DE10344229A1 - Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit - Google Patents

Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit Download PDF

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Publication number
DE10344229A1
DE10344229A1 DE10344229A DE10344229A DE10344229A1 DE 10344229 A1 DE10344229 A1 DE 10344229A1 DE 10344229 A DE10344229 A DE 10344229A DE 10344229 A DE10344229 A DE 10344229A DE 10344229 A1 DE10344229 A1 DE 10344229A1
Authority
DE
Germany
Prior art keywords
cavity
blocking element
liquid
carrier
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE10344229A
Other languages
German (de)
English (en)
Inventor
Klaus Dr. Kadel
Gert Dr. Blankenstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Microparts GmbH
Original Assignee
Steag Microparts GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Steag Microparts GmbH filed Critical Steag Microparts GmbH
Priority to DE10344229A priority Critical patent/DE10344229A1/de
Priority to EP04021864.6A priority patent/EP1518604B1/de
Priority to JP2004278569A priority patent/JP2005096866A/ja
Priority to CN200410011713.4A priority patent/CN100467128C/zh
Priority to US10/948,792 priority patent/US20050093087A1/en
Publication of DE10344229A1 publication Critical patent/DE10344229A1/de
Priority to US12/292,029 priority patent/US7964161B2/en
Ceased legal-status Critical Current

Links

Classifications

    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16KVALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00Subject matter not provided for in other groups of this subclass
    • F16K99/0001Microvalves
    • F16K99/0003Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0017Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16KVALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00Subject matter not provided for in other groups of this subclass
    • F16K99/0001Microvalves
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16KVALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00Subject matter not provided for in other groups of this subclass
    • F16K99/0001Microvalves
    • F16K99/0003Constructional types of microvalves; Details of the cutting-off member
    • F16K99/003Valves for single use only
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16KVALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00Subject matter not provided for in other groups of this subclass
    • F16K99/0001Microvalves
    • F16K99/0034Operating means specially adapted for microvalves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16Reagents, handling or storing thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • B01L2300/044Connecting closures to device or container pierceable, e.g. films, membranes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/046Function or devices integrated in the closure
    • B01L2300/047Additional chamber, reservoir
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0672Integrated piercing tool
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0638Valves, specific forms thereof with moving parts membrane valves, flap valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/065Valves, specific forms thereof with moving parts sliding valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Rigid containers without fluid transport within
    • B01L3/5085Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52Containers specially adapted for storing or dispensing a reagent
    • B01L3/523Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Closures For Containers (AREA)
DE10344229A 2003-09-24 2003-09-24 Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit Ceased DE10344229A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE10344229A DE10344229A1 (de) 2003-09-24 2003-09-24 Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit
EP04021864.6A EP1518604B1 (de) 2003-09-24 2004-09-15 Mikrostrukturierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit
JP2004278569A JP2005096866A (ja) 2003-09-24 2004-09-24 少量の液体を取出し可能に貯留するための微細構造装置および該装置に貯留された液体の取出し方法
CN200410011713.4A CN100467128C (zh) 2003-09-24 2004-09-24 用于可取出地存储微量液体的微结构装置和用于取出存储在该装置中的液体的方法
US10/948,792 US20050093087A1 (en) 2003-09-24 2004-09-24 Microstructured device for removable storage of small amounts of liquid and a process for removal of the liquid stored in this device
US12/292,029 US7964161B2 (en) 2003-09-24 2008-11-10 Microstructured device for removable storage of small amounts of liquid and a process for removal of liquid stored in this device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10344229A DE10344229A1 (de) 2003-09-24 2003-09-24 Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit

Publications (1)

Publication Number Publication Date
DE10344229A1 true DE10344229A1 (de) 2005-05-19

Family

ID=34177921

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10344229A Ceased DE10344229A1 (de) 2003-09-24 2003-09-24 Mikrostruktuierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen und Verfahren zum Entnehmen der in dieser Vorrichtung gespeicherten Flüssigkeit

Country Status (5)

Country Link
US (2) US20050093087A1 (https=)
EP (1) EP1518604B1 (https=)
JP (1) JP2005096866A (https=)
CN (1) CN100467128C (https=)
DE (1) DE10344229A1 (https=)

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DE102008005686A1 (de) * 2008-01-23 2009-07-30 Epcos Ag MEMS-Bauelement, Verfahren zur Herstellung eines MEMS-Bauelements und Verfahren zur Handhabung eines MEMS-Bauelements
US9562540B2 (en) 2011-09-29 2017-02-07 Protectlife International Biomedical Inc. Centrifugal rotor

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DE102008042196A1 (de) 2008-09-18 2010-03-25 Robert Bosch Gmbh Verfahren zum Herstellen eines mikrofluidischen Bauelementes sowie mikrofluidisches Bauelement
EP2329884B1 (de) * 2009-11-04 2012-02-22 Boehringer Ingelheim microParts GmbH Verfahren zur Aushärtung eines Klebstoffs
US8720036B2 (en) 2010-03-09 2014-05-13 Netbio, Inc. Unitary biochip providing sample-in to results-out processing and methods of manufacture
ES2930133T3 (es) * 2010-03-09 2022-12-07 Ande Corp Biochip con almacenamiento de reactivo
DE102011004125A1 (de) * 2011-02-15 2012-08-16 Robert Bosch Gmbh Vorrichtung zur hermetisch abgeschlossenen Bevorratung von Flüssigkeiten für ein mikrofluidisches System
JP6116490B2 (ja) * 2011-03-09 2017-04-19 ピクセル メディカル テクノロジーズ リミテッド 分析対象の細胞を含む試料流体の調製に用いる使い捨てカートリッジ
EP3124236A1 (en) 2011-06-17 2017-02-01 Fiberweb, Inc. Vapor permeable, substantially water impermeable multilayer article
EP2723568B1 (en) 2011-06-23 2017-09-27 Fiberweb, LLC Vapor permeable, substantially water impermeable multilayer article
US10369769B2 (en) 2011-06-23 2019-08-06 Fiberweb, Inc. Vapor-permeable, substantially water-impermeable multilayer article
EP2723567A4 (en) 2011-06-24 2014-12-24 Fiberweb Inc MULTILAYER ARTICLE PERMEABLE TO WATER VAPOR, BUT ESSENTIALLY WATERPROOF
US8470153B2 (en) * 2011-07-22 2013-06-25 Tecan Trading Ag Cartridge and system for manipulating samples in liquid droplets
US9435765B2 (en) 2011-07-22 2016-09-06 Tecan Trading Ag Cartridge and system for manipulating samples in liquid droplets
US9857332B2 (en) 2011-07-22 2018-01-02 Tecan Trading Ag System for manipulating samples in liquid droplets
WO2013042435A1 (ja) * 2011-09-20 2013-03-28 富士紡ホールディングス株式会社 試薬容器
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WO2014108186A1 (en) * 2013-01-09 2014-07-17 Tecan Trading Ag System for manipulating samples in liquid droplets
CN105992648B (zh) * 2013-05-31 2019-04-26 彼克斯赛尔医疗科技有限公司 用于制备含有用于分析的细胞的样品流体的盒
DE102013106353B4 (de) * 2013-06-18 2018-06-28 Tdk Corporation Verfahren zum Aufbringen einer strukturierten Beschichtung auf ein Bauelement
US20160236196A1 (en) * 2013-09-30 2016-08-18 Hitachi, Ltd. Reagent Holding Container, Liquid Delivery Device, Reagent Discharge Method
US9795968B2 (en) * 2014-04-21 2017-10-24 Lawrence Livermore National Security, LLCq Multi-chamber nucleic acid amplification and detection device
JP5788562B1 (ja) * 2014-05-01 2015-09-30 株式会社タスコ 宝石
EP3245002A4 (en) 2015-01-14 2018-08-01 Pixcell Medical Technologies Ltd. Disposable cartridge for sample fluid analysis
CN107533077B (zh) * 2015-04-30 2020-11-06 希森美康株式会社 液体密封盒体、样本分析装置以及样本分析方法
CN109154625A (zh) * 2016-09-14 2019-01-04 积水化学工业株式会社 微芯片
JP6421159B2 (ja) 2016-10-28 2018-11-07 シスメックス株式会社 液体封止カートリッジおよび送液方法
DE102017210459A1 (de) * 2017-06-22 2018-12-27 Robert Bosch Gmbh Mikromechanische Vorrichtung mit einer ersten Kaverne und einer zweiten Kaverne
US11975321B2 (en) 2018-03-27 2024-05-07 Lawrence Livermore National Security, Llc Multi-channel optical detection system and method for multi-chamber assays
CN112638535B (zh) * 2018-09-11 2022-08-02 豪夫迈·罗氏有限公司 带液体包的料筒
JP2020125915A (ja) * 2019-02-01 2020-08-20 株式会社エンプラス 流体取扱システムおよびカートリッジ
JP7445403B2 (ja) 2019-09-27 2024-03-07 シスメックス株式会社 液体封止カートリッジおよび送液方法

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US3825410A (en) * 1970-05-13 1974-07-23 K Bagshawe Performance of routine chemical reactions in compartmentalized containers
US3704206A (en) * 1971-02-25 1972-11-28 Miles Lab Device for the detection of bacteria in aqueous fluids
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US5364591A (en) * 1992-06-01 1994-11-15 Eastman Kodak Company Device for moving a target-bearing solid through a liquid for detection while being contained
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DE10137561A1 (de) 2001-08-01 2003-02-13 Christian Hoernicke Gelenkstreifen zur Verbindung zweier schrittweise gegeneinander zu verdrehenden Gegenstände

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US8674464B2 (en) 2008-01-23 2014-03-18 Epcos Ag MEMS component, method for producing a MEMS component, and method for handling a MEMS component
DE102008005686B4 (de) * 2008-01-23 2019-01-31 Tdk Corporation MEMS-Bauelement und Verfahren zur Herstellung eines MEMS-Bauelements
DE102008005686B9 (de) * 2008-01-23 2019-06-27 Tdk Corporation MEMS-Bauelement und Verfahren zur Herstellung eines MEMS-Bauelements
US9562540B2 (en) 2011-09-29 2017-02-07 Protectlife International Biomedical Inc. Centrifugal rotor
DE112011105686B4 (de) * 2011-09-29 2017-05-11 Protectlife International Biomedical Inc. Zentrifugenrotor

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CN100467128C (zh) 2009-03-11
US20090074626A1 (en) 2009-03-19
CN1608735A (zh) 2005-04-27
EP1518604A3 (de) 2009-07-01
US7964161B2 (en) 2011-06-21
US20050093087A1 (en) 2005-05-05
JP2005096866A (ja) 2005-04-14
EP1518604B1 (de) 2018-06-13

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