CA3012989C - Method for detecting basophil activation - Google Patents

Method for detecting basophil activation

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Publication number
CA3012989C
CA3012989C CA3012989A CA3012989A CA3012989C CA 3012989 C CA3012989 C CA 3012989C CA 3012989 A CA3012989 A CA 3012989A CA 3012989 A CA3012989 A CA 3012989A CA 3012989 C CA3012989 C CA 3012989C
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CA
Canada
Prior art keywords
basophils
chemiluminescence
allergen
ligand
marker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3012989A
Other languages
English (en)
French (fr)
Other versions
CA3012989A1 (en
Inventor
Julia GRUHNE
Henning Seismann
Alf WEIMANN
Original Assignee
Euroimmun Medizinische Labordiagnostika AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP17001352.8A external-priority patent/EP3441763A1/de
Application filed by Euroimmun Medizinische Labordiagnostika AG filed Critical Euroimmun Medizinische Labordiagnostika AG
Publication of CA3012989A1 publication Critical patent/CA3012989A1/en
Application granted granted Critical
Publication of CA3012989C publication Critical patent/CA3012989C/en
Active legal-status Critical Current
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ecology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
CA3012989A 2017-08-08 2018-08-01 Method for detecting basophil activation Active CA3012989C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17001352.8 2017-08-08
EP17001352.8A EP3441763A1 (de) 2017-08-08 2017-08-08 Verfahren zum nachweis einer basophilenaktivierung
EP17001979.8 2017-12-05
EP17001979 2017-12-05

Publications (2)

Publication Number Publication Date
CA3012989A1 CA3012989A1 (en) 2019-02-08
CA3012989C true CA3012989C (en) 2026-02-10

Family

ID=63041937

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3012989A Active CA3012989C (en) 2017-08-08 2018-08-01 Method for detecting basophil activation

Country Status (13)

Country Link
US (1) US11119109B2 (https=)
EP (1) EP3441765B1 (https=)
JP (1) JP7265325B2 (https=)
KR (1) KR102547565B1 (https=)
CN (1) CN109387636B (https=)
AU (1) AU2018213977B2 (https=)
BR (1) BR102018015288A2 (https=)
CA (1) CA3012989C (https=)
DE (1) DE102018006212A1 (https=)
ES (1) ES2904354T3 (https=)
LT (1) LT3441765T (https=)
PL (1) PL3441765T3 (https=)
SG (1) SG10201806697RA (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210382070A1 (en) * 2020-06-04 2021-12-09 The Chinese University Of Hong Kong Diagnostic biomarkers for shrimp allergy
CN112630423A (zh) * 2020-12-31 2021-04-09 杭州福德敏生物技术有限公司 一种小麦免疫荧光检测试纸条及应用
KR102497904B1 (ko) * 2021-02-10 2023-02-10 재단법인 아산사회복지재단 세포 원심분리 및 농축을 이용한 면역세포 검출 방법 및 면역세포 검출용 칩

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3132491A1 (de) 1980-08-22 1982-07-01 Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad Verfahren zur durchfuehrung analytischer bestimmungen mittels der chemilumineszenzmethode und anwendung des verfahrens fuer immunassays
US4902613A (en) 1984-05-14 1990-02-20 Becton, Dickinson And Company Lysing agent for analysis of peripheral blood cells
DE3587636T2 (de) 1984-05-31 1994-03-10 Coulter Corp Reagenssystem und verfahren zum nachweis, aufzählen und prüfen der klassen und unterklassen von blutleukozyten.
US6835551B2 (en) 1997-01-20 2004-12-28 Orpegen Pharma Gmbh Basophil degranulation test
FR2778413B1 (fr) 1998-05-07 2000-08-04 Immunotech Sa Nouveaux reactifs et methode de lyse des erythrocytes
CZ292686B6 (cs) * 2001-09-17 2003-11-12 Imumed S. R. O. Způsob měření aktivace basofilů po stimulaci alergenem pro stanovení přecitlivělosti na tento alergen a příslušný kit
DE10235310B4 (de) 2002-08-01 2012-05-16 Molecular And Clinical Drug Research Verfahren zur Bestimmung allergener Potenz von Produkten
RU2289138C2 (ru) * 2004-12-14 2006-12-10 Научно-исследовательский институт микробиологии Министерства обороны Российской Федерации Способ аллергодиагностики по показателям хемилюминесцентного свечения нейтрофилов
EP2037269B1 (en) * 2007-09-11 2014-04-02 Bühlmann Laboratories AG Allergy test based on flow cytometric analysis
JP2009236798A (ja) 2008-03-28 2009-10-15 Sysmex Corp 好塩基球の分類計数方法
US20100167317A1 (en) * 2008-08-05 2010-07-01 Institut Pasteur Process for enriching basophils in a blood sample
WO2012028167A2 (en) 2010-05-20 2012-03-08 Innohyphen Bv Acridinium ester chemiluminescence upon reductive triggering
US20120083007A1 (en) 2010-10-01 2012-04-05 Nadeau Kari C Basophil Activation Based Allergy Diagnostic Test
JP5937970B2 (ja) * 2011-01-31 2016-06-22 大鵬薬品工業株式会社 新規ヒノキ花粉アレルゲン
WO2014066271A1 (en) * 2012-10-22 2014-05-01 Becton, Dickinson And Company Non-b-lineage cells capable of producing antibody
PL3051928T3 (pl) 2015-01-29 2019-07-31 Kjellberg-Stiftung Palnik plazmowy
CN104677810B (zh) * 2015-01-30 2017-08-22 广东医学院附属医院 嗜碱性粒细胞活化的检测试剂盒及其使用方法
CN104777303B (zh) * 2015-04-29 2017-02-01 何韶衡 一种嗜碱性粒细胞激活、脱颗粒的鉴定方法
EP3196209B1 (en) 2016-01-25 2019-10-23 Euroimmun Medizinische Labordiagnostika AG A macadamia allergen
EP3244212A1 (en) 2017-02-15 2017-11-15 Euroimmun Medizinische Labordiagnostika AG An improved assay for the diagnosis of peanut allergy

Also Published As

Publication number Publication date
AU2018213977A1 (en) 2019-02-28
AU2018213977B2 (en) 2025-02-20
US20190049461A1 (en) 2019-02-14
BR102018015288A2 (pt) 2021-11-09
DE102018006212A1 (de) 2019-02-14
CA3012989A1 (en) 2019-02-08
JP2019032317A (ja) 2019-02-28
LT3441765T (lt) 2022-01-10
KR20190016446A (ko) 2019-02-18
KR102547565B1 (ko) 2023-06-26
EP3441765A1 (de) 2019-02-13
US11119109B2 (en) 2021-09-14
EP3441765B1 (de) 2021-10-20
CN109387636A (zh) 2019-02-26
SG10201806697RA (en) 2019-03-28
PL3441765T3 (pl) 2022-02-14
JP7265325B2 (ja) 2023-04-26
ES2904354T3 (es) 2022-04-04
CN109387636B (zh) 2023-07-04

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