DE1593760A1 - Verfahren zur Herstellung neuer Benz-epinderivate - Google Patents

Verfahren zur Herstellung neuer Benz-epinderivate

Info

Publication number
DE1593760A1
DE1593760A1 DE19671593760 DE1593760A DE1593760A1 DE 1593760 A1 DE1593760 A1 DE 1593760A1 DE 19671593760 DE19671593760 DE 19671593760 DE 1593760 A DE1593760 A DE 1593760A DE 1593760 A1 DE1593760 A1 DE 1593760A1
Authority
DE
Germany
Prior art keywords
addition salts
acid addition
hydroxy
tetrahydro
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19671593760
Other languages
German (de)
English (en)
Inventor
Peter Dr Danneberg
Zeile Karl Prof Dr
Rolf Dr Giesemann
Dr Hauptmann Karl Heinz
Karl-Heinz Dr Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of DE1593760A1 publication Critical patent/DE1593760A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19671593760 1967-02-01 1967-02-01 Verfahren zur Herstellung neuer Benz-epinderivate Pending DE1593760A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB0090994 1967-02-01

Publications (1)

Publication Number Publication Date
DE1593760A1 true DE1593760A1 (de) 1972-06-08

Family

ID=6985591

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19671593760 Pending DE1593760A1 (de) 1967-02-01 1967-02-01 Verfahren zur Herstellung neuer Benz-epinderivate

Country Status (4)

Country Link
CH (1) CH513111A (https=)
DE (1) DE1593760A1 (https=)
FR (2) FR1603343A (https=)
GB (1) GB1211258A (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024560A1 (de) * 1979-08-02 1981-03-11 Kali-Chemie Pharma GmbH Neue 3-Amino-1-benzoxepin-Derivate und ihre Salze; Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0025109A3 (en) * 1979-08-02 1981-07-15 Kali-Chemie Pharma Gmbh 1-benzoxepin-5(2h)-one derivatives and their salts, processes and intermediates for their preparation and medicaments containing them
EP0180889A3 (en) * 1984-11-05 1987-08-19 Kali-Chemie Pharma Gmbh 3-amino-2,3-dihydro-1-benzoxepine compounds, process for their preparation and medicaments containing these compounds
EP0250265A1 (en) * 1986-06-20 1987-12-23 Suntory Limited 2-Phenylbenzoxepin derivative
FR2698873A1 (fr) * 1992-12-07 1994-06-10 Lipha Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant.

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2353519A1 (fr) * 1975-12-08 1977-12-30 Roussel Uclaf Nouveaux derives de l'aminobenzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments desdits produits
NZ207110A (en) * 1983-02-15 1986-05-09 Merrell Dow Pharma (4a,11b)-3,4,4a,5,6,11b-hexahydro-2h-(1)benzoxepino(5,4,b)-1,4-oxazine derivatives and pharmaceutical compositions
NZ207111A (en) * 1983-02-15 1986-07-11 Merrell Dow Pharma (4a,11b)-3,4,4a,5,6,11b-hexahydro-2h-(1)benzoxepino(5,4-b)-1,4 oxazine derivatives and pharmaceutical compositions
US4975461A (en) * 1986-06-19 1990-12-04 E. R. Squibb & Sons, Inc. P-aminophenols, derivatives thereof and method of use
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
DK0781278T3 (da) * 1994-09-13 2001-04-17 Monsanto Co Nye benzothiepiner, som har aktivitet som inhibitorer af ileal galdsyretransport og taurocholatoptagelse
NZ331813A (en) * 1996-03-11 2001-03-30 G Benzothiepine compounds having activity as inhibitors of ileal bile acid transport and taurocholate uptake
BR9708042A (pt) * 1996-03-11 1999-07-27 Searle & Co Novas benzotiepinas tendo atividade como inibidores de transporte de ácido de bile ileal e de absorção de taurocolato
EP1440972A1 (en) * 1996-03-11 2004-07-28 G.D. Searle & Co. Novel benzothiepines having pharmaceutical activity.
US6221897B1 (en) 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
EP1340510A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
CN1342090A (zh) 1998-12-23 2002-03-27 G·D·瑟尔有限公司 适用于心血管疾病的回肠胆汁酸转运抑制剂和贝酸衍生物的组合
JP2002533414A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ
JP2002533410A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤およびフィブリン酸誘導体の組み合わせ
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
US6489366B1 (en) 1998-12-23 2002-12-03 G. D. Searle, Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
PL348508A1 (en) 1998-12-23 2002-05-20 Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
WO2001068637A2 (en) 2000-03-10 2001-09-20 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
MXPA04003524A (es) 2001-11-02 2004-07-23 Searle Llc Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato.
BR0306643A (pt) 2002-01-17 2004-10-19 Pharmacia Corp Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical
CN104023727B (zh) 2011-10-28 2017-04-05 鲁美纳医药公司 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂
CA2852957C (en) 2011-10-28 2020-08-04 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024560A1 (de) * 1979-08-02 1981-03-11 Kali-Chemie Pharma GmbH Neue 3-Amino-1-benzoxepin-Derivate und ihre Salze; Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0025109A3 (en) * 1979-08-02 1981-07-15 Kali-Chemie Pharma Gmbh 1-benzoxepin-5(2h)-one derivatives and their salts, processes and intermediates for their preparation and medicaments containing them
US4320061A (en) 1979-08-02 1982-03-16 Kali-Chemie Pharma Gmbh 2,3,4,5-Tetrahydro-1-benzoxepin-3,5-dione derivatives
EP0180889A3 (en) * 1984-11-05 1987-08-19 Kali-Chemie Pharma Gmbh 3-amino-2,3-dihydro-1-benzoxepine compounds, process for their preparation and medicaments containing these compounds
EP0250265A1 (en) * 1986-06-20 1987-12-23 Suntory Limited 2-Phenylbenzoxepin derivative
US4845094A (en) * 1986-06-20 1989-07-04 Suntory Limited 2-phenylbenzoxepin derivative
FR2698873A1 (fr) * 1992-12-07 1994-06-10 Lipha Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant.
WO1994013658A3 (en) * 1992-12-07 1994-08-04 Merck Patent Gmbh Benzocycloheptenes, benzoxepines and benzothiepines

Also Published As

Publication number Publication date
FR1603343A (https=) 1971-04-05
FR8052M (https=) 1970-06-29
GB1211258A (en) 1970-11-04
CH513111A (de) 1971-09-30

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