DE1212090B - Verfahren zur Herstellung von 10-(Piperazinopropyl)-3-trifluormethyl-phenothiazinverbindungen und ihren Salzen - Google Patents
Verfahren zur Herstellung von 10-(Piperazinopropyl)-3-trifluormethyl-phenothiazinverbindungen und ihren SalzenInfo
- Publication number
- DE1212090B DE1212090B DEO6182A DEO0006182A DE1212090B DE 1212090 B DE1212090 B DE 1212090B DE O6182 A DEO6182 A DE O6182A DE O0006182 A DEO0006182 A DE O0006182A DE 1212090 B DE1212090 B DE 1212090B
- Authority
- DE
- Germany
- Prior art keywords
- general formula
- trifluoromethylphenothiazine
- derivative
- preparation
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B7/00—Working up raw materials other than ores, e.g. scrap, to produce non-ferrous metals and compounds thereof; Methods of a general interest or applied to the winning of more than two metals
- C22B7/006—Wet processes
- C22B7/007—Wet processes by acid leaching
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/20—Recycling
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Geology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68321957 US3227708A (en) | 1957-09-11 | 1957-09-11 | Trifluoromethyl phenothiazines |
Publications (1)
Publication Number | Publication Date |
---|---|
DE1212090B true DE1212090B (de) | 1966-03-10 |
Family
ID=24743059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEO6182A Pending DE1212090B (de) | 1957-09-11 | 1958-05-17 | Verfahren zur Herstellung von 10-(Piperazinopropyl)-3-trifluormethyl-phenothiazinverbindungen und ihren Salzen |
Country Status (8)
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3194733A (en) * | 1961-04-26 | 1965-07-13 | Olin Mathicson Chemical Corp | Phenothiazine compositions and method of treating mental disorders |
US3968118A (en) * | 1968-08-31 | 1976-07-06 | Hoechst Aktiengesellschaft | Process for the manufacture of 1-hydroxy-2-pyridones |
GB1460713A (en) * | 1973-06-08 | 1977-01-06 | Kefalas As | 7-fluoro substituted phenothiazines method for preparation thereof and compositions bladed rotor for a gas turbine engine |
US7544681B2 (en) * | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
CN101445494A (zh) | 2001-09-27 | 2009-06-03 | 特拉维夫大学拉莫特有限公司 | 共轭的精神抑制药及其用途 |
CA2610838A1 (en) * | 2005-06-07 | 2006-12-14 | Ramot At Tel Aviv University Ltd. | Novel salts of conjugated psychotropic drugs and processes of preparing same |
JP5192485B2 (ja) * | 2006-07-17 | 2013-05-08 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド | 向精神性薬物またはgabaアゴニストと有機酸とを含むコンジュゲート、ならびに疼痛および他のcns障害を治療するためのそれらの使用 |
US8207369B2 (en) * | 2008-02-11 | 2012-06-26 | Ramot At Tel-Aviv University Ltd. | Conjugates for treating neurodegenerative diseases and disorders |
WO2011070579A1 (en) * | 2009-12-09 | 2011-06-16 | Biolinerx Ltd. | Methods of improving cognitive functions |
WO2012038963A1 (en) | 2010-09-22 | 2012-03-29 | Ramot At Tel-Aviv University Ltd. | An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE558008A (US20100056889A1-20100304-C00004.png) * | 1956-06-21 | |||
DE910301C (de) * | 1950-12-21 | 1954-04-29 | Rhone Poulenc Sa | Verfahren zur Herstellung von neuen Phenthiazinderivaten |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2587660A (en) * | 1952-03-04 | Trifluoromethyl phenothiazine | ||
US2645640A (en) * | 1953-07-14 | Phenthiazine derivatives | ||
US2678926A (en) * | 1954-05-18 | Dialkyl phsnoihiazins stulfoniss | ||
US2838507A (en) * | 1958-06-10 | Chr-chi | ||
US2902484A (en) * | 1954-04-27 | 1959-09-01 | Rhone Poulenc Sa | Phenthiazine derivatives and processes for their preparation |
FR1171918A (fr) * | 1954-10-18 | 1959-02-03 | Rhone Poulenc Sa | Nouveaux dérivés de la pipérazine et leurs procédés de préparation |
BE553467A (US20100056889A1-20100304-C00004.png) * | 1955-03-19 | |||
US2787617A (en) * | 1955-09-20 | 1957-04-02 | Searle & Co | Derivatives of oxopiperazinoalkylhalophenothiazines |
FR1186155A (fr) * | 1956-04-07 | 1959-08-17 | Rhone Poulenc Sa | Nouveaux dérivés de la méthanesulfonyl-3 phénothiazine et leur procédé de préparation |
NL108827C (US20100056889A1-20100304-C00004.png) * | 1956-04-09 | |||
BE569430A (US20100056889A1-20100304-C00004.png) * | 1957-07-17 |
-
0
- NL NL227699D patent/NL227699A/xx unknown
- NL NL105973D patent/NL105973C/xx active
- BE BE568837D patent/BE568837A/xx unknown
-
1957
- 1957-09-11 US US68321957 patent/US3227708A/en not_active Expired - Lifetime
-
1958
- 1958-05-06 GB GB14468/58A patent/GB884760A/en not_active Expired
- 1958-05-08 DK DK173058A patent/DK118404B/da unknown
- 1958-05-17 DE DEO6182A patent/DE1212090B/de active Pending
- 1958-06-02 CH CH6014758A patent/CH387044A/fr unknown
- 1958-06-10 FR FR767568A patent/FR1274378A/fr not_active Expired
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE910301C (de) * | 1950-12-21 | 1954-04-29 | Rhone Poulenc Sa | Verfahren zur Herstellung von neuen Phenthiazinderivaten |
BE558008A (US20100056889A1-20100304-C00004.png) * | 1956-06-21 |
Also Published As
Publication number | Publication date |
---|---|
NL227699A (US20100056889A1-20100304-C00004.png) | 1900-01-01 |
GB884760A (en) | 1961-12-13 |
NL105973C (US20100056889A1-20100304-C00004.png) | 1900-01-01 |
DK118404B (da) | 1970-08-17 |
BE568837A (US20100056889A1-20100304-C00004.png) | 1900-01-01 |
CH387044A (fr) | 1965-01-31 |
FR1274378A (fr) | 1961-10-27 |
US3227708A (en) | 1966-01-04 |
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