DE112004002321B4 - Vorrichtung zum Ausbilden einer Gradientenzusammensetzung in einem Kapillarsystem sowie Vorrichtung zum Messen von Flussraten einer Flüssigkeit in einem Kapillarsystem - Google Patents

Vorrichtung zum Ausbilden einer Gradientenzusammensetzung in einem Kapillarsystem sowie Vorrichtung zum Messen von Flussraten einer Flüssigkeit in einem Kapillarsystem Download PDF

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Publication number
DE112004002321B4
DE112004002321B4 DE112004002321.1T DE112004002321T DE112004002321B4 DE 112004002321 B4 DE112004002321 B4 DE 112004002321B4 DE 112004002321 T DE112004002321 T DE 112004002321T DE 112004002321 B4 DE112004002321 B4 DE 112004002321B4
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Germany
Prior art keywords
flow
pressure
flow path
sensor
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE112004002321.1T
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German (de)
English (en)
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DE112004002321T5 (de
Inventor
Geoff C. Gerhardt
Joseph A. Luongo
Keith Fadgen
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Waters Technologies Corp
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Waters Technologies Corp
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Publication date
Priority claimed from US10/723,973 external-priority patent/US7332087B2/en
Application filed by Waters Technologies Corp filed Critical Waters Technologies Corp
Publication of DE112004002321T5 publication Critical patent/DE112004002321T5/de
Application granted granted Critical
Publication of DE112004002321B4 publication Critical patent/DE112004002321B4/de
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/05—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects
    • G01F1/34—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure
    • G01F1/36—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure the pressure or differential pressure being created by the use of flow constriction
    • G01F1/363—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure the pressure or differential pressure being created by the use of flow constriction with electrical or electro-mechanical indication
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/68—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using thermal effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/10—Preparation using a splitter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D11/00—Control of flow ratio
    • G05D11/02—Controlling ratio of two or more flows of fluid or fluent material
    • G05D11/13—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means
    • G05D11/131—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means by measuring the values related to the quantity of the individual components
    • G05D11/132—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means by measuring the values related to the quantity of the individual components by controlling the flow of the individual components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Automation & Control Theory (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Volume Flow (AREA)
DE112004002321.1T 2003-11-26 2004-11-23 Vorrichtung zum Ausbilden einer Gradientenzusammensetzung in einem Kapillarsystem sowie Vorrichtung zum Messen von Flussraten einer Flüssigkeit in einem Kapillarsystem Expired - Lifetime DE112004002321B4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/723,973 US7332087B2 (en) 2003-11-26 2003-11-26 Flow sensing apparatus used to monitor/provide feedback to a split flow pumping system
US10/723,973 2003-11-26
US10/851,497 US7186336B2 (en) 2003-11-26 2004-05-21 Flow sensing apparatus
US10/851,497 2004-05-21
PCT/US2004/039415 WO2005053813A1 (en) 2003-11-26 2004-11-23 Flow sensing apparatus

Publications (2)

Publication Number Publication Date
DE112004002321T5 DE112004002321T5 (de) 2006-10-12
DE112004002321B4 true DE112004002321B4 (de) 2022-05-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE112004002321.1T Expired - Lifetime DE112004002321B4 (de) 2003-11-26 2004-11-23 Vorrichtung zum Ausbilden einer Gradientenzusammensetzung in einem Kapillarsystem sowie Vorrichtung zum Messen von Flussraten einer Flüssigkeit in einem Kapillarsystem

Country Status (5)

Country Link
US (1) US7186336B2 (https=)
JP (1) JP4949039B2 (https=)
DE (1) DE112004002321B4 (https=)
GB (1) GB2425070B (https=)
WO (1) WO2005053813A1 (https=)

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JP4077674B2 (ja) * 2002-07-24 2008-04-16 憲一 工藤 ナノ／ミクロ液体クロマトグラフのグラジエント送液装置および送液方法
JP2005147756A (ja) * 2003-11-12 2005-06-09 Shimadzu Corp 送液ポンプ装置
US7332087B2 (en) * 2003-11-26 2008-02-19 Waters Investments Limited Flow sensing apparatus used to monitor/provide feedback to a split flow pumping system
JP4959565B2 (ja) * 2004-05-21 2012-06-27 ウオーターズ・テクノロジーズ・コーポレイシヨン 低流量動作を可能にするためのｈｐｌｃ定流量ポンプの閉ループ流量制御
JP4453589B2 (ja) * 2005-03-25 2010-04-21 株式会社島津製作所 移動相供給装置及びその移動相供給装置を用いた液体クロマトグラフ
EP1938097A4 (en) * 2005-09-09 2009-12-09 Eksigent Technologies Llc SYSTEM WITH CHANGING FLOW SPEED FOR COLUMN CHROMATOGRAPHY
JP4645437B2 (ja) * 2005-12-22 2011-03-09 株式会社島津製作所 グラジエント送液装置
CN101400418B (zh) * 2006-03-17 2012-11-14 沃特世科技公司 保持流体完整性和预先形成梯度的适于液相色谱的溶剂输送系统
ES1063841Y (es) * 2006-09-01 2007-03-16 Aigeltec Ingenieria S L Equipo de control para un grupo de presion
US20080092639A1 (en) * 2006-10-19 2008-04-24 Lee Dian Y Apparatus And Methods For Controlling Flow In Liquid Chromatography
US8858787B2 (en) 2007-10-22 2014-10-14 Baxter International Inc. Dialysis system having non-invasive fluid velocity sensing
KR20130083490A (ko) * 2007-12-05 2013-07-22 올테크 어소시에이츠, 인크. 시료를 분석하고 시료 분획을 수집하기 위한 방법 및 장치
US8485030B2 (en) * 2008-01-18 2013-07-16 Waters Technologies Corporation Thermal loop flow sensor
WO2009098125A1 (en) * 2008-02-06 2009-08-13 Proxeon Biosystems A/S Flow control in high performance liquid chromatography
EP2313182A4 (en) * 2008-07-22 2012-11-07 Massachusetts Inst Technology REINFORCED ELECTROCINETIC LIQUID PUMPING, SWITCHING AND PURIFICATION
JP5386927B2 (ja) * 2008-10-21 2014-01-15 東ソー株式会社 微小流量送液装置、及び送液方法
CN202582614U (zh) * 2009-01-22 2012-12-05 安捷伦科技有限公司 用于在通道中产生小流率的装置
EP2421631B1 (en) * 2009-04-23 2021-05-26 Global Life Sciences Solutions USA LLC Chromatography system and method with feedback control for variable speed loading
US20130014569A1 (en) * 2009-12-18 2013-01-17 Waters Technologies Corporation Thermal-based flow sensing apparatus and method for high-performance liquid chromatography
US20130026100A1 (en) * 2010-03-31 2013-01-31 Ge Healthcare Bio-Sciences Ab Parallel separation system
CN103026220B (zh) 2010-07-07 2014-12-24 通用电气健康护理生物科学股份公司 在一次性流体处理系统中的流体混合
DE102010043686A1 (de) 2010-11-10 2012-05-10 Agilent Technologies Inc. Bestimmen einer Flüssigkeitszusammensetzung aus unterschiedlich gewonnenen Flusssignalen
WO2012149956A1 (en) * 2011-05-03 2012-11-08 Agilent Technologies, Inc. Flow stabilization by capacitive load
DE102011115244A1 (de) * 2011-09-28 2013-03-28 Airbus Operations Gmbh Verfahren und System zur Überwachung des Betriebszustands einer Pumpe
JP5957973B2 (ja) * 2012-03-07 2016-07-27 東ソー株式会社 微小流量送液方法および前記方法を利用した装置
JP6037707B2 (ja) * 2012-08-07 2016-12-07 株式会社日立ハイテクノロジーズ プラズマ処理装置及びプラズマ処理装置の診断方法
EP3776133B1 (en) * 2018-04-12 2022-05-11 Nordson Corporation Systems and methods for dispensing multi-component materials
CA3105189A1 (en) * 2018-07-06 2020-01-09 Becton, Dickinson And Company Flow sensor and method for adjusting fluid flow measurement
CN113574348B (zh) * 2019-02-15 2026-04-17 富俊水创新有限责任公司 流体用量监控系统

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EP1324033A1 (de) 2001-12-21 2003-07-02 Agilent Technologies, Inc. (a Delaware corporation) Verfahren zur Bereitstellung von Volumenströmen von Fluiden

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DE69120386T2 (de) 1991-01-17 1996-10-31 Lc Packings Nederland Bv Mikrofluss-Prozessor
DE19914358A1 (de) 1999-03-30 2000-10-19 Agilent Technologies Inc Vorrichtung und Verfahren zur Bereitstellung von Volumenströmen von Flüssigkeiten in Kapillaren
EP1324033A1 (de) 2001-12-21 2003-07-02 Agilent Technologies, Inc. (a Delaware corporation) Verfahren zur Bereitstellung von Volumenströmen von Fluiden

Also Published As

Publication number Publication date
GB2425070A (en) 2006-10-18
JP2007513338A (ja) 2007-05-24
JP4949039B2 (ja) 2012-06-06
US7186336B2 (en) 2007-03-06
WO2005053813A1 (en) 2005-06-16
DE112004002321T5 (de) 2006-10-12
GB0612488D0 (en) 2006-08-30
GB2425070B (en) 2007-08-29
US20050109698A1 (en) 2005-05-26

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