DE102018006212A1 - Verfahren zum Nachweis einer Basophilenaktivierung - Google Patents

Verfahren zum Nachweis einer Basophilenaktivierung Download PDF

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Publication number
DE102018006212A1
DE102018006212A1 DE102018006212.1A DE102018006212A DE102018006212A1 DE 102018006212 A1 DE102018006212 A1 DE 102018006212A1 DE 102018006212 A DE102018006212 A DE 102018006212A DE 102018006212 A1 DE102018006212 A1 DE 102018006212A1
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Prior art keywords
basophils
allergen
ligand
marker
activated
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Withdrawn
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DE102018006212.1A
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German (de)
English (en)
Inventor
Julia GRUHNE
Henning Seismann
Alf WEIMANN
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Euroimmun Medizinische Labordiagnostika AG
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Euroimmun Medizinische Labordiagnostika AG
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Priority claimed from EP17001352.8A external-priority patent/EP3441763A1/de
Application filed by Euroimmun Medizinische Labordiagnostika AG filed Critical Euroimmun Medizinische Labordiagnostika AG
Publication of DE102018006212A1 publication Critical patent/DE102018006212A1/de
Withdrawn legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ecology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
DE102018006212.1A 2017-08-08 2018-08-07 Verfahren zum Nachweis einer Basophilenaktivierung Withdrawn DE102018006212A1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17001352.8 2017-08-08
EP17001352.8A EP3441763A1 (de) 2017-08-08 2017-08-08 Verfahren zum nachweis einer basophilenaktivierung
EP17001979.8 2017-12-05
EP17001979 2017-12-05

Publications (1)

Publication Number Publication Date
DE102018006212A1 true DE102018006212A1 (de) 2019-02-14

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ID=63041937

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102018006212.1A Withdrawn DE102018006212A1 (de) 2017-08-08 2018-08-07 Verfahren zum Nachweis einer Basophilenaktivierung

Country Status (13)

Country Link
US (1) US11119109B2 (https=)
EP (1) EP3441765B1 (https=)
JP (1) JP7265325B2 (https=)
KR (1) KR102547565B1 (https=)
CN (1) CN109387636B (https=)
AU (1) AU2018213977B2 (https=)
BR (1) BR102018015288A2 (https=)
CA (1) CA3012989C (https=)
DE (1) DE102018006212A1 (https=)
ES (1) ES2904354T3 (https=)
LT (1) LT3441765T (https=)
PL (1) PL3441765T3 (https=)
SG (1) SG10201806697RA (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210382070A1 (en) * 2020-06-04 2021-12-09 The Chinese University Of Hong Kong Diagnostic biomarkers for shrimp allergy
CN112630423A (zh) * 2020-12-31 2021-04-09 杭州福德敏生物技术有限公司 一种小麦免疫荧光检测试纸条及应用
KR102497904B1 (ko) * 2021-02-10 2023-02-10 재단법인 아산사회복지재단 세포 원심분리 및 농축을 이용한 면역세포 검출 방법 및 면역세포 검출용 칩

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985005640A1 (en) 1984-05-31 1985-12-19 Coulter Electronics, Inc. A reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes
US4902613A (en) 1984-05-14 1990-02-20 Becton, Dickinson And Company Lysing agent for analysis of peripheral blood cells
WO1998032014A1 (de) 1997-01-20 1998-07-23 Orpegen Pharma Gmbh Basophilen-degranulationstest
US6143567A (en) 1998-05-07 2000-11-07 Immunotech Reagents and a method for the lysis of erythrocytes
DE10235310A1 (de) 2002-08-01 2004-02-12 Molecular And Clinical Drug Research Verfahren zur Bestimmung allergener Potenz von Produkten
EP2037269A1 (en) 2007-09-11 2009-03-18 Bühlmann Laboratories AG Allergy test based on flow cytometric analysis
US20090246805A1 (en) 2008-03-28 2009-10-01 Sysmex Corporation Method for classifying and counting basophils
WO2012028167A2 (en) 2010-05-20 2012-03-08 Innohyphen Bv Acridinium ester chemiluminescence upon reductive triggering
WO2012044756A2 (en) 2010-10-01 2012-04-05 The Board Of Trustees Of The Leland Stanford Junior University Basophil activation based allergy diagnostic test

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DE3132491A1 (de) 1980-08-22 1982-07-01 Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad Verfahren zur durchfuehrung analytischer bestimmungen mittels der chemilumineszenzmethode und anwendung des verfahrens fuer immunassays
CZ292686B6 (cs) * 2001-09-17 2003-11-12 Imumed S. R. O. Způsob měření aktivace basofilů po stimulaci alergenem pro stanovení přecitlivělosti na tento alergen a příslušný kit
RU2289138C2 (ru) * 2004-12-14 2006-12-10 Научно-исследовательский институт микробиологии Министерства обороны Российской Федерации Способ аллергодиагностики по показателям хемилюминесцентного свечения нейтрофилов
US20100167317A1 (en) * 2008-08-05 2010-07-01 Institut Pasteur Process for enriching basophils in a blood sample
JP5937970B2 (ja) * 2011-01-31 2016-06-22 大鵬薬品工業株式会社 新規ヒノキ花粉アレルゲン
WO2014066271A1 (en) * 2012-10-22 2014-05-01 Becton, Dickinson And Company Non-b-lineage cells capable of producing antibody
PL3051928T3 (pl) 2015-01-29 2019-07-31 Kjellberg-Stiftung Palnik plazmowy
CN104677810B (zh) * 2015-01-30 2017-08-22 广东医学院附属医院 嗜碱性粒细胞活化的检测试剂盒及其使用方法
CN104777303B (zh) * 2015-04-29 2017-02-01 何韶衡 一种嗜碱性粒细胞激活、脱颗粒的鉴定方法
EP3196209B1 (en) 2016-01-25 2019-10-23 Euroimmun Medizinische Labordiagnostika AG A macadamia allergen
EP3244212A1 (en) 2017-02-15 2017-11-15 Euroimmun Medizinische Labordiagnostika AG An improved assay for the diagnosis of peanut allergy

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US4902613A (en) 1984-05-14 1990-02-20 Becton, Dickinson And Company Lysing agent for analysis of peripheral blood cells
WO1985005640A1 (en) 1984-05-31 1985-12-19 Coulter Electronics, Inc. A reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes
WO1998032014A1 (de) 1997-01-20 1998-07-23 Orpegen Pharma Gmbh Basophilen-degranulationstest
US6143567A (en) 1998-05-07 2000-11-07 Immunotech Reagents and a method for the lysis of erythrocytes
DE10235310A1 (de) 2002-08-01 2004-02-12 Molecular And Clinical Drug Research Verfahren zur Bestimmung allergener Potenz von Produkten
EP2037269A1 (en) 2007-09-11 2009-03-18 Bühlmann Laboratories AG Allergy test based on flow cytometric analysis
US20090246805A1 (en) 2008-03-28 2009-10-01 Sysmex Corporation Method for classifying and counting basophils
WO2012028167A2 (en) 2010-05-20 2012-03-08 Innohyphen Bv Acridinium ester chemiluminescence upon reductive triggering
WO2012044756A2 (en) 2010-10-01 2012-04-05 The Board Of Trustees Of The Leland Stanford Junior University Basophil activation based allergy diagnostic test

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C L Kepley, S S Craig and L B Schwartz. Identification and partial characterization of a unique marker for human basophils. J Immunol June 15, 1995, 154 (12) 6548-6555
I Weeks, I Beheshti, F McCapra, A K Campbell, J S Woodhead. Acridinium esters as high specific activity labels in immunoassay. Clin Chem 29: 1474-1479 (1983)
J. Allergy Clin. Immunol. 2003 Jul;112(1):102-8.
Joulia R, Valitutti S, Didier A, Espinosa E. Direct monitoring of basophil degranulation by using avidin-based probes. J Allergy Clin Immunol. 2017
Journal of Allergy and Clinical Immunology, 88(3), 328-338
Knol, E. F., Mul, F. P., Jansen, H., Calafat, J., & Roos, D. (1991)
Knol, E. F., Mul, F. P., Jansen, H., Calafat, J., & Roos, D. (1991). Monitoring human basophil activation via CD63 monoclonal antibody 435. Journal of Allergy and Clinical Immunology, 88(3), 328-338
Kricka L J. (2003).Clinical applications of chemiluminescence. Analytica chimica acta, 500(1): 279-286
Mochizuki A, McEuen AR, Buckley MG, Walls AF. The release of basogranulin in response to IgE-dependent and IgE-independent stimuli: validity of basogranulin measurement as an indicator of basophil activation. J. Allergy Clin. Immunol. 2003 Jul;112(1):102-8.
Natrajan et al. (2010) Enhanced immunoassay sensitivity using chemiluminescent acridinium esters with increased light output, Analytical Biochemistry, 27 July 2010
Neupert, W., Oelkers, R., Brune, K., Geisslinger, G. A new reliable chemiluminescence immunoassay (CLIA) for prostaglandin E2 using enhanced luminol as substrate. Prostaglandins. 1996 Nov;52(5):385-401
Rogers et al. (1993) Recombinant FeI d.I: Expression, purification, IgE binding and reaction with cat-allergic human T cells., Molecular Immunology, 30 April 2010 (6), 559-568
Sainte-Laudy, J. Sabba, A., Vallon C, Guerin JC (1998). Analysis of anti-IgE and allergen induced human basophil activation by flow cytometry. Comparison with histamine release. Inflamm Res. 47(10), 401-8.
Xiaoming Zhou, Debin Zhu, Yuhui Liao, Weipeng Liu, Hongxing Liu, Zhaokui Ma & Da Xing (2014). Synthesis, labeling and bioanalytical applications of a tris(2,2-bipyridyl)ruthenium(II)-based electrochemiluminescence probe. Nature Protocols Volume 9, Pages: 1146-1159

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Publication number Publication date
AU2018213977A1 (en) 2019-02-28
AU2018213977B2 (en) 2025-02-20
CA3012989C (en) 2026-02-10
US20190049461A1 (en) 2019-02-14
BR102018015288A2 (pt) 2021-11-09
CA3012989A1 (en) 2019-02-08
JP2019032317A (ja) 2019-02-28
LT3441765T (lt) 2022-01-10
KR20190016446A (ko) 2019-02-18
KR102547565B1 (ko) 2023-06-26
EP3441765A1 (de) 2019-02-13
US11119109B2 (en) 2021-09-14
EP3441765B1 (de) 2021-10-20
CN109387636A (zh) 2019-02-26
SG10201806697RA (en) 2019-03-28
PL3441765T3 (pl) 2022-02-14
JP7265325B2 (ja) 2023-04-26
ES2904354T3 (es) 2022-04-04
CN109387636B (zh) 2023-07-04

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