB27032/67A patent/GB1176077A/en not_active Expired
-
1968
- 1968-05-27 BE BE715739D patent/BE715739A/xx unknown
- 1968-05-27 CH CH780968A patent/CH481036A/fr not_active IP Right Cessation
- 1968-05-30 FR FR1587351D patent/FR1587351A/fr not_active Expired
- 1968-06-11 ES ES354887A patent/ES354887A1/es not_active Expired
- 1968-06-12 DE DE19681768656 patent/DE1768656C3/de not_active Expired
- 1968-06-12 NL NL6808261A patent/NL6808261A/xx unknown
- 1968-07-24 FR FR160342A patent/FR7959M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR7959M (enrdf_load_stackoverflow) | 1970-06-01 |
| NL6808261A (enrdf_load_stackoverflow) | 1968-12-13 |
| GB1176077A (en) | 1970-01-01 |
| DE1768656B2 (enrdf_load_stackoverflow) | 1974-01-24 |
| CH481036A (fr) | 1969-11-15 |
| DE1768656A1 (enrdf_load_stackoverflow) | 1971-12-02 |
| FR1587351A (enrdf_load_stackoverflow) | 1970-03-20 |
| NL131914C (enrdf_load_stackoverflow) | |
| BE715739A (enrdf_load_stackoverflow) | 1968-10-16 |
| ES354887A1 (es) | 1969-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 | ||
| 8339 | Ceased/non-payment of the annual fee |