NO20072969L - Fenylpiperazinderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering - Google Patents

Fenylpiperazinderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering

Info

Publication number
NO20072969L
NO20072969L NO20072969A NO20072969A NO20072969L NO 20072969 L NO20072969 L NO 20072969L NO 20072969 A NO20072969 A NO 20072969A NO 20072969 A NO20072969 A NO 20072969A NO 20072969 L NO20072969 L NO 20072969L
Authority
NO
Norway
Prior art keywords
serotonin reuptake
combination
reuptake inhibition
phenylpiperazine derivatives
receptor agonism
Prior art date
Application number
NO20072969A
Other languages
English (en)
Inventor
Gustaaf Johan Mar Scharrenburg
Roelof W Feenstra
Cornelis Gerrit Kruse
Andrew C Mccreary
Maria L Pras-Raves
Mayke B Hesselink
Jan-Willem Terpstra
Axel Stoit
Bernard J Van Vliet
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of NO20072969L publication Critical patent/NO20072969L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Oppfinnelsen angår en gruppe nye fenylpiperazinderivater med en dual virkningsmodus: serotoningjenopptakingsinhibering og delvis agonisme på dopamin-D2 reseptorer. Oppfinnelsen angår også anvendelse av en forbindelse beskrevet heri for fremstilling av et medikament som gir en fordelaktig effekt. Forbindelsene har den generelle formelen (1): hvori symbolene har betydningene gitt i beskrivelsen, og tautomerer, stereoisomerer og N-oksider derav, så vel som farmakologisk akseptable salter, hydrater og solvater av nevnte forbindelser med formel (1) og dens tautomerer, stereoisomerer og N-oksider.
NO20072969A 2004-12-08 2007-06-11 Fenylpiperazinderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering NO20072969L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63407404P 2004-12-08 2004-12-08
EP04106394 2004-12-08
PCT/EP2005/056507 WO2006061378A1 (en) 2004-12-08 2005-12-06 Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition

Publications (1)

Publication Number Publication Date
NO20072969L true NO20072969L (no) 2007-08-31

Family

ID=35744728

Family Applications (4)

Application Number Title Priority Date Filing Date
NO20072981A NO20072981L (no) 2004-12-08 2007-06-11 Fenylpiperazinderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering
NO20072974A NO20072974L (no) 2004-12-08 2007-06-11 Fenylpiperazinderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering
NO20072977A NO20072977L (no) 2004-12-08 2007-06-11 Aryloksyetylaminderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering
NO20072969A NO20072969L (no) 2004-12-08 2007-06-11 Fenylpiperazinderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering

Family Applications Before (3)

Application Number Title Priority Date Filing Date
NO20072981A NO20072981L (no) 2004-12-08 2007-06-11 Fenylpiperazinderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering
NO20072974A NO20072974L (no) 2004-12-08 2007-06-11 Fenylpiperazinderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering
NO20072977A NO20072977L (no) 2004-12-08 2007-06-11 Aryloksyetylaminderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering

Country Status (18)

Country Link
EP (4) EP1824479B1 (no)
JP (4) JP2008523031A (no)
KR (4) KR20070085988A (no)
AT (2) ATE413173T1 (no)
AU (4) AU2005313390A1 (no)
BR (1) BRPI0518613A2 (no)
CA (4) CA2587357A1 (no)
DE (2) DE602005008471D1 (no)
DK (2) DK1824479T3 (no)
ES (2) ES2317335T3 (no)
HR (2) HRP20080538T3 (no)
IL (4) IL183064A0 (no)
NO (4) NO20072981L (no)
PL (2) PL1824479T3 (no)
PT (2) PT1827427E (no)
RU (4) RU2007125658A (no)
SI (2) SI1827427T1 (no)
WO (4) WO2006061376A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1979323A1 (en) * 2006-01-30 2008-10-15 Speedel Experimenta AG Process for the stereoselective preparation of alcohols from alpha, beta-insaturated compounds
US8063062B2 (en) 2006-12-20 2011-11-22 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition
US8138174B2 (en) 2007-01-10 2012-03-20 Solvay Pharmaceuticals B.V. Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
EA200970672A1 (ru) * 2007-01-10 2010-02-26 Солвей Фармасьютикалс Б.В. Соединения с комбинацией каннабиноид-свантагонизма и ингибирования обратного захвата серотонина
PT2148873E (pt) * 2007-04-23 2012-11-20 Janssen Pharmaceutica Nv Derivados da 4-alcoxipiridazina antagonistas de dissociação rápida do recetor da dopamina 2
KR20100016498A (ko) * 2007-04-23 2010-02-12 얀센 파마슈티카 엔.브이. 속해리성 도파민 2 수용체 길항제로서의 피리딘 유도체
JP5431306B2 (ja) * 2007-04-23 2014-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしてのチア（ジア）ゾール
CN103360342B (zh) * 2012-04-09 2015-12-16 江苏恩华药业股份有限公司 3-氰基苯胺烷基芳基哌嗪衍生物及在制备药物中的应用
CN103570698B (zh) * 2012-08-01 2016-08-03 江苏恩华药业股份有限公司 用于制备维拉佐酮的化合物及其中间体和应用
ITMI20130392A1 (it) * 2013-03-15 2014-09-16 Dipharma Francis Srl Sintesi di un inibitore della ricaptazione della serotonina
CA2914132A1 (en) 2013-06-21 2014-12-24 Lupin Limited Substituted heterocyclic compounds as crac modulators
AU2014300629A1 (en) 2013-06-24 2015-12-24 Lupin Limited Chromane and chromene derivatives and their use as CRAC modulators
WO2015014256A1 (en) 2013-07-29 2015-02-05 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
CA2327359A1 (en) * 1998-04-08 1999-10-14 Wyeth N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents)
EP1089997A1 (en) * 1998-06-19 2001-04-11 H.Lundbeck A/S 4,5,6 and 7-indole and indoline derivatives, their preparation and use
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
TR200200460T2 (tr) * 1999-08-23 2002-06-21 Solvay Pharmaceuticals B.V. Yeni fenilpiperazinler
BR0317126A (pt) * 2002-12-10 2005-10-25 Merck Patent Gmbh Derivados de indol e o uso dos mesmos como ligantes de 5-ht

Also Published As

Publication number Publication date
EP1824480A1 (en) 2007-08-29
IL183063A0 (en) 2007-09-20
AU2005313311A1 (en) 2006-06-15
IL183062A0 (en) 2007-09-20
WO2006061376A1 (en) 2006-06-15
HRP20090015T3 (en) 2009-02-28
KR20070085988A (ko) 2007-08-27
SI1824479T1 (sl) 2009-04-30
CA2587357A1 (en) 2006-06-15
IL183064A0 (en) 2007-09-20
DE602005010902D1 (de) 2008-12-18
PT1827427E (pt) 2008-11-03
WO2006061378A1 (en) 2006-06-15
JP2008523031A (ja) 2008-07-03
WO2006061377A1 (en) 2006-06-15
JP2008537725A (ja) 2008-09-25
RU2007125660A (ru) 2009-01-20
ES2311245T3 (es) 2009-02-01
NO20072981L (no) 2007-09-05
RU2007125659A (ru) 2009-01-20
JP2008523030A (ja) 2008-07-03
ATE413173T1 (de) 2008-11-15
AU2005313312A1 (en) 2006-06-15
EP1827426A1 (en) 2007-09-05
ES2317335T3 (es) 2009-04-16
AU2005313391A1 (en) 2006-06-15
RU2007125661A (ru) 2009-01-20
SI1827427T1 (sl) 2008-12-31
KR20070085975A (ko) 2007-08-27
IL183061A0 (en) 2007-09-20
PT1824479E (pt) 2009-01-30
EP1827427A1 (en) 2007-09-05
KR20070085959A (ko) 2007-08-27
EP1824479B1 (en) 2008-11-05
PL1824479T3 (pl) 2009-04-30
CA2587381A1 (en) 2006-06-15
WO2006061379A1 (en) 2006-06-15
NO20072977L (no) 2007-09-05
DK1824479T3 (da) 2009-03-09
KR20070085916A (ko) 2007-08-27
BRPI0518613A2 (pt) 2008-11-25
DE602005008471D1 (de) 2008-09-04
EP1827427B1 (en) 2008-07-23
AU2005313390A1 (en) 2006-06-15
EP1824479A1 (en) 2007-08-29
DK1827427T3 (da) 2008-11-24
NO20072974L (no) 2007-08-23
HRP20080538T3 (en) 2008-12-31
ATE401883T1 (de) 2008-08-15
PL1827427T3 (pl) 2009-01-30
CA2587559A1 (en) 2006-06-15
CA2587202A1 (en) 2006-06-15
JP2008523029A (ja) 2008-07-03
RU2007125658A (ru) 2009-01-20

Similar Documents

Publication Publication Date Title
NO20072981L (no) Fenylpiperazinderivater med en kombinasjon av partiell dopamin-D2-receptoragonisme og serotoningjenopptaksinhibering
SG151254A1 (en) Substituted morpholine and thiomorpholine derivatives
TW201000473A (en) Benzene or thiophene derivative and use thereof as VAP-1 inhibitor
UY31940A (es) Derivados sustituido del 4,5-(sustituido-piridin-3-il)-1-metil-1h-indol, sus sales farmacéuticamente aceptables, polimorfos, rotámeros, pro-fármacos, anantiómeros, hidratos, solvatos del mismo, composiciones conteniéndolos y aplicaciones
NO20082136L (no) 1,5-substituerte indol-2-yl-amidderivater
UA92670C2 (ru) Пиразолиновые соединения и их фармацевтическое применение, композиция на их основе
MX2009003713A (es) Inhibidor de progresion de enfermedad de alzheimer que contiene un compuesto heterociclico con estructura especifica.
NO20082096L (no) Azaindol-2-karboksamidderivativer
MXPA05010000A (es) Derivados de p-diaminobenceno substituidos.
TW200639177A (en) Dihydroimidazothiazole derivatives
UA94603C2 (ru) Производные тетрагидронафталина, способ их получения и их применения в качестве ингибиторов воспаления
TW200621703A (en) Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
TW200631952A (en) Benzdioxan piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
TW200633987A (en) Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
TW200716555A (en) Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
TW200634009A (en) Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
SG171472A1 (en) Substituted aniline derivatives
NO20073390L (no) Fenylpiperaziner med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter
ATE522530T1 (de) 2-piperazin-1-yl-3h-imidazoä4,5-bü- pyridinderivate

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application