DE102008057867A1 - Fettemulsion zur künstlichen Ernährung von schwerkranken Intensivpatienten - Google Patents

Fettemulsion zur künstlichen Ernährung von schwerkranken Intensivpatienten Download PDF

Info

Publication number
DE102008057867A1
DE102008057867A1 DE102008057867A DE102008057867A DE102008057867A1 DE 102008057867 A1 DE102008057867 A1 DE 102008057867A1 DE 102008057867 A DE102008057867 A DE 102008057867A DE 102008057867 A DE102008057867 A DE 102008057867A DE 102008057867 A1 DE102008057867 A1 DE 102008057867A1
Authority
DE
Germany
Prior art keywords
acid
triglyceride
pharmaceutical preparation
fatty acids
fat emulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102008057867A
Other languages
German (de)
English (en)
Inventor
Michael Boll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Braun Melsungen AG
Original Assignee
B Braun Melsungen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41581163&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE102008057867(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by B Braun Melsungen AG filed Critical B Braun Melsungen AG
Priority to DE102008057867A priority Critical patent/DE102008057867A1/de
Priority to US13/126,245 priority patent/US20110207819A1/en
Priority to JP2011536823A priority patent/JP2012509292A/ja
Priority to RU2011124887/15A priority patent/RU2528108C2/ru
Priority to BRPI0921917A priority patent/BRPI0921917B8/pt
Priority to CA2739390A priority patent/CA2739390C/en
Priority to EP09760502.6A priority patent/EP2355813B1/de
Priority to PCT/EP2009/064839 priority patent/WO2010057804A1/de
Priority to MX2011005201A priority patent/MX338223B/es
Priority to CN200980145702.6A priority patent/CN102215839B/zh
Priority to ES09760502.6T priority patent/ES2561207T3/es
Priority to KR1020117010418A priority patent/KR20110084513A/ko
Publication of DE102008057867A1 publication Critical patent/DE102008057867A1/de
Priority to US14/930,723 priority patent/US20160051506A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0029Parenteral nutrition; Parenteral nutrition compositions as drug carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Food Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE102008057867A 2008-11-18 2008-11-18 Fettemulsion zur künstlichen Ernährung von schwerkranken Intensivpatienten Withdrawn DE102008057867A1 (de)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DE102008057867A DE102008057867A1 (de) 2008-11-18 2008-11-18 Fettemulsion zur künstlichen Ernährung von schwerkranken Intensivpatienten
KR1020117010418A KR20110084513A (ko) 2008-11-18 2009-11-09 중증 집중치료 환자를 인공적으로 영양공급하기 위한 지방 유제
EP09760502.6A EP2355813B1 (de) 2008-11-18 2009-11-09 Fettemulsion zur künstlichen ernährung von schwerkranken intensivpatienten
MX2011005201A MX338223B (es) 2008-11-18 2009-11-09 Emulsion de grasas para alimentar artificialmente a pacientes seriamente enfermos en cuidados intensivos.
RU2011124887/15A RU2528108C2 (ru) 2008-11-18 2009-11-09 Жировая эмульсия для искусственного питания тяжелобольных, нуждающихся в интенсивной терапии
BRPI0921917A BRPI0921917B8 (pt) 2008-11-18 2009-11-09 formulação farmacêutica.
CA2739390A CA2739390C (en) 2008-11-18 2009-11-09 Fat emulsion for artificially feeding seriously ill intensive care patients
US13/126,245 US20110207819A1 (en) 2008-11-18 2009-11-09 Fat Emulsion for Artificially Feeding Seriously Ill Intensive Care Patients
PCT/EP2009/064839 WO2010057804A1 (de) 2008-11-18 2009-11-09 Fettemulsion zur künstlichen ernährung von schwerkranken intensivpatienten
JP2011536823A JP2012509292A (ja) 2008-11-18 2009-11-09 重症の集中治療患者への人工栄養のための脂肪乳剤
CN200980145702.6A CN102215839B (zh) 2008-11-18 2009-11-09 用于人工喂养重病的重症特护患者的脂肪乳剂
ES09760502.6T ES2561207T3 (es) 2008-11-18 2009-11-09 Emulsión grasa para alimentar artificialmente a pacientes gravemente enfermos de cuidados intensivos
US14/930,723 US20160051506A1 (en) 2008-11-18 2015-11-03 Fat Emulsion for Artificially Feeding Seriously Ill Intensive Care Patients

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102008057867A DE102008057867A1 (de) 2008-11-18 2008-11-18 Fettemulsion zur künstlichen Ernährung von schwerkranken Intensivpatienten

Publications (1)

Publication Number Publication Date
DE102008057867A1 true DE102008057867A1 (de) 2010-05-20

Family

ID=41581163

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102008057867A Withdrawn DE102008057867A1 (de) 2008-11-18 2008-11-18 Fettemulsion zur künstlichen Ernährung von schwerkranken Intensivpatienten

Country Status (12)

Country Link
US (2) US20110207819A1 (https=)
EP (1) EP2355813B1 (https=)
JP (1) JP2012509292A (https=)
KR (1) KR20110084513A (https=)
CN (1) CN102215839B (https=)
BR (1) BRPI0921917B8 (https=)
CA (1) CA2739390C (https=)
DE (1) DE102008057867A1 (https=)
ES (1) ES2561207T3 (https=)
MX (1) MX338223B (https=)
RU (1) RU2528108C2 (https=)
WO (1) WO2010057804A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009013914B4 (de) * 2009-03-19 2011-05-05 Bruker Daltonik Gmbh Kalibriersubstanzen für Atmosphärendruck-Ionenquellen
CN103338761A (zh) * 2011-01-31 2013-10-02 日本脏器制药株式会社 抗癌剂所引起的周围神经病的预防或治疗剂
US8183227B1 (en) 2011-07-07 2012-05-22 Chemo S. A. France Compositions, kits and methods for nutrition supplementation
US8168611B1 (en) 2011-09-29 2012-05-01 Chemo S.A. France Compositions, kits and methods for nutrition supplementation
CN106900888B (zh) * 2015-12-23 2021-12-24 丰益(上海)生物技术研发中心有限公司 含有奇数碳脂肪酸结构脂的油脂组合物及其应用
MX2018015188A (es) 2016-06-08 2019-08-21 Sunregen Healthcare Ag Lipidos con un numero impar de atomos de carbono y su uso como una composicion farmaceutica o como un suplemento nutricional.
CN109602704A (zh) * 2019-01-23 2019-04-12 广东嘉博制药有限公司 丁酸氯维地平脂肪乳注射液及其制备工艺
CN110326789A (zh) * 2019-06-11 2019-10-15 上海互众药业有限公司 一种脂肪乳食品补充液及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526902A (en) 1983-10-24 1985-07-02 Century Laboratories, Inc. Combined fatty acid composition for treatment or prophylaxis of thrombo-embolic conditions
EP0120169B1 (fr) 1981-10-23 1986-11-20 Roussel-Uclaf Nouveaux triglycérides, procédé de préparation, applications en diététique et en thérapeutique et les compositions les renfermant
DE3721137A1 (de) 1987-06-26 1989-01-05 Dietl Hans Fettemulsion zur intravenoesen anwendung
EP0298293A2 (de) 1987-07-08 1989-01-11 Fresenius AG Fettemulsion, Verfahren zu ihrer Herstellung und ihre Verwendung
US6740679B1 (en) 1999-02-05 2004-05-25 Baylor University Medical Center Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid
US20080132571A1 (en) 2006-09-26 2008-06-05 Baylor Research Institute Nutrient Sensor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3734147C2 (de) * 1987-10-09 1998-10-29 Braun Melsungen Ag Isotone omega-3-fettsäurenhaltige Fettemulsion und ihre Verwendung
AU682894B2 (en) * 1993-10-28 1997-10-23 Institut National De La Recherche Agronomique Composition based on amino acids intended for the treatment of sepsis or of an attack bringing about an inflammatory reaction, in animals and man
RU2155612C2 (ru) * 1997-01-30 2000-09-10 Скрипченко Наталия Викторовна Способ лечения острых инфекционных заболеваний периферической нервной системы
US20030162833A1 (en) * 2001-08-01 2003-08-28 Roe Charles R. Fatty acid treatment for cardiac patients
WO2000045649A1 (en) * 1999-02-05 2000-08-10 Baylor University Medical Center Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid
YU29804A (sh) * 2001-10-11 2006-08-17 Applied Research Systems Ars Holding N.V. Upotreba aktivatora gp-130 u dijabetskoj neuropatiji
US8399515B2 (en) * 2003-05-20 2013-03-19 Baylor Research Institute Five and fifteen carbon fatty acids for treating metabolic disorders and as nutritional supplements
EP1773317A4 (en) * 2004-07-02 2012-10-03 Baylor Res Inst METHOD OF TREATING OVERLOADING DISEASE DUE TO ACCUMULATION OF GLYCOGENES OR POLYSACCHARIDES
DE502005000555D1 (de) * 2005-02-16 2007-05-16 Streatmans Chemische Produktio Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an chemischen UV-Filtern und Triheptanonin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0120169B1 (fr) 1981-10-23 1986-11-20 Roussel-Uclaf Nouveaux triglycérides, procédé de préparation, applications en diététique et en thérapeutique et les compositions les renfermant
US4526902A (en) 1983-10-24 1985-07-02 Century Laboratories, Inc. Combined fatty acid composition for treatment or prophylaxis of thrombo-embolic conditions
DE3721137A1 (de) 1987-06-26 1989-01-05 Dietl Hans Fettemulsion zur intravenoesen anwendung
EP0298293A2 (de) 1987-07-08 1989-01-11 Fresenius AG Fettemulsion, Verfahren zu ihrer Herstellung und ihre Verwendung
US6740679B1 (en) 1999-02-05 2004-05-25 Baylor University Medical Center Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid
US20080132571A1 (en) 2006-09-26 2008-06-05 Baylor Research Institute Nutrient Sensor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
M. Alb, S. Hirner, T. Luecke, Anästhesiol. Intensivmed. Notfallmed. Schmerzther. 2007, 4, 250-258
M. S. Herridge, A. M. Cheung, C. M. Tansey, N. Engl. J. Med. 2003, 348, 683-693
O. Friedrich, E. Hund, Anaesthesist 2006, 55, 1271-1280

Also Published As

Publication number Publication date
EP2355813B1 (de) 2015-11-04
JP2012509292A (ja) 2012-04-19
WO2010057804A1 (de) 2010-05-27
EP2355813A1 (de) 2011-08-17
CN102215839A (zh) 2011-10-12
BRPI0921917B1 (pt) 2020-08-25
BRPI0921917A2 (pt) 2015-12-29
ES2561207T3 (es) 2016-02-25
MX2011005201A (es) 2011-06-01
KR20110084513A (ko) 2011-07-25
CA2739390C (en) 2016-05-03
BRPI0921917B8 (pt) 2021-05-25
US20110207819A1 (en) 2011-08-25
RU2011124887A (ru) 2012-12-27
MX338223B (es) 2016-04-08
RU2528108C2 (ru) 2014-09-10
CA2739390A1 (en) 2010-05-27
CN102215839B (zh) 2016-08-24
US20160051506A1 (en) 2016-02-25

Similar Documents

Publication Publication Date Title
EP0607231B1 (de) Verwendung einer emulsion, zur herstellung eines arzneimittels zur i.v.-verabreichung zur behandlung von hauterkrankungen
EP0456670B1 (de) Omega-3-fettsäurehaltige fettemulsion zur intraperitonealen applikation, ihre herstellung und anwendung
EP2355813B1 (de) Fettemulsion zur künstlichen ernährung von schwerkranken intensivpatienten
AT398779B (de) Fettsäurezusammensetzung, verfahren zu ihrer herstellung, ihre verwendung und pharmazeutische zusammensetzung, die sie enthält
DE69818704T2 (de) Verfahren zur verbesserung der absorption und des transport von lipidlöslichen verbindungen mittels strukturierter glyceriden
DE60116625T2 (de) Therapeutische kombinationen von fettsäuren
DE60129134T2 (de) O/w emulsion
DE69232564T2 (de) Phospholipide
DE3734147C2 (de) Isotone omega-3-fettsäurenhaltige Fettemulsion und ihre Verwendung
DE68905863T2 (de) Zusammensetzungen essentieller fettsaeuren.
EP0637957B1 (de) Verwendung einer omega-3-fettsäuren enthaltenden emulsion zur herstellung eines parenteral zu verabreichenden arzneimittels zur behandlung von entzündlichen erkrankungen
EP1633325B1 (de) Emulsion zur postnatalen hormonsubstitution
DE2905979C2 (de) Verwendung von acetylierten, destillierten Monoglyceriden zur Behandlung von Fettstoffwechselstörungen beim Menschen
DE69625616T3 (de) Lipidemulsionen mit optimierter hydrolyse sowie deren verwendung
DE3785849T2 (de) Jod enthaltende emulsion.
EP3285749A1 (de) Gelkapsel enthaltend sterol und solubilisator
DE69317716T2 (de) Verwendung von Fettsäuren zur Behandlung von abnormalen Verkalkung des Gewebes
WO2000040236A1 (de) Taxane enthaltende stabile und sterile emulsion und verfahren zu ihrer herstellung
DE3884945T2 (de) Emulsion für parenterale verabreichung.
DE102009003980A1 (de) Propofol in triheptanoinhaltiger Trägeremulsion
WO2000016770A1 (de) Taxane enthaltende pharmazeutische zubereitung und verfahren zu ihrer herstellung
EP1147769A2 (de) Verwendung von mehrfach ungesättigten Fettsäuren, insbesondere Omega-3-Fettsäuren, zur Behandlung von Enuresis und Inkontinenz

Legal Events

Date Code Title Description
R012 Request for examination validly filed
R120 Application withdrawn or ip right abandoned