DE102013016750A1 - Neue Poly(ethylenimin) basierte Copolymere zur Anbindung und Freisetzung von genetischem Material, insbesondere von DNA/RNA, sowie Verfahren zu deren Herstellung und Verwendung - Google Patents

Neue Poly(ethylenimin) basierte Copolymere zur Anbindung und Freisetzung von genetischem Material, insbesondere von DNA/RNA, sowie Verfahren zu deren Herstellung und Verwendung Download PDF

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Publication number
DE102013016750A1
DE102013016750A1 DE102013016750.7A DE102013016750A DE102013016750A1 DE 102013016750 A1 DE102013016750 A1 DE 102013016750A1 DE 102013016750 A DE102013016750 A DE 102013016750A DE 102013016750 A1 DE102013016750 A1 DE 102013016750A1
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DE
Germany
Prior art keywords
ethyleneimine
release
genetic material
based copolymers
units
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE102013016750.7A
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German (de)
English (en)
Inventor
Christoph Englert
Lutz Tauhardt
Michael Gottschaldt
Ulrich S. Schubert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smartdyelivery GmbH
Original Assignee
Friedrich Schiller Universtaet Jena FSU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friedrich Schiller Universtaet Jena FSU filed Critical Friedrich Schiller Universtaet Jena FSU
Priority to DE102013016750.7A priority Critical patent/DE102013016750A1/de
Priority to ES14803038.0T priority patent/ES2691094T3/es
Priority to HUE14803038A priority patent/HUE040402T2/hu
Priority to PCT/DE2014/000500 priority patent/WO2015048940A1/de
Priority to EP14803038.0A priority patent/EP3052545B1/de
Priority to CN201480059919.6A priority patent/CN105683256B/zh
Priority to US15/026,882 priority patent/US10131747B2/en
Priority to CA2926154A priority patent/CA2926154C/en
Priority to DK14803038.0T priority patent/DK3052545T3/en
Priority to JP2016519856A priority patent/JP6431533B2/ja
Publication of DE102013016750A1 publication Critical patent/DE102013016750A1/de
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE102013016750.7A 2013-10-02 2013-10-02 Neue Poly(ethylenimin) basierte Copolymere zur Anbindung und Freisetzung von genetischem Material, insbesondere von DNA/RNA, sowie Verfahren zu deren Herstellung und Verwendung Granted DE102013016750A1 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DE102013016750.7A DE102013016750A1 (de) 2013-10-02 2013-10-02 Neue Poly(ethylenimin) basierte Copolymere zur Anbindung und Freisetzung von genetischem Material, insbesondere von DNA/RNA, sowie Verfahren zu deren Herstellung und Verwendung
ES14803038.0T ES2691094T3 (es) 2013-10-02 2014-10-02 Nuevos copolímeros basados en poli(etilenimina) para el enlace y liberación de material genético, particularmente de ADN/ARN, así como método para su fabricación y uso
HUE14803038A HUE040402T2 (hu) 2013-10-02 2014-10-02 Új poli(etilénimin) alapú kopolimerek kötésre genetikai anyaghoz, elsõsorban DNS/RNS-hez, és annak elbocsátásához, és eljárás ezen kopolimerek elõállítására és alkalmazására
PCT/DE2014/000500 WO2015048940A1 (de) 2013-10-02 2014-10-02 Neue poly(ethylenimin) basierte copolymere zur anbindung und freisetzung von genetischem material, insbesondere von dna/rna, sowie verfahren zu deren herstellung und verwendung
EP14803038.0A EP3052545B1 (de) 2013-10-02 2014-10-02 Neue poly(ethylenimin) basierte copolymere zur anbindung und freisetzung von genetischem material, insbesondere von dna/rna, sowie verfahren zu deren herstellung und verwendung
CN201480059919.6A CN105683256B (zh) 2013-10-02 2014-10-02 用于连接和释放遗传物质，特别是dna/rna，的新型聚乙烯亚胺‑基共聚物及其制备方法和用途
US15/026,882 US10131747B2 (en) 2013-10-02 2014-10-02 Poly(ethylene imine)-based copolymers for bonding to and releasing genetic material, in particular DNA/RNA, and method for the production and use of same
CA2926154A CA2926154C (en) 2013-10-02 2014-10-02 New poly(ethylene imine)-based copolymers for bonding to and releasing genetic material, in particular dna/rna, and method for the production and use of same
DK14803038.0T DK3052545T3 (en) 2013-10-02 2014-10-02 New poly (ethyleneimine) -based copolymers for binding to and releasing genetic material, especially DNA / RNA, and methods for their preparation and use
JP2016519856A JP6431533B2 (ja) 2013-10-02 2014-10-02 遺伝物質、特にｄｎａ／ｒｎａへの結合及びその放出のための新規ポリ（エチレンイミン）系コポリマー、並びに該コポリマーの製造方法及び使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102013016750.7A DE102013016750A1 (de) 2013-10-02 2013-10-02 Neue Poly(ethylenimin) basierte Copolymere zur Anbindung und Freisetzung von genetischem Material, insbesondere von DNA/RNA, sowie Verfahren zu deren Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
DE102013016750A1 true DE102013016750A1 (de) 2015-04-02

Family

ID=51986963

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102013016750.7A Granted DE102013016750A1 (de) 2013-10-02 2013-10-02 Neue Poly(ethylenimin) basierte Copolymere zur Anbindung und Freisetzung von genetischem Material, insbesondere von DNA/RNA, sowie Verfahren zu deren Herstellung und Verwendung

Country Status (10)

Country Link
US (1) US10131747B2 (https=)
EP (1) EP3052545B1 (https=)
JP (1) JP6431533B2 (https=)
CN (1) CN105683256B (https=)
CA (1) CA2926154C (https=)
DE (1) DE102013016750A1 (https=)
DK (1) DK3052545T3 (https=)
ES (1) ES2691094T3 (https=)
HU (1) HUE040402T2 (https=)
WO (1) WO2015048940A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101892955B1 (ko) 2017-01-25 2018-08-29 국방과학연구소 치환된 Poly[2-(3-butenyl)-2-oxazoline] 및 Nylon-6,6를 포함하는 섬유 및 그 제조방법
EP4229115A1 (en) * 2020-10-19 2023-08-23 Universiteit Gent Cross-linkable allylamido polymers

Citations (8)

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DE19726186A1 (de) * 1997-06-20 1998-12-24 Boehringer Ingelheim Int Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen
JP2005137253A (ja) * 2003-11-06 2005-06-02 Kawamura Inst Of Chem Res ポリイオン会合体およびポリイオン会合体からなる生体物質キャリアー
DE20122328U1 (de) * 2001-12-07 2006-02-09 Sandler Ag Neue modifizierte Poly-2-oxazoline
WO2007084797A1 (en) 2006-01-23 2007-07-26 Abbott Laboratories Chemically modified polycation polymer for sirna delivery
WO2009102952A2 (en) 2008-02-13 2009-08-20 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
US20090215166A1 (en) * 2005-08-17 2009-08-27 Universitat Regensburg Cationic Polymer for Transporting Nucleic Acids in Cells
WO2011162366A1 (ja) 2010-06-25 2011-12-29 東レ株式会社 水溶性ポリマー及び水溶性ナノ粒子複合体
WO2012149591A1 (de) 2011-05-03 2012-11-08 Ke-Kelit Kunststoffwerk Gesellschaft M.B.H. Verwendung von kontaktbioziden basierend auf poly (2 - substituierten) oxazolinen

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US3251778A (en) * 1960-08-04 1966-05-17 Petrolite Corp Process of preventing scale
DE10029028A1 (de) * 2000-06-13 2001-12-20 Basf Ag Verwendung von acylierten Polyaminen zur Modifizierung von Oberflächen
US20050238825A1 (en) * 2004-04-26 2005-10-27 Isp Investments Inc. Crosslinked polymeric composition
JP5642673B2 (ja) * 2008-07-10 2014-12-17 セリナ・セラピユーテイツクス・インコーポレーテツド 不活性末端基を有するポリオキサゾリン類、保護された開始基から調製されるポリオキサゾリン類及び関連化合物
CN101768276B (zh) * 2008-12-26 2011-11-30 中国科学技术大学 聚乙二醇单甲醚-聚己内酯-聚乙烯亚胺三嵌段共聚物及其应用
RU2593755C2 (ru) * 2011-01-04 2016-08-10 Бендер Аналитикал Холдинг Б.В. Сшитые полимеры и имплантаты, произведенные из электрофильно активированного полиоксазолина
EP2683420B1 (en) * 2011-03-11 2018-05-23 W. L. Gore & Associates, Inc. Improvements to immobilised biological entities
US9416228B2 (en) * 2012-03-16 2016-08-16 Bender Analytical Holding B.V. Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline

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Publication number Priority date Publication date Assignee Title
DE19726186A1 (de) * 1997-06-20 1998-12-24 Boehringer Ingelheim Int Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen
DE20122328U1 (de) * 2001-12-07 2006-02-09 Sandler Ag Neue modifizierte Poly-2-oxazoline
JP2005137253A (ja) * 2003-11-06 2005-06-02 Kawamura Inst Of Chem Res ポリイオン会合体およびポリイオン会合体からなる生体物質キャリアー
US20090215166A1 (en) * 2005-08-17 2009-08-27 Universitat Regensburg Cationic Polymer for Transporting Nucleic Acids in Cells
WO2007084797A1 (en) 2006-01-23 2007-07-26 Abbott Laboratories Chemically modified polycation polymer for sirna delivery
US20080112916A1 (en) * 2006-01-23 2008-05-15 Ernst Wagner CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY
WO2009102952A2 (en) 2008-02-13 2009-08-20 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
WO2011162366A1 (ja) 2010-06-25 2011-12-29 東レ株式会社 水溶性ポリマー及び水溶性ナノ粒子複合体
WO2012149591A1 (de) 2011-05-03 2012-11-08 Ke-Kelit Kunststoffwerk Gesellschaft M.B.H. Verwendung von kontaktbioziden basierend auf poly (2 - substituierten) oxazolinen

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A. Gress, A. Völkel, H. Schlaad; Thio-click modification of poly[2-(3-butenyl)-2-oxazoline] Macromolecules 40, 2007, 7928-7933
A. M. Doody, J. N. Korley, K. P. Dang, P. N. Zawaneh, D. Putnam: Characterizing the structure/function parameter space of hydrocarbonconjugated branched polyethylenimine for DNA delivery in vitro, J. Control. Release 116, 2006, 227-237
D. Sehgal, I. K. Vijay: A method for the high efficiency of water-soluble carbodiimide-mediated amidation, Anal. Biochem. 218, 1994, 87-91
H. Tian, F. Li, J. Chen, Y. Huang, X. Chen: N-Isopropylacrylamide-Modified Polyethylenimines as Effective Gene Carriers, Macromolecular. Bioscience 12, 2012, 1680-1688
L. Van, W. T. S. Huck, X. -M. Zhao, G. M. Whitesides: Patterning Thin Films of Poly(ethylene imine) an a Reactive SAM Using Microcontact Printing, Langmuir 15, 1999, 1208-1214
M. L. Forrest, G. E. Meister, J. T. Koerber, D. W. Packl: Partial Acetylation of Polyethylenimin Enhances In Vitro Gene Delivery, Pharm. Res. 21, 2004, 365-371
M. Thomas, A. M. Klibanov: Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells, PNAS 99, 2002, 14640-14645
NIMESH, Surendra et. al.: Influence of acyl chain length on transfection mediated by acylated PEI nanoparticles. In: International Journal of Pharmaceutics, Vol. 337, (2007), 265-374 *
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Also Published As

Publication number Publication date
HUE040402T2 (hu) 2019-03-28
US10131747B2 (en) 2018-11-20
JP6431533B2 (ja) 2018-11-28
CA2926154A1 (en) 2015-04-09
CA2926154C (en) 2022-08-30
EP3052545B1 (de) 2018-07-25
CN105683256B (zh) 2018-02-23
CN105683256A (zh) 2016-06-15
DK3052545T3 (en) 2018-10-29
ES2691094T3 (es) 2018-11-23
JP2016533409A (ja) 2016-10-27
US20170166697A1 (en) 2017-06-15
WO2015048940A1 (de) 2015-04-09
EP3052545A1 (de) 2016-08-10

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