CY1112741T1 - Αλας φουμαρικου οξεος και 3-[2-(διμεθυλαμινο)μεθυλο-(κυκλοεξ-1-υλο)]-φαινολη και οι κρυσταλλικες μορφες της - Google Patents

Αλας φουμαρικου οξεος και 3-[2-(διμεθυλαμινο)μεθυλο-(κυκλοεξ-1-υλο)]-φαινολη και οι κρυσταλλικες μορφες της

Info

Publication number
CY1112741T1
CY1112741T1 CY20121100333T CY121100333T CY1112741T1 CY 1112741 T1 CY1112741 T1 CY 1112741T1 CY 20121100333 T CY20121100333 T CY 20121100333T CY 121100333 T CY121100333 T CY 121100333T CY 1112741 T1 CY1112741 T1 CY 1112741T1
Authority
CY
Cyprus
Prior art keywords
cyclohex
methyl
salum
fenol
dimethylamine
Prior art date
Application number
CY20121100333T
Other languages
English (en)
Inventor
Michael Gruss
Wolfgang Hell
Martin Szelagiewicz
Jörg Berghausen
Paul Susan Margaret De
Raumer Markus Von
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1112741T1 publication Critical patent/CY1112741T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η 3-[2-(διμεθυλαμινο)μεθυλο-(κυκλοεξ-1-υλο)]-φαινόλη-φουμαρικό είναι ένα αναλγητικό με μια πολύ καλή δράση. Η κρυσταλλική μορφή Β αποδείχθηκε τόσο χημικά όσο επίσης φυσικά πολύ σταθερή και κατάλληλη ιδιαίτερα για την παρασκευή της δραστικής ουσίας και φαρμακευτικών συνθέσεων.
CY20121100333T 2005-07-22 2012-04-04 Αλας φουμαρικου οξεος και 3-[2-(διμεθυλαμινο)μεθυλο-(κυκλοεξ-1-υλο)]-φαινολη και οι κρυσταλλικες μορφες της CY1112741T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005034973A DE102005034973A1 (de) 2005-07-22 2005-07-22 Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen
EP06776326A EP1907350B1 (de) 2005-07-22 2006-07-20 Salz von fumarsäure und 3- (2-dimethylamino) methyl- ( cyclohex-1-yl) ) phenol un dessen kristalline formen

Publications (1)

Publication Number Publication Date
CY1112741T1 true CY1112741T1 (el) 2016-02-10

Family

ID=37101332

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100333T CY1112741T1 (el) 2005-07-22 2012-04-04 Αλας φουμαρικου οξεος και 3-[2-(διμεθυλαμινο)μεθυλο-(κυκλοεξ-1-υλο)]-φαινολη και οι κρυσταλλικες μορφες της

Country Status (14)

Country Link
EP (1) EP1907350B1 (el)
JP (1) JP5205260B2 (el)
AR (1) AR057673A1 (el)
AT (1) ATE540919T1 (el)
CA (1) CA2615741A1 (el)
CY (1) CY1112741T1 (el)
DE (1) DE102005034973A1 (el)
DK (1) DK1907350T3 (el)
ES (1) ES2380799T3 (el)
PE (1) PE20070375A1 (el)
PL (1) PL1907350T3 (el)
PT (1) PT1907350E (el)
SI (1) SI1907350T1 (el)
WO (1) WO2007009793A1 (el)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE10000312A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
DE10218862A1 (de) * 2002-04-26 2003-11-06 Gruenenthal Gmbh Verfahren zur Chlorierung tertiärer Alkohole
DE10233048A1 (de) * 2002-07-19 2004-01-29 Grünenthal GmbH Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken
DE10356362A1 (de) * 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen

Also Published As

Publication number Publication date
SI1907350T1 (sl) 2012-04-30
CA2615741A1 (en) 2007-01-25
EP1907350B1 (de) 2012-01-11
EP1907350A1 (de) 2008-04-09
PT1907350E (pt) 2012-03-29
PL1907350T3 (pl) 2012-06-29
JP5205260B2 (ja) 2013-06-05
PE20070375A1 (es) 2007-05-12
ATE540919T1 (de) 2012-01-15
DK1907350T3 (da) 2012-05-07
ES2380799T3 (es) 2012-05-18
DE102005034973A1 (de) 2007-02-15
JP2009502758A (ja) 2009-01-29
AR057673A1 (es) 2007-12-12
WO2007009793A1 (de) 2007-01-25

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