DE102005034973A1 - Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen - Google Patents

Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen Download PDF

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Publication number
DE102005034973A1
DE102005034973A1 DE102005034973A DE102005034973A DE102005034973A1 DE 102005034973 A1 DE102005034973 A1 DE 102005034973A1 DE 102005034973 A DE102005034973 A DE 102005034973A DE 102005034973 A DE102005034973 A DE 102005034973A DE 102005034973 A1 DE102005034973 A1 DE 102005034973A1
Authority
DE
Germany
Prior art keywords
methyl
cyclohex
dimethylamino
crystalline form
phenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102005034973A
Other languages
German (de)
English (en)
Inventor
Michael Dr. Gruss
Wolfgang Dr. Hell
Martin Szelagiewicz
Jörg Dr. Berghausen
Susan Margaret de Dr. Paul
Markus von Dr. Raumer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE102005034973A priority Critical patent/DE102005034973A1/de
Priority to PCT/EP2006/007163 priority patent/WO2007009794A1/de
Priority to EP06776327A priority patent/EP1907351A1/de
Priority to CA002615741A priority patent/CA2615741A1/en
Priority to JP2008521895A priority patent/JP5205260B2/ja
Priority to PCT/EP2006/007161 priority patent/WO2007009793A1/de
Priority to EP06776326A priority patent/EP1907350B1/de
Priority to JP2008521896A priority patent/JP5323480B2/ja
Priority to DK06776326.8T priority patent/DK1907350T3/da
Priority to EP10014791A priority patent/EP2336103A3/de
Priority to PL06776326T priority patent/PL1907350T3/pl
Priority to CA002615742A priority patent/CA2615742A1/en
Priority to PE2006000872A priority patent/PE20070375A1/es
Priority to SI200631292T priority patent/SI1907350T1/sl
Priority to ES06776326T priority patent/ES2380799T3/es
Priority to AT06776326T priority patent/ATE540919T1/de
Priority to PT06776326T priority patent/PT1907350E/pt
Priority to ARP060103154A priority patent/AR057673A1/es
Priority to US11/491,100 priority patent/US20070032551A1/en
Priority to PCT/EP2006/008113 priority patent/WO2007025649A1/de
Publication of DE102005034973A1 publication Critical patent/DE102005034973A1/de
Priority to US12/016,506 priority patent/US8058476B2/en
Priority to US12/627,190 priority patent/US20100076085A1/en
Priority to US13/165,331 priority patent/US20110251287A1/en
Priority to CY20121100333T priority patent/CY1112741T1/el
Priority to JP2012198012A priority patent/JP2013018776A/ja
Priority to US13/874,851 priority patent/US20130245125A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE102005034973A 2005-07-22 2005-07-22 Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen Withdrawn DE102005034973A1 (de)

Priority Applications (26)

Application Number Priority Date Filing Date Title
DE102005034973A DE102005034973A1 (de) 2005-07-22 2005-07-22 Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen
ES06776326T ES2380799T3 (es) 2005-07-22 2006-07-20 Sal de ácido fumárico y 3-(2-dimetilamino)metil- (cicloex-1-il))-fenol y sus formas cristalinas
SI200631292T SI1907350T1 (sl) 2005-07-22 2006-07-20 Sol fumarne kisline in 3-(2-dimetilamino)metil-(cikloheks-1-il)fenola in njene kristalinične oblike
CA002615741A CA2615741A1 (en) 2005-07-22 2006-07-20 Salt of fumaric acid and 3-(2-dimethylamino)methyl(cyclohex-1-yl))phenol and its crystalline forms
JP2008521895A JP5205260B2 (ja) 2005-07-22 2006-07-20 フマル酸と３−（２−ジメチルアミノ）メチル−（シクロヘキシ−１−イル）フェノールとの塩及びその結晶形
PCT/EP2006/007161 WO2007009793A1 (de) 2005-07-22 2006-07-20 Salz von fumarsäure und 3- (2-dimethylamino) methyl- ( cyclohex-1-yl) ) phenol un dessen kristalline formen
EP06776326A EP1907350B1 (de) 2005-07-22 2006-07-20 Salz von fumarsäure und 3- (2-dimethylamino) methyl- ( cyclohex-1-yl) ) phenol un dessen kristalline formen
JP2008521896A JP5323480B2 (ja) 2005-07-22 2006-07-20 ３−［２−（ジメチルアミノ）メチル−（シクロヘキシ−１−イル）］−フェノールのＨＣｌ多形体
DK06776326.8T DK1907350T3 (da) 2005-07-22 2006-07-20 Salt af fumarsyre og 3-(2-dimethylamino)methyl-(cyclohex-1-yl)phenol og krystalline former deraf
EP10014791A EP2336103A3 (de) 2005-07-22 2006-07-20 HCL-Polymorphe von 3-[2-(Dimethylamino)methyl-(cyclohex-1-yl)]phenol
EP06776327A EP1907351A1 (de) 2005-07-22 2006-07-20 Hcl-polymorphe von 3 - ( 2- (dimethylamino) methyl- ( cyclohex-i-yl) ) phenol
CA002615742A CA2615742A1 (en) 2005-07-22 2006-07-20 Hcl polymorphs of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol
AT06776326T ATE540919T1 (de) 2005-07-22 2006-07-20 Salz von fumarsäure und 3- (2-dimethylamino) methyl- ( cyclohex-1-yl) ) phenol un dessen kristalline formen
PCT/EP2006/007163 WO2007009794A1 (de) 2005-07-22 2006-07-20 Hcl-polymorphe von 3 - ( 2- (dimethylamino) methyl- ( cyclohex-i-yl) ) phenol
PL06776326T PL1907350T3 (pl) 2005-07-22 2006-07-20 Sole kwasu fumarowego i 3-(2-dimetyloamino)-metylo-(cyklohek-1-ylo)-fenolu i ich formy krystaliczne
PE2006000872A PE20070375A1 (es) 2005-07-22 2006-07-20 Sal fumarato del 3-[2-(dimetilamino)metil-(ciclohex-1-il)]-fenol y sus formas cristalinas
PT06776326T PT1907350E (pt) 2005-07-22 2006-07-20 Sal do ácido fumárico e de 3-[2-(dimetilamino)metil-(ciclohex- 1-il)]-fenol e suas formas cristalinas
ARP060103154A AR057673A1 (es) 2005-07-22 2006-07-21 Sal de dimetilaminometil - fenil ciclohexano y su forma cristalina
US11/491,100 US20070032551A1 (en) 2005-07-22 2006-07-24 Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof
PCT/EP2006/008113 WO2007025649A1 (de) 2005-07-22 2006-08-17 Verfahren zur herstellung von polyesterpolyolen und deren verwendung
US12/016,506 US8058476B2 (en) 2005-07-22 2008-01-18 HCI polymorphs of 3-((2-(dimethylamino)methyl(cyclohex-1-yl)) phenol
US12/627,190 US20100076085A1 (en) 2005-07-22 2009-11-30 HCl Polymorphs of 3-((2-(Dimethylamino)methyl-(cyclohex-1-yl))phenol
US13/165,331 US20110251287A1 (en) 2005-07-22 2011-06-21 Hci polymorphs of 3-((2-(dimethylamino)methyl (cyclohex-1-yl))phenol
CY20121100333T CY1112741T1 (el) 2005-07-22 2012-04-04 Αλας φουμαρικου οξεος και 3-[2-(διμεθυλαμινο)μεθυλο-(κυκλοεξ-1-υλο)]-φαινολη και οι κρυσταλλικες μορφες της
JP2012198012A JP2013018776A (ja) 2005-07-22 2012-09-10 ３−［２−（ジメチルアミノ）メチル−（シクロヘキシ−１−イル）］−フェノールのＨＣｌ多形体
US13/874,851 US20130245125A1 (en) 2005-07-22 2013-05-01 HCl Polymorphs of 3-((2-(Dimethylamino)methyl(cyclohex-1-yl))phenol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005034973A DE102005034973A1 (de) 2005-07-22 2005-07-22 Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen

Publications (1)

Publication Number Publication Date
DE102005034973A1 true DE102005034973A1 (de) 2007-02-15

Family

ID=37101332

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102005034973A Withdrawn DE102005034973A1 (de) 2005-07-22 2005-07-22 Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen

Country Status (14)

Country Link
EP (1) EP1907350B1 (https=)
JP (1) JP5205260B2 (https=)
AR (1) AR057673A1 (https=)
AT (1) ATE540919T1 (https=)
CA (1) CA2615741A1 (https=)
CY (1) CY1112741T1 (https=)
DE (1) DE102005034973A1 (https=)
DK (1) DK1907350T3 (https=)
ES (1) ES2380799T3 (https=)
PE (1) PE20070375A1 (https=)
PL (1) PL1907350T3 (https=)
PT (1) PT1907350E (https=)
SI (1) SI1907350T1 (https=)
WO (1) WO2007009793A1 (https=)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525137A1 (de) * 1995-07-11 1997-01-16 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen als pharmazeutische Wirkstoffe
DE10000312A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
DE10233048A1 (de) * 2002-07-19 2004-01-29 Grünenthal GmbH Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10218862A1 (de) * 2002-04-26 2003-11-06 Gruenenthal Gmbh Verfahren zur Chlorierung tertiärer Alkohole
DE10356362A1 (de) * 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525137A1 (de) * 1995-07-11 1997-01-16 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen als pharmazeutische Wirkstoffe
DE10000312A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
DE10233048A1 (de) * 2002-07-19 2004-01-29 Grünenthal GmbH Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken

Also Published As

Publication number Publication date
JP5205260B2 (ja) 2013-06-05
SI1907350T1 (sl) 2012-04-30
EP1907350A1 (de) 2008-04-09
EP1907350B1 (de) 2012-01-11
JP2009502758A (ja) 2009-01-29
CA2615741A1 (en) 2007-01-25
ES2380799T3 (es) 2012-05-18
WO2007009793A1 (de) 2007-01-25
PT1907350E (pt) 2012-03-29
AR057673A1 (es) 2007-12-12
DK1907350T3 (da) 2012-05-07
CY1112741T1 (el) 2016-02-10
PL1907350T3 (pl) 2012-06-29
PE20070375A1 (es) 2007-05-12
ATE540919T1 (de) 2012-01-15

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Legal Events

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OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
R012 Request for examination validly filed

Effective date: 20120606

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20140201