DE102005048824A1 - Behandlung und Prophylaxe von Mikroangiopathien - Google Patents

Behandlung und Prophylaxe von Mikroangiopathien Download PDF

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Publication number
DE102005048824A1
DE102005048824A1 DE102005048824A DE102005048824A DE102005048824A1 DE 102005048824 A1 DE102005048824 A1 DE 102005048824A1 DE 102005048824 A DE102005048824 A DE 102005048824A DE 102005048824 A DE102005048824 A DE 102005048824A DE 102005048824 A1 DE102005048824 A1 DE 102005048824A1
Authority
DE
Germany
Prior art keywords
oxo
chloro
methyl
phenyl
oxazolidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102005048824A
Other languages
German (de)
English (en)
Inventor
Elisabeth Dr. Perzborn
Frank Dr. Misselwitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Priority to DE102005048824A priority Critical patent/DE102005048824A1/de
Priority to PCT/EP2006/009373 priority patent/WO2007042146A1/de
Priority to CA002624963A priority patent/CA2624963A1/en
Priority to BRPI0617202-4A priority patent/BRPI0617202A2/pt
Priority to CNA2006800463670A priority patent/CN101325957A/zh
Priority to RU2008118100/15A priority patent/RU2008118100A/ru
Priority to US12/089,650 priority patent/US20100160301A1/en
Priority to EP06792284A priority patent/EP1937271A1/de
Priority to AU2006301650A priority patent/AU2006301650A1/en
Priority to JP2008534890A priority patent/JP2009511513A/ja
Priority to KR1020087011170A priority patent/KR20080067647A/ko
Publication of DE102005048824A1 publication Critical patent/DE102005048824A1/de
Priority to ZA200803048A priority patent/ZA200803048B/xx
Priority to IL190745A priority patent/IL190745A0/en
Priority to CR9878A priority patent/CR9878A/es
Priority to SV2008002865A priority patent/SV2009002865A/es
Priority to EC2008008358A priority patent/ECSP088358A/es
Priority to NO20082120A priority patent/NO20082120L/no
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE102005048824A 2005-10-10 2005-10-10 Behandlung und Prophylaxe von Mikroangiopathien Withdrawn DE102005048824A1 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE102005048824A DE102005048824A1 (de) 2005-10-10 2005-10-10 Behandlung und Prophylaxe von Mikroangiopathien
JP2008534890A JP2009511513A (ja) 2005-10-10 2006-09-27 微小血管障害の処置および予防
KR1020087011170A KR20080067647A (ko) 2005-10-10 2006-09-27 미세혈관병증의 치료 및 예방
BRPI0617202-4A BRPI0617202A2 (pt) 2005-10-10 2006-09-27 uso de um composto e método para o controle de microangiopatias
CNA2006800463670A CN101325957A (zh) 2005-10-10 2006-09-27 微血管病的治疗和预防
RU2008118100/15A RU2008118100A (ru) 2005-10-10 2006-09-27 Лечение и профилактика микроангиопатий
US12/089,650 US20100160301A1 (en) 2005-10-10 2006-09-27 Microangiopathy treatment and prevention
EP06792284A EP1937271A1 (de) 2005-10-10 2006-09-27 Behandlung und prophylaxe von mikroangiopathien
AU2006301650A AU2006301650A1 (en) 2005-10-10 2006-09-27 Microangiopathy treatment and prevention
PCT/EP2006/009373 WO2007042146A1 (de) 2005-10-10 2006-09-27 Behandlung und prophylaxe von mikroangiopathien
CA002624963A CA2624963A1 (en) 2005-10-10 2006-09-27 Microangiopathy treatment and prevention
ZA200803048A ZA200803048B (en) 2005-10-10 2008-04-07 Microangiopathy treatment and prevention
IL190745A IL190745A0 (en) 2005-10-10 2008-04-09 Microangiopathy treatment and prevention
CR9878A CR9878A (es) 2005-10-10 2008-04-09 Tratamiento y profilaxis de microangiopatias
SV2008002865A SV2009002865A (es) 2005-10-10 2008-04-09 Uso de oxazolidinonas para el tratamiento y profilaxis de microangiopatias
EC2008008358A ECSP088358A (es) 2005-10-10 2008-04-09 Tratamiento y profilaxis de microangiopatías
NO20082120A NO20082120L (no) 2005-10-10 2008-05-06 Behandling og forebyggelse av mikroangiopati

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005048824A DE102005048824A1 (de) 2005-10-10 2005-10-10 Behandlung und Prophylaxe von Mikroangiopathien

Publications (1)

Publication Number Publication Date
DE102005048824A1 true DE102005048824A1 (de) 2007-04-12

Family

ID=37492407

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102005048824A Withdrawn DE102005048824A1 (de) 2005-10-10 2005-10-10 Behandlung und Prophylaxe von Mikroangiopathien

Country Status (17)

Country Link
US (1) US20100160301A1 (US07585860-20090908-C00112.png)
EP (1) EP1937271A1 (US07585860-20090908-C00112.png)
JP (1) JP2009511513A (US07585860-20090908-C00112.png)
KR (1) KR20080067647A (US07585860-20090908-C00112.png)
CN (1) CN101325957A (US07585860-20090908-C00112.png)
AU (1) AU2006301650A1 (US07585860-20090908-C00112.png)
BR (1) BRPI0617202A2 (US07585860-20090908-C00112.png)
CA (1) CA2624963A1 (US07585860-20090908-C00112.png)
CR (1) CR9878A (US07585860-20090908-C00112.png)
DE (1) DE102005048824A1 (US07585860-20090908-C00112.png)
EC (1) ECSP088358A (US07585860-20090908-C00112.png)
IL (1) IL190745A0 (US07585860-20090908-C00112.png)
NO (1) NO20082120L (US07585860-20090908-C00112.png)
RU (1) RU2008118100A (US07585860-20090908-C00112.png)
SV (1) SV2009002865A (US07585860-20090908-C00112.png)
WO (1) WO2007042146A1 (US07585860-20090908-C00112.png)
ZA (1) ZA200803048B (US07585860-20090908-C00112.png)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009018807A1 (de) * 2007-08-06 2009-02-12 Schebo Biotech Ag Oxazolidinone als faktor xa- inhibitoren, verfahren zu ihrer herstellung und ihre verwendung in der therapie
EP3078378A1 (en) 2015-04-08 2016-10-12 Vaiomer Use of factor xa inhibitors for regulating glycemia

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
SG166126A1 (en) 2005-10-04 2010-11-29 Bayer Schering Pharma Ag Novel polymorphous form and the amorphous form of 5-chloro-n-({(5s)-2-oxo- 3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
US7700590B2 (en) 2006-02-09 2010-04-20 University Of New Orleans Research And Technology Foundation, Inc. Antibacterial agents
MX2009009304A (es) * 2007-03-01 2009-11-18 Novartis Ag Inhibidores de cinasa pim y metodos para su uso.
DE102007018662A1 (de) * 2007-04-20 2008-10-23 Bayer Healthcare Ag Oxazolidinone zur Behandlung und Prophylaxe von pulmonaler Hypertonie
WO2009103439A1 (en) * 2008-02-21 2009-08-27 Sanofi-Aventis Chlorothiophene-isoxazoles as inhibitors of coagulation factors xa and thrombin
US7816355B1 (en) 2009-04-28 2010-10-19 Apotex Pharmachem Inc Processes for the preparation of rivaroxaban and intermediates thereof
CN104693139B (zh) * 2011-01-07 2017-04-19 浙江九洲药业股份有限公司 一种合成利伐沙班中间体的新工艺
CN102746287B (zh) * 2012-06-21 2014-05-28 成都苑东药业有限公司 一种恶唑烷酮化合物及其制备方法
CN103724336B (zh) * 2013-12-24 2015-10-21 悦康药业集团有限公司 一种新型抗凝血药物的合成方法
CN104402876A (zh) * 2014-11-25 2015-03-11 沈阳药科大学 噁唑烷酮类化合物及其应用
CN104478866B (zh) * 2014-12-05 2017-07-07 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN104447730B (zh) * 2014-12-05 2017-11-07 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN104447728B (zh) * 2014-12-05 2017-01-04 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN104478869B (zh) * 2014-12-05 2017-04-12 广东东阳光药业有限公司 噁唑烷酮类化合物及其在药物中的应用
CN104497008B (zh) * 2014-12-09 2016-11-16 广东东阳光药业有限公司 取代噁唑烷酮类化合物及其使用方法和用途
US11608320B2 (en) 2020-02-02 2023-03-21 Kuwait University Oxazolidinone hydroxamic acid derivatives

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US2811555A (en) * 1955-05-02 1957-10-29 Eastman Kodak Co Reduction of 2-nitroso-5-diethylaminotoluene
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4128654A (en) * 1978-02-10 1978-12-05 E. I. Du Pont De Nemours And Company 5-Halomethyl-3-phenyl-2-oxazolidinones
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
CA2119556C (en) * 1991-11-01 2004-07-06 Michael Robert Barbachyn Substituted aryl- and heteroaryl-phenyloxazolidinones
US5349045A (en) * 1993-01-26 1994-09-20 United States Surgical Corporation Polymer derived from cyclic amide and medical devices manufactured therefrom
ES2134870T3 (es) * 1993-05-01 1999-10-16 Merck Patent Gmbh Antagonistas del receptor de adhesion.
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DE19524765A1 (de) * 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009018807A1 (de) * 2007-08-06 2009-02-12 Schebo Biotech Ag Oxazolidinone als faktor xa- inhibitoren, verfahren zu ihrer herstellung und ihre verwendung in der therapie
EP3078378A1 (en) 2015-04-08 2016-10-12 Vaiomer Use of factor xa inhibitors for regulating glycemia
WO2016162472A1 (en) 2015-04-08 2016-10-13 Vaiomer Use of factor xa inhibitors for regulating glycemia

Also Published As

Publication number Publication date
NO20082120L (no) 2008-06-18
EP1937271A1 (de) 2008-07-02
SV2009002865A (es) 2009-01-14
KR20080067647A (ko) 2008-07-21
AU2006301650A1 (en) 2007-04-19
JP2009511513A (ja) 2009-03-19
US20100160301A1 (en) 2010-06-24
CR9878A (es) 2008-07-29
CN101325957A (zh) 2008-12-17
RU2008118100A (ru) 2009-11-20
CA2624963A1 (en) 2007-04-19
IL190745A0 (en) 2008-12-29
ZA200803048B (en) 2009-08-26
BRPI0617202A2 (pt) 2011-07-19
ECSP088358A (es) 2008-06-30
WO2007042146A1 (de) 2007-04-19

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Legal Events

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8139 Disposal/non-payment of the annual fee