DE10302787A1 - Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik - Google Patents

Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik Download PDF

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Publication number
DE10302787A1
DE10302787A1 DE2003102787 DE10302787A DE10302787A1 DE 10302787 A1 DE10302787 A1 DE 10302787A1 DE 2003102787 DE2003102787 DE 2003102787 DE 10302787 A DE10302787 A DE 10302787A DE 10302787 A1 DE10302787 A1 DE 10302787A1
Authority
DE
Germany
Prior art keywords
solvates
formula
salts
compound
dye according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE2003102787
Other languages
German (de)
English (en)
Inventor
Kai Licha
Christine Perlitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE2003102787 priority Critical patent/DE10302787A1/de
Priority to NZ541414A priority patent/NZ541414A/en
Priority to YUP-2005/0561A priority patent/RS20050561A/sr
Priority to DE60323766T priority patent/DE60323766D1/de
Priority to ES03767544T priority patent/ES2311736T3/es
Priority to JP2004566758A priority patent/JP2006513293A/ja
Priority to CA002514131A priority patent/CA2514131A1/en
Priority to BR0318028-0A priority patent/BR0318028A/pt
Priority to UAA200508207A priority patent/UA82684C2/uk
Priority to MXPA05007668A priority patent/MXPA05007668A/es
Priority to KR1020057013493A priority patent/KR20050103907A/ko
Priority to AT03767544T priority patent/ATE409209T1/de
Priority to EA200501064A priority patent/EA009386B1/ru
Priority to PCT/EP2003/012735 priority patent/WO2004065491A1/en
Priority to EP03767544A priority patent/EP1585791B1/en
Priority to CN 200380109197 priority patent/CN1742057A/zh
Priority to AU2003292019A priority patent/AU2003292019A1/en
Priority to PL03376459A priority patent/PL376459A1/xx
Priority to US10/762,582 priority patent/US20040260072A1/en
Publication of DE10302787A1 publication Critical patent/DE10302787A1/de
Priority to CR7925A priority patent/CR7925A/es
Priority to NO20053919A priority patent/NO20053919L/no
Priority to EC2005005975A priority patent/ECSP055975A/es
Priority to ZA200506759A priority patent/ZA200506759B/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE2003102787 2003-01-24 2003-01-24 Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik Ceased DE10302787A1 (de)

Priority Applications (23)

Application Number Priority Date Filing Date Title
DE2003102787 DE10302787A1 (de) 2003-01-24 2003-01-24 Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik
AT03767544T ATE409209T1 (de) 2003-01-24 2003-11-14 Hydrophile, thiolreaktive cyaninfarbstoffe und deren konjugate mit biomolekülen für fluoreszenzdiagnose
PL03376459A PL376459A1 (en) 2003-01-24 2003-11-14 Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
DE60323766T DE60323766D1 (de) 2003-01-24 2003-11-14 En konjugate mit biomolekülen für fluoreszenzdiagnose
ES03767544T ES2311736T3 (es) 2003-01-24 2003-11-14 Tintes hidrofilicos de cianina tiol reactivo y conjugados de los mismos con biomoleculas para el diagnostico por fluorescencia.
JP2004566758A JP2006513293A (ja) 2003-01-24 2003-11-14 親水性チオール−反応性シアニン色素及び蛍光診断のための生物分子との接合体
CA002514131A CA2514131A1 (en) 2003-01-24 2003-11-14 Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
BR0318028-0A BR0318028A (pt) 2003-01-24 2003-11-14 Corantes hidrofìlicos de cianina reativos a tiol e conjugados dos mesmos com biomoléculas para diagnóstico por fluorescência
UAA200508207A UA82684C2 (uk) 2003-01-24 2003-11-14 Гідрофільні, реакційні відносно тіол-групи ціанінові барвники, спосіб їх одержання, їх кон'югати з біомолекулами, спосіб одержання останніх та їх застосування, а також діагностичний набір
MXPA05007668A MXPA05007668A (es) 2003-01-24 2003-11-14 Colorantes hidrofilicos de cianina, reactivos a tiol y conjugados de los mismos con biomoleculas para diagnostico por fluorescencia.
KR1020057013493A KR20050103907A (ko) 2003-01-24 2003-11-14 형광 진단을 위한 친수성의 티올-반응성 시아닌 염료 및그의 생체분자와의 접합체
NZ541414A NZ541414A (en) 2003-01-24 2003-11-14 Indotricarbocyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
EA200501064A EA009386B1 (ru) 2003-01-24 2003-11-14 Гидрофильные, реакционные в отношении тиол-группы цианиновые красители, и их конъюгаты с биомолекулами для флюоресцентной диагностики
CN 200380109197 CN1742057A (zh) 2003-01-24 2003-11-14 用于荧光诊断的亲水性硫醇反应性花青染料及其与生物分子的缀合物
EP03767544A EP1585791B1 (en) 2003-01-24 2003-11-14 Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
PCT/EP2003/012735 WO2004065491A1 (en) 2003-01-24 2003-11-14 Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
AU2003292019A AU2003292019A1 (en) 2003-01-24 2003-11-14 Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
YUP-2005/0561A RS20050561A (en) 2003-01-24 2003-11-14 HYDROPHILIC, THIOL-REACTIVE CYANINE DYES AND CONjUGATES THEREOF WITH BIOMOLECULES FOR FLUORESCENCE DIAGNOSIS
US10/762,582 US20040260072A1 (en) 2003-01-24 2004-01-23 Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
CR7925A CR7925A (es) 2003-01-24 2005-07-28 Tinturas de cianina hidrofilicas, reactivas con tiol y conjugados de las mismas con biomoleculas para diagnostico por fluorescencia
NO20053919A NO20053919L (no) 2003-01-24 2005-08-23 Hydrofile tiol-reaktive cyaninfargestoffer og konjugater av disse med biomolekyler for fluorisensdiagnostikk.
EC2005005975A ECSP055975A (es) 2003-01-24 2005-08-23 Tinturas de cianina hidrofílicas, reactivas con tiol y conjugados de las mismas con biomoléculas para diagnóstico por fluorescencia
ZA200506759A ZA200506759B (en) 2003-01-24 2005-08-23 Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2003102787 DE10302787A1 (de) 2003-01-24 2003-01-24 Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik

Publications (1)

Publication Number Publication Date
DE10302787A1 true DE10302787A1 (de) 2004-08-12

Family

ID=32694952

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2003102787 Ceased DE10302787A1 (de) 2003-01-24 2003-01-24 Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik

Country Status (6)

Country Link
CN (1) CN1742057A (zh)
DE (1) DE10302787A1 (zh)
NO (1) NO20053919L (zh)
RS (1) RS20050561A (zh)
UA (1) UA82684C2 (zh)
ZA (1) ZA200506759B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3001197A1 (en) * 2014-09-23 2016-03-30 Universität Heidelberg Fluorescent protein stains

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8367842B2 (en) * 2009-07-16 2013-02-05 Beckman Coulter, Inc. Fluorescent dyes and uses thereof
CN107488657A (zh) * 2017-08-15 2017-12-19 苏州泽科生物科技有限公司 核酸的活性染料偶联标记、检测及提纯方法
US10968386B2 (en) 2018-01-09 2021-04-06 Shenzhen University Pentamethine cyanine dye and preparation method therefor
CN108192376A (zh) * 2018-01-09 2018-06-22 深圳大学 一种五甲川菁染料及制备方法
CN108727245B (zh) * 2018-07-02 2021-09-28 广州中医药大学(广州中医药研究院) 一种水杨酸类化合物及其制备方法和应用
CN110201189B (zh) * 2019-06-03 2021-12-07 沈阳药科大学 白蛋白结合型近红外荧光染料-马来酰亚胺共轭物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002503A (en) * 1997-10-23 1999-12-14 Ciena Corporation Optical add/drop multiplexer
US6180085B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
US6225050B1 (en) * 1986-04-18 2001-05-01 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225050B1 (en) * 1986-04-18 2001-05-01 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US6002503A (en) * 1997-10-23 1999-12-14 Ciena Corporation Optical add/drop multiplexer
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
US6180085B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes
WO2001052745A1 (en) * 2000-01-18 2001-07-26 Mallinckrodt Inc. Novel dyes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3001197A1 (en) * 2014-09-23 2016-03-30 Universität Heidelberg Fluorescent protein stains
WO2016045782A1 (en) * 2014-09-23 2016-03-31 Universität Heidelberg Fluorescent protein stains

Also Published As

Publication number Publication date
RS20050561A (en) 2007-09-21
ZA200506759B (en) 2007-01-31
NO20053919L (no) 2005-10-24
UA82684C2 (uk) 2008-05-12
CN1742057A (zh) 2006-03-01
NO20053919D0 (no) 2005-08-23

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8127 New person/name/address of the applicant

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE

8131 Rejection