DE102014213783B3 - Verfahren zur Identifizierung hochaffiner Komplexe aus zwei Liganden und einem Rezeptor, Vorrichtung zur Durchführung des Verfahrens und selbst-assemblierende chemische Bibliothek zur Verwendung in dem Verfahren - Google Patents
Verfahren zur Identifizierung hochaffiner Komplexe aus zwei Liganden und einem Rezeptor, Vorrichtung zur Durchführung des Verfahrens und selbst-assemblierende chemische Bibliothek zur Verwendung in dem Verfahren Download PDFInfo
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- DE102014213783B3 DE102014213783B3 DE102014213783.7A DE102014213783A DE102014213783B3 DE 102014213783 B3 DE102014213783 B3 DE 102014213783B3 DE 102014213783 A DE102014213783 A DE 102014213783A DE 102014213783 B3 DE102014213783 B3 DE 102014213783B3
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102014213783.7A DE102014213783B3 (de) | 2014-07-16 | 2014-07-16 | Verfahren zur Identifizierung hochaffiner Komplexe aus zwei Liganden und einem Rezeptor, Vorrichtung zur Durchführung des Verfahrens und selbst-assemblierende chemische Bibliothek zur Verwendung in dem Verfahren |
| ES18207435T ES3002709T3 (en) | 2014-07-16 | 2015-07-10 | Method for identification of high affinity complexes comprising two ligands and a receptor, device for carrying out said method and self-assembling chemical library for use in the method |
| PCT/EP2015/065874 WO2016008822A2 (de) | 2014-07-16 | 2015-07-10 | Verfahren zur identifizierung hochaffiner komplexe aus zwei liganden und einem rezeptor, vorrichtung zur durchführung des verfahrens und selbst-assemblierende chemische bibliothek zur verwendung in dem verfahren |
| DK15744501.6T DK3169832T3 (en) | 2014-07-16 | 2015-07-10 | Method for identifying high-affinity complexes of two ligands and a receptor |
| US15/326,172 US11365439B2 (en) | 2014-07-16 | 2015-07-10 | Method for identifying high-affinity complexes made of two ligands and one receptor, device for implementing the method and self-assembling chemical library for use in the method |
| JP2017502621A JP6831776B2 (ja) | 2014-07-16 | 2015-07-10 | ２個のリガンドと１個のレセプタとからなる高親和性錯体の特定方法と該方法を実行する装置及び該方法に用いられる自己集合型ケミカルライブラリ |
| CA2955087A CA2955087C (en) | 2014-07-16 | 2015-07-10 | Method for identifying high-affinity complexes of two ligands and a receptor using a self-assemblying chemical library of ligands |
| EP18207435.1A EP3477299B1 (de) | 2014-07-16 | 2015-07-10 | Verfahren zur identifizierung hochaffiner komplexe aus zwei liganden und einem rezeptor, vorrichtung zur durchführung des verfahrens und selbst-assemblierende chemische bibliothek zur verwendung in dem verfahren |
| ES15744501T ES2712899T3 (es) | 2014-07-16 | 2015-07-10 | Procedimiento para la identificación de complejos altamente afines a base de dos ligandos y un receptor |
| EP15744501.6A EP3169832B1 (de) | 2014-07-16 | 2015-07-10 | Verfahren zur identifizierung hochaffiner komplexe aus zwei liganden und einem rezeptor |
| JP2021013303A JP7112540B2 (ja) | 2014-07-16 | 2021-01-29 | ２個のリガンドと１個のレセプタとからなる高親和性錯体の特定方法と該方法を実行する装置及び該方法に用いられる自己集合型ケミカルライブラリ |
| US17/834,197 US20220298552A1 (en) | 2014-07-16 | 2022-06-07 | Method for identifying high-affinity complexes made of two ligands and one receptor, device for implementing the method and self-assembling chemical library for use in the method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102014213783.7A DE102014213783B3 (de) | 2014-07-16 | 2014-07-16 | Verfahren zur Identifizierung hochaffiner Komplexe aus zwei Liganden und einem Rezeptor, Vorrichtung zur Durchführung des Verfahrens und selbst-assemblierende chemische Bibliothek zur Verwendung in dem Verfahren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102014213783B3 true DE102014213783B3 (de) | 2015-06-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102014213783.7A Active DE102014213783B3 (de) | 2014-07-16 | 2014-07-16 | Verfahren zur Identifizierung hochaffiner Komplexe aus zwei Liganden und einem Rezeptor, Vorrichtung zur Durchführung des Verfahrens und selbst-assemblierende chemische Bibliothek zur Verwendung in dem Verfahren |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11365439B2 (enExample) |
| EP (2) | EP3477299B1 (enExample) |
| JP (2) | JP6831776B2 (enExample) |
| CA (1) | CA2955087C (enExample) |
| DE (1) | DE102014213783B3 (enExample) |
| DK (1) | DK3169832T3 (enExample) |
| ES (2) | ES2712899T3 (enExample) |
| WO (1) | WO2016008822A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109312492B (zh) | 2016-06-16 | 2022-10-04 | 哈斯达克科学公司 | 寡核苷酸指导和记录的编码探针分子的组合合成 |
| US11795580B2 (en) | 2017-05-02 | 2023-10-24 | Haystack Sciences Corporation | Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same |
| CN107652453B (zh) * | 2017-09-26 | 2020-05-05 | 天津工业大学 | 接枝rgd短肽温敏可注射水凝胶及其制备方法和应用 |
| EP3604525B1 (en) * | 2018-08-02 | 2021-03-10 | TU Dresden | Method for providing a dna-encoded library, dna-encoded library and method of decoding a dna-encoded library |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003076943A1 (en) * | 2002-03-08 | 2003-09-18 | Eidgenössische Technische Hochschule Zürich | Encoded self-assembling chemical libraries (esachel) |
| WO2008036273A2 (en) * | 2006-09-18 | 2008-03-27 | Ensemble Discovery Corporation | Receptor family profiling |
| WO2010150103A2 (en) * | 2009-06-22 | 2010-12-29 | Universite De Strasbourg | Method of preparing an adduct |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512439A (en) * | 1988-11-21 | 1996-04-30 | Dynal As | Oligonucleotide-linked magnetic particles and uses thereof |
| US7018793B1 (en) * | 1995-12-07 | 2006-03-28 | Diversa Corporation | Combinatorial screening of mixed populations of organisms |
| DE19619373A1 (de) * | 1996-05-14 | 1997-11-20 | Hoechst Ag | Neue Substanzbibliothek und damit hergestellte supramolekulare Komplexe |
| AU2002307152A1 (en) * | 2001-04-06 | 2002-10-21 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| EP1615948B1 (en) * | 2003-04-18 | 2015-04-01 | Becton Dickinson and Company | Immuno-amplification |
| US7229769B2 (en) * | 2005-03-25 | 2007-06-12 | Illumina, Inc. | Compositions and methods for detecting protease activity |
| JP2009034052A (ja) * | 2007-08-02 | 2009-02-19 | Canon Inc | ハイブリダイゼーション方法および装置 |
| EP2138587A1 (en) * | 2008-06-23 | 2009-12-30 | Koninklijke Philips Electronics N.V. | Amplification of nucleic acids using temperature zones |
| CN102076870A (zh) | 2008-06-25 | 2011-05-25 | 实时基因组有限公司 | 对微阵列上的核酸进行解链曲线分析的方法和装置 |
| US10190986B2 (en) * | 2011-06-06 | 2019-01-29 | Abbott Laboratories | Spatially resolved ligand-receptor binding assays |
| BE1020816A5 (fr) | 2012-07-04 | 2014-05-06 | Coris Bioconcept Sprl | Procede et dispositif pour la detection rapide de sequences nucleotidiques amplifiees. |
| US9567632B2 (en) * | 2013-03-19 | 2017-02-14 | New England Biolabs, Inc. | Enrichment of target sequences |
-
2014
- 2014-07-16 DE DE102014213783.7A patent/DE102014213783B3/de active Active
-
2015
- 2015-07-10 ES ES15744501T patent/ES2712899T3/es active Active
- 2015-07-10 CA CA2955087A patent/CA2955087C/en active Active
- 2015-07-10 EP EP18207435.1A patent/EP3477299B1/de active Active
- 2015-07-10 US US15/326,172 patent/US11365439B2/en active Active
- 2015-07-10 EP EP15744501.6A patent/EP3169832B1/de active Active
- 2015-07-10 DK DK15744501.6T patent/DK3169832T3/en active
- 2015-07-10 ES ES18207435T patent/ES3002709T3/es active Active
- 2015-07-10 WO PCT/EP2015/065874 patent/WO2016008822A2/de not_active Ceased
- 2015-07-10 JP JP2017502621A patent/JP6831776B2/ja active Active
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2021
- 2021-01-29 JP JP2021013303A patent/JP7112540B2/ja active Active
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2022
- 2022-06-07 US US17/834,197 patent/US20220298552A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003076943A1 (en) * | 2002-03-08 | 2003-09-18 | Eidgenössische Technische Hochschule Zürich | Encoded self-assembling chemical libraries (esachel) |
| WO2008036273A2 (en) * | 2006-09-18 | 2008-03-27 | Ensemble Discovery Corporation | Receptor family profiling |
| WO2010150103A2 (en) * | 2009-06-22 | 2010-12-29 | Universite De Strasbourg | Method of preparing an adduct |
Non-Patent Citations (3)
| Title |
|---|
| SVENSEN, N. [u.a.]: Decoding a PNA encoded peptide library by PCR: the discovery of new cell surface receptor ligands. Chem. Biol. (2011) 18 (10) 1284-9 * |
| WINSSINGER, N. [u.a.]: DNA display of PNA-tagged ligands. Artificial DNA: PNA & XNA (2012) 3 (3) 105-108 * |
| WINSSINGER, N. [u.a.]: DNA display of PNA-tagged ligands. Artificial DNA: PNA & XNA (2012) 3 (3) 105–108 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2955087A1 (en) | 2016-01-21 |
| US11365439B2 (en) | 2022-06-21 |
| US20220298552A1 (en) | 2022-09-22 |
| EP3169832B1 (de) | 2018-12-05 |
| US20170198336A1 (en) | 2017-07-13 |
| EP3169832A2 (de) | 2017-05-24 |
| EP3477299C0 (de) | 2024-12-11 |
| CA2955087C (en) | 2023-03-07 |
| EP3477299B1 (de) | 2024-12-11 |
| WO2016008822A3 (de) | 2016-05-19 |
| JP6831776B2 (ja) | 2021-02-17 |
| ES3002709T3 (en) | 2025-03-07 |
| WO2016008822A2 (de) | 2016-01-21 |
| JP7112540B2 (ja) | 2022-08-03 |
| JP2017529062A (ja) | 2017-10-05 |
| EP3477299A1 (de) | 2019-05-01 |
| ES2712899T3 (es) | 2019-05-16 |
| DK3169832T3 (en) | 2019-03-25 |
| JP2021092576A (ja) | 2021-06-17 |
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