DK1824479T3 - Phenylpiperazin-derivater med en kombination af delvis dopamin-D2-receptoragonisme og serotonin-genoptagelsesinhibering - Google Patents

Phenylpiperazin-derivater med en kombination af delvis dopamin-D2-receptoragonisme og serotonin-genoptagelsesinhibering

Info

Publication number
DK1824479T3
DK1824479T3 DK05816322T DK05816322T DK1824479T3 DK 1824479 T3 DK1824479 T3 DK 1824479T3 DK 05816322 T DK05816322 T DK 05816322T DK 05816322 T DK05816322 T DK 05816322T DK 1824479 T3 DK1824479 T3 DK 1824479T3
Authority
DK
Denmark
Prior art keywords
serotonin reuptake
combination
reuptake inhibition
phenylpiperazine derivatives
receptor agonism
Prior art date
Application number
DK05816322T
Other languages
English (en)
Inventor
Roelof W Feenstra
Axel Stoit
Jan-Willem Terpstra
Maria L Pras-Raves
Andrew C Mccreary
Vliet Bernard J Van
Mayke B Hesselink
Cornelis G Kruse
Scharrenburg G J M Van
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Application granted granted Critical
Publication of DK1824479T3 publication Critical patent/DK1824479T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
DK05816322T 2004-12-08 2005-12-06 Phenylpiperazin-derivater med en kombination af delvis dopamin-D2-receptoragonisme og serotonin-genoptagelsesinhibering DK1824479T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63407404P 2004-12-08 2004-12-08
EP04106394 2004-12-08
PCT/EP2005/056507 WO2006061378A1 (en) 2004-12-08 2005-12-06 Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition

Publications (1)

Publication Number Publication Date
DK1824479T3 true DK1824479T3 (da) 2009-03-09

Family

ID=35744728

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05850037T DK1827427T3 (da) 2004-12-08 2005-12-06 Aryloxyethylaminderivater med en kombination af partiel dopamin-D2 receptoragonisme og inhibition af genoptag af serotonin
DK05816322T DK1824479T3 (da) 2004-12-08 2005-12-06 Phenylpiperazin-derivater med en kombination af delvis dopamin-D2-receptoragonisme og serotonin-genoptagelsesinhibering

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK05850037T DK1827427T3 (da) 2004-12-08 2005-12-06 Aryloxyethylaminderivater med en kombination af partiel dopamin-D2 receptoragonisme og inhibition af genoptag af serotonin

Country Status (18)

Country Link
EP (4) EP1824480A1 (da)
JP (4) JP2008523030A (da)
KR (4) KR20070085959A (da)
AT (2) ATE413173T1 (da)
AU (4) AU2005313311A1 (da)
BR (1) BRPI0518613A2 (da)
CA (4) CA2587202A1 (da)
DE (2) DE602005008471D1 (da)
DK (2) DK1827427T3 (da)
ES (2) ES2311245T3 (da)
HR (2) HRP20080538T3 (da)
IL (4) IL183063A0 (da)
NO (4) NO20072969L (da)
PL (2) PL1827427T3 (da)
PT (2) PT1824479E (da)
RU (4) RU2007125659A (da)
SI (2) SI1824479T1 (da)
WO (4) WO2006061378A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007085651A1 (en) * 2006-01-30 2007-08-02 Speedel Experimenta Ag Process for the stereoselective preparation of alcohols from alpha, beta- insaturated compounds
US8063062B2 (en) 2006-12-20 2011-11-22 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition
US8138174B2 (en) 2007-01-10 2012-03-20 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
CA2671554A1 (en) * 2007-01-10 2008-07-17 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
RU2480462C2 (ru) * 2007-04-23 2013-04-27 Янссен Фармацевтика Н.В. Производные пиридина, используемые в качестве быстро диссоциирующихся антагонистов допаминовых рецепторов 2
PT2148873E (pt) * 2007-04-23 2012-11-20 Janssen Pharmaceutica Nv Derivados da 4-alcoxipiridazina antagonistas de dissociação rápida do recetor da dopamina 2
MX2009011416A (es) * 2007-04-23 2009-11-05 Janssen Pharmaceutica Nv Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida.
CN103360342B (zh) * 2012-04-09 2015-12-16 江苏恩华药业股份有限公司 3-氰基苯胺烷基芳基哌嗪衍生物及在制备药物中的应用
CN103570698B (zh) * 2012-08-01 2016-08-03 江苏恩华药业股份有限公司 用于制备维拉佐酮的化合物及其中间体和应用
ITMI20130392A1 (it) * 2013-03-15 2014-09-16 Dipharma Francis Srl Sintesi di un inibitore della ricaptazione della serotonina
EP3010586A1 (en) 2013-06-21 2016-04-27 Lupin Limited Substituted heterocyclic compounds as crac modulators
US9790231B2 (en) 2013-06-24 2017-10-17 Lupin Limited Chromane and chromene derivatives and their use as CRAC modulators
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
AU3386199A (en) * 1998-04-08 1999-10-25 American Home Products Corporation N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents)
AU765317C (en) * 1998-06-19 2004-05-20 H. Lundbeck A/S 4,5,6 and 7-indole and indoline derivatives, their preparation and use
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
BR0013498A (pt) * 1999-08-23 2002-05-14 Solvay Pharm Bv Composto, método para a preparação do mesmo, composição farmacêutica, e, métodos para a preparação da mesma e para o tratamento de distúrbios do snc
KR20050085472A (ko) * 2002-12-10 2005-08-29 메르크 파텐트 게엠베하 인돌 유도체 및 ５-ｈｔ 리간드로서의 이의 용도

Also Published As

Publication number Publication date
PT1824479E (pt) 2009-01-30
HRP20080538T3 (en) 2008-12-31
CA2587381A1 (en) 2006-06-15
DE602005008471D1 (de) 2008-09-04
HRP20090015T3 (en) 2009-02-28
ATE413173T1 (de) 2008-11-15
JP2008537725A (ja) 2008-09-25
JP2008523031A (ja) 2008-07-03
IL183061A0 (en) 2007-09-20
WO2006061376A1 (en) 2006-06-15
SI1824479T1 (sl) 2009-04-30
KR20070085959A (ko) 2007-08-27
AU2005313312A1 (en) 2006-06-15
SI1827427T1 (sl) 2008-12-31
EP1824480A1 (en) 2007-08-29
RU2007125660A (ru) 2009-01-20
IL183063A0 (en) 2007-09-20
IL183064A0 (en) 2007-09-20
EP1824479A1 (en) 2007-08-29
PL1824479T3 (pl) 2009-04-30
PT1827427E (pt) 2008-11-03
CA2587202A1 (en) 2006-06-15
AU2005313311A1 (en) 2006-06-15
EP1824479B1 (en) 2008-11-05
CA2587357A1 (en) 2006-06-15
AU2005313390A1 (en) 2006-06-15
KR20070085916A (ko) 2007-08-27
EP1827427A1 (en) 2007-09-05
AU2005313391A1 (en) 2006-06-15
IL183062A0 (en) 2007-09-20
WO2006061379A1 (en) 2006-06-15
EP1827426A1 (en) 2007-09-05
DE602005010902D1 (de) 2008-12-18
DK1827427T3 (da) 2008-11-24
KR20070085975A (ko) 2007-08-27
WO2006061378A1 (en) 2006-06-15
CA2587559A1 (en) 2006-06-15
ES2317335T3 (es) 2009-04-16
NO20072974L (no) 2007-08-23
RU2007125659A (ru) 2009-01-20
ES2311245T3 (es) 2009-02-01
JP2008523029A (ja) 2008-07-03
JP2008523030A (ja) 2008-07-03
PL1827427T3 (pl) 2009-01-30
NO20072981L (no) 2007-09-05
BRPI0518613A2 (pt) 2008-11-25
WO2006061377A1 (en) 2006-06-15
NO20072969L (no) 2007-08-31
EP1827427B1 (en) 2008-07-23
NO20072977L (no) 2007-09-05
KR20070085988A (ko) 2007-08-27
RU2007125661A (ru) 2009-01-20
RU2007125658A (ru) 2009-01-20
ATE401883T1 (de) 2008-08-15

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