DE10208987A1 - Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen - Google Patents
Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in ArzneistoffenInfo
- Publication number
- DE10208987A1 DE10208987A1 DE10208987A DE10208987A DE10208987A1 DE 10208987 A1 DE10208987 A1 DE 10208987A1 DE 10208987 A DE10208987 A DE 10208987A DE 10208987 A DE10208987 A DE 10208987A DE 10208987 A1 DE10208987 A1 DE 10208987A1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- compounds
- alkyl
- phenyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 239000003814 drug Substances 0.000 title claims description 4
- 229940079593 drug Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 59
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 19
- 239000001257 hydrogen Substances 0.000 claims abstract description 19
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 13
- 150000002367 halogens Chemical class 0.000 claims abstract description 13
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 13
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 9
- 125000003118 aryl group Chemical group 0.000 claims abstract description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 6
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- 125000004104 aryloxy group Chemical group 0.000 claims abstract 2
- -1 phenoxy-substituted phenyl Chemical group 0.000 claims description 43
- 150000003839 salts Chemical class 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 8
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- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims description 4
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- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 2
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- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940068917 polyethylene glycols Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000005932 reductive alkylation reaction Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229960001947 tripalmitin Drugs 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Steroid Compounds (AREA)
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10208987A DE10208987A1 (de) | 2002-02-28 | 2002-02-28 | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
| PE2003000134A PE20030928A1 (es) | 2002-02-28 | 2003-02-05 | 3-fenil-5-alcoxi-1,3,4-oxadiazol-2-onas sustituidas y su preparacion |
| IL16368303A IL163683A0 (en) | 2002-02-28 | 2003-02-14 | Substituted 3-phenyl-5-alkoxy-1,3,4,-oxadiazol-2-ones, their preparation and use in medicaments |
| HR20040782A HRP20040782A2 (en) | 2002-02-28 | 2003-02-14 | Substituted 3-phenyl-5-akoxy-1,3,4-oxadiazol-2-ones, the production therof and their use in medicaments |
| CA002477031A CA2477031A1 (en) | 2002-02-28 | 2003-02-14 | Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, the production thereof and their use in medicaments |
| PL03370423A PL370423A1 (en) | 2002-02-28 | 2003-02-14 | Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, the production thereof and their use in medicaments |
| EP03742936A EP1480960B1 (de) | 2002-02-28 | 2003-02-14 | Substituierte 3-Phenyl-5-alkoxy-1,3,4-oxadiazol-2-one sowie ihre Herstellung und Verwendung in Arzneistoffen |
| CNA038047837A CN1639137A (zh) | 2002-02-28 | 2003-02-14 | 取代的3－苯基－5－烷氧基－1,3,4－噁二唑－2－酮、其制备及其在药物中的用途 |
| MXPA04007960A MXPA04007960A (es) | 2002-02-28 | 2003-02-14 | 3-fenil-5-alcoxi-1,3,4-oxadiazol-2-onas sustituidas, su produccion y su uso en medicamentos. |
| AU2003226977A AU2003226977A1 (en) | 2002-02-28 | 2003-02-14 | Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, the production thereof and their use in medicaments |
| JP2003571261A JP4486363B2 (ja) | 2002-02-28 | 2003-02-14 | 置換３−フェニル−５−アルコキシ−１，３，４−オキサジアゾール−２−オン、これの製造方法および薬剤での使用 |
| BR0307921-0A BR0307921A (pt) | 2002-02-28 | 2003-02-14 | 3-fenil-5-alcóxi-1,3,4-oxadiazol-2-onas substituìdas, bem como sua preparação e uso em medicamentos |
| KR10-2004-7013485A KR20040095240A (ko) | 2002-02-28 | 2003-02-14 | 치환된 3-페닐-5-알콕시-1,3,4-옥사디아졸-2-온, 이의제조방법 및 약물에서의 이의 용도 |
| AT03742936T ATE557012T1 (de) | 2002-02-28 | 2003-02-14 | Substituierte 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-one sowie ihre herstellung und verwendung in arzneistoffen |
| PCT/EP2003/001484 WO2003072555A1 (de) | 2002-02-28 | 2003-02-14 | Substituierte 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-one sowie ihre herstellung und verwendung in arzneistoffen |
| RU2004128933/04A RU2004128933A (ru) | 2002-02-28 | 2003-02-14 | Замещенные 3-фенил-5-алкокси-1,3,4-оксадиазол-2-оны, а также их получение и применение в лекарственных средствах |
| HU0402671A HUP0402671A3 (en) | 2002-02-28 | 2003-02-14 | Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, the production thereof and their use in medicaments |
| ARP030100624A AR038701A1 (es) | 2002-02-28 | 2003-02-26 | 3-fenil-5-alcoxi-1,3,4-oxadiazol-2-onas sustituidas, su preparacion y medicamentos que comprenden el compuesto activo |
| TW092103969A TW200400951A (en) | 2002-02-28 | 2003-02-26 | Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, their preparation and use in medicaments |
| US10/375,247 US6900233B2 (en) | 2002-02-28 | 2003-02-27 | Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof |
| MA27803A MA27172A1 (fr) | 2002-02-28 | 2004-07-27 | 3-phenyl-5-alcoxy-1,3,4-oxdiazol-2-ones substitues, ainsi que leur production et leur utilisation dans des medicaments |
| CO04083779A CO5611146A2 (es) | 2002-02-28 | 2004-08-26 | 3-fenil-5-alcoxi-1,3,4-oxadiazol-2-onas sustituidas, su produccion y su uso en medicamentos |
| NO20044090A NO20044090L (no) | 2002-02-28 | 2004-09-27 | Substituert 3-fenyl-5-alkoksy-1,3,4-oksadiazol-24neJr, fremstilling derav og anvendelse i medikamenter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10208987A DE10208987A1 (de) | 2002-02-28 | 2002-02-28 | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10208987A1 true DE10208987A1 (de) | 2003-09-11 |
Family
ID=27740558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10208987A Withdrawn DE10208987A1 (de) | 2002-02-28 | 2002-02-28 | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1480960B1 (enExample) |
| JP (1) | JP4486363B2 (enExample) |
| KR (1) | KR20040095240A (enExample) |
| CN (1) | CN1639137A (enExample) |
| AR (1) | AR038701A1 (enExample) |
| AT (1) | ATE557012T1 (enExample) |
| AU (1) | AU2003226977A1 (enExample) |
| BR (1) | BR0307921A (enExample) |
| CA (1) | CA2477031A1 (enExample) |
| CO (1) | CO5611146A2 (enExample) |
| DE (1) | DE10208987A1 (enExample) |
| HR (1) | HRP20040782A2 (enExample) |
| HU (1) | HUP0402671A3 (enExample) |
| IL (1) | IL163683A0 (enExample) |
| MA (1) | MA27172A1 (enExample) |
| MX (1) | MXPA04007960A (enExample) |
| NO (1) | NO20044090L (enExample) |
| PE (1) | PE20030928A1 (enExample) |
| PL (1) | PL370423A1 (enExample) |
| RU (1) | RU2004128933A (enExample) |
| TW (1) | TW200400951A (enExample) |
| WO (1) | WO2003072555A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7074822B2 (en) | 2004-02-23 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them |
| CA2585175A1 (en) | 2004-10-25 | 2006-05-04 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions |
| CA2710743A1 (en) * | 2007-12-27 | 2009-07-09 | Bial-Portela & Ca., S.A. | 5-o-substituted 3-n-phenyl-1,3,4-oxadiazolones for medical use |
| TW201028406A (en) | 2008-12-23 | 2010-08-01 | Bial Portela & Ca Sa | 5-O-substituted 3-N-aryl-1,3,4-oxadiazolones for medical use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19942354A1 (de) * | 1999-09-04 | 2001-03-08 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln |
| WO2001066531A1 (de) * | 2000-03-07 | 2001-09-13 | Aventis Pharma Deutschland Gmbh | Substituierte 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one (und) ihre verwendung zur hemmung der hormonsensitiven lipase |
-
2002
- 2002-02-28 DE DE10208987A patent/DE10208987A1/de not_active Withdrawn
-
2003
- 2003-02-05 PE PE2003000134A patent/PE20030928A1/es not_active Application Discontinuation
- 2003-02-14 AT AT03742936T patent/ATE557012T1/de active
- 2003-02-14 CN CNA038047837A patent/CN1639137A/zh active Pending
- 2003-02-14 AU AU2003226977A patent/AU2003226977A1/en not_active Abandoned
- 2003-02-14 HU HU0402671A patent/HUP0402671A3/hu unknown
- 2003-02-14 JP JP2003571261A patent/JP4486363B2/ja not_active Expired - Fee Related
- 2003-02-14 MX MXPA04007960A patent/MXPA04007960A/es unknown
- 2003-02-14 KR KR10-2004-7013485A patent/KR20040095240A/ko not_active Withdrawn
- 2003-02-14 EP EP03742936A patent/EP1480960B1/de not_active Expired - Lifetime
- 2003-02-14 PL PL03370423A patent/PL370423A1/xx not_active Application Discontinuation
- 2003-02-14 WO PCT/EP2003/001484 patent/WO2003072555A1/de not_active Ceased
- 2003-02-14 HR HR20040782A patent/HRP20040782A2/hr not_active Application Discontinuation
- 2003-02-14 IL IL16368303A patent/IL163683A0/xx unknown
- 2003-02-14 CA CA002477031A patent/CA2477031A1/en not_active Abandoned
- 2003-02-14 BR BR0307921-0A patent/BR0307921A/pt not_active Application Discontinuation
- 2003-02-14 RU RU2004128933/04A patent/RU2004128933A/ru not_active Application Discontinuation
- 2003-02-26 TW TW092103969A patent/TW200400951A/zh unknown
- 2003-02-26 AR ARP030100624A patent/AR038701A1/es unknown
-
2004
- 2004-07-27 MA MA27803A patent/MA27172A1/fr unknown
- 2004-08-26 CO CO04083779A patent/CO5611146A2/es not_active Application Discontinuation
- 2004-09-27 NO NO20044090A patent/NO20044090L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20040782A2 (en) | 2005-02-28 |
| NO20044090L (no) | 2004-11-04 |
| PE20030928A1 (es) | 2003-12-17 |
| EP1480960B1 (de) | 2012-05-09 |
| EP1480960A1 (de) | 2004-12-01 |
| AU2003226977A1 (en) | 2003-09-09 |
| AR038701A1 (es) | 2005-01-26 |
| JP4486363B2 (ja) | 2010-06-23 |
| CO5611146A2 (es) | 2006-02-28 |
| KR20040095240A (ko) | 2004-11-12 |
| MA27172A1 (fr) | 2005-01-03 |
| CN1639137A (zh) | 2005-07-13 |
| RU2004128933A (ru) | 2005-04-20 |
| BR0307921A (pt) | 2004-12-21 |
| MXPA04007960A (es) | 2004-11-26 |
| ATE557012T1 (de) | 2012-05-15 |
| TW200400951A (en) | 2004-01-16 |
| IL163683A0 (en) | 2005-12-18 |
| HUP0402671A2 (hu) | 2005-04-28 |
| WO2003072555A1 (de) | 2003-09-04 |
| CA2477031A1 (en) | 2003-09-04 |
| JP2005519085A (ja) | 2005-06-30 |
| HUP0402671A3 (en) | 2006-07-28 |
| PL370423A1 (en) | 2005-05-30 |
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