DE152030T1 - Adult-t-zell-leukemiavirus-antigenpolypeptid. - Google Patents

Adult-t-zell-leukemiavirus-antigenpolypeptid.

Info

Publication number
DE152030T1
DE152030T1 DE1985101063 DE85101063T DE152030T1 DE 152030 T1 DE152030 T1 DE 152030T1 DE 1985101063 DE1985101063 DE 1985101063 DE 85101063 T DE85101063 T DE 85101063T DE 152030 T1 DE152030 T1 DE 152030T1
Authority
DE
Germany
Prior art keywords
adult
recombinant plasmid
cell leukemia
leukemia virus
microorganism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE1985101063
Other languages
English (en)
Inventor
Tetsuro Machida-Shi Tokyo Kuga
Haruo Suginami-Ku Tokyo Sugano
Tadatsugu Ibaraki-Shi Osaka-Fu Taniguchi
Mitsuaki Meguro-Ku Tokyo Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japanese Foundation for Cancer Research
Original Assignee
Japanese Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59016952A external-priority patent/JPS60166624A/ja
Priority claimed from JP59046687A external-priority patent/JPS60192591A/ja
Application filed by Japanese Foundation for Cancer Research filed Critical Japanese Foundation for Cancer Research
Publication of DE152030T1 publication Critical patent/DE152030T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (12)

Patentansprüche
1. Antigenes Polypeptid des Erwachsenen-T-Zell-Leukämie-Virus,codiert vom env-Gen des Erwachsenen-T-Zell-Leukämie-Virus.
2. Rekombinantes Plasmid, dadurch gekennzeichnet, daß ein DNA-Fragment eingesetzt ist, welches das env-Gen des Erwachsenen-T-Zell-Leukämie-Virus enthält.
3. Rekombinantes Plasmid nach Anspruch 2, dadurch gekennzeichnet, daß das rekombinante Plasmid den P-60-Promotor trägt.
4. Rekombinantes Plasmid nach Anspruch 3, dadurch gekennzeichnet, daß es pATYE307 ist.
5. Verfahren zur Herstellung eines antigenen Polypeptids des Erwachsenen-T-Zell-Leukämie-Virus, dadurch gekennzeichnet, daß man einen ein rekombinantes Plasmid, in das ein DNA-Fragment eingesetzt ist, welches das env-Gen des Erwachsenen-T-Zell-Leukämie-Virus enthält,tragenden Mikroorganismus in einem Medium kultiviert, das vom env-Gen des Erwachsenen-T-Zell-Leukämie-Virus codierte antigene Polypeptid in der Kultur ansammelt und das Peptid daraus wiedergewinnt.
6. Verfahren nach Anspruch 5, dadurch gekennzeichnet, daß das rekombinante Plasmid den P-60-Promotor trägt.
1 7. Verfahren nach Anspruch 5, dadurch gekennzeichnet, daß der Mikroorganismus zur Gattung Saccharomyces gehört.
8. Verfahren nach Anspruch 7, dadurch gekennzeichnet, daß 5 der Mikroorganismus zu Saccharomyces cerevisiae gehört.
9. Verfahren nach Anspruch 5, dadurch gekennzeichnet, daß das rekombinante Plasmid pATYE307 ist.
10 10.Mikroorganismus, dadurch gekennzeichnet, daß er ein rekombinantes Plasmid trägt, in das ein DNA-Fragment eingesetzt ist, welches das env-Gen des Erwachsenen-T-Zell-Leukämie-Virus enthält.
15 11.Mikroorganismus nach Anspruch 10, dadurch gekennzeichnet, daß das rekombinante Plasmid den P-60-Promotor trägt.
12.Mikroorganismus nach Anspruch 11, dadurch gekennzeichnet,
daß der Mikroorganismus zu Saccharomyces cerevisiae gehört. 20
DE1985101063 1984-02-03 1985-02-01 Adult-t-zell-leukemiavirus-antigenpolypeptid. Pending DE152030T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59016952A JPS60166624A (ja) 1984-02-03 1984-02-03 成人ｔ細胞白血病ウイルス抗原ポリペプチド
JP59046687A JPS60192591A (ja) 1984-03-12 1984-03-12 成人ｔ細胞白血病ウイルス抗原ポリペプチド

Publications (1)

Publication Number Publication Date
DE152030T1 true DE152030T1 (de) 1986-02-27

Family

ID=26353403

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1985101063 Pending DE152030T1 (de) 1984-02-03 1985-02-01 Adult-t-zell-leukemiavirus-antigenpolypeptid.

Country Status (2)

Country Link
EP (1) EP0152030A3 (de)
DE (1) DE152030T1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724258A (en) * 1984-02-03 1988-02-09 Juridical Foundation, Japanese Foundation For Cancer Research Adult T cell leukemia virus antigen polypeptide
US4794168A (en) * 1984-04-24 1988-12-27 Scripps Clinic And Research Foundation Leukemia-associated virus immunogen, vaccine and assay
CA1341423C (en) * 1984-10-31 2003-03-04 Paul A. Luciw Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome
US7285271B1 (en) 1984-10-31 2007-10-23 Novartis Vaccines And Diagnostics, Inc. Antigenic composition comprising an HIV gag or env polypeptide
US7393949B1 (en) * 1987-12-24 2008-07-01 Novartis Vaccines And Diagnostics, Inc. Human immunodeficiency virus (HIV) nucleotide sequences
US7273695B1 (en) * 1984-10-31 2007-09-25 Novartis Vaccines And Diagnostics, Inc. HIV immunoassays using synthetic envelope polypeptides
US4774175A (en) * 1985-03-01 1988-09-27 Centocor, Inc. Immunochemical methods for the detection of antibody against HTLV-III
US5773210A (en) * 1985-04-19 1998-06-30 The United States Of America As Represented By The Department Of Health And Human Services Acquired immune deficiency syndrome (AIDS) viral envelope protein and method of testing for AIDS
DK171119B1 (da) * 1985-04-19 1996-06-17 Hoffmann La Roche AIDS-viruskappeprotein, ekspressionsvektor bærende viruskappeproteinet, transformanter transformeret med ekspressionsvektoren, fremgangsmåde til fremstilling af viruskappeproteinet, fremgangsmåde til detektion af AIDS-antistoffer, fremgangsmåde til bestemmelse af AIDS-virus, vaccine mod AIDS, antistoffer mod viruskappeproteinet samt anvendelse af dette til fremstilling af en vaccine og til testnin
JP2564268B2 (ja) * 1985-08-28 1996-12-18 協和醗酵工業株式会社 融合抗原ポリペプチド
DE3877294T2 (de) * 1987-09-04 1993-05-06 Int Murex Tech Corp Festphasenimmunoassay fuer einen antikoerper und hierbei verwendete biologische produkte.
US5017687A (en) * 1988-03-10 1991-05-21 Virovahl, S.A. Peptides for the detection of HTLV-1 infection
JPH02150283A (ja) * 1988-07-21 1990-06-08 Takeda Chem Ind Ltd 発現プラスミドおよびその用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59104325A (ja) * 1982-12-07 1984-06-16 Japan Found Cancer ヒト白血病ウイルスの遺伝子ｒｎａに相補性を示すｄｎａ
JP2780020B2 (ja) * 1983-04-27 1998-07-23 プレジデント アンド フェロウズ オブ ハーバード カレッジ ヒトｔ細胞白血病ウイルス抗原及び該抗原を用いる検出方法
US4724258A (en) * 1984-02-03 1988-02-09 Juridical Foundation, Japanese Foundation For Cancer Research Adult T cell leukemia virus antigen polypeptide

Also Published As

Publication number Publication date
EP0152030A3 (de) 1986-08-13
EP0152030A2 (de) 1985-08-21

Similar Documents

Publication Publication Date Title
DE152030T1 (de) Adult-t-zell-leukemiavirus-antigenpolypeptid.
Levy et al. Selective stimulation of nonhistone chromatin protein synthesis in lymphoid cells by phytohemagglutinin
ATE54167T1 (de) Promotoren fuer die expression von fremden genen in hefe, plasmide, die diese promotoren enthalten, sowie deren verwendung zur herstellung von polypeptiden.
ATE77104T1 (de) Menge und verfahren zur herstellung rekombinierter erzeugnisse in grosser ausbeute.
NO174351C (no) Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten
DE151475T1 (de) Adult-t-zell-leukemiavirus-antigenpolypeptid.
YU46597B (sh) Postupak za proizvodnju hibridni interferoni humanih leukocita
RU96105702A (ru) ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК, ТРАНСФОРМИРОВАННАЯ КЛЕТКА, СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОЙ ПЕПТИДИЛГЛИЦИНα-АМИДИРУЮЩЕЙ МОНООКСИГЕНАЗЫ И СПОСОБ ПОЛУЧЕНИЯ АМИДИРОВАННЫХ ПЕПТИДОВ
CA2220133A1 (en) Recombinant vesiculoviruses and their uses
EP0192392A3 (en) Insulin receptor, its purification, its production in recombinant cells, dna therefor, antibodies to insulin receptor and their preparation, and pharmaceutical compositions containing them
JPS57159489A (en) Developement of polypeptide in yeast
EP0667393A3 (de) Prozess, Konstrukt und Konjugat zur Herstellung mehreren Nukleinsäureproben.
MX9206041A (es) Proceso para producir interferon inmune humano.
HK64591A (en) Synthesis of human virus antigens by yeast
MY102594A (en) Expression of plasmodium falciparum polypeptides from cloney cdna
ES8703520A1 (es) Procedimiento de preparar particulas que contienen secuencias de aminoacidos y que tienen propiedades inmunogenas
DE152076T1 (de) Derivat des adult-t-zell-leukemiavirus-antigenpeptids.
EP0291728A3 (de) Herstellung von Immun-Interferon und seiner m-RNS
NZ211356A (en) Hepatitis b virus vaccine and diagnostic methods
DE146944T1 (de) Menschliches gamma-interferonpolypeptidderivat.
DE3667488D1 (de) Verfahren zur herstellung von glucagon oder dessen derivaten in einem transformierten hefestamm.
DE139216T1 (de) Adult t-zell-leukemiavirus-antigenpeptid.
EP0048455A3 (de) Synthetisches DNS und Verfahren dafür
EP0228036A3 (de) Verfahren zur Herstellung von spezifischen Polypeptiden in virusinfizierten Insektzellen und daraus isolierte Polypeptide
EP0248410A3 (de) Hefe-Promotor und Verfahren zur Herstellung von heterologen Proteinen