DE1470336A1 - Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung - Google Patents

Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung

Info

Publication number
DE1470336A1
DE1470336A1 DE19621470336 DE1470336A DE1470336A1 DE 1470336 A1 DE1470336 A1 DE 1470336A1 DE 19621470336 DE19621470336 DE 19621470336 DE 1470336 A DE1470336 A DE 1470336A DE 1470336 A1 DE1470336 A1 DE 1470336A1
Authority
DE
Germany
Prior art keywords
radical
dihydrothieno
ethanol
group
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19621470336
Other languages
German (de)
English (en)
Inventor
Woitun Dipl-Chem Dr Eberhard
Ohnacker Dipl-Chem Dr Gerhard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of DE1470336A1 publication Critical patent/DE1470336A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19621470336 1962-07-04 1962-07-04 Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung Pending DE1470336A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DET0022407 1962-07-04

Publications (1)

Publication Number Publication Date
DE1470336A1 true DE1470336A1 (de) 1969-03-20

Family

ID=7550528

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19621470336 Pending DE1470336A1 (de) 1962-07-04 1962-07-04 Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung

Country Status (5)

Country Link
US (3) US3272811A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE1470336A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES301102A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1048986A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL6504085A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931204A (en) * 1971-07-13 1976-01-06 U.C.B. Societe Anonyme Thieno[3,4-d]pyrimidines
US3960860A (en) * 1973-01-08 1976-06-01 International Flavors & Fragrances Inc. 2-Methyl-5,7-dihydrothieno-[3,4d]-pyrimidine
US4287340A (en) * 1979-08-27 1981-09-01 Warner-Lambert Company Dihydro-oxo-pyrido[1,2-a]thienopyrimidine compounds
NL8300656A (nl) * 1982-02-25 1983-09-16 Maruko Pharmaceutical Co Thiopyranopyrimidineverbindingen en zuuradditiezouten daarvan.
DE3335472A1 (de) * 1983-09-30 1985-04-11 Gödecke AG, 1000 Berlin 5h-(1)benzopyrano-(2,3,-d)pyrimidin-derivate, verfahren zu deren herstellung sowie deren verwendung bei der bekaempfung von gastralen und duodenalen schleimhautlaesionen
DE3335473A1 (de) * 1983-09-30 1985-04-11 Gödecke AG, 1000 Berlin 4-thioxo-benzopyrano(2,3-d)pyrimidin-derivate sowie verfahren zu deren herstellung
US4670560A (en) * 1986-04-28 1987-06-02 Ortho Pharmaceutical Corporation Thienopyrimidine-2,4-dione derivatives and intermediates thereof
US4797486A (en) * 1986-09-08 1989-01-10 Pfizer Inc. Heterocyclic ring fused pyrimidine-4(3H)-ones as anticoccidial agents
US4725599A (en) * 1986-09-08 1988-02-16 Pfizer Inc. Heterocyclic ring fused pyrimidine-4 (3H)-ones as anticoccidial agents
US4871739A (en) * 1987-01-21 1989-10-03 Merck & Co., Inc. Substituted 6H-7,8-dihydrothiapyrano(3,2-D)-pyrimidines as hyopglycemic agents
US4889856A (en) * 1987-08-31 1989-12-26 Merck & Co., Inc. 7,8-dihydro-4-(1-pierazinyl)-6H-thiopyrano-[3,2-d] pyrimidines as β-blockers
EP0276057B1 (en) * 1987-01-21 1994-03-09 Merck & Co. Inc. Piperazinylpyrimidines as beta-adrenergic receptor blocking agents
US4994464A (en) * 1987-08-31 1991-02-19 Merck & Co., Inc. Piperazinylpyrimidines as β-adrenergic receptor blockers
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
ES2221414T3 (es) * 1998-08-27 2004-12-16 Sumitomo Pharmaceuticals Company, Limited Derivados de pirimidina.
WO2000042025A1 (fr) * 1999-01-14 2000-07-20 Meiji Seika Kaisha, Ltd. Inhibiteurs de poly(adp-ribose) polymerase consistant en des derives de pyrimidine
US7968545B2 (en) 2003-08-05 2011-06-28 Vertex Pharmaceuticals Inc. Compositions useful as inhibitors of voltage-gated ion channels
TW200621257A (en) * 2004-10-20 2006-07-01 Astellas Pharma Inc Pyrimidine derivative fused with nonaromatic ring
DE102005019201A1 (de) * 2006-04-19 2006-11-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Verbindungen zur Behandlung von entzündlichen Erkrankungen
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
NZ592534A (en) * 2007-10-18 2013-03-28 Boehringer Ingelheim Int Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein
JP5563466B2 (ja) 2007-10-19 2014-07-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ピペラジノ−ジヒドロチエノピリミジン誘導体
CA2702524A1 (en) * 2007-10-19 2009-04-23 Boehringer Ingelheim International Gmbh Heterocycle-substituted piperazino-dihydrothienopyrimidines
ME01330B (me) 2007-10-19 2013-12-20 Boehringer Ingelheim Int Supstituisani piperidino-dihidrotienopirimidini
US8471010B2 (en) * 2008-05-13 2013-06-25 Boehringer Ingelheim International Gmbh Synthesis of dihydrothieno[3,2-d]pyrimidine diols
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
WO2014124860A1 (en) 2013-02-14 2014-08-21 Boehringer Ingelheim International Gmbh Specific pde4b-inhibitors for the treatment of diabetes mellitus
CN116925099B (zh) * 2023-07-21 2025-06-03 厦门大学 手性二氢噻吩并嘧啶亚砜的制备方法及其应用与其2、4位取代化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB617435A (en) * 1945-08-10 1949-02-07 Lederle Lab Inc Improvements in or relating to tetrahydro thieno uracils and method of preparing same
US2792394A (en) * 1954-01-25 1957-05-14 Phillips Petroleum Co Preparation of sulfenyl dithiocarbamates
NL112551C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1954-10-05
US2937118A (en) * 1956-06-27 1960-05-17 Raschig Gmbh Dr F Aminopyridine compositions
US3063902A (en) * 1961-01-18 1962-11-13 Irwin Neisler & Co Analgesic aralkyl-pyridines
US3244594A (en) * 1962-01-12 1966-04-05 Egyt Gyogyszervegyeszeti Gyar 1, 6-bis-(beta-chloro-ethyl-amino)-1, 6-deoxy-d-mannitol heparinate

Also Published As

Publication number Publication date
ES301102A1 (es) 1965-01-16
US3318883A (en) 1967-05-09
GB1048986A (en) 1966-11-23
US3272811A (en) 1966-09-13
NL6504085A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1966-10-03
US3318881A (en) 1967-05-09

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