DE102008027038A1 - Verfahren zum Detektieren von chemischen oder biologischen Species sowie Elektrodenanordnung hierfür - Google Patents
Verfahren zum Detektieren von chemischen oder biologischen Species sowie Elektrodenanordnung hierfür Download PDFInfo
- Publication number
- DE102008027038A1 DE102008027038A1 DE102008027038A DE102008027038A DE102008027038A1 DE 102008027038 A1 DE102008027038 A1 DE 102008027038A1 DE 102008027038 A DE102008027038 A DE 102008027038A DE 102008027038 A DE102008027038 A DE 102008027038A DE 102008027038 A1 DE102008027038 A1 DE 102008027038A1
- Authority
- DE
- Germany
- Prior art keywords
- electrode
- species
- molecule
- electrodes
- redox reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/404—Cells with anode, cathode and cell electrolyte on the same side of a permeable membrane which separates them from the sample fluid, e.g. Clark-type oxygen sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/30—Electrochemically active labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008027038A DE102008027038A1 (de) | 2008-06-06 | 2008-06-06 | Verfahren zum Detektieren von chemischen oder biologischen Species sowie Elektrodenanordnung hierfür |
| PCT/EP2009/056616 WO2009147093A1 (de) | 2008-06-06 | 2009-05-29 | Verfahren zum detektieren von chemischen oder biologischen species sowie elektrodenanordnung hierfür |
| CN200980121017.XA CN102057273B (zh) | 2008-06-06 | 2009-05-29 | 用于检测化学或生物成分的方法以及用于此的电极布置 |
| EP09757475.0A EP2286227B1 (de) | 2008-06-06 | 2009-05-29 | Verfahren zum detektieren von chemischen oder biologischen species sowie vorrichtung zum durchführen des verfahrens |
| US12/995,923 US8900440B2 (en) | 2008-06-06 | 2009-05-29 | Method for detecting chemical or biological species and electrode arrangement therefor |
| JP2011512083A JP5675594B2 (ja) | 2008-06-06 | 2009-05-29 | 化学的又は生物学的な種を検知するための方法及びそのための電極配列 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008027038A DE102008027038A1 (de) | 2008-06-06 | 2008-06-06 | Verfahren zum Detektieren von chemischen oder biologischen Species sowie Elektrodenanordnung hierfür |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102008027038A1 true DE102008027038A1 (de) | 2009-12-17 |
Family
ID=41023150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102008027038A Ceased DE102008027038A1 (de) | 2008-06-06 | 2008-06-06 | Verfahren zum Detektieren von chemischen oder biologischen Species sowie Elektrodenanordnung hierfür |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8900440B2 (https=) |
| EP (1) | EP2286227B1 (https=) |
| JP (1) | JP5675594B2 (https=) |
| CN (1) | CN102057273B (https=) |
| DE (1) | DE102008027038A1 (https=) |
| WO (1) | WO2009147093A1 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010064251A1 (de) | 2010-12-28 | 2012-06-28 | Robert Bosch Gmbh | Handmessgerät zum Nachweis von verdeckten Schimmelschäden in Innenräumen |
| WO2013144225A1 (de) | 2012-03-29 | 2013-10-03 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Integriertes einweg-chipkartuschensystem für mobile multiparameteranalysen chemischer und/oder biologischer substanzen |
| DE102012018539A1 (de) * | 2012-09-19 | 2014-03-20 | Seuffer Gmbh & Co.Kg | Verfahren und Vorrichtung zur Erfassung von Eigenschaften fluider Medien |
| US11119101B2 (en) | 2017-01-13 | 2021-09-14 | Taiwan Semiconductor Manufacturing Co., Ltd. | Cartridge and analyzer for fluid analysis |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011179893A (ja) * | 2010-02-26 | 2011-09-15 | Jfe Steel Corp | 金属内部への侵入水素量の測定方法および移動体の金属部位内部へ侵入する水素量のモニタリング方法 |
| ES2410754T3 (es) * | 2010-05-25 | 2013-07-03 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Procedimiento para la detección electroquímica de reacciones de unión |
| JP5777098B2 (ja) * | 2011-08-26 | 2015-09-09 | Jfeスチール株式会社 | 金属内部への侵入水素量の測定方法および移動体の金属部位内部へ侵入する水素量のモニタリング方法 |
| JP5754566B2 (ja) * | 2011-08-26 | 2015-07-29 | Jfeスチール株式会社 | 金属内部への侵入水素量の測定装置 |
| JP5700673B2 (ja) * | 2011-08-26 | 2015-04-15 | Jfeスチール株式会社 | 金属内部への侵入水素量の測定方法および移動体の金属部位内部へ侵入する水素量のモニタリング方法 |
| CN103175872A (zh) * | 2011-12-23 | 2013-06-26 | 长沙中生众捷生物技术有限公司 | 便携式电化学检测试纸条及其制备方法 |
| KR101364647B1 (ko) * | 2012-03-14 | 2014-02-21 | 한국수력원자력 주식회사 | 고농도 비수용액 전해질에 적용가능한 금속이온 또는 산소이온의 모니터링 방법 |
| GB201207869D0 (en) * | 2012-05-04 | 2012-06-20 | Accunostics Ltd | Pulsed signal testing of biological fluid |
| MX367230B (es) * | 2012-06-28 | 2019-08-09 | Siemens Healthcare Diagnostics Inc | Dispositivo lector y método de amplificación de señal. |
| JP5979731B2 (ja) * | 2014-01-08 | 2016-08-31 | Jfeスチール株式会社 | 移動体の金属部位内部へ侵入する水素量のモニタリング方法 |
| US10761053B2 (en) | 2014-04-23 | 2020-09-01 | Terumo Kabushiki Kaisha | Non-enzymatic electrochemical sensor for measuring analytes |
| JP6130447B2 (ja) * | 2015-07-29 | 2017-05-17 | Jfeスチール株式会社 | 移動体の金属部位内部へ侵入する水素量のモニタリング方法 |
| US20240310322A1 (en) * | 2023-03-16 | 2024-09-19 | Robert Bosch Gmbh | Diffusion-based electrochemical sensors |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4318519A1 (de) | 1993-06-03 | 1994-12-08 | Fraunhofer Ges Forschung | Elektrochemischer Sensor |
| DE19916867A1 (de) | 1999-04-14 | 2000-10-19 | Fraunhofer Ges Forschung | Anordnung und Verfahren zur Herstellung planarer Arrays mit immobilisierten Molekülen |
| WO2002081739A2 (en) | 2001-04-09 | 2002-10-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Non-enzymatic liposome-linked closely spaced array electrodes assay (nel-ela) for detecting and quantifying nucleic acids |
| WO2002082078A2 (en) | 2001-04-09 | 2002-10-17 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Activated enzyme-linked detection systems for detecting and quantifying nucleid acids, antigens antibodies and other analytes |
| EP0886773B1 (de) | 1996-03-14 | 2004-10-13 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Detektion von molekülen und molekülkomplexen |
| DE102005007539A1 (de) * | 2005-02-17 | 2006-08-31 | Universität Rostock | Einrichtung zur Bestimmung redoxaktiver Stoffe |
| DE202005020141U1 (de) * | 2005-11-29 | 2007-01-11 | Farco-Pharma Gmbh | Detektionseinheit, insbesondere Biosensor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04118554A (ja) * | 1989-12-28 | 1992-04-20 | Tosoh Corp | 電気化学的酵素測定方法およびバイオセンサ |
| AU8903998A (en) | 1997-08-12 | 1999-03-01 | Fraunhofer Institut Siliziumtechnologie | Electrochemical reporter system for detecting analytical immunoassay and mol ecular biology procedures |
| JP2003513274A (ja) * | 1999-11-02 | 2003-04-08 | アドバンスド センサー テクノロジーズ, インコーポレイテッド | 電流滴定センサおよび電位差センサの微視的組み合わせ |
| US7455975B2 (en) * | 2000-04-14 | 2008-11-25 | Esa Biosciences, Inc. | Electrochemical detection of nucleic acid sequences |
| GB2428484B (en) * | 2004-01-29 | 2008-09-10 | Siemens Ag | Method for measuring the concentration or change in concentration of a redox-active substance and associated device |
| JP4007606B2 (ja) * | 2004-02-03 | 2007-11-14 | キヤノン株式会社 | センサおよび検出方法 |
| DE102005037436A1 (de) * | 2005-08-04 | 2007-02-15 | Siemens Ag | Verfahren und System zur Konzentrationsbestimmung eines Analyt-Enzym-Komplexes oder Analyt-Enzym-Konjugats, insbesondere zur elektrochemischen Detektion des Analyten, und zugehörige Messvorrichtung |
| DE102005062159A1 (de) | 2005-11-29 | 2007-05-31 | Farco-Pharma Gmbh | Detektionseinheit, insbesondere Biosensor, und ihre Verwendung |
-
2008
- 2008-06-06 DE DE102008027038A patent/DE102008027038A1/de not_active Ceased
-
2009
- 2009-05-29 US US12/995,923 patent/US8900440B2/en active Active
- 2009-05-29 JP JP2011512083A patent/JP5675594B2/ja active Active
- 2009-05-29 EP EP09757475.0A patent/EP2286227B1/de active Active
- 2009-05-29 CN CN200980121017.XA patent/CN102057273B/zh active Active
- 2009-05-29 WO PCT/EP2009/056616 patent/WO2009147093A1/de not_active Ceased
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4318519A1 (de) | 1993-06-03 | 1994-12-08 | Fraunhofer Ges Forschung | Elektrochemischer Sensor |
| EP0886773B1 (de) | 1996-03-14 | 2004-10-13 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Detektion von molekülen und molekülkomplexen |
| DE19916867A1 (de) | 1999-04-14 | 2000-10-19 | Fraunhofer Ges Forschung | Anordnung und Verfahren zur Herstellung planarer Arrays mit immobilisierten Molekülen |
| WO2002081739A2 (en) | 2001-04-09 | 2002-10-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Non-enzymatic liposome-linked closely spaced array electrodes assay (nel-ela) for detecting and quantifying nucleic acids |
| WO2002082078A2 (en) | 2001-04-09 | 2002-10-17 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Activated enzyme-linked detection systems for detecting and quantifying nucleid acids, antigens antibodies and other analytes |
| DE102005007539A1 (de) * | 2005-02-17 | 2006-08-31 | Universität Rostock | Einrichtung zur Bestimmung redoxaktiver Stoffe |
| DE202005020141U1 (de) * | 2005-11-29 | 2007-01-11 | Farco-Pharma Gmbh | Detektionseinheit, insbesondere Biosensor |
Non-Patent Citations (5)
| Title |
|---|
| E. Nebling et al., "Electrical Detection of Viral DNA Using Ultramicroelectrode Arrays", Anal. Chem. (2004), 76(3): 689-696 |
| E. Nebling et al., Anal. Chem. (2004) 76(3), 689-696 |
| J. Albers et al., "Electrical biochip technology - a tool for microarrays and continuous monitoring", Anal Bioanal. Chem. (2003), 377(3): 521-7 |
| O. Niwa et al., Anal. Chem. (1993) 65, 1559-1563 |
| R. Hintsche et al., "Fully electrical microarrays", Electrochemistry of Nucleic acids and Proteins, Toward Electrochemical Sensors for Genomics and Proteomics, 247-277, Herausgeber E. Palecek, F. Scheller und J. Wang, Elsevier, Amsterdam, 2005 |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010064251A1 (de) | 2010-12-28 | 2012-06-28 | Robert Bosch Gmbh | Handmessgerät zum Nachweis von verdeckten Schimmelschäden in Innenräumen |
| WO2012089417A1 (de) | 2010-12-28 | 2012-07-05 | Robert Bosch Gmbh | Handmessgerät zum nachweis von verdeckten schimmelschäden |
| WO2013144225A1 (de) | 2012-03-29 | 2013-10-03 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Integriertes einweg-chipkartuschensystem für mobile multiparameteranalysen chemischer und/oder biologischer substanzen |
| DE102012018539A1 (de) * | 2012-09-19 | 2014-03-20 | Seuffer Gmbh & Co.Kg | Verfahren und Vorrichtung zur Erfassung von Eigenschaften fluider Medien |
| US9632047B2 (en) | 2012-09-19 | 2017-04-25 | Seuffer gmbH & Co. KG | Method and device for the detection of properties of fluid media |
| US11119101B2 (en) | 2017-01-13 | 2021-09-14 | Taiwan Semiconductor Manufacturing Co., Ltd. | Cartridge and analyzer for fluid analysis |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110156722A1 (en) | 2011-06-30 |
| EP2286227A1 (de) | 2011-02-23 |
| US8900440B2 (en) | 2014-12-02 |
| JP2011522266A (ja) | 2011-07-28 |
| CN102057273B (zh) | 2015-09-23 |
| EP2286227B1 (de) | 2017-12-13 |
| WO2009147093A1 (de) | 2009-12-10 |
| JP5675594B2 (ja) | 2015-02-25 |
| CN102057273A (zh) | 2011-05-11 |
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| Date | Code | Title | Description |
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| OP8 | Request for examination as to paragraph 44 patent law | ||
| R002 | Refusal decision in examination/registration proceedings | ||
| R003 | Refusal decision now final | ||
| R082 | Change of representative |
Representative=s name: STREHL SCHUEBEL-HOPF & PARTNER MBB PATENTANWAE, DE |