CN105683256B - 用于连接和释放遗传物质，特别是dna/rna，的新型聚乙烯亚胺‑基共聚物及其制备方法和用途 - Google Patents

用于连接和释放遗传物质，特别是dna/rna，的新型聚乙烯亚胺‑基共聚物及其制备方法和用途 Download PDF

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CN105683256B
CN105683256B CN201480059919.6A CN201480059919A CN105683256B CN 105683256 B CN105683256 B CN 105683256B CN 201480059919 A CN201480059919 A CN 201480059919A CN 105683256 B CN105683256 B CN 105683256B
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genetic material
polyethyleneimine
units
linking
copolymer
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Chinese (zh)
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CN105683256A (zh
Inventor
C·恩勒特
L·陶哈尔特
M·戈特沙尔克
U·S·舒伯特
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Smat Dai Li Li Co Ltd
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Friedrich Schiller Universtaet Jena FSU
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480059919.6A 2013-10-02 2014-10-02 用于连接和释放遗传物质，特别是dna/rna，的新型聚乙烯亚胺‑基共聚物及其制备方法和用途 Active CN105683256B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102013016750.7A DE102013016750A1 (de) 2013-10-02 2013-10-02 Neue Poly(ethylenimin) basierte Copolymere zur Anbindung und Freisetzung von genetischem Material, insbesondere von DNA/RNA, sowie Verfahren zu deren Herstellung und Verwendung
DE102013016750.7 2013-10-02
PCT/DE2014/000500 WO2015048940A1 (de) 2013-10-02 2014-10-02 Neue poly(ethylenimin) basierte copolymere zur anbindung und freisetzung von genetischem material, insbesondere von dna/rna, sowie verfahren zu deren herstellung und verwendung

Publications (2)

Publication Number Publication Date
CN105683256A CN105683256A (zh) 2016-06-15
CN105683256B true CN105683256B (zh) 2018-02-23

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CN201480059919.6A Active CN105683256B (zh) 2013-10-02 2014-10-02 用于连接和释放遗传物质，特别是dna/rna，的新型聚乙烯亚胺‑基共聚物及其制备方法和用途

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US (1) US10131747B2 (https=)
EP (1) EP3052545B1 (https=)
JP (1) JP6431533B2 (https=)
CN (1) CN105683256B (https=)
CA (1) CA2926154C (https=)
DE (1) DE102013016750A1 (https=)
DK (1) DK3052545T3 (https=)
ES (1) ES2691094T3 (https=)
HU (1) HUE040402T2 (https=)
WO (1) WO2015048940A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101892955B1 (ko) 2017-01-25 2018-08-29 국방과학연구소 치환된 Poly[2-(3-butenyl)-2-oxazoline] 및 Nylon-6,6를 포함하는 섬유 및 그 제조방법
EP4229115A1 (en) * 2020-10-19 2023-08-23 Universiteit Gent Cross-linkable allylamido polymers

Citations (4)

* Cited by examiner, † Cited by third party
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US3251778A (en) * 1960-08-04 1966-05-17 Petrolite Corp Process of preventing scale
CN101768276A (zh) * 2008-12-26 2010-07-07 中国科学技术大学 聚乙二醇单甲醚-聚己内酯-聚乙烯亚胺三嵌段共聚物及其应用
CN102971361A (zh) * 2010-06-25 2013-03-13 东丽株式会社 水溶性聚合物及水溶性纳米粒子复合体
WO2013137736A1 (en) * 2012-03-16 2013-09-19 Bender Analytical Holding B.V. Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline

Family Cites Families (12)

* Cited by examiner, † Cited by third party
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DE19726186A1 (de) * 1997-06-20 1998-12-24 Boehringer Ingelheim Int Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen
DE10029028A1 (de) * 2000-06-13 2001-12-20 Basf Ag Verwendung von acylierten Polyaminen zur Modifizierung von Oberflächen
DE20122328U1 (de) * 2001-12-07 2006-02-09 Sandler Ag Neue modifizierte Poly-2-oxazoline
JP4368183B2 (ja) * 2003-11-06 2009-11-18 財団法人川村理化学研究所 ポリイオン会合体およびポリイオン会合体からなる生体物質キャリアー
US20050238825A1 (en) * 2004-04-26 2005-10-27 Isp Investments Inc. Crosslinked polymeric composition
DE102005039154A1 (de) * 2005-08-17 2007-03-01 GÖPFERICH, Achim, Prof. Dr. Bioabbaubare Polymere für den Transport von Nukleinsäuren in Zellen
US20070231392A1 (en) * 2006-01-23 2007-10-04 Ernst Wagner CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY
CA2711455C (en) 2008-02-13 2016-06-07 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
JP5642673B2 (ja) * 2008-07-10 2014-12-17 セリナ・セラピユーテイツクス・インコーポレーテツド 不活性末端基を有するポリオキサゾリン類、保護された開始基から調製されるポリオキサゾリン類及び関連化合物
RU2593755C2 (ru) * 2011-01-04 2016-08-10 Бендер Аналитикал Холдинг Б.В. Сшитые полимеры и имплантаты, произведенные из электрофильно активированного полиоксазолина
EP2683420B1 (en) * 2011-03-11 2018-05-23 W. L. Gore & Associates, Inc. Improvements to immobilised biological entities
AT511386B1 (de) 2011-05-03 2013-03-15 Ke Kelit Kunststoffwerk Gmbh Kontaktbiozid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3251778A (en) * 1960-08-04 1966-05-17 Petrolite Corp Process of preventing scale
CN101768276A (zh) * 2008-12-26 2010-07-07 中国科学技术大学 聚乙二醇单甲醚-聚己内酯-聚乙烯亚胺三嵌段共聚物及其应用
CN102971361A (zh) * 2010-06-25 2013-03-13 东丽株式会社 水溶性聚合物及水溶性纳米粒子复合体
WO2013137736A1 (en) * 2012-03-16 2013-09-19 Bender Analytical Holding B.V. Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline

Also Published As

Publication number Publication date
HUE040402T2 (hu) 2019-03-28
US10131747B2 (en) 2018-11-20
JP6431533B2 (ja) 2018-11-28
CA2926154A1 (en) 2015-04-09
CA2926154C (en) 2022-08-30
EP3052545B1 (de) 2018-07-25
CN105683256A (zh) 2016-06-15
DK3052545T3 (en) 2018-10-29
ES2691094T3 (es) 2018-11-23
JP2016533409A (ja) 2016-10-27
DE102013016750A1 (de) 2015-04-02
US20170166697A1 (en) 2017-06-15
WO2015048940A1 (de) 2015-04-09
EP3052545A1 (de) 2016-08-10

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HK1225051B (zh) 用於连接和释放遗传物质，特别是dna/rna，的新型聚乙烯亚胺-基共聚物及其制备方法和用途

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