CY1109208T1 - Μηλεϊκη 3-(2-(διμεθυλαμινο) μεθυλ (κυκλοεξ-1-υλ)) φαινολη και οι κρυσταλλικες μορφες της - Google Patents

Μηλεϊκη 3-(2-(διμεθυλαμινο) μεθυλ (κυκλοεξ-1-υλ)) φαινολη και οι κρυσταλλικες μορφες της

Info

Publication number
CY1109208T1
CY1109208T1 CY20091100706T CY091100706T CY1109208T1 CY 1109208 T1 CY1109208 T1 CY 1109208T1 CY 20091100706 T CY20091100706 T CY 20091100706T CY 091100706 T CY091100706 T CY 091100706T CY 1109208 T1 CY1109208 T1 CY 1109208T1
Authority
CY
Cyprus
Prior art keywords
methyl
malexic
bimethylamino
cycloex
final
Prior art date
Application number
CY20091100706T
Other languages
English (en)
Inventor
Martin Szelagiewicz
Wolfgang Hell
Raumer Markus Von
Paul Susan Margaret De
Jörg Berghausen
Michael Gruss
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1109208T1 publication Critical patent/CY1109208T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Η μηλεϊκή 3-[2-(διμεθυλαμινο) μεθυλ (κυκλοεξ-1-υλ)] φαινόλη είναι ένα αναλγητικό με πολύ καλή δράση. Ο κρυσταλλικός Τύπος Α έχει αποδειχτεί πολύ σταθερή τόσο από χημικής όσο και από φυσικής άποψης και είναι ιδιαίτερα κατάλληλη για την παρασκευή της δραστικής ουσίας και φαρμακευτικών συνθέσεων.
CY20091100706T 2005-07-22 2009-07-03 Μηλεϊκη 3-(2-(διμεθυλαμινο) μεθυλ (κυκλοεξ-1-υλ)) φαινολη και οι κρυσταλλικες μορφες της CY1109208T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005034974A DE102005034974A1 (de) 2005-07-22 2005-07-22 Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen
EP06776325A EP1881956B1 (de) 2005-07-22 2006-07-20 3-(2-(dimethylamino)methyl-(cyclohex-1-yl))phenol-maleat und dessen kristalline formen

Publications (1)

Publication Number Publication Date
CY1109208T1 true CY1109208T1 (el) 2014-07-02

Family

ID=37084866

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100706T CY1109208T1 (el) 2005-07-22 2009-07-03 Μηλεϊκη 3-(2-(διμεθυλαμινο) μεθυλ (κυκλοεξ-1-υλ)) φαινολη και οι κρυσταλλικες μορφες της

Country Status (26)

Country Link
EP (1) EP1881956B1 (el)
JP (1) JP5205259B2 (el)
KR (1) KR20080033436A (el)
CN (1) CN101228110A (el)
AR (1) AR057674A1 (el)
AT (1) ATE431332T1 (el)
AU (1) AU2006271856B2 (el)
BR (1) BRPI0614057A2 (el)
CA (1) CA2615926A1 (el)
CY (1) CY1109208T1 (el)
DE (2) DE102005034974A1 (el)
DK (1) DK1881956T3 (el)
EC (1) ECSP088088A (el)
ES (1) ES2326493T3 (el)
HK (1) HK1112612A1 (el)
HR (1) HRP20090412T1 (el)
IL (1) IL188897A (el)
MX (1) MX2008000743A (el)
NO (1) NO20080826L (el)
PE (1) PE20070368A1 (el)
PL (1) PL1881956T3 (el)
PT (1) PT1881956E (el)
RU (1) RU2434845C2 (el)
SI (1) SI1881956T1 (el)
WO (1) WO2007009792A1 (el)
ZA (1) ZA200801703B (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI384986B (zh) * 2007-01-17 2013-02-11 Lg Life Sciences Ltd 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
HUE031126T2 (en) * 2007-12-07 2017-07-28 Gruenenthal Gmbh Crystalline modifications of (1R, 2R) -3- (3-Dimethylamino-1-ethyl-2-methylpropyl) phenol
EP2085081A1 (de) 2008-02-04 2009-08-05 Grünenthal GmbH 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE10218862A1 (de) * 2002-04-26 2003-11-06 Gruenenthal Gmbh Verfahren zur Chlorierung tertiärer Alkohole
DE10356362A1 (de) * 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen

Also Published As

Publication number Publication date
RU2008106455A (ru) 2009-08-27
PE20070368A1 (es) 2007-05-12
ZA200801703B (en) 2009-08-26
NO20080826L (no) 2008-02-20
RU2434845C2 (ru) 2011-11-27
JP5205259B2 (ja) 2013-06-05
AR057674A1 (es) 2007-12-12
EP1881956B1 (de) 2009-05-13
ATE431332T1 (de) 2009-05-15
BRPI0614057A2 (pt) 2012-12-11
WO2007009792A1 (de) 2007-01-25
PT1881956E (pt) 2009-06-26
KR20080033436A (ko) 2008-04-16
PL1881956T3 (pl) 2009-10-30
IL188897A0 (en) 2008-04-13
HRP20090412T1 (hr) 2009-09-30
ES2326493T3 (es) 2009-10-13
DE102005034974A1 (de) 2007-04-19
IL188897A (en) 2012-12-31
CN101228110A (zh) 2008-07-23
AU2006271856B2 (en) 2012-03-01
SI1881956T1 (sl) 2009-10-31
DK1881956T3 (da) 2009-09-07
HK1112612A1 (en) 2008-09-12
ECSP088088A (es) 2008-02-20
EP1881956A1 (de) 2008-01-30
JP2009502757A (ja) 2009-01-29
CA2615926A1 (en) 2007-01-25
DE502006003728D1 (de) 2009-06-25
AU2006271856A1 (en) 2007-01-25
MX2008000743A (es) 2008-03-10

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